Major interaction on record — check this product against your medications before combining. Based on 4 of 5 ingredients. Check your meds →
Dietary supplement

Deep Detox Ingredients & Drug Interactions

by Gaia Herbs SystemSupport

Deep Detox label
See full label image
Capsule Category: Botanical
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Deep Detox against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Deep Detox is a dietary supplement by Gaia Herbs SystemSupport with 5 active ingredients. Its ingredients are commonly taken for genital and skin warts (topical), constipation (historical/traditional laxative), digestive complaints (homeopathic).Based on those ingredients, 79 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Yellow Dock, Figwort. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Deep Detox by Gaia Herbs SystemSupport

Ask about any prescription or over-the-counter medication and we check it for interactions with Deep Detox by Gaia Herbs SystemSupport — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Deep Detox by Gaia Herbs SystemSupport

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Extract Blend” is a proprietary blend — the label gives one combined amount (990 mg) without saying how much of each component you get.

Deep Detox contains five active ingredients. The product includes a proprietary extract blend — that's a mix whose exact proportions aren't listed on the label — plus mayapple, alder, corydalis, figwort, and yellow dock.

The inactive ingredients are vegetable glycerin and the capsule itself.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Promotes lymphatic drainage and detoxification.
  • We looked for evidence on: Lymphatic support, Detoxification, Immune drainage.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

We hold no effectiveness ratings for any of the active ingredients in this product. The evidence supporting whether these herbs work for detoxification or any other specific health goal isn't established in the data we have.

The evidence, ingredient by ingredient Podophyllum Smooth Alder Figwort Yellow Dock

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

This product carries real safety concerns. Mayapple is toxic and rated likely unsafe in pregnancy and while breastfeeding — the safety data advises against it during both.

Yellow dock is rated possibly unsafe in pregnancy and lactation because of its laxative properties and oxalate content; it can cause serious effects like low calcium and kidney stones if raw leaves are used or if large amounts are taken. Alder has very little human safety research, and the data recommends caution and avoiding it in pregnancy and while nursing.

Figwort has limited safety data and should be used short-term only; it's best avoided during pregnancy and breastfeeding. Corydalis safety information is not on file.

Overall, several of these ingredients carry cautions or warnings that make short-term use at most appropriate — talk with your pharmacist before starting, especially if you're pregnant, nursing, or have kidney or heart concerns.

Side effects, ingredient by ingredient Podophyllum Smooth Alder Figwort Yellow Dock

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 2 of the 4 matched ingredients can interact with medications — Figwort, Yellow Dock.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; heart-rhythm medications; lithium.
  • For scale: 79 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Deep Detox, check with your pharmacist if you take water pills (diuretics), digoxin (Lanoxin) for your heart, warfarin (Coumadin) for blood clotting, or lithium for mood. These are the medication types with documented interactions — yellow dock poses Major-level concerns with diuretics and digoxin.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product is not for everyone. If you take water pills, heart medications like digoxin, blood thinners like warfarin, or lithium, you need to check your specific medications with our tool before using it.

Pregnant or nursing? These ingredients carry warnings — ask your pharmacist or doctor first.

Even if no drug interactions apply to you, the safety profile here is limited, so short-term use only and with professional guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Deep Detox, straight from the product label.

Brand Gaia Herbs SystemSupport
Barcode (UPC) 751063996853
Net contents 28 Vegetarian Liquid Phyto-Cap(s)(TM)
Market status Off market
Date entered into DSLD Jun 25, 2012
DSLD ID 9909
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Deep Detox by Gaia Herbs SystemSupport, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
14
UPC/BARCODE
751063996853
IngredientAmount% DV
Calories20 {Calories}--
Proprietary Extract Blend990 mg--
Mayapple0 NP--
Alder0 NP--
Corydalis0 NP--
Figwort0 NP--
Yellow Dock0 NP--

Other ingredients: Vegetable Glycerin, Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Promotes lymphatic drainage & detoxification*

BEST BY

Laboratory tested for purity

Natural separation may occur. This does not affect product quality.

The Gaia Difference

FDA Statement of Identity

DIETARY SUPPLEMENT

Suggested/Recommended/Usage/Directions

Use only as directed on label.

Suggested Use 1/2 hour before breakfast, adults take 2 capsules with 4-8 oz of water.

Formulation

Free of heavy-metal toxicity

100% vegetarian, dairy free, no gluten-containing ingredients

Formula

Each 2 capsules contain 1,810 mg dry herb equivalent.

Plant-derived capsule

Liquid potency, easy absorption Alcohol-free, Liquid Phyto-Caps(TM)

Figwort

Precautions

Safety sealed for your protection.

Not to be used during pregnancy or lactation.

Keep away from children.

