Major interaction on record — check this product against your medications before combining. Based on 5 of 10 ingredients. Check your meds →
Dietary supplement

AMPED Tri-Release Protein Vanilla Custard Flavor Ingredients & Drug Interactions

by Isagenix

AMPED Tri-Release Protein Vanilla Custard Flavor label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking AMPED Tri-Release Protein Vanilla Custard Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

AMPED Tri-Release Protein Vanilla Custard Flavor is a dietary supplement by Isagenix with 10 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 486 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Chromium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix

Ask about any prescription or over-the-counter medication and we check it for interactions with AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 5 of its 9 active ingredients.
  • “Muscle-Building Matrix” is a proprietary blend — the label gives one combined amount (31.75 Gram(s)) without saying how much of each component you get.

AMPED Tri-Release Protein contains 9 ingredients total. The active protein sources are undenatured whey protein isolate, milk protein concentrate, and egg white protein—each designed to digest at different rates so your body gets a steady release of amino acids.

The formula also includes sodium, potassium, phosphorus, and calcium for electrolyte and mineral balance, plus chromium to support blood sugar metabolism. A proprietary Muscle-Building Matrix blends these with other components.

The rest is inactive ingredients: medium-chain triglyceride oil powder, fructose, digestion-resistant maltodextrin, natural flavors, xanthan gum, sea salt, and stevia leaf extract.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Fuel muscles and maximize muscle protein synthesis.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, HIV/AIDS-related wasting, Sarcopenia, Muscle recovery, Strength gains — and 1 related terms.
  • The strongest evidence on file: Whey Protein is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.
  • Also on file: Whey Protein is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS-related wasting, Sarcopenia, Exercise-induced muscle damage.

The whey protein in this formula is possibly effective for athletic performance based on available evidence. For osteoporosis prevention, however, whey has been rated possibly ineffective, and evidence is insufficient to assess its benefit in age-related cognitive decline or HIV/AIDS-related wasting.

Calcium is effective for kidney failure, dyspepsia (indigestion), hypocalcemia (low blood calcium), and hyperkalemia (high blood potassium), and likely effective for osteoporosis. Chromium is likely effective for chromium deficiency and possibly effective for type 2 diabetes, but possibly ineffective for prediabetes.

We have no effectiveness data in our files for the milk protein concentrate, egg white protein, or the Velositol complex.

The evidence, ingredient by ingredient Sodium Potassium Calcium Chromium Whey Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken at recommended amounts, calcium and whey protein are generally well tolerated. Sodium at normal dietary levels is fine, but the safety notes caution against supplemental sodium or very high intake without medical guidance.

Potassium from food is appropriate; supplements warrant doctor oversight, especially during pregnancy and breastfeeding. Chromium is usually well tolerated at typical doses, but long-term or high doses may pose risks.

Whey protein side effects include bloating, cramps, diarrhea, nausea, and reflux—most dose-related—and several case reports link it to acne or worsening of existing acne. Calcium side effects are mild (constipation, upset stomach) but serious cases of kidney stones and calciphylaxis have been reported rarely.

High sodium intake is linked to high blood pressure and increased risk of gastric cancer and heart strain. High potassium can cause heart rhythm problems, and high chromium is rarely linked to kidney damage and blood disorders.

Side effects, ingredient by ingredient Sodium Potassium Calcium Chromium Whey Protein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Calcium, Whey Protein, Potassium, Chromium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 486 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on HIV integrase inhibitors (dolutegravir, elvitegravir), levodopa for Parkinson's disease, ceftriaxone or other antibiotics (especially quinolones and tetracyclines), or bisphosphonate bone medications—these carry Major or Moderate risks. Also flag blood pressure medications (antihypertensives), blood thinners, lithium, potassium-sparing water pills, ACE inhibitors or ARBs, corticosteroids, thyroid hormone (levothyroxine), beta-blockers (sotalol), and diabetes or insulin medications.

Chromium may also interact with NSAIDs and aspirin. The interaction checker below will help you cross-reference your complete medication list.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This powder works as a muscle-building supplement and is generally well tolerated by healthy adults at recommended doses. However, the sodium and potassium content matters if you take blood pressure meds, heart medications, or lithium, and the calcium and whey can interfere with antibiotics, HIV drugs, thyroid hormone, and bone medications.

If you take any prescription drugs—especially for blood pressure, heart, thyroid, diabetes, bone health, or HIV—check your exact medications with our tool before starting, and talk to your pharmacist about timing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about AMPED Tri-Release Protein Vanilla Custard Flavor, straight from the product label.

