No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Mayapple Ingredients & Drug Interactions

by Pure Herbs

Mayapple label
See full label image
Liquid Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mayapple against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Mayapple is a dietary supplement by Pure Herbs with 1 active ingredient. Its ingredients are commonly taken for genital and skin warts (topical), constipation (historical/traditional laxative), digestive complaints (homeopathic).We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Mayapple by Pure Herbs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: mayapple root extract. The extract is derived from podophyllum, a plant whose resin has been used topically under strict medical supervision for certain skin conditions.

This is a liquid form, with no other inactive ingredients listed.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: maintaining lung health and occasional constipation.
  • We looked for evidence on: constipation, lung health.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

Mayapple root extract is rated likely effective for human papillomavirus (HPV) infection. For hairy leukoplakia and corns, the evidence isn't strong enough to establish whether it works — there's insufficient reliable data to rate it either way.

The evidence, ingredient by ingredient Podophyllum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This is where we need to be direct: podophyllum and its resin are toxic, and this product carries serious safety warnings. The plant should only be used as a standardized prescription topical product under medical supervision — never as a home remedy or over-the-counter supplement.

Orally or topically, it can cause severe abdominal pain, vomiting, diarrhea, bone marrow depression, liver and kidney damage, heart problems, nerve damage, and in rare cases, death. Podophyllum is likely unsafe in pregnancy and likely unsafe while breastfeeding; it can harm a developing baby and pass into breast milk.

Because the compounds are toxic, safety while breastfeeding is not established and should be avoided.

Side effects, ingredient by ingredient Podophyllum

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for mayapple root extract. However, the serious safety profile of this ingredient means you should discuss it with your pharmacist or doctor before starting it, regardless of your current medications.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Even though mayapple has shown some effectiveness for HPV, the serious toxicity risks mean this isn't something to self-treat with. If you're considering it for any condition, talk with your doctor or pharmacist first — prescription topical formulas exist and are safer under proper medical oversight.

Do not use this product during pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 13, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mayapple, straight from the product label.

Brand Pure Herbs
Net contents 1 Fluid Ounce(s); 30 mL
Market status On market
Date entered into DSLD Dec 13, 2022
DSLD ID 278810
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mayapple by Pure Herbs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 mL
Maximum serving Sizes:
2 mL
Servings per container
15
IngredientAmount% DV
Mayapple Root Extract1911 mg--

Other ingredients: None

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, mix 2 mL (abt. 1/2 tsp) of extract in 2 fl. oz (60 mL) water one time daily preferably with a meal.

Shake well before use

Formulation

Beneficial for maintaining lung health and occasional constipation.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Warning: Not intended for use by pregnant or nursing women. If you have a medical condition or are taking medication, consult your doctor prior to use.

Discontinue use and consult with your doctor if any adverse reactions occur.

Keep out of reach of children

Brand IP Statement(s)

Pure Herbs, Ltd. Natural Herbal Extracts

FDA Statement of Identity

Dietary Supplement

General Statements

"No expense has been spared to provide the finest nature has to offer."

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mayapple by Pure Herbs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mayapple label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mayapple by Pure Herbs

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 mL Dosage formLiquid Servings per container15 Amounts shown are per serving.

Mayapple Root Extract

No known
interactions
1911 mg per serving

Podophyllum (American mayapple) is a toxic plant whose resin contains podophyllotoxin, used in prescription topical products to treat warts. The raw p...

Mayapple Root Extract monograph & interactions

Other (inactive) ingredients: None. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mayapple by Pure Herbs Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Mayapple. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Mayapple, from the product label.