If you have a medical condition or take medications please consult with your doctor before using this product.

Storage

Keep bottle capped at all times and store in a cool dry place.

Brand IP Statement(s)

U.S. Patent No. 6,238,696 B1

General

E09001 V2 [003] 1411-0212

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Deep Detox by Gaia Herbs SystemSupport label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Deep Detox label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Deep Detox by Gaia Herbs SystemSupport

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container14 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Extract Blend

990 mg per serving

Other (inactive) ingredients: Vegetable Glycerin, Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Deep Detox by Gaia Herbs SystemSupport Drug Interactions

Want to check YOUR meds against Deep Detox?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
79Drugs
76 Major 3 Moderate

Ingredients driving the most interactions

Yellow Dock 78
Figwort 76

Individual Drug Interactions

The ingredients in Deep Detox interact with 79 drugs. Click any drug to see the details.

2 of the 5 ingredients in Deep Detox interact with drugs. Each result below shows which ingredient is responsible. Yellow Dock Figwort

Each ingredient & the kinds of drugs it affects

For each ingredient in Deep Detox with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Yellow Dock3 drug types · 78 drugs

Digoxin (Lanoxin)

Theoretically, yellow dock might increase the risk of digoxin toxicity when used long-term or in large amount.
When yellow dock is used chronically or in large amounts, hypokalemia may occur. This might increase the toxic effects of digoxin.

Likelihood Probable Evidence D
Diuretic Drugs

Theoretically, yellow dock might increase the risk of hypokalemia when taken with diuretics.
When yellow dock is used chronically or in large amounts, hypokalemia may occur, and overuse of yellow dock might compound diuretic-induced potassium loss.

Likelihood Probable Evidence D
Warfarin (Coumadin)

Theoretically, the laxative effects of yellow dock might increase the effects of warfarin, including the risk of bleeding.
The anthraquinones in yellow dock have a mild stimulant laxative effect. Consuming excessive amounts can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Yellow Dock full monograph & interactions

Figwort2 drug types · 76 drugs

Diuretic Drugs

Theoretically, overuse of figwort might compound diuretic-induced potassium loss. There is some concern that people taking figwort along with potassium depleting diuretics might have an increased risk for hypokalemia. Initiation of potassium supplementation or an increase in potassium supplement dose may be necessary for some patients. Some diuretics that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, Hydrodiuril, Microzide), and others.

Likelihood Possible Evidence D
Lithium

Figwort is thought to have diuretic properties. Theoretically, due to these potential diuretic effects, figwort might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Figwort full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Deep Detox, from the product label.

Gaia Herbs SystemSupport

See all Gaia Herbs SystemSupport products
Name
Gaia Herbs, Inc.
Street Address
101 Gaia Herbs Dr.
City
Brevard
State
NC
ZipCode
28712
Web Address
GaiaHerbs.com
Pharmacist Counseling Corner

Deep Detox by Gaia Herbs SystemSupport: Common Questions

Does Deep Detox by Gaia Herbs SystemSupport interact with any medications?
Yes. Based on its ingredients, Deep Detox has a known interaction with 79 medications, including 76 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Deep Detox contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
No — at least not without talking to your doctor or pharmacist first. Mayapple is rated likely unsafe for both pregnancy and breastfeeding. Yellow dock is rated possibly unsafe during both, and alder and figwort should be avoided because their safety hasn't been studied in pregnancy or while nursing. This is a conversation you need to have with your healthcare provider.
What does mayapple do in this formula?
According to our data, mayapple is likely effective for human papillomavirus (HPV) when used as a standardized prescription topical product under medical supervision. However, the plant itself and its raw resin are toxic and regarded as unsafe for oral use — only supervised prescription forms should be used.
Is yellow dock a laxative?
Yes, yellow dock acts as a mild stimulant laxative, especially when used in large amounts or long-term. This is one reason the safety data cautions short-term use only and recommends avoiding it during pregnancy and breastfeeding. It's also why there's a concern it might increase bleeding risk if you take warfarin.
Does this product actually work for detoxification?
We don't have effectiveness ratings for the ingredients in Deep Detox, so the evidence supporting its use for detoxification isn't established in our data. Detoxification claims for herbs are often not backed by strong research.
Why should I be careful with water pills if I take this?
Both yellow dock and figwort may have diuretic properties. Combined with prescription water pills, they could increase your risk of low potassium in your blood — that's a problem because low potassium can affect your heart rhythm and overall health. Yellow dock raises this risk to Major severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Deep Detox is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Deep Detox label
Go deeper

The Full Monographs Behind Deep Detox’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Podophyllum

Podophyllum (American mayapple) is a toxic plant whose resin contains podophyllotoxin, used in prescription topical products to treat warts. The raw plant and crude resin are poisonous if ta...

