Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

David Winston's Selection: Scudder's Alterative Ingredients & Drug Interactions

by Herbalist & Alchemist

David Winston's Selection: Scudder's Alterative label
See full label image
Liquid Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking David Winston's Selection: Scudder's Alterative against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

David Winston's Selection: Scudder's Alterative is a dietary supplement by Herbalist & Alchemist with 5 active ingredients. Its ingredients are commonly taken for constipation, digestive support, skin conditions.Based on those ingredients, 1,166 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Corydalis yanhusuo, Yellow Dock, Figwort. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against David Winston's Selection: Scudder's Alterative by Herbalist & Alchemist

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HelloPharmacist Scorecard of David Winston's Selection: Scudder's Alterative by Herbalist & Alchemist

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1.50 mL) without saying how much of each component you get.

Scudder's Alterative is a liquid blend of five herbal ingredients: Yellow Dock, Corydalis yanhusuo, Red Alder, Mayapple, and Figwort. The product also contains distilled water, ethyl alcohol (as a preservative and solvent), unrefined cane sugar, black cherry juice concentrate, and vegetable glycerin as inactive ingredients.

This is a traditional botanical formula — a "proprietary blend" means the exact amounts of each herb aren't disclosed, so the relative strength of each ingredient isn't transparent on the label.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Promotes lymphatic, liver, bowel and kidney function.
  • We looked for evidence on: Constipation, Dyspepsia, Headache, Lymphatic support, Liver support, Kidney function.
  • The closest evidence on file: Corydalis Yanhusuo is rated "Insufficient Reliable Evidence To Rate" for Headache (Natural Medicines).
  • Also on file: Corydalis Yanhusuo is rated "Insufficient Reliable Evidence To Rate" for Constipation, Dyspepsia.

The evidence we hold does not establish how well this product works. Corydalis yanhusuo has insufficient reliable evidence for the conditions commonly listed for it (headache, constipation, depression, indigestion).

Mayapple is likely effective for human papillomavirus (HPV) when used as a standardized topical prescription product, but this is a liquid herbal blend, not that kind of preparation. Yellow Dock, Figwort, and Red Alder have no effectiveness ratings in our data.

If you're considering this for a specific health concern, your pharmacist or doctor can help you weigh what's actually known.

The evidence, ingredient by ingredient Yellow Dock Corydalis Yanhusuo Podophyllum Figwort

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Yellow Dock and Mayapple both carry serious safety concerns. Yellow Dock acts as a laxative and contains oxalates; the safety data advises against use during pregnancy and lactation, and it should be used short-term only.

Raw yellow dock leaves or rhizomes can cause calcium deficiency, kidney stones, and vomiting; very large amounts have been linked to breathing problems and death. Mayapple is toxic — the plant and crude resin are unsafe to take by mouth or apply topically without prescription supervision, and the safety data advises firmly against use in pregnancy and lactation because it can harm a developing baby and poison through breast milk.

Corydalis yanhusuo has limited human safety data and varying product quality; the safety data advises against use in pregnancy (likely unsafe) and breastfeeding (likely unsafe). Figwort and Red Alder have limited safety information — use short-term only.

This product is an ethanol-based liquid (it contains alcohol as a preservative), so keep that in mind if you avoid alcohol or take medications sensitive to it.

Side effects, ingredient by ingredient Yellow Dock Corydalis Yanhusuo Podophyllum Figwort

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Corydalis Yanhusuo, Figwort, Yellow Dock.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 1,167 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take any diuretics (water pills), digoxin (Lanoxin), warfarin (Coumadin) or other blood thinners, antiplatelet drugs like aspirin or clopidogrel, CNS depressants (sedatives, sleep aids, narcotic painkillers, alcohol), antihypertensive drugs (blood-pressure medications), antidiabetes drugs or metformin, medications broken down by your liver (CYP2D6, CYP2C9, or CYP3A4 substrates — a very large group), or lithium. The medication search tool on this page can check your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This is a traditional herbal blend with significant interaction potential and serious safety concerns around some of its ingredients — particularly Mayapple, which is toxic, and Yellow Dock, which carries Major-severity medication risks. If you take any prescription medications (especially heart drugs, blood thinners, diabetes medications, psychiatric drugs, or blood-pressure medications), or if you're pregnant, nursing, or planning to become pregnant, talk with your pharmacist or doctor before using this product.

Even without medications, the toxicity profile of some ingredients here warrants caution.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about David Winston's Selection: Scudder's Alterative, straight from the product label.