Brand Isagenix
Barcode (UPC) 390101203
Net contents 37 Ounce(s); 1050 Gram(s)
Market status On market
Date entered into DSLD Dec 26, 2020
DSLD ID 238829
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
37.5 Gram(s)
Maximum serving Sizes:
37.5 Gram(s)
Servings per container
28
UPC/BARCODE
390101203
IngredientAmount% DV
Calories140 Calorie(s)--
Total Carbohydrates6 Gram(s)2%
Sodium150 mg7%
Potassium110 mg2%
Cholesterol10 mg3%
Phosphorus170 mg14%
Calcium310 mg24%
Total Fat1.5 Gram(s)2%
Added Sugars1 Gram(s)2%
undenatured Whey Protein isolate0 NP--
Total Sugars2 Gram(s)--
Saturated Fat1 Gram(s)5%
Protein25 Gram(s)50%
Chromium500 mcg1429%
Muscle-Building Matrix31.75 Gram(s)--
undenatured Milk Protein concentrate0 NP--
Egg White Protein0 NP--
Velositol Amylopectin Chromium Complex0 NP--

Other ingredients: Medium Chain Triglyceride Oil powder, Fructose, digestion-resistant Maltodextrin, Natural flavors, Xanthan Gum, Sea Salt, Stevia (Stevia rebaudiana) leaf extract

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Soy-free Gluten-free

Supports muscle strength and performance goals

Protein derived from animals that are not treated with hormones or routine antibiotics

Sustained and enhanced muscle building support

Made with natural ingredients and no artificial flavors, colors, or sweeteners

Formula

Fuel your muscles to maximize results When you're building strength, size, or speed from training, your results depend on a process called muscle protein synthesis (MPS). It's crucial your body gets a sustained supply of quality protien to optimize MPS and achieve the best results from your training. AMPED Tri-Release Protein contains a premium blend of fast-, medium-, and slow-release proteins for a rapid and sustained release of amino acids - including an excellent branched-chain amino acid (BCAA) profile - to help extend MPS.

This innovative protein blend is combined with the revolutionary patented ingredient Velositol. When paired with quality protein, Velositol improves the efficiency of BCAAs to maximize MPS for greater gains, improved strength, and faster recovery.

25g blend of whey protein isolate, egg white protein, and milk protein concentrate

Excellent amino acid profile including BCAAS

25g fast-, medium-, and slow-release high-protein blend Undenatured, grass-fed whey and milk protein with egg white protein With Velositol to help maximize muscle protein synthesis Made with natural ingredients and no artificial flavors, colors, or sweeteners Low fat and 2g of sugar 25g protein 6g carbs 2g sugar 1.5g fat

Keto-friendly

Velositol Amylopectin chromium complex Power up your protein

Suggested/Recommended/Usage/Directions

Ideal to consume at any time

Suggested Use: Mix 1 scoop with 6-8 fl oz purified water. Drink immediately after mixing. Adjust protein amount according to taste or nutritional goals.

Usage benefits Pre-workout: fast release of amino acids to help fuel working muscles during exercise. Post-workout: fast release of amino acids to support recovering muscles plus medium and slow release for prolonged muscle-building support after exercise. Nontraining days and between meals: provides high-quality protein and amino acids plus Velositol to support muscle strength and supplement daily protein intake.

General Statements

Protein release profiles Whey protein isolate Egg white protein Milk protein concentrate Fast Sustained amino acid release Slow

Amino acids per serving Alanine 1,160 mg Arginine 810 mg Aspartic Acid 2,400 mg Cysteine 510 mg Glutamic acid 4,425 mg Glycine 520 mg Histidine 555 mg Isoleucine 1,470 mg Leucine 2,690 mg Lysine 2,300 mg Methionine 710 mg Phenylalanine 1,050 mg Proline 1,980 mg Serine 1,440 mg Threonine 1,410 mg Tryptophan 405 mg Tyrosine 990 mg Valine 1,600 mg Since amino acids are naturally occurring, amounts may vary.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

Informed-Sport.com Trusted by sport

Precautions

Contains milk & egg ingredients

Note: If you are pregnant or breastfeeding or have a medical condition, consult your physician before using this product.

Discontinue use if adverse reaction occurs.

For ages 18+.

Storage

Store in a cool, dry place.

Brand IP Statement(s)

Velositol is a registered trademark of Nutrition 21, LLC and patent protected.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

AMPED Tri-Release Protein Vanilla Custard Flavor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix

These are the 10 active ingredients this product is made of. Select any to open its full monograph.

