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Dietary supplement

LongJax 400 mg Ingredients & Drug Interactions

by Swanson Passion

LongJax 400 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking LongJax 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

LongJax 400 mg is a dietary supplement by Swanson Passion with 1 active ingredient. Its ingredients are commonly taken for low testosterone or low libido in men, male fertility support, athletic performance and muscle strength.Based on those ingredients, 248 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are LongJaX 20:1 exrtract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against LongJax 400 mg by Swanson Passion

Ask about any prescription or over-the-counter medication and we check it for interactions with LongJax 400 mg by Swanson Passion — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of LongJax 400 mg by Swanson Passion

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

LongJax 400 mg contains a single active ingredient: Eurycoma longifolia extract (20:1 concentration, meaning 20 pounds of plant material concentrated into 1 pound of extract) at 400 mg per capsule. The capsules also hold three inactive ingredients—gelatin, rice flour, and magnesium stearate—which are fillers and binders that give the capsule its form and stability.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: sexual satisfaction and male enhancement.
  • We looked for evidence on: Erectile dysfunction (ED), Sexual desire, Male Infertility, Muscle strength, Athletic performance, Age-related testosterone deficiency — and 3 related terms.
  • The strongest evidence on file: Eurycoma Longifolia is rated "Possibly Effective" for Sexual desire (Natural Medicines).
  • Also on file: Eurycoma Longifolia is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Eurycoma Longifolia is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Muscle strength, Age-related testosterone deficiency, Male Infertility.

The evidence for LongJax is limited and mixed. For sexual desire, the data suggests it's possibly effective—studies do show some benefit for this use.

For athletic performance, the evidence points to possibly ineffective. For back pain, osteoporosis, and diabetes, there's insufficient reliable evidence to rate whether it works; we simply don't have enough data from quality studies to say one way or the other.

The evidence, ingredient by ingredient Eurycoma Longifolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Eurycoma longifolia is generally well tolerated in short-term studies, but long-term safety data and product quality consistency remain uncertain. Because the extract may raise testosterone levels beyond normal and data on its hormonal effects in pregnancy and breastfeeding is lacking, the safety notes advise against use during pregnancy and breastfeeding.

If testosterone levels rise above the normal range, there's a risk of testosterone-related side effects including acne, insulin resistance, and liver problems.

Side effects, ingredient by ingredient Eurycoma Longifolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • For scale: 248 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check propranolol (Inderal) or other beta blockers with your pharmacist — the extract can meaningfully lower their effectiveness. You should also verify any drugs that go through the liver enzymes CYP1A2, CYP2C19, or CYP2A6, or if you're taking testosterone supplements or hormone medications.

Use the interaction search tool on this page to enter your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

LongJax may be worth considering if you're exploring options for sexual desire and don't take propranolol or medications that depend on the liver enzymes CYP1A2, CYP2C19, or CYP2A6. If you take any prescription medication, are pregnant, breastfeeding, or considering testosterone supplementation, talk with your doctor or pharmacist before starting.

The long-term safety picture still needs more research.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about LongJax 400 mg, straight from the product label.

Brand Swanson Passion
Barcode (UPC) 087614080185
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD May 24, 2018
DSLD ID 175743
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for LongJax 400 mg by Swanson Passion, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
087614080185
IngredientAmount% DV
LongJaX 20:1 exrtract400 mg--

Other ingredients: Gelatin, Rice Flour, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Products for more sexual satisfaction

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

Formula

Eurycoma longifolia Jack extract

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Guaranteed purity & potency

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take one capsule per day with water or as needed.

Brand IP Statement(s)

LongJaX is a registered trademark of AIDP, Inc. All rights reserved. LongJaX—“the only One Capsule A Day solution”

General

SWP018 Rev 1 05 11 17

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

LongJax 400 mg by Swanson Passion label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

LongJax 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in LongJax 400 mg by Swanson Passion

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

LongJaX 20:1 exrtract

Interacts with
248 drugs
400 mg per serving

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small huma...

