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Dietary supplement

Magnolia Extract Ingredients & Drug Interactions

by BulkSupplements.com

Powder Category: Botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Magnolia Extract is a dietary supplement by BulkSupplements.com with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 351 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Magnolia Bark Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Magnolia Extract by BulkSupplements.com

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: magnolia bark extract. The extract is standardized to deliver the active compounds honokiol and magnolol, which are responsible for magnolia's effects.

The only other ingredient listed is dextrin, an inactive additive used as a filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Magnolia's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: sleep support and stress management.
  • We looked for evidence on: Anxiety, Stress, Sleep disorders, Insomnia.
  • The closest evidence on file: Magnolia is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Magnolia is rated "Insufficient Reliable Evidence To Rate" for Stress.

The evidence for magnolia extract is mixed. It's rated possibly effective for gingivitis, based on available research.

For allergic rhinitis (hay fever), anxiety, and dental plaque, the current evidence is insufficient to know whether it works—more research would be needed to establish whether it's truly beneficial for these uses.

The evidence, ingredient by ingredient Magnolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Magnolia extract is generally well tolerated when taken orally, though human safety data is limited overall and longer-term use isn't well studied. A small number of trial participants reported side effects in studies of combination products containing magnolia—including one case each of sexual dysfunction, shaking hands with numbness around the mouth, fatigue, and headache—but it's unclear whether magnolia was responsible.

Topically, it may cause contact dermatitis in some people. Magnolia is rated unsafe in pregnancy due to concerns it may affect the uterus, so avoid it if you are pregnant.

There isn't enough reliable safety data during breastfeeding, so it's best avoided while nursing.

Side effects, ingredient by ingredient Magnolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Magnolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 351 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking magnolia extract, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, clopidogrel, or aspirin for heart protection)—the Moderate risk of added bleeding is serious. Also flag any central nervous system depressants, including sedatives, sleep aids, or anxiety medications, as they may have additive drowsiness effects.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Magnolia extract may be worth considering if you're interested in gingivitis support, though evidence is limited. It's not right for you if you take blood thinners, antiplatelet drugs, or sedating medications without medical clearance—the interaction risks are real.

If you're pregnant or breastfeeding, skip it. Talk with your doctor or pharmacist before starting to make sure it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Magnolia Extract, straight from the product label.

Brand BulkSupplements.com
Barcode (UPC) X0019YZOA3
Net contents 1 Kilogram(s); 35.3 Ounce(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 294808
Product type Botanical
Supplement form Powder
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Magnolia Extract by BulkSupplements.com, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
800 mg
Maximum serving Sizes:
800 mg
Servings per container
1250
UPC/BARCODE
X0019YZOA3
IngredientAmount% DV
Magnolia Bark Extract720 mg--

Other ingredients: Dextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

BulkSupplements.com Clean & Pure Bulk Supplements

FDA Disclaimer Statement

Warning: This product is not intended to diagnose, treat, cure, or prevent any disease. Always consult a physician before taking any dietary supplement.

Precautions

Keep out of reach of children.

Formulation

Free of: Added sugar, Soy, Dairy, Yeast, Gluten, Additives

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement, take 800 mg (about 1/3 tsp) once daily, or as directed by a physician.

Storage

Store in a dry, cool place

General Statements

New - BulkSupplements.com Magnolia Extract Powder - Herb Extract - Sleep Supplements for Adults - Anti Cortisol - Sleep Herbs (1 Kilogram)

Formula

New - BulkSupplements.com Magnolia Extract Powder - Herb Extract - Sleep Supplements for Adults - Anti Cortisol - Sleep Herbs (1 Kilogram)

New - BulkSupplements.com Magnolia Extract Powder - Herb Extract - Sleep Supplements for Adults - Anti Cortisol - Sleep Herbs (1 Kilogram)

See for yourself

Magnolia Extract by BulkSupplements.com label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Magnolia Extract by BulkSupplements.com

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size800 mg Dosage formPowder Servings per container1250 Amounts shown are per serving.

Magnolia Bark Extract

Interacts with
351 drugs
720 mg per serving Form: Magnolia officinalis Bark Extract

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human r...

Magnolia Bark Extract monograph & interactions

Other (inactive) ingredients: Dextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Magnolia Extract by BulkSupplements.com Drug Interactions

Want to check YOUR meds against Magnolia Extract?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
351Drugs
351 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Magnolia Extract with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnolia Bark Extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for Magnolia Extract, from the product label.

BulkSupplements.com

See all BulkSupplements.com products
Name
BulkSupplements.com
Street Address
7511 Eastgate Rd
City
Henderson
State
NV
ZipCode
89011
Web Address
BulkSupplements.com
Pharmacist Counseling Corner

Magnolia Extract by BulkSupplements.com: Common Questions

Does Magnolia Extract by BulkSupplements.com interact with any medications?
Yes. Based on its ingredients, Magnolia Extract has a known interaction with 351 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Magnolia Extract contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No. Magnolia extract is rated unsafe during pregnancy because it may affect the uterus. There also isn't enough safety data during breastfeeding, so it's best to avoid it. Talk with your doctor or pharmacist if you have questions about what's safe for you during these times.
What is gingivitis and why is magnolia possibly effective for it?
Gingivitis is inflammation of the gums, usually caused by buildup of plaque and bacteria. Magnolia extract is rated possibly effective for gingivitis, though the evidence is still limited. Lab studies suggest its active compounds may have some anti-inflammatory or antimicrobial action, but more human research is needed to confirm benefit.
Will this help with anxiety?
The evidence isn't established. While animal studies show magnolia's compounds have sedative properties, there isn't enough reliable evidence to say whether the extract actually reduces anxiety in people. If anxiety is your reason for considering it, talk with your doctor or pharmacist about what's proven to work.
What side effects should I watch for?
Magnolia extract is generally well tolerated when taken by mouth. A few trial participants reported sexual dysfunction, shaking hands with mouth numbness, fatigue, and headache, but it's unclear if magnolia caused these. Topically, it may cause contact dermatitis in sensitive people.
Why is the interaction with blood thinners a concern?
Magnolia's active compounds can slow blood clotting on their own. If you're already taking a blood thinner to prevent clots or reduce bleeding risk, adding magnolia could increase that effect too much and raise your risk of dangerous bleeding. That's why it needs a check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Magnolia Extract is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Magnolia Extract label
Sources

Sources & How We Checked

Magnolia Extract's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

See these in context on the Magnolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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