Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Lutein Plus 20 mg Ingredients & Drug Interactions

by BIOVEA

Lutein Plus 20 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lutein Plus 20 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lutein Plus 20 mg is a dietary supplement by BIOVEA with 3 active ingredients. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry fruit powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lutein Plus 20 mg by BIOVEA

Ask about any prescription or over-the-counter medication and we check it for interactions with Lutein Plus 20 mg by BIOVEA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lutein Plus 20 mg by BIOVEA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Lutein Plus 20 mg contains 3 active ingredients: bilberry fruit powder, and Lutemax (a lutein extract that appears twice in the formula). Bilberry is rich in anthocyanidins, pigments that give it its deep color.

Lutemax is a concentrated source of lutein and related carotenoids — naturally occurring compounds that accumulate in the retina and help protect eye tissue. The capsule also contains several inactive ingredients: cellulose, spinach powder, gelatin, rosemary extract powder, magnesium stearate, silica, and vitamin E succinate (D-alpha-tocopheryl succinate) — these serve as fillers, binders, and preservatives.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Eye and vision health.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Bilberry is rated "Insufficient Reliable Evidence To Rate" for Age-related macular degeneration (AMD), Cataracts, Diabetic retinopathy, Dry eye, and more.

Lutein (Lutemax) is possibly effective for age-related macular degeneration (AMD) and cataracts, the most common eye conditions this product targets. For bilberry, the evidence is much weaker: it is rated possibly ineffective for night vision, and the data is insufficient to say whether it helps with age-related cognitive decline, atherosclerosis, high cholesterol, or venous insufficiency.

In short, you're getting solid evidence for the lutein component and limited evidence for bilberry's claimed benefits.

The evidence, ingredient by ingredient Bilberry Lutein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein from supplements at typical doses — including the 20 mg daily in this product — is generally well tolerated, with no adverse effects reported in trials at this dose. Bilberry fruit and extracts are also well tolerated in most people, though some trial participants reported dark-colored or black stools, flatulence, and mild gastrointestinal discomfort.

A small number experienced temporary upset stomach. Bilberry can also darken your tongue and stain your teeth; these effects are harmless but may be noticeable.

Both ingredients are rated likely safe in pregnancy and lactation, though long-term supplement safety data for bilberry is limited, so talk with your doctor if you're pregnant or nursing and want to confirm it's right for you.

Side effects, ingredient by ingredient Bilberry Lutein

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Lutein Plus 20 mg, confirm with your doctor or pharmacist if you take blood thinners (anticoagulants) or antiplatelet drugs — bilberry may increase bleeding risk. Also double-check if you take diabetes medications, since bilberry may lower blood sugar.

If you're on erlotinib (Tarceva) or other drugs metabolized by the CYP2E1 liver enzyme, flag this product as well, because bilberry may reduce their effectiveness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lutein Plus 20 mg is a reasonable option if you're concerned about age-related eye diseases, particularly AMD or cataracts — the lutein here has solid evidence behind it. However, if you take blood thinners, diabetes medications, or certain cancer drugs, you'll need to check with your doctor or pharmacist before starting, because bilberry may interfere with how they work.

The same applies if you're pregnant or nursing and want reassurance the product is right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lutein Plus 20 mg, straight from the product label.

Brand BIOVEA
Barcode (UPC) 811079036704
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Apr 23, 2024
DSLD ID 303217
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lutein Plus 20 mg by BIOVEA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
811079036704
IngredientAmount% DV
Bilberry fruit powder25 mg--
Lutemax20 mcg--
Lutemax1000 mcg--

Other ingredients: Cellulose, Spinach powder, Gelatin, Water, Rosemary extract powder, Magnesium Stearate, Silica, D-Alpha-Tocopheryl Succinate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no sugar, dairy, wheat, gluten, eggs, peanuts, tree nuts, soy, sesame, fish, shellfish, preservatives, artificial colors or flavors.

Natural color variations may occur in this product.

Non GMO Gluten Free

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, adults take one (1) capsule, one (1) to three (3) times daily with meals, or as directed by a healthcare professional.

Storage

Store in a cool, dry place and away from direct light.

