Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

Lung, Bronchial & Sinus Health Ingredients & Drug Interactions

by Natural Factors

Lung, Bronchial & Sinus Health label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lung, Bronchial & Sinus Health against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Lung, Bronchial & Sinus Health is a dietary supplement by Natural Factors with 6 active ingredients. Its ingredients are commonly taken for thinning mucus in lung conditions, acetaminophen (tylenol) overdose treatment, antioxidant and glutathione support.Based on those ingredients, 2,116 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Marshmallow extract, Wild Cherry extract, N-Acetyl-L-Cysteine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Lung, Bronchial & Sinus Health by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with Lung, Bronchial & Sinus Health by Natural Factors — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Lung, Bronchial & Sinus Health by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Ivy extract” is listed as a grouped ingredient — the label gives one combined amount (50 mg) without saying how much of each component you get.

This product contains 6 active ingredients. N-acetyl cysteine (NAC) is a compound derived from the amino acid L-cysteine that helps break down mucus in the lungs and respiratory tract.

Marshmallow extract, mullein extract, and wild cherry extract are herbal ingredients traditionally used for respiratory support. Bromelain is an enzyme derived from pineapple that has proteolytic (protein-breaking) activity.

Ivy extract is included as a proprietary blend. The tablet also contains inactive ingredients — microcrystalline cellulose, croscarmellose sodium, a coating, and magnesium stearate — which are standard binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Nourish and support respiratory system.
  • We looked for evidence on: Asthma, Bronchitis, Bronchiectasis, Bronchopulmonary dysplasia, Cough, Cystic fibrosis — and 4 related terms.
  • The strongest evidence on file: N-acetyl Cysteine (nac) is rated "Possibly Effective" for Bronchitis (Natural Medicines).
  • Also on file: N-acetyl Cysteine (nac) is rated "Possibly Ineffective" for Bronchopulmonary dysplasia, Cystic fibrosis.
  • Also on file: Mullein is rated "Insufficient Reliable Evidence To Rate" for Bronchitis, Asthma, Cough, Pneumonia.

The evidence for these ingredients varies widely. N-acetyl cysteine is rated effective for acetaminophen poisoning, atelectasis (collapsed lung tissue), bronchial diagnostic studies, and tracheostomy care, and possibly effective for bronchitis.

For marshmallow extract, bromelain, mullein extract, and wild cherry extract, the evidence in our data is rated insufficient — we don't have reliable data to say whether they work for their intended respiratory uses. Effectiveness ratings for these ingredients in treating cough, bronchitis, or other respiratory conditions have not been established in the data we hold.

The evidence, ingredient by ingredient N-acetyl Cysteine (nac) Marshmallow Mullein Wild Cherry English Ivy Bromelain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

N-acetyl cysteine is generally well tolerated at typical doses. The most common side effects when taken by mouth are diarrhea, dry mouth, upset stomach, heartburn, nausea, and vomiting — most of these occur at doses above 9 grams per single dose or more than 30 grams daily.

Joint pain has been reported in clinical trials. Marshmallow extract is generally well tolerated for short-term use, but human safety data are limited.

Mullein extract is similarly well tolerated short-term, with rare case reports of skin irritation from topical exposure. Wild cherry contains cyanide-forming compounds — the product is considered safe in small amounts used in commercial cough products, but large amounts can be dangerous.

Bromelain is generally well tolerated by mouth but may cause diarrhea, gas, stomach upset, or headache. Allergic reactions, including asthma-like symptoms if inhaled, have been reported in people sensitive to bromelain.

During pregnancy, safety data for marshmallow extract, mullein extract, and bromelain are insufficient — talk with your doctor before use. Wild cherry is rated likely unsafe in pregnancy.

Breastfeeding safety data are not sufficient for any of these ingredients except wild cherry, which should be avoided.

Side effects, ingredient by ingredient N-acetyl Cysteine (nac) Marshmallow Mullein Wild Cherry English Ivy Bromelain

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Mullein, Marshmallow, Wild Cherry, Bromelain, N-acetyl Cysteine (nac).
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; lithium.
  • For scale: 2,102 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take nitroglycerin (for angina), do not use this product without talking to your prescriber first — the interaction is major. Check your blood pressure medications, blood thinners (anticoagulants and antiplatelet drugs like warfarin or aspirin), the antimalarial chloroquine, and any drugs metabolized by CYP3A4 (including certain statins and antifungal medications).

If you take tetracycline antibiotics or lithium, also flag those with your pharmacist before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product may help with respiratory and sinus health, but N-acetyl cysteine carries significant interactions — especially if you take nitroglycerin or blood pressure medications. If you're on any prescription or over-the-counter drugs, check them with the tool on this page before you start.

