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Dietary supplement

Lutein 40 mg Ingredients & Drug Interactions

by Natural Factors

Lutein 40 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein 40 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein 40 mg is a dietary supplement by Natural Factors with 2 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutein 40 mg by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein 40 mg by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lutein 40 mg by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This softgel delivers 2 active ingredients: LuteinRich Lutein and zeaxanthin, both carotenoids (plant pigments) that concentrate in the eye. The softgel capsule itself is made from safflower oil, organic flaxseed oil, yellow beeswax, and non-GMO sunflower lecithin — these help deliver the lutein and zeaxanthin and aren't therapeutic ingredients on their own.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye health and age-related macular degeneration.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts, the main reasons people take it. Zeaxanthin is also possibly effective for AMD.

The evidence for both is meaningful but not conclusive — it suggests benefit, but the research isn't airtight. For other conditions listed (retinitis pigmentosa, retinopathy of prematurity, bronchopulmonary dysplasia, Alzheimer disease, asthma, breast cancer, and cognitive decline), either the evidence is too weak to rate or points toward no benefit.

If you're taking this for eye health as you age, the data supports it; if you have another reason in mind, check with your pharmacist or doctor first.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein from food and typical supplement doses is generally well tolerated. Doses up to 20 mg daily haven't caused reported adverse effects, though this product contains 40 mg and safety data at that level in supplements isn't complete — your doctor can help you decide if it's right for you.

Zeaxanthin is also generally well tolerated at typical supplement doses. Both are rated likely safe in pregnancy and lactation, though supplement safety at concentrated doses during breastfeeding isn't well studied, so talk it over with your doctor if you're nursing.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take diabetes medications (insulin, metformin, sulfonylureas, or others), check with your doctor or pharmacist before using this product. Zeaxanthin may theoretically increase the risk of low blood sugar when combined with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lutein and zeaxanthin make sense if you're concerned about age-related eye changes like macular degeneration or cataracts. The main caution is if you take diabetes medication — zeaxanthin could theoretically lower your blood sugar further.

Chat with your doctor or pharmacist before starting, especially if you're on any medications or are pregnant or breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 22, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein 40 mg, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958010342
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Oct 22, 2015
DSLD ID 52877
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein 40 mg by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
068958010342
IngredientAmount% DV
LuteinRich Lutein40 mg--
Zeaxanthin7 mg--

Other ingredients: Softgel, Safflower Oil, organic Flaxseed Oil, yellow Beeswax, non-GMO Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Recyclable container and label.

MASS SPEC Documentation Lab Tested

Lutein is the principal carotenoid concentrated in the macula, the central area of the retina responsible for vision. Lutein and companion carotenoid zeaxanthin work in synergy to provide nutritional support to our eyes and skin* – the only organs of the body directly exposed to the outside environment. Their primary role is to provide antioxidant protection against sunlight-induced free radical damage.*

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada

FDA Statement of Identity

Dietary Supplement

Formula

7 mg Zeaxanthin

Natural Factors uses LuteinRich – a naturally-sourced lutein and zeaxanthin derived from marigold petals.

Brand IP Statement(s)

LuteinRich is a trademark of Inovobiologic Inc.

General

R2

Seals/Symbols

isura

Purity&Potency Guaranteed

Formulation

NON-GMO

LuteinRich is non-irradiated and non-GMO.

Contains no artificial preservatives or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, egg, fish, shellfish, salt, tree nuts, or GMOs.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested usage: 1 softgel per day or as directed by a health professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein 40 mg by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein 40 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein 40 mg by Natural Factors

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

LuteinRich Lutein

No known
interactions
40 mg per serving Form: Marigold flower extract

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

LuteinRich Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
7 mg per serving Form: Marigold flower extract

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Other (inactive) ingredients: Softgel, Safflower Oil, Organic Flaxseed Oil, Yellow Beeswax, Non-GMO Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein 40 mg by Natural Factors Drug Interactions

Want to check YOUR meds against Lutein 40 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in Lutein 40 mg interact with 86 drugs. Click any drug to see the details.

1 of the 2 ingredients in Lutein 40 mg interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein 40 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein 40 mg, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Lutein 40 mg by Natural Factors: Common Questions

Does Lutein 40 mg by Natural Factors interact with any medications?
Yes. Based on its ingredients, Lutein 40 mg has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein 40 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant or breastfeeding?
Both lutein and zeaxanthin are rated likely safe in pregnancy and lactation. That said, safety data on concentrated supplement doses during breastfeeding is limited, so it's worth discussing with your doctor or pharmacist to make sure it fits your situation.
How much lutein is actually in this?
The product contains 40 mg of LuteinRich Lutein per softgel. Research showing no adverse effects goes up to 20 mg daily, so you're getting more than the studied dose — again, something to discuss with your doctor.
Can this help with cataracts?
Lutein is possibly effective for cataracts, meaning the evidence suggests benefit but isn't conclusive. It's one of the reasons people take it, but results vary and it's not a proven treatment — talk with your eye doctor about whether it fits your plan.
Does this have any fillers?
The softgel capsule contains safflower oil, organic flaxseed oil, yellow beeswax, and non-GMO sunflower lecithin — these help deliver the active ingredients. There are no other listed fillers.
What is zeaxanthin and why is it in here?
Zeaxanthin is a carotenoid (plant pigment) that, like lutein, concentrates in the eye and is possibly effective for age-related macular degeneration. The two work together and often appear in eye-health supplements.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein 40 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein 40 mg label
Go deeper

The Full Monographs Behind Lutein 40 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

Lutein 40 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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