General Statements

Some settling may occur within capsules during shipping.

Precautions

Keep out of reach of children.

Brand IP Statement(s)

Biovea Premium Quality Guaranteed - Since 2001

Lutemax Free Lutein is a trademark of OmniActive Health Technologies Ltd.

Formula

Lutein Plus 20mg per serving

From Lutemax Free Lutein, standardized extract of dried flower of Marigold in the form of purified free lutein concentrate encapsulated in a matrix and stabilized with antioxidants. Lutein is an important antioxidant from the carotenoid family of nutrients. It has been the subject of many important scientific studies.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lutein Plus 20 mg by BIOVEA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lutein Plus 20 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lutein Plus 20 mg by BIOVEA

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Bilberry fruit powder

Interacts with
275 drugs
25 mg per serving

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry fruit powder monograph & interactions

Lutemax

No known
interactions
20 mcg per serving Form: Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutemax monograph & interactions

Lutemax

No known
interactions
1000 mcg per serving Form: Zeaxanthin

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutemax monograph & interactions

Other (inactive) ingredients: Cellulose, Spinach powder, Gelatin, Water, Rosemary extract powder, Magnesium Stearate, Silica, D-Alpha-Tocopheryl Succinate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lutein Plus 20 mg by BIOVEA Drug Interactions

Want to check YOUR meds against Lutein Plus 20 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry fruit powder 275

Individual Drug Interactions

The ingredients in Lutein Plus 20 mg interact with 275 drugs. Click any drug to see the details.

1 of the 3 ingredients in Lutein Plus 20 mg interact with drugs. Each result below shows which ingredient is responsible. Bilberry fruit powder

Each ingredient & the kinds of drugs it affects

For each ingredient in Lutein Plus 20 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry fruit powder4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry fruit powder full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lutein Plus 20 mg, from the product label.

BIOVEA

See all BIOVEA products
Name
Biovea
Street Address
2675 S. 16thSt.
City
Phoenix
State
AZ
ZipCode
85034
Web Address
www.biovea.com
Pharmacist Counseling Corner

Lutein Plus 20 mg by BIOVEA: Common Questions

Does Lutein Plus 20 mg by BIOVEA interact with any medications?
Yes. Based on its ingredients, Lutein Plus 20 mg has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lutein Plus 20 mg contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product actually improve vision?
Lutein — the main ingredient — is possibly effective for age-related macular degeneration and cataracts. Bilberry is rated possibly ineffective for night vision specifically, and we don't have enough evidence to say whether it helps with other eye or brain concerns. So you're getting solid science for lutein, but the bilberry benefit is less clear.
Will Lutein Plus 20 mg interfere with my blood thinner?
Yes, possibly. Bilberry fruit may increase bleeding risk when combined with blood thinners or antiplatelet drugs by making platelets less sticky. Check with your doctor or pharmacist before you start this product if you're on any of these medications.
What are the side effects?
Both ingredients are well tolerated. The most common effects from bilberry are dark or black stools, gas, and mild stomach upset — harmless but noticeable. Bilberry can also darken your tongue temporarily. Lutein at this dose has shown no adverse effects in trials.
Is it safe during pregnancy or while breastfeeding?
Both bilberry and lutein are rated likely safe in pregnancy and lactation. That said, long-term safety data for bilberry supplements is limited, so talk with your doctor or pharmacist before taking it while pregnant or nursing to confirm it's the right choice for you.
Can I take this with my diabetes medication?
Bilberry may lower blood sugar and increase the risk of low blood sugar when combined with diabetes drugs. Check with your doctor or pharmacist to see if this product is safe for you or if your diabetes medication needs adjustment.
What's Lutemax?
Lutemax is a concentrated extract of lutein, a natural pigment found in leafy greens and the retina of your eye. It's the active form used in supplements to support eye health, especially for age-related macular degeneration and cataracts.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lutein Plus 20 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lutein Plus 20 mg label
Go deeper

The Full Monographs Behind Lutein Plus 20 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph → Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph →
Sources

Sources & How We Checked

Lutein Plus 20 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 16 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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