Talk to your pharmacist or doctor, particularly if you're pregnant, breastfeeding, or taking blood thinners or heart medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lung, Bronchial & Sinus Health, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958035055
Net contents 90 Tablet(s)
Market status On market
Date entered into DSLD May 22, 2021
DSLD ID 247485
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lung, Bronchial & Sinus Health by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
068958035055
IngredientAmount% DV
N-Acetyl-L-Cysteine200 mg--
Marshmallow extract100 mg--
Mullein extract100 mg--
Wild Cherry extract100 mg--
Ivy extract50 mg--
Bromelain100 mg--
Hederocoside C5 mg--

Other ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Coating, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols

Isura Non-GMO - Mass spec Documentation - Lab tested

Suggested/Recommended/Usage/Directions

Suggested Usage: Adults and children over 12 years of age: 1 tablet 3–4 times per day or as directed by a health professional. Children 6–12 years of age: 1 tablet 3 times per day or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formulation

Lung, Bronchial & Sinus Health is a natural source formula designed to nourish and support the entire respiratory system.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Contains no artificial preservatives or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs.

Respiratory health

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Product in Canada Recyclable container and label.

Item # Q058140

FDA Statement of Identity

Dietary Supplement

Formula

GDU (Gelatin Digesting Units)

Brand IP Statement(s)

Isura is a registered trademark of ISURA

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lung, Bronchial & Sinus Health by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lung, Bronchial & Sinus Health label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lung, Bronchial & Sinus Health by Natural Factors

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

N-Acetyl-L-Cysteine

Interacts with
294 drugs
200 mg per serving

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established...

N-Acetyl-L-Cysteine monograph & interactions

Marshmallow extract

Interacts with
2,040 drugs
100 mg per serving

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats,...

Marshmallow extract monograph & interactions

Mullein extract

Interacts with
122 drugs
100 mg per serving

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality huma...

Mullein extract monograph & interactions

Wild Cherry extract

Interacts with
643 drugs
100 mg per serving

Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific evidence p...

Wild Cherry extract monograph & interactions

Ivy extract

Interacts with
280 drugs
50 mg per serving

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many...

Ivy extract monograph & interactions
  • › Hederocoside C

Bromelain

Interacts with
141 drugs
100 mg per serving Form: Pineapple

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Croscarmellose Sodium, Coating, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lung, Bronchial & Sinus Health by Natural Factors Drug Interactions

Want to check YOUR meds against Lung, Bronchial & Sinus Health?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,116Drugs
1 Major 979 Moderate 1,136 Minor

Ingredients driving the most interactions

Marshmallow extract 2,040
Wild Cherry extract 643
N-Acetyl-L-Cysteine 294
Ivy extract 280
Bromelain 141

Individual Drug Interactions

The ingredients in Lung, Bronchial & Sinus Health interact with 2,116 drugs. Click any drug to see the details.

6 of the 6 ingredients in Lung, Bronchial & Sinus Health interact with drugs. Each result below shows which ingredient is responsible. Marshmallow extract Wild Cherry extract N-Acetyl-L-Cysteine Ivy extract Bromelain Mullein extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lung, Bronchial & Sinus Health with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Marshmallow extract3 drug types · 2,040 drugs

Lithium

Theoretically, due to potential diuretic effects, marshmallow might reduce excretion and increase levels of lithium.
Marshmallow is thought to have diuretic properties. To avoid lithium toxicity, the dose of lithium might need to be decreased when used with marshmallow.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, marshmallow flower might have antiplatelet effects.
Animal research suggests that marshmallow flower extract has antiplatelet effects. However, the root and leaf of marshmallow, not the flower, are the plant parts most commonly found in dietary supplements. Theoretically, use of marshmallow flower with anticoagulant/antiplatelet drugs can have additive effects, and might increase the risk for bleeding in some patients.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, mucilage in marshmallow might impair absorption of oral drugs.
Marshmallow contains mucilage which can affect oral drug absorption. To avoid changes in absorption, take marshmallow 30-60 minutes after oral medications.

Likelihood Possible Evidence D
Marshmallow extract full monograph & interactions

Wild Cherry extract1 drug type · 643 drugs

Cytochrome P450 3A4 (Cyp3A4) Substrates

In vitro research suggests that wild cherry can inhibit cytochrome P450 3A4 (CYP3A4) enzymes. Theoretically, wild cherry might increase levels of drugs metabolized by CYP3A4. However, so far, this interaction has not been reported in humans.
Some drugs metabolized by CYP3A4 include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and others.