Brand Herbalist & Alchemist
Barcode (UPC) 667056125158
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 297466
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for David Winston's Selection: Scudder's Alterative by Herbalist & Alchemist, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
1.5 mL
Servings per container
40
UPC/BARCODE
667056125158
IngredientAmount% DV
Proprietary Blend1.5 mL--
Yellow Dock0 NP--
Corydalis yanhusuo0 NP--
Red Alder0 NP--
Mayapple0 NP--
Figwort0 NP--

Other ingredients: distilled Water, Ethyl Alcohol, Cane Sugar, Unrefined, Black Cherry Juice Concentrate, Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Promotes Lymphatic, Liver, Bowel and Kidney Function

Certified Organic

Ecologically Harvested

FDA Statement of Identity

Herbal Supplement

Suggested/Recommended/Usage/Directions

Suggested use: 20-30 drops (1-1.5mL) in juice or water. Take 3 times per day. Shake well before using.

Precautions

Contraindications: Do not use during pregnancy, lactation or if you have diarrhea.

Use under the supervision of a qualified expert.

Keep out of children's reach

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

OK (Kosher)

Seals/Symbols

OK (Kosher)

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See for yourself

David Winston's Selection: Scudder's Alterative by Herbalist & Alchemist label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

David Winston's Selection: Scudder's Alterative label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in David Winston's Selection: Scudder's Alterative by Herbalist & Alchemist

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container40 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1.5 mL per serving

Other (inactive) ingredients: Distilled Water, Ethyl Alcohol, Cane Sugar, Unrefined, Black Cherry Juice Concentrate, Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

David Winston's Selection: Scudder's Alterative by Herbalist & Alchemist Drug Interactions

Want to check YOUR meds against David Winston's Selection: Scudder's Alterative?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,166Drugs
76 Major 1,090 Moderate

Ingredients driving the most interactions

Corydalis yanhusuo 1,160
Yellow Dock 78
Figwort 76

Individual Drug Interactions

The ingredients in David Winston's Selection: Scudder's Alterative interact with 1,166 drugs. Click any drug to see the details.

3 of the 5 ingredients in David Winston's Selection: Scudder's Alterative interact with drugs. Each result below shows which ingredient is responsible. Corydalis yanhusuo Yellow Dock Figwort

Each ingredient & the kinds of drugs it affects

For each ingredient in David Winston's Selection: Scudder's Alterative with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Corydalis yanhusuo14 drug types · 1,160 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, Corydalis yanhusuo might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Corydalis yanhusuo contains berberine. In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, Corydalis yanhusuo might also inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, Corydalis yanhusuo may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Corydalis yanhusuo contains berberine. Clinical research shows that berberine may lower blood glucose levels. Theoretically, Corydalis yanhusuo might also lower blood glucose levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, Corydalis yanhusuo might have additive effects with antihypertensive drugs.
Corydalis yanhusuo contains berberine. Animal research suggests that berberine can have hypotensive effects. Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone. Theoretically, Corydalis yanhusuo might also reduce blood pressure.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, Corydalis yanhusuo might increase the sedative effects of CNS depressants.
Corydalis yanhusuo contains berberine. Animal research suggests that berberine may have sedative effects. Theoretically, Corydalis yanhusuo might also have CNS depressants effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, Corydalis yanhusuo might increase blood levels of cyclosporine.
Corydalis yanhusuo contains berberine. Preliminary clinical research shows that berberine can reduce metabolism of cyclosporine and increase serum levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine. Theoretically, Corydalis yanhusuo might also reduce the metabolism of cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2C9.
Corydalis yanhusuo contains berberine. Preliminary clinical research shows that berberine can inhibit CYP2C9. Theoretically, Corydalis yanhusuo might also inhibit CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP2D6.
Corydalis yanhusuo contains berberine. In vitro research and preliminary clinical evidence show that berberine can inhibit CYP2D6. Theoretically, Corydalis yanhusuo might also inhibit CYP2D6.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, Corydalis yanhusuo might increase serum levels of drugs metabolized by CYP3A4.
Corydalis yanhusuo contains berberine. In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, Corydalis yanhusuo might also inhibit CYP3A4.

