Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

AMPED BCAA Plus Raspberry Lemonade Flavor Ingredients & Drug Interactions

by Isagenix

Powder Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

AMPED BCAA Plus Raspberry Lemonade Flavor is a dietary supplement by Isagenix with 6 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 278 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sodium, L-Glutamine, L-Tyrosine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of AMPED BCAA Plus Raspberry Lemonade Flavor by Isagenix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 8 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (6,100 mg) without saying how much of each component you get.
  • “Branched-Chain Amino Acids” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

AMPED BCAA Plus contains eight ingredients, including five amino acids: L-glutamine, L-leucine, L-isoleucine, L-tyrosine, L-valine, and L-histidine hydrochloride, plus L-carnitine tartrate and sodium. The product also contains a proprietary blend and branched-chain amino acids (BCAAs) — a group of three amino acids that support muscle recovery and energy during and after exercise.

The remaining ingredients are inactive excipients like dextrose, natural flavors, cane sugar, fructose, citric acid, and stevia.

Does it work?

Leans against
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Leans against

The strongest graded evidence we hold for the stated purpose leans against a benefit.

Why this rating?
  • The label markets this product for: muscle building and exercise performance support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Fatigue, Muscle cramps, muscle recovery — and 2 related terms.
  • The closest evidence on file: Glutamine is rated "Possibly Ineffective" for Athletic performance (Natural Medicines).
  • Also on file: Tyrosine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

The evidence on these ingredients is mixed. L-tyrosine is effective for phenylketonuria (PKU) and possibly effective for cognitive function and memory, but possibly ineffective for athletic performance.

L-glutamine is effective for sickle cell disease and possibly effective for postoperative recovery and critical illness from trauma. L-carnitine is effective for L-carnitine deficiency and possibly effective for high cholesterol, congestive heart failure, and angina.

L-histidine is possibly effective for cholera but has insufficient evidence for eczema, kidney failure, and rheumatoid arthritis. The evidence for BCAAs as a group for sports performance isn't established in the data we hold.

The evidence, ingredient by ingredient Sodium Glutamine Tyrosine Histidine L-carnitine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated but should be used only under medical supervision if you have kidney or liver disease; avoid supplemental doses unless your doctor recommends them, and avoid them while breastfeeding unless advised by a clinician. Common side effects include belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting.

L-tyrosine is generally well tolerated in healthy adults but isn't well studied at high doses — talk to a healthcare provider before regular use, and safety while breastfeeding isn't well established. Common side effects include fatigue, headache, heartburn, and nausea.

L-carnitine is generally well tolerated at typical doses but can cause stomach upset, a fishy body odor, and rarely seizures at high doses; safety while breastfeeding is not well studied. L-histidine is likely safe in food amounts, but higher supplement doses haven't been well studied, so avoid them unless your doctor advises otherwise.

Sodium is linked to high blood pressure and heart strain at excess levels — avoid sodium supplements or very high intake without medical advice. Pregnancy safety is likely safe for glutamine, histidine, and sodium, possibly unsafe for sodium in some contexts, and insufficient data exist for tyrosine.

Side effects, ingredient by ingredient Sodium Glutamine Tyrosine Histidine L-carnitine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Glutamine, L-carnitine, Tyrosine, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; seizure medications; lithium; Parkinson's medications.
  • For scale: 278 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take blood pressure medications (antihypertensives), corticosteroids, lithium, didanosine, sodium phosphates, tolvaptan, other sodium-containing drugs, levodopa, thyroid hormones, warfarin, or acenocoumarol. These represent the main medication interactions documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with graded evidence leaning against its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

AMPED BCAA Plus is designed for muscle recovery and energy support during exercise. If you take blood pressure medications, thyroid hormones, anticonvulsants, levodopa, warfarin, or lithium, you need to check your specific medications with the tool on this page before starting.

Talk with your pharmacist about your full medication list and whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AMPED BCAA Plus Raspberry Lemonade Flavor, straight from the product label.