Pure Herbs

See all Pure Herbs products
Name
Pure Herbs, Ltd.
City
Sterling Heights
State
MI
Phone Number
(800) 860-4372
Web Address
www.pureherbs.com
Pharmacist Counseling Corner

Mayapple by Pure Herbs: Common Questions

Does Mayapple by Pure Herbs interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Mayapple. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Mayapple contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is mayapple safe to take by mouth?
No. Podophyllum and its resin are toxic when taken orally or applied to skin outside of a controlled prescription setting. Serious effects — including abdominal pain, severe vomiting, diarrhea, bone marrow damage, liver and kidney failure, and heart problems — have been reported, and fatalities have occurred. This product should not be used at home.
Can I use this while pregnant or breastfeeding?
No. Mayapple is rated likely unsafe in pregnancy because it can harm a developing baby. It's also rated likely unsafe while breastfeeding because the toxic compounds pass into breast milk and safety is not established. Do not use this product if you're pregnant, trying to become pregnant, or breastfeeding.
What is mayapple actually used for?
Mayapple extract is rated likely effective for human papillomavirus (HPV) infection. For other conditions like hairy leukoplakia and corns, there isn't enough reliable evidence to say whether it works. Any use should be under medical supervision with a prescription topical product, not over-the-counter.
What are the main side effects?
Serious side effects from podophyllum include severe abdominal pain, vomiting, diarrhea, bone marrow depression (which affects your blood-making cells), liver and kidney damage, heart problems, nerve damage, hallucinations, and paralysis. Deaths have been reported with both oral and topical use outside of medical supervision.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mayapple is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mayapple label
Go deeper

The Full Monographs Behind Mayapple’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Podophyllum

Podophyllum (American mayapple) is a toxic plant whose resin contains podophyllotoxin, used in prescription topical products to treat warts. The raw plant and crude resin are poisonous if ta...

Read the full Podophyllum monograph →
Sources

Sources & How We Checked

Mayapple's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 13 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Podophyllum 13 references
  1. Cassidy DE, Drewry J, Fanning JP. Podophyllum toxicity: a report of a fatal case and a review of the literature. J Toxicol Clin Toxicol 1982;19:35-44. PubMed
  2. Rosenstein G, Rosenstein H, Freeman M, Weston N. Podophyllum-a dangerous laxative. Pediatrics 1976;57:419-21. DOI
  3. Lozada-Nur F, Costa C. Retrospective findings of the clinical benefits of podophyllum resin 25% sol on hairy leukoplakia. Clinical results in nine patients. Oral Surg Oral Med Oral Pathol 1992;73:555-8. PubMed
  4. Frasca T, Brett AS, Yoo SD. Mandrake toxicity. A case of mistaken identity. Arch Intern Med 1997;157:2007-9.
  5. Schwartz J, Norton SA. Useful plants of dermatology. VI. The mayapple (Podophyllum). J Am Acad Dermatol 2002;47:774-5. PubMed
  6. Mack RB. Living mortals run mad. Mandrake (podophyllum) poisoning. N C Med J 1992;53:98-9.
  7. Longstaff E, von Krogh G. Condyloma eradication: self-therapy with 0.15-0.5% podophyllotoxin versus 20-25% podophyllin preparations--an integrated safety assessment. Regul Toxicol Pharmacol 2001;33:117-37. PubMed
  8. Wiley DJ, Douglas J, Beutner K, et al. External genital warts: diagnosis, treatment, and prevention. Clin Infect Dis 2002;35:S210-24. PubMed
  9. Moura, M. D., Guimaraes, T. R., Fonseca, L. M., de, Almeida Pordeus, I, and Mesquita, R. A. A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir c
  10. Martin, L. K., Rubin, A. I., Theocharous, C., and Murrell, D. F. Podophyllin reaction mimicking Bowen's disease in a patient with delusions of verrucosis. Clin Exp.Dermatol 2008;33(4):443-445. PubMed
  11. Chamberlain, M. J., Reynolds, A. L., and Yeoman, W. B. Medical memoranda. Toxic effect of podophyllum application in pregnancy. Br.Med.J. 8-12-1972;3(823):391-392. PubMed
  12. Karol, M. D., Conner, C. S., Watanabe, A. S., and Murphrey, K. J. Podophyllum: suspected teratogenicity from topical application. Clin.Toxicol. 1980;16(3):283-286. PubMed
  13. Gowdey, G., Lee, R. K., and Carpenter, W. M. Treatment of HIV-related hairy leukoplakia with podophyllum resin 25% solution. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 1995;79(1):64-67. PubMed

See these in context on the Podophyllum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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