LongJaX 20:1 exrtract monograph & interactions

Other (inactive) ingredients: Gelatin, Rice Flour, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

LongJax 400 mg by Swanson Passion Drug Interactions

Want to check YOUR meds against LongJax 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
248Drugs
3 Moderate 245 Minor

Ingredients driving the most interactions

LongJaX 20:1 exrtract 248

Individual Drug Interactions

The ingredients in LongJax 400 mg interact with 248 drugs. Click any drug to see the details.

1 of the 1 ingredient in LongJax 400 mg interact with drugs. Each result below shows which ingredient is responsible. LongJaX 20:1 exrtract

Each ingredient & the kinds of drugs it affects

For each ingredient in LongJax 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

LongJaX 20:1 exrtract5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
LongJaX 20:1 exrtract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for LongJax 400 mg, from the product label.

Swanson Passion

See all Swanson Passion products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

LongJax 400 mg by Swanson Passion: Common Questions

Does LongJax 400 mg by Swanson Passion interact with any medications?
Yes. Based on its ingredients, LongJax 400 mg has a known interaction with 248 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
LongJax 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does LongJax really improve sexual desire?
The evidence is possibly effective for sexual desire based on clinical data, though the quality and size of studies are limited. Results vary from person to person, so it may work for you or it may not — talk with your doctor if you're considering it for this reason.
Can I take this while I'm on propranolol for my heart?
Not without checking first. Eurycoma longifolia reduces propranolol levels by up to 29% in studies, which can make it less effective at controlling your heart rate or blood pressure. Talk to your doctor or pharmacist before combining them.
Is it safe to take long-term?
Short-term studies show it's generally well tolerated, but we don't have solid data on long-term safety or consistent product quality across brands. If you're thinking about taking it for months, discuss that timeline with your healthcare provider.
Is LongJax safe during pregnancy or breastfeeding?
No. The safety data doesn't exist for pregnancy, and the extract may affect hormone levels, so pregnancy is not recommended. For breastfeeding, there's no reliable safety information, so it's best to avoid it then too. Talk with your doctor if you're pregnant or planning to become pregnant.
What are the side effects if testosterone goes too high?
If Eurycoma longifolia raises your testosterone above the normal range, you could see acne, insulin resistance, and liver problems. This risk is higher if you're also taking testosterone supplements or medications, so check with your pharmacist.
What is Eurycoma longifolia and what does it do?
Eurycoma longifolia, also called Tongkat Ali, is a plant extract traditionally used to support sexual function and male vitality. This product contains a 20:1 concentrated extract, meaning the plant material has been concentrated to increase potency.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

LongJax 400 mg label
Go deeper

The Full Monographs Behind LongJax 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph →
Sources

Sources & How We Checked

LongJax 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Eurycoma Longifolia 4 references
  1. Salman SA, Amrah S, Wahab MS, et al. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. J Clin Pharm Ther 2010;35:691-6. PubMed
  2. Tambi MI, Imran MK, Henkel RR. Standardised water-soluble extract of Eurycoma longifolia, Tongkat ali, as testosterone booster for managing men with late-onset hypogonadism? Andrologia 2011 Jun 15. doi: 10.1111/j.1439-0272.2011.01168.x. [Epub ahead of pri PubMed
  3. Han YM, Kim IS, Rehman SU, Choe K, Yoo HH. In vitro evaluation of the effects of Eurycoma longifolia extract on CYP-mediated drug metabolism. Evid Based Complement Alternat Med 2015;2015:631329.
  4. Chinnappan SM, George A, Pandey P, Narke G, Choudhary YK. Effect of Eurycoma longifolia standardised aqueous root extract-Physta ® on testosterone levels and quality of life in ageing male subjects: a randomised, double-blind, placebo-controlled multicent

See these in context on the Eurycoma Longifolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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