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Dietary supplement

Lycopene 5 mg Ingredients & Drug Interactions

by Puritan's Pride

Lycopene 5 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lycopene 5 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lycopene 5 mg is a dietary supplement by Puritan's Pride with 1 active ingredient. Its ingredients are commonly taken for heart health, prostate health, antioxidant support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lycopene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lycopene 5 mg by Puritan's Pride

Ask about any prescription or over-the-counter medication and we check it for interactions with Lycopene 5 mg by Puritan's Pride — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lycopene 5 mg by Puritan's Pride

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: lycopene 5 mg per softgel. Lycopene is a red-orange pigment found naturally in tomatoes, watermelon, and other red fruits.

The inactive ingredients are soybean oil, gelatin, corn oil, vegetable glycerin, and yellow beeswax — these are the capsule and carrier components that hold the lycopene.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports prostate and heart health.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Cardiovascular disease (CVD), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Hyperlipidemia, Hypertension, Prostate cancer — and 2 related terms.
  • The strongest evidence on file: Lycopene is rated "Possibly Effective" for Prostate cancer (Natural Medicines).
  • Also on file: Lycopene is rated "Insufficient Reliable Evidence To Rate" for Benign prostatic hyperplasia (BPH), Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence for lycopene is mixed and incomplete. It's rated Possibly Effective for prostate cancer, meaning there's some promising research but it's not yet conclusive.

For bladder cancer and diabetes, it's rated Possibly Ineffective based on current data. For high cholesterol (hyperlipidemia), exercise-induced asthma, and ALS (Lou Gehrig's disease), we don't have enough reliable evidence to rate it either way.

The evidence, ingredient by ingredient Lycopene

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lycopene from food is considered safe, and supplement doses are generally well tolerated. The most common side effects reported with lycopene supplements are gastrointestinal — diarrhea, gas, bloating, nausea, vomiting, heartburn, and loss of appetite.

A rare case of chest pain was reported in a pregnant patient taking a different lycopene product, but the role of lycopene itself was unclear. For pregnancy, food amounts of lycopene are fine, but supplement doses haven't been well studied — talk with your doctor about whether to take it.

For breastfeeding, there isn't enough safety data on supplements, so check with your doctor or pharmacist.

Side effects, ingredient by ingredient Lycopene

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lycopene.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take blood thinners or antiplatelet drugs — warfarin, clopidogrel, aspirin, or similar medications — check with your doctor or pharmacist before adding this supplement. Lycopene may increase bleeding risk when combined with these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Lycopene may be worth considering if you're interested in prostate health support, though the evidence is still developing. If you take blood thinners or antiplatelet drugs, check with your doctor or pharmacist before starting — the combination carries a moderate bleeding risk.

Otherwise, it's generally well tolerated, though it can cause digestive upset in some people. Talk it over with your doctor or pharmacist to see if it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 24, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lycopene 5 mg, straight from the product label.

Brand Puritan's Pride
Barcode (UPC) 074312148811
Net contents 100 Rapid Release Softgel(s)
Market status On market
Date entered into DSLD Jun 24, 2016
DSLD ID 62209
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lycopene 5 mg by Puritan's Pride, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
074312148811
IngredientAmount% DV
Lycopene5 mg--

Other ingredients: Soybean Oil, Gelatin, Corn Oil, Vegetable Glycerin, yellow Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Supports Prostate & Heart Health*

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take one (1) softgel four to eight times daily, preferably with meals.

Formulation

No Artificial Color, Flavor or Sweetener, No Preservatives, No Sugar, No Starch, No Milk, No Lactose, No Gluten, No Wheat, No Yeast, No Fish. Sodium Free.

Brand IP Statement(s)

Puritan' Pride supplements are produced from the finest raw materials under our stringent quality control standards.

2016 Puritan's Pride, Inc.

General Statements

Our state-of-the-art manufacturing and packaging facilities ensure you the highest quality nutritional supplements money can buy. When it comes to your health....choose the best.

shop online www.puritan.com To reorder item # 4881

Precautions

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Keep out of reach of children.

Do not use if seal under cap is broken or missing.

Storage

Store at room temperature.

General

Item # 4881 B4882 06D

Seals/Symbols

QUALITY ASSURED QA

FDA Disclaimer Statement

*This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lycopene 5 mg by Puritan's Pride label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lycopene 5 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lycopene 5 mg by Puritan's Pride

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Lycopene

Interacts with
122 drugs
5 mg per serving

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Corn Oil, Vegetable Glycerin, Yellow Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lycopene 5 mg by Puritan's Pride Drug Interactions

Want to check YOUR meds against Lycopene 5 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Lycopene 122

Individual Drug Interactions

The ingredients in Lycopene 5 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lycopene 5 mg interact with drugs. Each result below shows which ingredient is responsible. Lycopene

Each ingredient & the kinds of drugs it affects

For each ingredient in Lycopene 5 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lycopene 5 mg, from the product label.

Puritan's Pride

See all Puritan's Pride products
Name
Puritan's Pride, Inc.
City
Holbrook
State
NY
ZipCode
11741
Phone Number
1-800-645-1030
Web Address
www.puritan.com
Pharmacist Counseling Corner

Lycopene 5 mg by Puritan's Pride: Common Questions

Does Lycopene 5 mg by Puritan's Pride interact with any medications?
Yes. Based on its ingredients, Lycopene 5 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lycopene 5 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lycopene and where does it come from?
Lycopene is a red-orange pigment found naturally in tomatoes, watermelon, and other red fruits. This supplement provides a concentrated dose in softgel form.
Can I take this if I'm pregnant or breastfeeding?
Food amounts of lycopene are fine in pregnancy, but supplement doses haven't been well studied — talk with your doctor about whether to take it. For breastfeeding, there isn't enough safety data on supplements, so check with your doctor or pharmacist for personalized advice.
What side effects might I experience?
Gastrointestinal upset is the main concern — some people report diarrhea, gas, bloating, nausea, vomiting, or heartburn. These effects are usually mild and go away with continued use or dose adjustment.
Does lycopene actually work for prostate cancer?
The evidence is promising but not yet conclusive — it's rated Possibly Effective, meaning there's some solid research backing it, but larger studies are still needed. Talk with your doctor about whether it might be part of your overall health plan.
Is there anything in this I should be allergic to?
The inactive ingredients are soybean oil, gelatin, corn oil, vegetable glycerin, and yellow beeswax. If you have allergies to soy, gelatin, or bee products, check the label or ask your pharmacist before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lycopene 5 mg label
Go deeper

The Full Monographs Behind Lycopene 5 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph →
Sources

Sources & How We Checked

Lycopene 5 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
  8. Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
  9. Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
  10. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

See these in context on the Lycopene monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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