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Dietary supplement

Magnolia Extract Honokiol + Magnolol 90% Ingredients & Drug Interactions

by NutriCology

Magnolia Extract Honokiol + Magnolol 90% label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Magnolia Extract Honokiol + Magnolol 90% against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Magnolia Extract Honokiol + Magnolol 90% is a dietary supplement by NutriCology with 1 active ingredient. Its ingredients are commonly taken for anxiety and stress, sleep problems, digestive upset.Based on those ingredients, 351 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Magnolia (bark) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Magnolia Extract Honokiol + Magnolol 90% by NutriCology

Ask about any prescription or over-the-counter medication and we check it for interactions with Magnolia Extract Honokiol + Magnolol 90% by NutriCology — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Magnolia Extract Honokiol + Magnolol 90% by NutriCology

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: magnolia bark extract, standardized to deliver 90% honokiol and magnolol—the two compounds believed to be responsible for magnolia's effects. The capsule itself includes three inactive ingredients: hydroxypropyl methylcellulose (the capsule material), microcrystalline cellulose, and L-leucine.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Magnolia's overall clinical evidence instead.

Moderate

Some clinical evidence supports Magnolia for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Gingivitis — rated "Possibly Effective" (Natural Medicines).

Magnolia extract is possibly effective for gingivitis (gum inflammation), based on the evidence we have on file. For allergic rhinitis (hay fever) and anxiety, the evidence isn't strong enough to rate—we don't hold reliable data showing it works.

Dental plaque is also in the insufficient-evidence category. If you're thinking about this product for one of those uses, talk it over with your doctor or dentist about whether the current evidence supports it for your situation.

The evidence, ingredient by ingredient Magnolia

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, magnolia is generally well tolerated in the short term, though human safety data is limited. One trial participant in a combination product reported sexual dysfunction, and others reported shaking hands, numbness around the mouth, fatigue, and headache—but it's unclear whether magnolia or another ingredient caused these.

Topically, contact dermatitis has been reported. Magnolia is considered unsafe in pregnancy—safety data advises against it.

There isn't enough reliable safety information for breastfeeding, so it's best avoided then as well. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Magnolia

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Magnolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 351 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking this product if you use blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, etc.)—magnolia may increase bleeding risk. Also check if you take any CNS depressants (benzodiazepines, opioids, sedating antidepressants, sleep aids)—the combination could worsen drowsiness and impaired alertness.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Magnolia extract may help with gum inflammation, but the evidence for other common uses is weak or absent. It's a concern if you take blood thinners or sedating medications—the combination could theoretically boost bleeding risk or drowsiness.

It's off-limits in pregnancy and breastfeeding. Check your medications with your doctor or pharmacist before starting, especially if you're on any blood thinner or CNS depressant.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Magnolia Extract Honokiol + Magnolol 90%, straight from the product label.

Brand NutriCology
Barcode (UPC) 713947563902
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 235532
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Magnolia Extract Honokiol + Magnolol 90% by NutriCology, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
713947563902
IngredientAmount% DV
Magnolia (bark) extract200 mg--

Other ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, L-Leucine

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Magnolia Extract provides an extract containing honokiol and magnolol concentrated to 90%.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 1 capsule daily, or as directed by a healthcare practitioner.

Precautions

Warning: May cause drowsiness. Do not operate a motor vehicle or other machinery after ingesting.

Storage

Keep in a cool, dry place, tightly capped. Avoid high temperatures for extended periods.

General Statements

NutriCology Innovative Nutrition

Formulation

Hypoallergenic

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Magnolia Extract Honokiol + Magnolol 90% by NutriCology label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Magnolia Extract Honokiol + Magnolol 90% label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Magnolia Extract Honokiol + Magnolol 90% by NutriCology

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Magnolia (bark) extract

Interacts with
351 drugs
200 mg per serving Form: Honokiol, Magnolol

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human r...

Magnolia (bark) extract monograph & interactions

Other (inactive) ingredients: Hydroxypropyl Methylcellulose, Microcrystalline Cellulose, L-Leucine. These complete the product’s ingredient list but are not active constituents.

Interaction report

Magnolia Extract Honokiol + Magnolol 90% by NutriCology Drug Interactions

Want to check YOUR meds against Magnolia Extract Honokiol + Magnolol 90%?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
351Drugs
351 Moderate

Ingredients driving the most interactions

Magnolia (bark) extract 351

Individual Drug Interactions

The ingredients in Magnolia Extract Honokiol + Magnolol 90% interact with 351 drugs. Click any drug to see the details.

