Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Thyroid Pituitary Plus Ingredients & Drug Interactions

by Vinco

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Thyroid Pituitary Plus is a dietary supplement by Vinco with 4 active ingredients. Its ingredients are commonly taken for high cholesterol, joint pain and arthritis, weight management.Based on those ingredients, 757 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Guggul, Deer Antler Velvet. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Thyroid Pituitary Plus by Vinco

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 ingredients. The two active ones are guggul (a tree resin used traditionally for thyroid and metabolic support) and deer antler velvet (the soft covering on growing deer antlers, sometimes used for general wellness).

The other two—thyroid gland and pituitary gland—are also included but we have no interaction data on file for them. The capsule itself is made with gelatin and vegetable stearate, which are inactive ingredients used to hold everything together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: thyroid pituitary axis and metabolic support.
  • We looked for evidence on: Fatigue, Obesity, Thyroid function, Metabolic rate, Goiter.
  • The closest evidence on file: Guggul is rated "Possibly Ineffective" for Obesity (Natural Medicines).
  • Also on file: Deer Velvet is rated "Insufficient Reliable Evidence To Rate" for Fatigue.

The evidence we hold for guggul in obesity is insufficient or possibly ineffective, and we don't have enough reliable data to rate it for acne, hemorrhoids, or high cholesterol. For deer antler velvet, evidence is insufficient to rate it for wound healing, heart disease, high blood pressure, bone health, sexual function, or aging.

Because this product is marketed for thyroid support, and we have no effectiveness data on file for the thyroid gland or pituitary gland ingredients themselves, we can't tell you from our data whether those components are backed by research.

The evidence, ingredient by ingredient Guggul Deer Velvet

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Guggul is generally well tolerated, but digestive upset and skin reactions are the main concerns. The most common side effects are belching, bloating, diarrhea, headache, nausea, bad taste, and vomiting; skin reactions (rash, itching) happen in a dose-dependent way—more common at higher doses.

Serious side effects like muscle breakdown (rhabdomyolysis) are rare. Deer antler velvet appears generally well tolerated in short-term use, but long-term safety isn't well studied.

Guggul should be avoided during pregnancy because it may stimulate the uterus, and it should also be avoided while breastfeeding. Deer antler velvet has insufficient safety data for pregnancy and breastfeeding, so it's best avoided in both.

There's no pregnancy or breastfeeding data on file for the thyroid gland and pituitary gland ingredients.

Side effects, ingredient by ingredient Guggul Deer Velvet

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Guggul, Deer Velvet.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 758 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check with your pharmacist if you take blood thinners or antiplatelet drugs (like warfarin or clopidogrel), heart or blood pressure medications (propranolol, diltiazem, calcium-channel blockers), birth control pills or estrogen therapy, thyroid hormone replacement, any drug that your liver breaks down via CYP3A4—which includes a huge range of common medications—or tamoxifen for breast cancer. These are the main drug types affected by guggul.

Deer antler velvet has minor interactions with birth control and estrogen drugs. We could not check thyroid gland or pituitary gland, as we hold no data for them.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

If you take any blood pressure or heart medication, blood thinners, birth control, estrogen, thyroid hormone, or cancer drugs, you need to check your specific medications against this product before starting—guggul has broad interactions. The digestive and skin side effects are usually mild.

Pregnant women and those breastfeeding should avoid this product. Talk to your pharmacist about whether this product is right for you and your medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Thyroid Pituitary Plus, straight from the product label.

Brand Vinco
Barcode (UPC) 739930275089
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 258822
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Thyroid Pituitary Plus by Vinco, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
739930275089
IngredientAmount% DV
Guggul400 mg--
Deer Antler Velvet300 mg--
Thyroid Gland120 mg--
Pituitary Gland30 mg--

Other ingredients: Gelatin, Vegetable Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions for use: As a dietary supplement for adults and children twelve or more years of age, take one capsule, two times daily, or as directed by a qualified healthcare professional.

Formulation

The ingredients in Vinco's Thyroid Pituitary Plus have been shown to be beneficial in supporting metabolic pathways. It provides contemporary ingredients at full therapeutic doses, giving you a fresh approach for thyroid-pituitary axis support.

Metabolic support

Gluten free

No wheat, no gluten, no corn, no soy, no dairy, yeast free

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

General Statements

Professional formulation

Precautions

Keep out of reach of children

Tamper resistant. Do not purchase if seal is broken.

Storage

Store in a cool, dry place.

See for yourself

Thyroid Pituitary Plus by Vinco label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Thyroid Pituitary Plus by Vinco

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Guggul

Interacts with
757 drugs
400 mg per serving Form: Guggulsterones

Guggul is a gum resin from the Commiphora wightii tree, long used in Ayurvedic medicine for cholesterol, joint, and skin problems. Modern studies are...

Guggul monograph & interactions

Deer Antler Velvet

Interacts with
52 drugs
300 mg per serving

Deer velvet is a traditional remedy made from the soft, growing antlers of deer or elk, and it is most often promoted for energy, athletic performance...