Read the full Podophyllum monograph → Herb & supplement monograph

Smooth Alder

Smooth Alder is a North American shrub used in traditional and folk medicine, mainly as an astringent for skin and mouth complaints. Modern scientific evidence supporting any health benefit...

Read the full Smooth Alder monograph → Herb & supplement monograph

Figwort

Interacts with 76 drugs

Figwort is a traditional herb used mainly for skin problems and minor swelling, but solid human studies are lacking, so its benefits remain unproven. It is generally used short-term and topi...

Read the full Figwort monograph → Herb & supplement monograph

Yellow Dock

Interacts with 78 drugs

Yellow dock is a traditional herb used mostly as a mild laxative and a digestive and skin tonic. Good-quality human studies are lacking, so its benefits are largely unproven, and its natural...

Read the full Yellow Dock monograph →
Sources

Sources & How We Checked

Deep Detox's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 24 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Podophyllum 13 references
  1. Cassidy DE, Drewry J, Fanning JP. Podophyllum toxicity: a report of a fatal case and a review of the literature. J Toxicol Clin Toxicol 1982;19:35-44. PubMed
  2. Rosenstein G, Rosenstein H, Freeman M, Weston N. Podophyllum-a dangerous laxative. Pediatrics 1976;57:419-21. DOI
  3. Lozada-Nur F, Costa C. Retrospective findings of the clinical benefits of podophyllum resin 25% sol on hairy leukoplakia. Clinical results in nine patients. Oral Surg Oral Med Oral Pathol 1992;73:555-8. PubMed
  4. Frasca T, Brett AS, Yoo SD. Mandrake toxicity. A case of mistaken identity. Arch Intern Med 1997;157:2007-9.
  5. Schwartz J, Norton SA. Useful plants of dermatology. VI. The mayapple (Podophyllum). J Am Acad Dermatol 2002;47:774-5. PubMed
  6. Mack RB. Living mortals run mad. Mandrake (podophyllum) poisoning. N C Med J 1992;53:98-9.
  7. Longstaff E, von Krogh G. Condyloma eradication: self-therapy with 0.15-0.5% podophyllotoxin versus 20-25% podophyllin preparations--an integrated safety assessment. Regul Toxicol Pharmacol 2001;33:117-37. PubMed
  8. Wiley DJ, Douglas J, Beutner K, et al. External genital warts: diagnosis, treatment, and prevention. Clin Infect Dis 2002;35:S210-24. PubMed
  9. Moura, M. D., Guimaraes, T. R., Fonseca, L. M., de, Almeida Pordeus, I, and Mesquita, R. A. A random clinical trial study to assess the efficiency of topical applications of podophyllin resin (25%) versus podophyllin resin (25%) together with acyclovir c
  10. Martin, L. K., Rubin, A. I., Theocharous, C., and Murrell, D. F. Podophyllin reaction mimicking Bowen's disease in a patient with delusions of verrucosis. Clin Exp.Dermatol 2008;33(4):443-445. PubMed
  11. Chamberlain, M. J., Reynolds, A. L., and Yeoman, W. B. Medical memoranda. Toxic effect of podophyllum application in pregnancy. Br.Med.J. 8-12-1972;3(823):391-392. PubMed
  12. Karol, M. D., Conner, C. S., Watanabe, A. S., and Murphrey, K. J. Podophyllum: suspected teratogenicity from topical application. Clin.Toxicol. 1980;16(3):283-286. PubMed
  13. Gowdey, G., Lee, R. K., and Carpenter, W. M. Treatment of HIV-related hairy leukoplakia with podophyllum resin 25% solution. Oral Surg.Oral Med.Oral Pathol.Oral Radiol.Endod. 1995;79(1):64-67. PubMed

See these in context on the Podophyllum monograph →

Smooth Alder 2 references
  1. Herbs at a Glance — NIH NCCIH Source
  2. Herbs and Supplements — MedlinePlus Source

See these in context on the Smooth Alder monograph →

Figwort 1 reference
  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

See these in context on the Figwort monograph →

Yellow Dock 8 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Foster S, Tyler VE. Tyler's Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies. 3rd ed., Binghamton, NY: Haworth Herbal Press, 1993.
  3. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  4. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  5. Ellenhorn MJ, et al. Ellenhorn's Medical Toxicology: Diagnoses and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins, 1997.
  6. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  7. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  8. Latif A, Fichadiya H, Abid F, Capo G. Herbal Teas and Thrombocytopenia: A Curious Case of Yellow Dock and Burdock-Induced Thrombocytopenia. Eur J Case Rep Intern Med 2022;9(3):003247. PubMed

See these in context on the Yellow Dock monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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