Likelihood Possible Evidence D
Dextromethorphan (Robitussin Dm, Others)

Theoretically, Corydalis yanhusuo may increase serum levels of dextromethorphan.
Corydalis yanhusuo contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan. Theoretically, Corydalis yanhusuo may also inhibit the metabolism of dextromethorphan.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, Corydalis yanhusuo might reduce the therapeutic effects of losartan by decreasing its conversion to its active form.
Corydalis yanhusuo contains berberine. Preliminary clinical research suggests that berberine can inhibit cytochrome P450 2C9 (CYP2C9) activity and reduce metabolism of losartan. Theoretically, Corydalis yanhusuo might also inhibit the metabolism of losartan.

Likelihood Possible Evidence D
Metformin (Glucophage)

Theoretically, Corydalis yanhusuo might increase the therapeutic and adverse effects of metformin.
Corydalis yanhusuo contains berberine. In vitro and animal studies show that berberine can increase the systemic exposure and half-life of metformin, potentially increasing metformin's effects and side effects. This interaction seems to be most apparent when berberine is administered 2 hours prior to metformin. Taking berberine and metformin at the same time does not appear to increase systemic exposure to metformin. It is unclear if Corydalis yanhusuo might have this same effect.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, Corydalis yanhusuo might reduce metabolism of midazolam, which might increase the risk of severe adverse effects.
Corydalis yanhusuo contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam. Theoretically, Corydalis yanhusuo might also inhibit the metabolism of midazolam.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, Corydalis yanhusuo might increase the sedative effect of pentobarbital.
Corydalis yanhusuo contains berberine. Animal research shows that berberine can prolong pentobarbital-induced sleeping time. Theoretically, Corydalis yanhusuo might increase the sedative effects of pentobarbital.

Likelihood Possible Evidence D
Tacrolimus (Prograf)

Theoretically, Corydalis yanhusuo might increase blood levels of tacrolimus.
Corydalis yanhusuo contains berberine. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with tacrolimus 6.5 mg twice daily, intake of berberine 200 mg three times daily increased the blood concentration of tacrolimus from 8 to 22 ng/mL. Following a reduction of the tacrolimus dose to 3 mg daily, blood levels of tacrolimus decreased to 12 ng/mL. It is unclear if Corydalis yanhusuo might have this same effect.

Likelihood Possible Evidence D
Corydalis yanhusuo full monograph & interactions

Yellow Dock3 drug types · 78 drugs

Digoxin (Lanoxin)

Theoretically, yellow dock might increase the risk of digoxin toxicity when used long-term or in large amount.
When yellow dock is used chronically or in large amounts, hypokalemia may occur. This might increase the toxic effects of digoxin.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
When yellow dock is used chronically or in large amounts, hypokalemia may occur, and overuse of yellow dock might compound diuretic-induced potassium loss.

Likelihood Probable Evidence D
Warfarin (Coumadin)

Theoretically, the laxative effects of yellow dock might increase the effects of warfarin, including the risk of bleeding.
The anthraquinones in yellow dock have a mild stimulant laxative effect. Consuming excessive amounts can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Yellow Dock full monograph & interactions

Figwort2 drug types · 76 drugs

Diuretic Drugs

Theoretically, overuse of figwort might compound diuretic-induced potassium loss. There is some concern that people taking figwort along with potassium depleting diuretics might have an increased risk for hypokalemia. Initiation of potassium supplementation or an increase in potassium supplement dose may be necessary for some patients. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.

Likelihood Possible Evidence D
Lithium

Figwort is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, figwort might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Figwort full monograph & interactions
The maker

Brand information

Manufacturer and brand details for David Winston's Selection: Scudder's Alterative, from the product label.

Herbalist & Alchemist

See all Herbalist & Alchemist products
Name
Herbalist & Alchemist, Inc.
City
Washington
State
NJ
ZipCode
07882
Phone Number
800-611-8235
Web Address
www.herbalist-alchemist.com
Pharmacist Counseling Corner

David Winston's Selection: Scudder's Alterative by Herbalist & Alchemist: Common Questions

