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Dietary supplement

Lycopene 10 mg Ingredients & Drug Interactions

by Natural Factors

Lycopene 10 mg label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lycopene 10 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lycopene 10 mg is a dietary supplement by Natural Factors with 2 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 123 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lycopene, Pumpkin seed Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lycopene 10 mg by Natural Factors

Ask about any prescription or over-the-counter medication and we check it for interactions with Lycopene 10 mg by Natural Factors — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lycopene 10 mg by Natural Factors

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • “Lycopene” is listed as a grouped ingredient — the label gives one combined amount (10 mg) without saying how much of each component you get.

This softgel contains 2 active ingredients: pumpkin seed oil and lycopene from tomato extract. Pumpkin seed oil is used in supplements mainly for urinary and prostate support, though evidence for most of those uses is limited.

Lycopene is a red pigment from tomatoes that may have antioxidant properties. The softgel capsule itself, along with yellow beeswax and soy lecithin, are inactive ingredients that help hold and deliver the formula.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: antioxidant support and cellular health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Pumpkin seed oil is possibly effective for benign prostatic hyperplasia (BPH) — an enlarged prostate that can cause urinary symptoms. For other uses — androgenic alopecia (pattern hair loss), interstitial cystitis (bladder pain), parasite infections, and UTIs — the evidence isn't strong enough to rate it.

Tomato extract's effectiveness is less clear. The evidence suggests it's probably not effective for bladder cancer, breast cancer, or diabetes.

For high cholesterol, exercise-triggered asthma, and BPH, there simply isn't enough reliable data to know either way.

The evidence, ingredient by ingredient Pumpkin Lycopene Tomato

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pumpkin seed oil and tomato extract are generally well tolerated in the amounts used in food. The most common side effects from pumpkin products are mild — abdominal discomfort, diarrhea, nausea, and vomiting.

A rare case reported anaphylaxis (a severe allergic reaction), and there are two isolated reports of temporary hair loss weeks after consuming very bitter pumpkin or squash with high levels of cucurbitacin (a natural plant compound). Tomato extracts also seem well tolerated; serious side effects from tomatine (a compound in tomato leaves and green tomatoes) happen only with excessive amounts.

For pregnancy, tomato extract is rated as likely safe. Pumpkin seed oil has limited pregnancy and breastfeeding data — the facts note there isn't enough information to know if concentrated supplements are safe during these times.

Talk with your doctor or pharmacist about whether this product is right for your situation.

Side effects, ingredient by ingredient Pumpkin Lycopene Tomato

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Pumpkin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take lithium, check with your doctor or pharmacist before starting this product. Pumpkin seed oil may reduce how your body clears lithium and cause levels to rise, possibly requiring a dose adjustment.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with prostate symptoms if pumpkin seed oil proves effective for you, but the evidence for tomato extract is weaker. The main concern is if you take lithium — that requires a conversation with your doctor or pharmacist first.

Otherwise, most people tolerate these ingredients well, though mild digestive upset is possible.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lycopene 10 mg, straight from the product label.

Brand Natural Factors
Barcode (UPC) 068958010168
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74744
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lycopene 10 mg by Natural Factors, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
UPC/BARCODE
068958010168
IngredientAmount% DV
Pumpkin seed Oil140 mg--
Lycopene10 mg--
Tomato extract167 mg--

Other ingredients: Softgel, yellow Beeswax, Soy Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Isura

Formulation

Non-GMO

Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, corn, soy, egg, fish, shellfish, salt, tree nuts, or GMOs.

General Statements

Mass spec Documentation Lab tested

Derived from tomato, lycopene is responsible for the healthy red color and is a more powerful free radical quencher than Beta Carotene. As a potent antioxidant, lycopene helps prevents damage to cellular structures throughout the human body.

Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.

Product of Canada Recyclable container and label.

Suggested/Recommended/Usage/Directions

Suggested Usage: 1-2 capsules per day with meals, or as directed by a health professional.

Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formula

Easy-to-swallow lycopene softgels contain 10 mg of the important carotenoid, lycopene.

Recent scientific research suggests that lycopene may be an important tool for men who want to protect prostate health and for those who wish to guard against UV.

Natural tomato lycopene Plus pumpkin seed oil

Storage

For freshness, store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Purity & potency guaranteed

FDA Statement of Identity

Dietary Supplement

General

R4

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lycopene 10 mg by Natural Factors label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lycopene 10 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lycopene 10 mg by Natural Factors

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pumpkin seed Oil

Interacts with
1 drug
140 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed Oil monograph & interactions

Lycopene

Interacts with
122 drugs
10 mg per serving

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Other (inactive) ingredients: Softgel, Yellow Beeswax, Soy Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lycopene 10 mg by Natural Factors Drug Interactions

Want to check YOUR meds against Lycopene 10 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
123Drugs
123 Moderate

Ingredients driving the most interactions

Lycopene 122
Pumpkin seed Oil 1

Individual Drug Interactions

The ingredients in Lycopene 10 mg interact with 123 drugs. Click any drug to see the details.

2 of the 2 ingredients in Lycopene 10 mg interact with drugs. Each result below shows which ingredient is responsible. Lycopene Pumpkin seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Lycopene 10 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Pumpkin seed Oil1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lycopene 10 mg, from the product label.

Natural Factors

See all Natural Factors products
Name
Natural Factors Canada
Pharmacist Counseling Corner

Lycopene 10 mg by Natural Factors: Common Questions

Does Lycopene 10 mg by Natural Factors interact with any medications?
Yes. Based on its ingredients, Lycopene 10 mg has a known interaction with 123 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lycopene 10 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this have any side effects?
Pumpkin seed oil and tomato extract are generally well tolerated. The most common side effects are mild — abdominal discomfort, diarrhea, nausea, and vomiting. Serious side effects are rare. Two isolated reports mention temporary hair loss after consuming very bitter pumpkin with high levels of cucurbitacin, a natural plant compound.
Is this safe during pregnancy or breastfeeding?
Tomato extract is rated as likely safe. Pumpkin seed oil doesn't have enough study data to say either way — the facts note concentrated supplements haven't been well evaluated in pregnancy and breastfeeding. Talk with your doctor or pharmacist about whether it's right for you.
What is pumpkin seed oil supposed to do?
Pumpkin seed oil is possibly effective for benign prostatic hyperplasia (BPH), an enlarged prostate that can cause urinary trouble. For other uses like hair loss, bladder pain, parasite infections, and UTIs, the evidence is too limited to know if it helps.
Does tomato extract actually work for anything?
The evidence suggests tomato extract is probably not effective for bladder cancer, breast cancer, or diabetes. For high cholesterol, exercise-triggered asthma, and prostate health, there simply isn't enough reliable data to know if it helps.
What are the inactive ingredients?
The softgel capsule itself is made with yellow beeswax and soy lecithin, which help hold and deliver the formula. These are excipients, not active ingredients.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lycopene 10 mg label
Go deeper

The Full Monographs Behind Lycopene 10 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Tomato

Tomato is a common food rich in vitamins, potassium, and the antioxidant lycopene, and eating it as part of a balanced diet is healthy for most people. Concentrated tomato or lycopene supple...

Read the full Tomato monograph →
Sources

Sources & How We Checked

Lycopene 10 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pumpkin 5 references
  1. Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
  2. Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
  3. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
  4. Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
  5. Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed

See these in context on the Pumpkin monograph →

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
  8. Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
  9. Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
  10. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

See these in context on the Lycopene monograph →

Tomato 3 references
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Asero R, Mistrello G, Amato S. Airborne allergy to tomato proteins. Allergy. 2010;65(12):1626-7. PubMed
  3. Friedman M. Tomato Glycoalkaloids: Role in the Plant and in the Diet. J Agric Food Chem. 2002;50(21):5751-80. PubMed

See these in context on the Tomato monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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