Likelihood Possible Evidence D
Wild Cherry extract full monograph & interactions

N-Acetyl-L-Cysteine5 drug types · 294 drugs

Nitroglycerin

N-acetyl cysteine can increase the risk for hypotension and headaches when taken with intravenous or transdermal nitroglycerin.
Clinical research shows that concomitant administration of N-acetyl cysteine and intravenous or transdermal nitroglycerin can cause severe hypotension and intolerable headaches. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Probable Evidence B
Activated Charcoal

N-acetyl cysteine might reduce the effects of activated charcoal, while activated charcoal might reduce the absorption of N-acetyl cysteine.
N-acetyl cysteine appears to reduce the capacity of activated charcoal to adsorb acetaminophen and salicylic acid. Conversely, although clinical research suggests that although activated charcoal can reduce the absorption of N-acetyl cysteine by up to 40%, it does not seem to reduce its clinical effects. Other clinical evidence suggests that activated charcoal does not affect the absorption of N-acetyl cysteine.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, N-acetyl cysteine might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Clinical research suggests that intravenous N-acetyl cysteine decreases prothrombin time, prolongs coagulation time, decreases platelet aggregation, and increases blood loss in surgical patients. Furthermore, in vitro research suggests that N-acetyl cysteine increases the anticoagulant activity of nitroglycerin.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, N-acetyl cysteine might increase the risk of hypotension when taken with antihypertensive drugs.
Animal research suggests that N-acetyl cysteine potentiates the hypotensive effects of the angiotensin-converting enzyme inhibitors (ACEIs) captopril and enalaprilat. Theoretically, combining N-acetyl cysteine with other antihypertensive drugs might increase the risk of hypotension.

Likelihood Possible Evidence D
Chloroquine (Aralen)

Theoretically, N-acetyl cysteine might interfere with the antimalarial effects of chloroquine.
Animal research suggests that N-acetyl cysteine might reduce the antimalarial effects of chloroquine by increasing cellular levels of glutathione.

Likelihood Possible Evidence D
N-Acetyl-L-Cysteine full monograph & interactions

Ivy extract3 drug types · 280 drugs

Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C19.
In vitro research shows that English ivy inhibits CYP2C19 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C8 (Cyp2C8) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2C8.
In vitro research shows that English ivy inhibits CYP2C8 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, English ivy might increase the levels of drugs metabolized by CYP2D6.
In vitro research shows that English ivy inhibits CYP2D6 enzymes. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Ivy extract full monograph & interactions

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions

Mullein extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Lab tests on extracts from different parts of common and dense-flowered mullein plants show that they do have some blood-thinning effects, as they increase the time it takes for blood to clot. This is likely due to at least one of the known constituents of muellein, triterpenoid saponins. However, the effects appear to be mild and results have been inconsistent. Extracts from different plant parts have been show to have varying anticoagulant strengths, with water-based ones being more potent than alcohol-based extracts.

Likelihood Unlikely Evidence A
Mullein extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lung, Bronchial & Sinus Health, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Lung, Bronchial & Sinus Health by Natural Factors: Common Questions

Does Lung, Bronchial & Sinus Health by Natural Factors interact with any medications?
Yes. Based on its ingredients, Lung, Bronchial & Sinus Health has a known interaction with 2,116 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lung, Bronchial & Sinus Health contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help me with a cough or bronchitis?
N-acetyl cysteine is rated possibly effective for bronchitis specifically. The other ingredients — marshmallow, mullein, wild cherry, bromelain — don't have reliable evidence in our data, so we can't say for certain whether they help. Your results may vary, and a pharmacist or doctor can advise whether it's a good fit for your situation.
Is it safe if I'm pregnant?
The safety data for marshmallow, mullein, and bromelain are insufficient — there isn't enough information either way, so talk with your doctor or pharmacist for personalized advice. Wild cherry is rated likely unsafe in pregnancy and should be avoided.
Can I take it while breastfeeding?
Marshmallow and mullein should be avoided while breastfeeding because there isn't enough safety data. For bromelain, safety while breastfeeding is unknown, so avoid it too. The data we hold doesn't cover Hederocoside C. Talk with your pharmacist or doctor before use.
What's N-acetyl cysteine doing in here?
N-acetyl cysteine helps thin and loosen mucus in the lungs and respiratory tract, making it easier to cough up. It's rated effective for several respiratory conditions, including possibly effective for bronchitis. However, it does interact with several medications, so check your prescriptions before starting.
I take a blood thinner — is it safe?
No — three ingredients in this product (N-acetyl cysteine, marshmallow, bromelain, and mullein) have interactions with blood thinners or antiplatelet drugs. Don't start this product without checking with your pharmacist or doctor first.
Can I take this with my other oral medications?
Marshmallow contains mucilage that can slow the absorption of oral medications into your bloodstream. If you take marshmallow, wait 30–60 minutes after your other medications before taking it. Some other ingredients also interact with specific drug classes, so use the medication checker on this page with your exact prescriptions.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lung, Bronchial & Sinus Health label
Go deeper

The Full Monographs Behind Lung, Bronchial & Sinus Health’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

N-acetyl Cysteine (nac)

Interacts with 294 drugs

N-acetyl cysteine (NAC) is a supplement form of the amino acid cysteine and a building block for the antioxidant glutathione. It has well-established prescription uses for acetaminophen over...