Deer Antler Velvet monograph & interactions

Thyroid Gland

120 mg per serving Form: Bovine tissue

Pituitary Gland

30 mg per serving Form: Bovine tissue

Other (inactive) ingredients: Gelatin, Vegetable Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Thyroid Pituitary Plus by Vinco Drug Interactions

Want to check YOUR meds against Thyroid Pituitary Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
757Drugs
757 Moderate

Ingredients driving the most interactions

Guggul 757

Each ingredient & the kinds of drugs it affects

For each ingredient in Thyroid Pituitary Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Guggul9 drug types · 757 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, guggul might increase the risk of bleeding when taken with anticoagulant/antiplatelet drugs.
In vitro research and preliminary clinical studies suggest that guggul might have antiplatelet and anticoagulant effects.

Likelihood Possible Evidence B
Contraceptive Drugs

Theoretically, guggul might increase the risk of adverse effects when taken with contraceptive drugs.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, guggul might reduce the effects of CYP3A4 substrates.
In vitro research shows that guggul constituents known as guggulsterones can induce CYP3A4.

Likelihood Probable Evidence D
Diltiazem (Cardizem, Others)

Guggul might reduce the effects of diltiazem.
A small pharmacokinetic study shows that concomitant use of guggul with diltiazem reduces the bioavailability of diltiazem.

Likelihood Probable Evidence B
Estrogens

Theoretically, guggul might increase the risk of adverse effects when taken with estrogens.
In vitro research shows that guggul constituents known as guggulsterones have estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Propranolol (Inderal)

Guggul might reduce the effects of propranolol.
A small pharmacokinetic study shows that concomitant use of guggul with propranolol reduces the bioavailability of propranolol.

Likelihood Probable Evidence B
Rosuvastatin (Crestor)

Theoretically, guggul might increase the effects and adverse effects of rosuvastatin.
Animal research shows that guggul increases the bioavailability and hypolipidemic effects of rosuvastatin. The mechanism of this interaction is unclear.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, guggul might interfere with tamoxifen therapy.
In vitro research shows that guggul has estrogen-alpha receptor agonist activity.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, guggul might increase the risk for adverse effects when taken with thyroid hormone therapy.
Animal research suggests that guggul has thyroid-stimulating effects.

Likelihood Probable Evidence B

Deer Antler Velvet2 drug types · 52 drugs

Contraceptive Drugs

Theoretically, deer velvet might interfere with the effectiveness of contraceptive drugs.
Laboratory research shows that deer velvet contains small quantities of estradiol and testosterone. While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured.

Likelihood Unlikely Evidence D
Estrogens

Theoretically, deer velvet might increase the effects and side effects of estrogens.
Laboratory evidence shows that deer velvet contains small quantities of estradiol and testosterone. While clinical research shows that taking deer velvet extract does not raise testosterone levels, estradiol levels were not measured.

Likelihood Unlikely Evidence D
The maker

Brand information

Manufacturer and brand details for Thyroid Pituitary Plus, from the product label.

Vinco

See all Vinco products
Name
Vinco Inc.
City
Evans City
State
PA
ZipCode
16033
Phone Number
1-800-245-1939
Web Address
www.vincoinc.com
Pharmacist Counseling Corner

Thyroid Pituitary Plus by Vinco: Common Questions

Does Thyroid Pituitary Plus by Vinco interact with any medications?
Yes. Based on its ingredients, Thyroid Pituitary Plus has a known interaction with 757 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Thyroid Pituitary Plus contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on birth control?
Both guggul and deer antler velvet interact with contraceptive drugs. Guggul's interaction is moderate and could theoretically increase side effects or reduce effectiveness; deer antler velvet's is minor. Because it affects how birth control works, you should talk to your pharmacist or doctor before adding this product if you're on any hormonal contraceptive.
What are the most common side effects of guggul?
The most common are digestive—belching, bloating, diarrhea, nausea, and an unpleasant taste—plus headache and vomiting. Skin reactions like rash and itching also happen, and they're more likely at higher doses. These side effects are usually mild, but if you're prone to digestive upset or skin sensitivity, this may not be the best fit for you.
Is this safe to take while pregnant or breastfeeding?
No. Guggul should be avoided during pregnancy because it may stimulate the uterus and its safety isn't established. Both guggul and deer antler velvet should be avoided while breastfeeding. If you're pregnant or nursing, talk to your doctor or pharmacist before taking any supplement.
Does this product actually work for thyroid health?
We don't have effectiveness data on file for the thyroid gland or pituitary gland ingredients in this product. For guggul, the evidence we hold rates it possibly ineffective for obesity and insufficient for other uses. We can't tell you from our data whether this product is effective for thyroid support specifically.
Why is there so much interaction data for this product?
Guggul, one of the two active ingredients, interacts with a very large class of drugs that your liver breaks down (CYP3A4 substrates), plus several other drug types for heart, blood thinning, and hormone therapy. That's why the total interaction count is high, even though only two of the four ingredients have interaction data we could check.
How long has deer antler velvet been studied for safety?
It appears to be well tolerated in short-term use, but long-term safety and product quality haven't been well studied. If you're thinking of taking this long-term, talk to your pharmacist about what we do and don't know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Thyroid Pituitary Plus is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Thyroid Pituitary Plus label
Sources

