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Dietary supplement

Magnolia Bark 400 mg Ingredients & Drug Interactions

by Swanson Premium Brand

Magnolia Bark 400 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Magnolia Bark 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Magnolia Bark 400 mg is a dietary supplement by Swanson Premium Brand with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 351 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Magnolia. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Magnolia Bark 400 mg by Swanson Premium Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Magnolia Bark 400 mg by Swanson Premium Brand — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Magnolia Bark 400 mg by Swanson Premium Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: 400 mg of magnolia bark per capsule. Magnolia bark contains compounds called honokiol and magnolol, which appear to be responsible for its main effects.

The capsule also contains brown rice flour and gelatin as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Magnolia's overall clinical evidence instead.

Moderate

Some clinical evidence supports Magnolia for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Gingivitis — rated "Possibly Effective" (Natural Medicines).

Magnolia bark is possibly effective for gingivitis (gum inflammation). For hay fever (allergic rhinitis), anxiety, and dental plaque, the evidence is too limited to know whether it works.

The data we hold doesn't establish its usefulness for these other uses.

The evidence, ingredient by ingredient Magnolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, magnolia bark is generally well tolerated in adults short-term, though human safety data is limited. During pregnancy, magnolia is rated unsafe — some sources caution it may affect the uterus, so it should be avoided.

Breastfeeding safety data is too sparse to know either way; talk with your doctor or pharmacist about whether it's right for you during lactation. In clinical trials, a small number of participants reported side effects including sexual dysfunction, hand tremor, numbness around the mouth, fatigue, and headache, though it's unclear whether magnolia itself was responsible.

Topical contact dermatitis has also been reported.

Side effects, ingredient by ingredient Magnolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Magnolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 351 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Magnolia Bark 400 mg, check with your doctor or pharmacist if you take blood thinners or antiplatelet medications (like warfarin, aspirin, or clopidogrel) — magnolia may increase bleeding risk. Also confirm it with any CNS depressants such as sedatives, sleep aids, benzodiazepines, or opioids, since magnolia's sedative effects could add to theirs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Magnolia bark may help with gum inflammation, but the evidence for other uses is weak. It's best suited for short-term use in adults without blood thinners, antiplatelet drugs, or CNS depressants on board — and it's off-limits in pregnancy.

Check with your doctor or pharmacist before starting, especially if you take any sedating medications or anticoagulants.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Magnolia Bark 400 mg, straight from the product label.

Brand Swanson Premium Brand
Barcode (UPC) 087614113784
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 21, 2018
DSLD ID 181220
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Magnolia Bark 400 mg by Swanson Premium Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
087614113784
IngredientAmount% DV
Magnolia400 mg--

Other ingredients: Brown Rice Flour, Gelatin, May contain one or both of the following

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Bringing wellness to the world since 1969

To reorder, call toll free 1-800-437-4148 or visit our website at www.swansonvitamins.com

FDA Statement of Identity

Herbal Supplement

Seals/Symbols

Guaranteed purity & potency

Precautions

Do not use if seal is broken.

Keep out of reach of children.

Warning: Not intended for use by children or pregnant or nursing women.

Warning: Not intended for use by children or pregnant or nursing women. Consult your healthcare provider before use if you are taking any prescription medications or have a medical condition.

Storage

Store in a cool, dry place.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take one capsule per day.

General

SW1378 Rev 1 06 08 17

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Magnolia Bark 400 mg by Swanson Premium Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Magnolia Bark 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Magnolia Bark 400 mg by Swanson Premium Brand

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Magnolia

Interacts with
351 drugs
400 mg per serving

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human r...

Magnolia monograph & interactions

Other (inactive) ingredients: Brown Rice Flour, Gelatin, May contain one or both of the following. These complete the product’s ingredient list but are not active constituents.

Interaction report

Magnolia Bark 400 mg by Swanson Premium Brand Drug Interactions

Want to check YOUR meds against Magnolia Bark 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
351Drugs
351 Moderate

Ingredients driving the most interactions

Magnolia 351

Individual Drug Interactions

The ingredients in Magnolia Bark 400 mg interact with 351 drugs. Click any drug to see the details.

1 of the 1 ingredient in Magnolia Bark 400 mg interact with drugs. Each result below shows which ingredient is responsible. Magnolia

Each ingredient & the kinds of drugs it affects

For each ingredient in Magnolia Bark 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnolia2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Magnolia Bark 400 mg, from the product label.

Swanson Premium Brand

See all Swanson Premium Brand products
Name
Swanson Health Products
City
Fargo
State
ND
ZipCode
58104
Phone Number
1-800-437-4148
Web Address
www.swansonvitamins.com
Pharmacist Counseling Corner

Magnolia Bark 400 mg by Swanson Premium Brand: Common Questions

Does Magnolia Bark 400 mg by Swanson Premium Brand interact with any medications?
Yes. Based on its ingredients, Magnolia Bark 400 mg has a known interaction with 351 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Magnolia Bark 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take magnolia bark if I'm pregnant?
No. Magnolia is rated unsafe in pregnancy because some sources caution it may affect the uterus. Avoid it during pregnancy and talk with your doctor about safer alternatives.
Is it safe while breastfeeding?
There isn't enough safety data to know. Talk with your doctor or pharmacist about whether it's okay for you while breastfeeding.
What does magnolia bark actually do?
The evidence shows it's possibly effective for gingivitis (inflamed gums). For hay fever, anxiety, and dental plaque, we don't have enough reliable evidence to say whether it works.
Does magnolia bark come with side effects?
When taken by mouth, it's generally well tolerated. A small number of trial participants reported sexual dysfunction, hand tremor, numbness, fatigue, and headache, though it's unclear if magnolia was the cause.
How long can I take this safely?
Human safety data is limited. It may be okay for short-term use in adults, but long-term safety isn't well established. Check with your doctor or pharmacist about the right duration for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Magnolia Bark 400 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Magnolia Bark 400 mg label
Go deeper

The Full Monographs Behind Magnolia Bark 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph →
Sources

Sources & How We Checked

Magnolia Bark 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

See these in context on the Magnolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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