Thyroid Pituitary Plus Ingredients & Drug Interactions
by Vinco
What is this page for?
First and foremost: checking Thyroid Pituitary Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Thyroid Pituitary Plus is a dietary supplement by Vinco with 4 active ingredients. Its ingredients are commonly taken for high cholesterol, joint pain and arthritis, weight management.Based on those ingredients, 757 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guggul, Deer Antler Velvet. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Thyroid Pituitary Plus by Vinco
Ask about any prescription or over-the-counter medication and we check it for interactions with Thyroid Pituitary Plus by Vinco — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Thyroid Pituitary Plus by Vinco
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains 4 ingredients. The two active ones are guggul (a tree resin used traditionally for thyroid and metabolic support) and deer antler velvet (the soft covering on growing deer antlers, sometimes used for general wellness).
The other two—thyroid gland and pituitary gland—are also included but we have no interaction data on file for them. The capsule itself is made with gelatin and vegetable stearate, which are inactive ingredients used to hold everything together.
Does it work?
Not established
The evidence we hold for guggul in obesity is insufficient or possibly ineffective, and we don't have enough reliable data to rate it for acne, hemorrhoids, or high cholesterol. For deer antler velvet, evidence is insufficient to rate it for wound healing, heart disease, high blood pressure, bone health, sexual function, or aging.
Because this product is marketed for thyroid support, and we have no effectiveness data on file for the thyroid gland or pituitary gland ingredients themselves, we can't tell you from our data whether those components are backed by research.
How safe is it?
Well-documented data
Guggul is generally well tolerated, but digestive upset and skin reactions are the main concerns. The most common side effects are belching, bloating, diarrhea, headache, nausea, bad taste, and vomiting; skin reactions (rash, itching) happen in a dose-dependent way—more common at higher doses.
Serious side effects like muscle breakdown (rhabdomyolysis) are rare. Deer antler velvet appears generally well tolerated in short-term use, but long-term safety isn't well studied.
Guggul should be avoided during pregnancy because it may stimulate the uterus, and it should also be avoided while breastfeeding. Deer antler velvet has insufficient safety data for pregnancy and breastfeeding, so it's best avoided in both.
There's no pregnancy or breastfeeding data on file for the thyroid gland and pituitary gland ingredients.
Meds to double-check
Moderate interaction found
Double-check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or clopidogrel), heart or blood pressure medications (propranolol, diltiazem, calcium-channel blockers), birth control pills or estrogen therapy, thyroid hormone replacement, any drug that your liver breaks down via CYP3A4—which includes a huge range of common medications—or tamoxifen for breast cancer. These are the main drug types affected by guggul.
Deer antler velvet has minor interactions with birth control and estrogen drugs. We could not check thyroid gland or pituitary gland, as we hold no data for them.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.
If you take any blood pressure or heart medication, blood thinners, birth control, estrogen, thyroid hormone, or cancer drugs, you need to check your specific medications against this product before starting—guggul has broad interactions. The digestive and skin side effects are usually mild.
Pregnant women and those breastfeeding should avoid this product. Talk to your pharmacist about whether this product is right for you and your medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Thyroid Pituitary Plus, straight from the product label.
| Brand | Vinco |
|---|---|
| Barcode (UPC) | 739930275089 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 22, 2022 |
| DSLD ID | 258822 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Thyroid Pituitary Plus by Vinco, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Guggul | 400 mg | -- |
| Deer Antler Velvet | 300 mg | -- |
| Thyroid Gland | 120 mg | -- |
| Pituitary Gland | 30 mg | -- |
Other ingredients: Gelatin, Vegetable Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Directions for use: As a dietary supplement for adults and children twelve or more years of age, take one capsule, two times daily, or as directed by a qualified healthcare professional.
Formulation
The ingredients in Vinco's Thyroid Pituitary Plus have been shown to be beneficial in supporting metabolic pathways. It provides contemporary ingredients at full therapeutic doses, giving you a fresh approach for thyroid-pituitary axis support.
Metabolic support
Gluten free
No wheat, no gluten, no corn, no soy, no dairy, yeast free
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
General Statements
Professional formulation
Precautions
Keep out of reach of children
Tamper resistant. Do not purchase if seal is broken.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Thyroid Pituitary Plus by Vinco label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Thyroid Pituitary Plus by Vinco
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Guggul
Interacts with757 drugs
Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...
Guggul monograph & interactionsDeer Antler Velvet
Interacts with52 drugs
Deer velvet is a traditional remedy made from the soft, growing antlers of deer or elk, and it is most often promoted for energy, athletic performance...
Deer Antler Velvet monograph & interactionsThyroid Gland
Pituitary Gland
Other (inactive) ingredients: Gelatin, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.
Thyroid Pituitary Plus by Vinco Drug Interactions
HelloPharmacist Interaction Report
Thyroid Pituitary Plus by Vinco contains guggul and deer antler velvet, both of which have documented interactions with medications.
Altogether, these interactions span 747 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Guggul is the main concern here. It can reduce how well propranolol (a beta-blocker for high blood pressure and heart conditions) works by lowering the amount of drug that gets into your bloodstream.
It may also interfere with a large class of drugs that your liver breaks down via the CYP3A4 enzyme pathway—these include many common medications across different categories, so this one's worth checking against your specific prescriptions.
Guggul also carries moderate-severity interactions with blood thinners (anticoagulants) and antiplatelet drugs like aspirin or clopidogrel, where it might raise bleeding risk. It can interfere with birth control pills and estrogen therapy by acting on estrogen receptors in your body.