Sources & How We Checked

Thyroid Pituitary Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 23 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Guggul 21 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Dalvi SS, Nayak VK, Pohujani SM, et al. Effect of gugulipid on bioavailability of diltiazem and propranolol. J Assoc Phys India 1994;42:454-5.
  3. Singh RB, Niaz MA, Ghosh S. Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovasc Drugs Ther 1994;8:659-64. PubMed
  4. Tripathi YB, Tripathi P, Malhotra OP, Tripathi SN. Thyroid stimulatory action of (Z)-guggulsterone: mechanism of action. Planta Med 1988;54:271-7.
  5. Agarwal RC, Singh SP, Saran RK, et al. Clinical trial of gugulipid – a new hypolipidemic agent of plant origin in primary hyperlipidemia. Ind J Med Res 1986;84:626-34.
  6. Malhotra SC, Ahuja MM, Sundaram KR. Long term clinical studies on the hypolipidaemic effect of Commiphora mukul (Guggulu) and clofibrate. Indian J Med Res 1977;65:390-5.
  7. Mester L, Mester M, Nityanand S. Inhibition of platelet aggregation by "guggulu" steroids. Planta Med 1979;37:367-9. PubMed
  8. Szapary PO, Wolfe ML, Bloedon LT, et al. Guggulipid for treatment of hypercholesterolemia: a randomized controlled trial. JAMA 2003;290:765-72.
  9. Brobst DE, Ding X, Creech KL, et al. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. J Pharmacol Exp Ther 2004;310:528-35. PubMed
  10. Bianchi A, Cantu P, Firenzuoli F, et al. Rhabdomyolysis caused by Commiphora mukul, a natural lipid-lowering agent. Ann Pharmacother 2004;38:1222-5.
  11. Gelfand JM, Crawford GH, Brod BA, Szazpary PO. Adverse cutaneous reactions to guggulipid. J Am Acad Dermatol 2005;52:533-4 PubMed
  12. Nohr, L. A., Rasmussen, L. B., and Straand, J. Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complement Ther.Med. 2009;17(1):16-22. PubMed
  13. Gelfand, J. M., Crawford, G. H., Brod, B. A., and Szazpary, P. O. Adverse cutaneous reactions to guggulipid. J.Am.Acad.Dermatol. 2005;52(3 Pt 1):533-534. PubMed
  14. Kolonte, A., Guillot, B., and Raison-Peyron, N. Allergic contact dermatitis to guggul extract contained in an anticellulite gel-cream. Contact Dermatitis 2006;54(4):226-227. PubMed
  15. Salavert, M., Amarger, S., Le Bouedec, M. C., Roger, H., Souteyrand, P., and D'incan, M. Allergic contact dermatitis to guggul in a slimming cream. Contact Dermatitis 2007;56(5):286-287. PubMed
  16. Malhotra SC, Ahuja MM. Comparative hypolipidaemic effectiveness of gum guggulu (Commiphora mukul) fraction 'A', ethyl-P-chlorophenoxyisobutyrate and Ciba-13437-Su. Indian J Med Res 1971;59:1621-1632.
  17. Gaur SP, Garg RK, Kar AM, et al. Gugulipid, a new hypolipidaemic agent, in patients of acute ischaemic stroke: effect on clinical outcome, platelet function and serum lipids. Asia Pacif J Pharm 1997;12:65-69.
  18. Baldwa VS, Sharma RC, Ranka PC, et al. Effect of Commiphora mukul (guggul) on fibrinolytic activity and platelet aggregation in coronary artery disease. Rajas Med J 1980;19:84-86.
  19. Donato F, Raffetti E, Toninelli G, Festa A, Scarcella C, Castellano M; TRIGU Project Working Group. Guggulu and Triphala for the Treatment of Hypercholesterolaemia: A Placebo-Controlled, Double-Blind, Randomised Trial. Complement Med Res 2021;28(3):216-22 PubMed
  20. Mehdi Z, Fatemeh P, Roja R, et al. Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial. J Tradit Chin Med 2021;41(2):301-307.
  21. Asad M, Asdaq SMB, Mohzari Y, et al. Pharmacokinetic and pharmacodynamic interaction of Rosuvastatin calcium with guggulipid extract in rats. Saudi J Biol Sci 2021;28(6):3490-3496. PubMed

See these in context on the Guggul monograph →

Deer Velvet 2 references
  1. Sleivert, G., Burke, V., Palmer, C., Walmsley, A., Gerrard, D., Haines, S., and Littlejohn, R. The effects of deer antler velvet extract or powder supplementation on aerobic power, erythropoiesis, and muscular strength and endurance characteristics. Int PubMed
  2. Bubenik, G. A., Miller, K. V., Lister, A. L., Osborn, D. A., Bartos, L., and van der Kraak, G. J. Testosterone and estradiol concentrations in serum, velvet skin, and growing antler bone of male white-tailed deer. J Exp Zoolog.A Comp Exp Biol 3-1-2005;30 PubMed

See these in context on the Deer Velvet monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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