Read the full N-acetyl Cysteine (nac) monograph → Herb & supplement monograph

Marshmallow

Interacts with 2,040 drugs

Marshmallow root is a traditional herb rich in soothing, gel-like fibers called mucilage, which is why it has long been used for coughs, sore throats, and stomach irritation. Evidence for th...

Read the full Marshmallow monograph → Herb & supplement monograph

Mullein

Interacts with 122 drugs

Mullein is a traditional herbal remedy most often used as a tea or syrup to soothe coughs, sore throats, and respiratory irritation. High-quality human studies are lacking, so its benefits a...

Read the full Mullein monograph → Herb & supplement monograph

Wild Cherry

Interacts with 643 drugs

Wild cherry bark is a traditional cough remedy found in many old-fashioned cough syrups and lozenges, but there is little modern scientific evidence proving it works. The bark, leaves, and s...

Read the full Wild Cherry monograph → Herb & supplement monograph

English Ivy

Interacts with 280 drugs

English ivy leaf extract is most commonly used in cough and cold syrups to help loosen mucus and ease coughing, and it is a popular ingredient in many European herbal products. Some research...

Read the full English Ivy monograph → Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph →
Sources

Sources & How We Checked

Lung, Bronchial & Sinus Health's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 129 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

N-acetyl Cysteine (nac) 86 references
  1. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  2. Jepsen S, Hansen AB. The influence of N-acetylcysteine on the measurement of prothrombin time and activated partial thromboplastin time in healthy subjects. Scand J Clin Lab Invest 1994;54:543-7. PubMed
  3. van Zandwijk N, Dalesio O, Pastorino U, et al. EUROSCAN, a randomized trial of vitamin A and N-acetylcysteine in patients with head and neck cancer or lung cancer. For the European Organization for Research and Treatment of Cancer Head and Neck and Lung C DOI
  4. Horowitz RS, Dart RC, Jarvie DR, et al. Placental transfer of N-acetylcysteine following human maternal acetaminophen toxicity. J Toxicol Clin Toxicol 1997;35:447-51.
  5. Bailey B, McGuigan MA. Management of anaphylactoid reactions to intravenous N-acetylcysteine. Ann Emerg Med 1998;31:710-5. PubMed
  6. Spiller HA, Krenzelok EP, Grande GA, et al. A prospective evaluation of the effect of activated charcoal before oral N-acetylcysteine in acetaminophen overdose. Ann Emerg Med 1994;23:519-23. PubMed
  7. Ardissino D, Merlini PA, Savonitto S, et al. Effect of transdermal nitroglycerin or N-acetylcysteine, or both, in the long-term treatment of unstable angina pectoris. J Am Coll Cardiol 1997;29:941-7. PubMed
  8. Horowitz JD, Henry CA, Syrjanen ML, et al. Nitroglycerine/N-acetylcysteine in the management of unstable angina pectoris. Eur Heart J 1988;9:95-100. PubMed
  9. Louwerse ES, Weverling GJ, Bossuyt PM, et al. Randomized, double-blind, controlled trial of acetylcysteine in amyotrophic lateral sclerosis. Arch Neurol 1995;52:559-64. PubMed
  10. Wiklund O, Fager G, Andersson A, et al. N-acetylcysteine treatment lowers plasma homocysteine but not serum lipoprotein(a) levels. Atherosclerosis 1996;119:99-106. PubMed
  11. De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J 1997;10:1535-41. PubMed
  12. Iversen HK. N-acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses. Clin Pharmacol Ther 1992;52:125-33. PubMed
  13. Behr J, Maier K, Degenkolb B, et al. Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression. Am J Respir Crit Care Med 1997;156:1897-901.
  14. Tenenbein PK, Sitar DS, Tenenbein M. Interaction between N-acetylcysteine and activated charcoal: implications for the treatment of acetaminophen poisoning. Pharmacotherapy 2001;21:1331-6.
  15. Arstall MA, Yang J, Stafford I, et al. N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of evolving acute myocardial infarction. Safety and biochemical effects. Circulation 1995;92:2855-62.
  16. Estensen RD, Levy M, Klopp SJ, et al. N-acetylcysteine suppression of the proliferative index in the colon of patients with previous adenomatous colonic polyps. Cancer Lett 1999;147:109-14. PubMed
  17. Pela R, Calcagni AM, Subiaco S, et al. N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD. Respiration 1999;66:495-500.. PubMed
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