It may also reduce how well diltiazem (a heart and blood pressure medication) works. Because guggul has thyroid-stimulating effects, it could theoretically increase the risk of side effects if you're already taking thyroid hormone replacement.
Finally, it may interfere with tamoxifen (a breast cancer drug) through its estrogen-receptor activity.
Deer antler velvet carries minor interactions with birth control and estrogen therapy, since laboratory tests show it contains trace amounts of estradiol and testosterone, though clinical studies haven't confirmed a meaningful hormone boost. We could not check thyroid gland or pituitary gland—we hold no data for those ingredients.
Use the medication checker below to run your exact drugs against this product before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Thyroid Pituitary Plus?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Thyroid Pituitary Plus interact with 757 drugs. Click any drug to see the details.
2 of the 4 ingredients in Thyroid Pituitary Plus interact with drugs. Each result below shows which ingredient is responsible. Guggul Deer Antler Velvet
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Guggul + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Guggul + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acalabrutinib interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Guggul + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Guggul + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
Read the full Guggul + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Thyroid Pituitary Plus — through 1 ingredient. Tap an ingredient for the detail:
GuggulCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
Read the full Guggul + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Thyroid Pituitary Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Guggul
Anticoagulant/Antiplatelet Drugs
Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.
Contraceptive Drugs
Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.
Diltiazem (Cardizem, Others)
Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.
Estrogens
Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.
Propranolol (Inderal)
Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.
Rosuvastatin (Crestor)
Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.
Tamoxifen (Nolvadex)
Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.
Thyroid Hormone
Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.
Deer Antler Velvet
Contraceptive Drugs
Theoretically, deer velvet might interfere with the effectiveness of contraceptive drugs.
Laboratory research shows that deer velvet contains small quantities of estradiol and testosterone. While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured.
Estrogens
Theoretically, deer velvet might increase the effects and side effects of estrogens.
Laboratory evidence shows that deer velvet contains small quantities of estradiol and testosterone. While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured.
Brand information
Manufacturer and brand details for Thyroid Pituitary Plus, from the product label.
Vinco
See all Vinco products- Name
- Vinco Inc.
- City
- Evans City
- State
- PA
- ZipCode
- 16033
- Phone Number
- 1-800-245-1939
- Web Address
- www.vincoinc.com
Thyroid Pituitary Plus by Vinco: Common Questions
Does Thyroid Pituitary Plus by Vinco interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm on birth control?
What are the most common side effects of guggul?
Is this safe to take while pregnant or breastfeeding?
Does this product actually work for thyroid health?
Why is there so much interaction data for this product?
How long has deer antler velvet been studied for safety?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Thyroid Pituitary Plus is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Thyroid Pituitary Plus’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Guggul
Interacts with 757 drugsGuggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are mixed and often low-quality, and it can...
Read the full Guggul monograph → Herb & supplement monographDeer Velvet
Interacts with 52 drugsDeer velvet is a traditional remedy made from the soft, growing antlers of deer or elk, and it is most often promoted for energy, athletic performance, and joint health. Good-quality human e...
Read the full Deer Velvet monograph →Sources & How We Checked
Thyroid Pituitary Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 23 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Guggul 21 references
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Dalvi SS, Nayak VK, Pohujani SM, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Phys India 1994;42:454-5.
- Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994;8:659-64. PubMed
- Tripathi YB, Tripathi P, Malhotra OP, Tripathi SN. Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. Planta Med 1988;54:271-7.
- Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid – a new hypolipidemic agent of plant origin in primary hyperlipidemia. Ind J Med Res 1986;84:626-34.
- Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977;65:390-5.
- Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by "guggulu" steroids. Planta Med 1979;37:367-9. PubMed
- Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290:765-72.
- Brobst DE, Ding X, Creech KL, et al. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther 2004;310:528-35. PubMed
- Bianchi A, Cantu P, Firenzuoli F, et al. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. Ann Pharmacother 2004;38:1222-5.
- Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J Am Acad Dermatol 2005;52:533-4 PubMed
- Nohr, L. A., Rasmussen, L. B., and Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther.Med. 2009;17(1):16-22. PubMed
- Gelfand, J. M., Crawford, G. H., Brod, B. A., and Szazpary, P. O. Adverse cutaneous reactions to guggulipid. J.Am.Acad.Dermatol. 2005;52(3 Pt 1):533-534. PubMed
- Kolonte, A., Guillot, B., and Raison-Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis 2006;54(4):226-227. PubMed
- Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2007;56(5):286-287. PubMed
- Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59:1621-1632.
- Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.
- Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19:84-86.
- Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
- Mehdi Z, Fatemeh P, Roja R, et al. Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial. J Tradit Chin Med 2021;41(2):301-307.
- Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed
Deer Velvet 2 references
- Sleivert, G., Burke, V., Palmer, C., Walmsley, A., Gerrard, D., Haines, S., and Littlejohn, R. The effects of deer antler velvet extract or powder supplementation on aerobic power, erythropoiesis, and muscular strength and endurance characteristics. Int PubMed
- Bubenik, G. A., Miller, K. V., Lister, A. L., Osborn, D. A., Bartos, L., and van der Kraak, G. J. Testosterone and estradiol concentrations in serum, velvet skin, and growing antler bone of male white-tailed deer. J Exp Zoolog.A Comp Exp Biol 3-1-2005;30 PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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