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Dietary supplement

Low-Dose Vitamin K2 45 mcg Ingredients & Drug Interactions

by Life Extension

Low-Dose Vitamin K2 45 mcg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Low-Dose Vitamin K2 45 mcg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Low-Dose Vitamin K2 45 mcg is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K2. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Low-Dose Vitamin K2 45 mcg by Life Extension

Ask about any prescription or over-the-counter medication and we check it for interactions with Low-Dose Vitamin K2 45 mcg by Life Extension — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Low-Dose Vitamin K2 45 mcg by Life Extension

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel capsule contains a single active ingredient: vitamin K2 at 45 mcg per dose. The remaining ingredients are inactive — medium chain triglycerides, gelatin, glycerin, purified water, beeswax, carob color, olive oil, and sunflower oil — which serve as the capsule matrix and help deliver the nutrient.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Vitamin K2 for bone and cardiovascular health.
  • We looked for evidence on: Cardiovascular disease (CVD), Osteoporosis, Vitamin K-dependent clotting factors deficiency (VKCFD), Hemorrhagic disease, Hypoprothrombinemia, Warfarin anticoagulation — and 3 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Hypoprothrombinemia, Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Vitamin K2 is effective for preventing and treating certain bleeding disorders tied to vitamin K deficiency, including hypoprothrombinemia (low levels of clotting proteins), vitamin K-dependent clotting factor deficiency, and hemorrhagic disease. It's also considered possibly effective for osteoporosis, though the evidence is less established than for bleeding prevention.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, vitamin K is generally well tolerated. The most common side effects are mild stomach upset — nausea, diarrhea, and abdominal pain — and most people don't experience them at this dose.

Vitamin K is rated likely safe in pregnancy and lactation. That said, because of its interaction with warfarin and other blood thinners, anyone on those medications should talk with their doctor or pharmacist before using a vitamin K supplement, even at low doses.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Warfarin (Coumadin) and other blood thinners (anticoagulants): Vitamin K2 can reduce their blood-thinning effects. Check with your doctor or pharmacist before taking this product alongside any anticoagulant.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This supplement is straightforward for most people: one active ingredient, minimal side effects, and a proven track record for bleeding prevention. But if you're on warfarin or another blood thinner, don't start it without clearing it with your own doctor or pharmacist first — vitamin K can interfere with how those drugs work.

Otherwise, it's worth discussing with your healthcare provider if you think you need it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Low-Dose Vitamin K2 45 mcg, straight from the product label.

Brand Life Extension
Barcode (UPC) 737870122593
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58957
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Low-Dose Vitamin K2 45 mcg by Life Extension, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
737870122593
IngredientAmount% DV
Vitamin K245 mcg56%

Other ingredients: Medium Chain Triglycerides, Gelatin, Glycerin, purified Water, Beeswax, Carob color, Olive Oil, Sunflower Oil

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Scan for product info

Promotes Arterial Health and Healthy Bones*

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Suggested/Recommended/Usage/Directions

Read the entire label and follow the directions carefully prior to use. Directions: Take one (1) softgel daily with food, or as recommended by a healthcare practitioner.

Precautions

CAUTION: If you are taking anti-coagulant or anti-platelet medications, or have a bleeding disorder, consult your healthcare provider before taking this product.

-DO NOT EXCEED RECOMMENDED DOSE. -Do not purchase if outer seal is broken or damaged.

-When using nutritional supplement, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

Contains soybeans.

Storage

Store tightly closed in a cool, dry place.

General

Q01225G

Brand IP Statement(s)

WARNINGS: -Keep out of reach of children.

Formula

Menaquinone-7 (MK-7)

Contains soybeans.

FDA Statement of Identity

Dietary Supplement

Formulation

Non-GMO

FDA Disclaimer Statement

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Low-Dose Vitamin K2 45 mcg by Life Extension label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Low-Dose Vitamin K2 45 mcg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Low-Dose Vitamin K2 45 mcg by Life Extension

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Vitamin K2

Interacts with
2 drugs
45 mcg per serving Form: Menaquinone-7

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K2 monograph & interactions

Other (inactive) ingredients: Medium Chain Triglycerides, Gelatin, Glycerin, Purified Water, Beeswax, Carob color, Olive Oil, Sunflower Oil. These complete the product’s ingredient list but are not active constituents.

Interaction report

Low-Dose Vitamin K2 45 mcg by Life Extension Drug Interactions

Want to check YOUR meds against Low-Dose Vitamin K2 45 mcg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K2 2

Individual Drug Interactions

The ingredients in Low-Dose Vitamin K2 45 mcg interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Low-Dose Vitamin K2 45 mcg interact with drugs. Each result below shows which ingredient is responsible. Vitamin K2

Each ingredient & the kinds of drugs it affects

For each ingredient in Low-Dose Vitamin K2 45 mcg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K21 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K2 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Low-Dose Vitamin K2 45 mcg, from the product label.

Life Extension

See all Life Extension products
Name
Quality Supplements and Vitamins, Inc.
City
Ft. Lauderdale
State
FL
ZipCode
33309
Phone Number
1-866-280-2852
Web Address
LifeExtension.com
Pharmacist Counseling Corner

Low-Dose Vitamin K2 45 mcg by Life Extension: Common Questions

Does Low-Dose Vitamin K2 45 mcg by Life Extension interact with any medications?
Yes. Based on its ingredients, Low-Dose Vitamin K2 45 mcg has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Low-Dose Vitamin K2 45 mcg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this give me stomach problems?
Nausea, diarrhea, and mild abdominal pain are the most common side effects when vitamin K is taken by mouth, but they're mild and not everyone gets them. At this 45 mcg dose, serious stomach issues are unlikely.
Is it safe to take while pregnant or breastfeeding?
Yes — vitamin K2 is rated likely safe during pregnancy and lactation. If you have specific health concerns, confirm with your own doctor or pharmacist.
What's the difference between vitamin K2 and other forms of vitamin K?
The facts here cover vitamin K2 specifically. Your doctor or pharmacist can explain how K2 compares to K1 and other forms if you're trying to decide which is right for you.
Does it really help with osteoporosis?
Vitamin K2 is possibly effective for osteoporosis according to the evidence we have — meaning it shows promise, but the science isn't as solid as it is for bleeding prevention. Talk with your doctor about whether it fits your bone health plan.
What's in the capsule besides the vitamin K?
The capsule itself is gelatin, and it also contains medium chain triglycerides, glycerin, beeswax, carob color, olive oil, sunflower oil, and purified water — all inactive ingredients that help hold and deliver the vitamin K.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Low-Dose Vitamin K2 45 mcg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Low-Dose Vitamin K2 45 mcg label
Go deeper

The Full Monographs Behind Low-Dose Vitamin K2 45 mcg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Low-Dose Vitamin K2 45 mcg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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