Brand Isagenix
Barcode (UPC) 390101485
Net contents 9.5 Ounce(s); 270 Gram(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 238744
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AMPED BCAA Plus Raspberry Lemonade Flavor by Isagenix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
13.5 Gram(s)
Maximum serving Sizes:
13.5 Gram(s)
Servings per container
20
UPC/BARCODE
390101485
IngredientAmount% DV
Calories45 Calorie(s)--
Total Carbohydrates7 Gram(s)3%
L-Glutamine0 NP--
Sodium50 mg2%
Proprietary Blend6100 mg--
L-Leucine0 NP--
L-Isoleucine0 NP--
L-Tyrosine0 NP--
L-Valine0 NP--
L-Histidine Hydrochloride0 NP--
Added Sugars5 Gram(s)10%
Total Sugars5 Gram(s)--
L-Carnitine Tartrate0 NP--
Branched-Chain Amino Acids0 NP--

Other ingredients: Dextrose, Natural flavors, Cane Sugar, Fructose, Citric Acid, Rice concentrate, Red Beet (Beta vulgaris) juice powder, Sodium Citrate, Sea Salt, Stevia (Stevia rebaudiana) leaf extract, Beta-Carotene

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

AMPED nutrient timing Pre During Post Anytime

Product of USA

Formulation

Soy-free Gluten-free Dairy-free

Vegetarian

The stimulant-free formula also features L-carnitine to help sustain energy levels while supporting fat burning during exercise.

Consume AMPED BCAA Plus during training to help reduce fatigue and maximize exercise capacity so you can crush your workout.

During workout Muscle fuel for maximum strength and endurance

Made with natural ingredients and no artificial flavors, colors, or sweeteners

Formula

Amplify your results AMPED BCAA Plus supplies branched-chain amino acids (BCAAs) and L-glutamine to help promote the building of lean muscle.

The stimulant-free formula also features L-carnitine to help sustain energy levels while supporting fat burning during exercise.

Made with natural ingredients and no artificial flavors, colors, or sweeteners

For ages 16+.

Suggested/Recommended/Usage/Directions

Consume AMPED BCAA Plus during training to help reduce fatigue and maximize exercise capacity so you can crush your workout. Directions: Mix 2 scoops with 8 fl oz of purified water or beverage of choice. If preferred, pour over ice.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Informed-Sport.com Trusted by sport

Storage

Store in a cool, dry place.

Precautions

Choking hazard: Keep out of reach of children.

Note: If you are pregnant or breastfeeding or have a medical condition, consult your physician before using this product.

Discontinue use if adverse reaction occurs.

See for yourself

AMPED BCAA Plus Raspberry Lemonade Flavor by Isagenix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in AMPED BCAA Plus Raspberry Lemonade Flavor by Isagenix

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size13.5 Gram(s) Dosage formPowder Servings per container20 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
50 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Proprietary Blend

6100 mg per serving

Other (inactive) ingredients: Dextrose, Natural flavors, Cane Sugar, Fructose, Citric Acid, Rice concentrate, Red Beet (Beta vulgaris) juice powder, Sodium Citrate, Sea Salt, Stevia (Stevia rebaudiana) leaf extract, Beta-Carotene. These complete the product’s ingredient list but are not active constituents.

Interaction report

AMPED BCAA Plus Raspberry Lemonade Flavor by Isagenix Drug Interactions

Want to check YOUR meds against AMPED BCAA Plus Raspberry Lemonade Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
278Drugs
278 Moderate

Ingredients driving the most interactions

Sodium 205

Each ingredient & the kinds of drugs it affects

For each ingredient in AMPED BCAA Plus Raspberry Lemonade Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D

L-Tyrosine2 drug types · 21 drugs

Levodopa

Theoretically, tyrosine might decrease the effectiveness of levodopa.
Tyrosine and levodopa compete for absorption in the proximal duodenum by the large neutral amino acid (LNAA) transport system. Advise patients to separate doses of tyrosine and levodopa by at least 2 hours.