Does David Winston's Selection: Scudder's Alterative by Herbalist & Alchemist interact with any medications?
Yes. Based on its ingredients, David Winston's Selection: Scudder's Alterative has a known interaction with 1,166 medications, including 76 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
David Winston's Selection: Scudder's Alterative contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this during pregnancy or while breastfeeding?
No. Two of the five ingredients — Corydalis yanhusuo and Yellow Dock — are rated likely unsafe or possibly unsafe in pregnancy and lactation. Mayapple is toxic and must be avoided entirely in pregnancy and while nursing because it can harm a developing baby and poison through breast milk. Talk with your doctor before considering this product if you're pregnant, nursing, or trying to conceive.
What does Yellow Dock do in this formula?
Yellow Dock is included as a traditional alterative herb, but we hold no effectiveness rating for it in our data. It does act as a mild laxative and contains oxalates, which is why the safety data recommend short-term use only and caution with certain medications.
Can I take this if I'm on a heart medication or blood thinner?
Not without checking with your pharmacist first. Yellow Dock carries Major-severity risks with heart medications like digoxin and blood thinners like warfarin, and Corydalis yanhusuo adds Moderate risk with blood thinners. The interaction risk depends on your specific drug, dose, and how long you'd use this blend.
What is Mayapple doing in this formula?
Mayapple is a traditional botanical ingredient in this blend. However, it is toxic — the plant itself and crude resin are unsafe to take by mouth. Only standardized prescription topical products should be used under medical supervision, so including it in a liquid herbal supplement raises serious safety concerns.
Does this product have any side effects?
Yellow Dock can act as a laxative and cause diarrhea, especially with heavy or long-term use; raw leaves or rhizomes may cause calcium deficiency, kidney stones, and vomiting. Mayapple is toxic and can cause serious adverse effects including abdominal pain, severe diarrhea, vomiting, liver and kidney damage, and bone marrow suppression — fatalities have been reported. Corydalis yanhusuo has limited human safety data. Because this is an ethanol-based liquid, it also contains alcohol.
What is this formula traditionally used for?
Scudder's Alterative is a traditional herbal blend, but we hold no effectiveness ratings in our data that tell us how well it actually works for any specific condition. If you're considering it for a particular health concern, your pharmacist or doctor can discuss what the evidence actually shows.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

David Winston's Selection: Scudder's Alterative label
Go deeper

The Full Monographs Behind David Winston's Selection: Scudder's Alterative’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Yellow Dock

Interacts with 78 drugs

Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefits are largely unproven, and its natural...

Read the full Yellow Dock monograph → Herb & supplement monograph

Corydalis Yanhusuo

Interacts with 1,160 drugs

Corydalis yanhusuo is a traditional Chinese herb used mainly for pain. Some early laboratory and animal research suggests its compounds may affect pain and the nervous system, but high-quali...

Read the full Corydalis Yanhusuo monograph → Herb & supplement monograph

Podophyllum

Podophyllum (American mayapple) is a toxic plant whose resin contains podophyllotoxin, used in prescription topical products to treat warts. The raw plant and crude resin are poisonous if ta...

Read the full Podophyllum monograph → Herb & supplement monograph

Figwort

Interacts with 76 drugs

Figwort is a traditional herb used mainly for skin problems and minor swelling, but solid human studies are lacking, so its benefits remain unproven. It is generally used short-term and topi...

Read the full Figwort monograph →
Sources

Sources & How We Checked

David Winston's Selection: Scudder's Alterative's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 43 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Yellow Dock 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  6. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  7. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  8. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed

See these in context on the Yellow Dock monograph →

Corydalis Yanhusuo 21 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  3. Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
  4. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  5. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  7. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
  8. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  9. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  10. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
  11. Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
  12. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
  13. Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
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  15. Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
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See these in context on the Corydalis Yanhusuo monograph →

Podophyllum 13 references
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  2. Rosenstein G, Rosenstein H, Freeman M, Weston N. Podophyllum-a dangerous laxative. Pediatrics 1976;57:419-21. DOI
  3. Lozada-Nur F, Costa C. Retrospective findings of the clinical benefits of podophyllum resin 25% sol on hairy leukoplakia. Clinical results in nine patients. Oral Surg Oral Med Oral Pathol 1992;73:555-8. PubMed
  4. Frasca T, Brett AS, Yoo SD. Mandrake toxicity. A case of mistaken identity. Arch Intern Med 1997;157:2007-9.
  5. Schwartz J, Norton SA. Useful plants of dermatology. VI. The mayapple (Podophyllum). J Am Acad Dermatol 2002;47:774-5. PubMed
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  7. Longstaff E, von Krogh G. Condyloma eradication: self-therapy with 0.15-0.5% podophyllotoxin versus 20-25% podophyllin preparations--an integrated safety assessment. Regul Toxicol Pharmacol 2001;33:117-37. PubMed
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See these in context on the Podophyllum monograph →

Figwort 1 reference
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Figwort monograph →

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