Serving size37.5 Gram(s) Dosage formPowder Servings per container28 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sodium

Interacts with
205 drugs
150 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Potassium

Interacts with
62 drugs
110 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium monograph & interactions

Phosphorus

170 mg per serving

Calcium

Interacts with
168 drugs
310 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Protein

25 Gram(s) per serving

Chromium

Interacts with
178 drugs
500 mcg per serving Form: Chromium Histidinate, Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

Muscle-Building Matrix

31.75 Gram(s) per serving

Other (inactive) ingredients: Medium Chain Triglyceride Oil powder, Fructose, Digestion-resistant Maltodextrin, Natural flavors, Xanthan Gum, Sea Salt, Stevia (Stevia rebaudiana) leaf extract. These complete the product’s ingredient list but are not active constituents.

Interaction report

AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix Drug Interactions

Want to check YOUR meds against AMPED Tri-Release Protein Vanilla Custard Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
486Drugs
12 Major 387 Moderate 87 Minor

Ingredients driving the most interactions

Sodium 205
Chromium 178
Calcium 168
Potassium 62
undenatured Whey Protein isolate 53

Individual Drug Interactions

The ingredients in AMPED Tri-Release Protein Vanilla Custard Flavor interact with 486 drugs. Click any drug to see the details.

5 of the 10 ingredients in AMPED Tri-Release Protein Vanilla Custard Flavor interact with drugs. Each result below shows which ingredient is responsible. Sodium Chromium Calcium Potassium undenatured Whey Protein isolate

Each ingredient & the kinds of drugs it affects

For each ingredient in AMPED Tri-Release Protein Vanilla Custard Flavor with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions

Potassium3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium full monograph & interactions

undenatured Whey Protein isolate4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
undenatured Whey Protein isolate full monograph & interactions
The maker

Brand information

Manufacturer and brand details for AMPED Tri-Release Protein Vanilla Custard Flavor, from the product label.

Isagenix

See all Isagenix products
Name
Isagenix International, LLC,
Street Address
155 E. Rivulon Blvd.,
City
Gilbert
State
AZ
ZipCode
85297
Web Address
Isagenix.com
Pharmacist Counseling Corner

AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix: Common Questions

Does AMPED Tri-Release Protein Vanilla Custard Flavor by Isagenix interact with any medications?
Yes. Based on its ingredients, AMPED Tri-Release Protein Vanilla Custard Flavor has a known interaction with 486 medications, including 12 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
AMPED Tri-Release Protein Vanilla Custard Flavor contains 10 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this protein powder have a lot of sodium in it?
The facts don't specify the exact sodium content per serving, but the ingredient list does include sodium. If you're on blood pressure medication, diuretics, or lithium, talk to your pharmacist about whether the sodium level is safe for you.
Can I take this if I'm pregnant?
Calcium in this product is likely safe in pregnancy at recommended amounts. Whey protein has no pregnancy safety rating in our data, so check with your doctor about its use during pregnancy. Chromium is likely safe and possibly safe in pregnancy. Always discuss supplements with your healthcare provider during pregnancy.
Is this good for building muscle?
Whey protein is possibly effective for athletic performance, so this product may help with muscle building when paired with training. The milk and egg proteins add variety to the amino acid profile, and chromium supports blood sugar stability during workouts.
Can I take this with my thyroid medication?
Not without timing your doses carefully. Calcium and chromium both reduce levothyroxine absorption. Separate your thyroid medicine from this powder by at least 4 hours. Ask your pharmacist for the best timing schedule for your specific dose.
What are the most common side effects?
Whey protein often causes bloating, gas, cramps, diarrhea, nausea, or reflux—usually dose-related, so they may ease if you start with a smaller amount. Calcium can cause constipation or stomach upset. A few case reports link whey protein to acne or worsening acne. Stop and talk to your doctor if side effects don't improve.
Is this safe for people with kidney disease?
No safety data for kidney disease is in our files for this product. People with kidney disease need careful attention to potassium, sodium, and phosphorus intake, so talk to your nephrologist or pharmacist before using this powder.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

AMPED Tri-Release Protein Vanilla Custard Flavor label
Go deeper

The Full Monographs Behind AMPED Tri-Release Protein Vanilla Custard Flavor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph → Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph →
Sources

Sources & How We Checked

AMPED Tri-Release Protein Vanilla Custard Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 190 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
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  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Potassium 12 references
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  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
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See these in context on the Potassium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

Whey Protein 25 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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