Likelihood Probable Evidence D
Thyroid Hormone

Theoretically, tyrosine might have additive effects with thyroid hormone medications.
Tyrosine is a precursor to thyroxine and might increase levels of thyroid hormones.

Likelihood Probable Evidence D

L-Carnitine Tartrate3 drug types · 19 drugs

Acenocoumarol (Sintrom)

Theoretically, L-carnitine might increase the anticoagulant effects of acenocoumarol.
L-carnitine might enhance the anticoagulant effects of acenocoumarol, an oral anticoagulant similar to warfarin, but shorter-acting. There are at least two case reports of INR elevation with concomitant use. In one case, a 33-year-old male with a previously stable INR had an elevated INR of 4.65 after L-carnitine was started and continued for 10 weeks. INR normalized after discontinuation of the L-carnitine-containing product.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, L-carnitine might decrease the effectiveness of thyroid hormone replacement.
L-carnitine appears to act as a peripheral thyroid hormone antagonist by inhibiting entry of thyroid hormone into the nucleus of cells. Taking L-carnitine also seems to diminish some of the symptoms of hyperthyroidism.

Likelihood Probable Evidence B
Warfarin (Coumadin)

Theoretically, L-carnitine might increase the anticoagulant effects of warfarin.
L-carnitine might increase the anticoagulant effects of acenocoumarol, a shorter-acting oral anticoagulant similar to warfarin. There is not enough information to know whether this interaction occurs with L-carnitine and warfarin.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for AMPED BCAA Plus Raspberry Lemonade Flavor, from the product label.

Isagenix

See all Isagenix products
Name
Isagenix International, LLC,
Street Address
155 E. Rivulon Blvd.,
City
Gilbert
State
AZ
ZipCode
85297
Web Address
Isagenix.com
Pharmacist Counseling Corner

AMPED BCAA Plus Raspberry Lemonade Flavor by Isagenix: Common Questions

Does AMPED BCAA Plus Raspberry Lemonade Flavor by Isagenix interact with any medications?
Yes. Based on its ingredients, AMPED BCAA Plus Raspberry Lemonade Flavor has a known interaction with 278 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AMPED BCAA Plus Raspberry Lemonade Flavor contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this product interfere with my blood pressure medication?
Possibly. The sodium in this product may reduce the effectiveness of blood pressure medications, and high sodium intake can increase your blood pressure. Talk to your pharmacist or doctor before adding it to your routine, especially if your blood pressure is already hard to control.
Can I take this if I'm on thyroid medication?
You should check with your pharmacist first. L-tyrosine and L-carnitine in this product might interact with thyroid hormones — tyrosine could have additive effects, and L-carnitine might decrease how well your thyroid medication works.
What are the most common side effects?
The main ones come from L-glutamine and L-carnitine: belching, bloating, diarrhea, constipation, nausea, vomiting, heartburn, and abdominal discomfort. Some people report a fishy body odor from L-carnitine. These are usually mild.
Is L-glutamine effective for muscle recovery?
The data we have show L-glutamine is effective for sickle cell disease and possibly effective for postoperative recovery and trauma recovery, but we don't have effectiveness ratings for general muscle recovery from exercise in our records.
Can I take this while breastfeeding?
Safety while breastfeeding hasn't been well studied for most of these ingredients. L-histidine is likely safe in food amounts. L-glutamine and L-carnitine safety isn't well established, so avoid supplemental doses unless your doctor advises it. Talk to your healthcare provider for personalized advice.
Does this product have fillers?
Yes. Inactive ingredients include dextrose, cane sugar, fructose, citric acid, rice concentrate, natural flavors, stevia, and others — these are fillers and binders used in the powder formula.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AMPED BCAA Plus Raspberry Lemonade Flavor label
Go deeper

The Full Monographs Behind AMPED BCAA Plus Raspberry Lemonade Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Sources

Sources & How We Checked

AMPED BCAA Plus Raspberry Lemonade Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 97 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
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Tyrosine 4 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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