1 of the 1 ingredient in Magnolia Extract Honokiol + Magnolol 90% interact with drugs. Each result below shows which ingredient is responsible. Magnolia (bark) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Magnolia Extract Honokiol + Magnolol 90% with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnolia (bark) extract2 drug types · 351 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, magnolia might have additive effects and increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
In vitro research shows that the chemicals magnolol and honokiol, isolated from magnolia bark, inhibit platelet aggregation that is experimentally induced by collagen and arachidonic acid. However, they do not inhibit platelet aggregation that is induced by adenosine diphosphate, platelet-activating factor, or thrombin. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use of large doses of magnolia bark and CNS depressants might have additive effects.
In vitro and animal research shows that constituents extracted from magnolia bark, especially honokiol and magnolol, have sedative effects. These effects may be due to the inhibition of catecholamine release and modulation of gamma-aminobutyric acid-A (GABA-A) receptors.

Likelihood Possible Evidence D
Magnolia (bark) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Magnolia Extract Honokiol + Magnolol 90%, from the product label.

NutriCology

See all NutriCology products
Name
NutriCology
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800.545.9960
Web Address
www.nutricology.com
Pharmacist Counseling Corner

Magnolia Extract Honokiol + Magnolol 90% by NutriCology: Common Questions

Does Magnolia Extract Honokiol + Magnolol 90% by NutriCology interact with any medications?
Yes. Based on its ingredients, Magnolia Extract Honokiol + Magnolol 90% has a known interaction with 351 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Magnolia Extract Honokiol + Magnolol 90% contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm pregnant or breastfeeding?
No. Magnolia is considered unsafe in pregnancy—safety data advises against it. There isn't enough reliable safety information for breastfeeding either, so it's best avoided then as well. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing.
Does magnolia actually work for anxiety?
The evidence we have on file isn't strong enough to say. While magnolia's compounds show sedative effects in lab and animal studies, we don't hold reliable evidence that it works for anxiety in people, so I can't recommend it for that use based on current data.
What side effects might I notice?
Magnolia is generally well tolerated when taken by mouth. In trials, a small number of participants reported sexual dysfunction, shaking hands, numbness around the mouth, fatigue, and headache—though it's unclear if magnolia caused these or another ingredient did. If you notice anything unusual, stop and talk to your pharmacist.
Is this product safe for long-term use?
Human safety data is limited. It may be okay short-term for many adults, but we don't have enough data to say it's safe for extended use. If you're thinking about taking it regularly, check in with your doctor or pharmacist first.
What exactly is honokiol and magnolol?
They're the two active compounds in magnolia bark extract. This product is standardized to 90% honokiol and magnolol, meaning the extract is concentrated to deliver a high amount of these compounds—the ones believed to produce magnolia's effects.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Magnolia Extract Honokiol + Magnolol 90% is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Magnolia Extract Honokiol + Magnolol 90% label
Go deeper

The Full Monographs Behind Magnolia Extract Honokiol + Magnolol 90%’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Magnolia

Interacts with 351 drugs

Magnolia bark and flower buds have a long history in traditional Chinese and Japanese medicine, often for stress, sleep, and digestion. Modern human research is still limited, so we can't be...

Read the full Magnolia monograph →
Sources

Sources & How We Checked

Magnolia Extract Honokiol + Magnolol 90%'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Magnolia 9 references
  1. Kuribara H, Kishi E, Hattori N, et al. The anxiolytic effect of two oriental herbal drugs in Japan attributed to honokiol from magnolia bark. J Pharm Pharmacol 2000;52:1425-9. PubMed
  2. Tachikawa E, Takahashi M, Kashimoto T. Effects of extract and ingredients isolated from Magnolia obovata thunberg on catecholamine secretion from bovine adrenal chromaffin cells. Biochem Pharmacol 2000;60:433-40. PubMed
  3. Jung KY, Kim DS, Oh SR, et al. Magnone A and B, novel anti-PAF tetrahydrofuran lignans from the flower buds of Magnolia fargesii. J Nat Prod 1998;61:808-11.
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Teng CM, Chen CC, Ko FN, et al. Two antiplatelet agents from Magnolia officinalis. Thromb Res 1988;50:757-65. PubMed
  6. Ghys K, De Palma A, Vandevenne A, Werbrouck J, Goossens A. Magnolia officinalis bark extract, a recently identified contact allergen in 'anti-ageing' cosmetics. Contact Dermatitis. 2015 Aug;73(2):130-2.
  7. Raison-Peyron N, Césaire A, Du-Thanh A, Dereure O. Allergic contact dermatitis caused by Magnolia officinalis bark extract in a facial anti-ageing cream. Contact Dermatitis. 2015 Jun;72(6):416-7.
  8. Nilausen TD, Johansen JD, Thyssen JP. Allergic contact dermatitis of the face caused by Magnolia officinalis bark extract. Contact Dermatitis. 2016;75(6):385-87.
  9. Amat-Samaranch V, López-Sánchez C, Tubau C, Puig L, Serra-Baldrich E. Vulvar allergic contact dermatitis caused by Magnolia officinalis bark extract. Contact Dermatitis 2022;87(1):96-97.

See these in context on the Magnolia monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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