Major interaction on record — check this product against your medications before combining. Check your meds →
Dietary supplement

MK-7 Ingredients & Drug Interactions

by Healthy Directions

MK-7 label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MK-7 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

MK-7 is a dietary supplement by Healthy Directions with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Menaquinone-7. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against MK-7 by Healthy Directions

Ask about any prescription or over-the-counter medication and we check it for interactions with MK-7 by Healthy Directions — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of MK-7 by Healthy Directions

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: menaquinone-7, a form of vitamin K that your body uses to help blood clot properly and may support bone health. The softgel also includes inactive ingredients (medium chain triglycerides, gelatin, glycerin, olive oil, and purified water) to deliver the menaquinone-7.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: bone and heart health support.
  • We looked for evidence on: Cardiovascular disease (CVD), Hemorrhagic disease, Hypoprothrombinemia, Osteoporosis, Vitamin K-dependent clotting factors deficiency (VKCFD), Warfarin anticoagulation — and 2 related terms.
  • The strongest evidence on file: Vitamin K is rated "Effective" for Hemorrhagic disease (Natural Medicines).
  • Also on file: Vitamin K is rated "Effective" for Hypoprothrombinemia, Warfarin anticoagulation, Vitamin K-dependent clotting factors deficiency (VKCFD).
  • Also on file: Vitamin K is rated "Possibly Effective" for Osteoporosis.

Menaquinone-7 is effective for treating vitamin K deficiency states — low blood clotting factors (hypoprothrombinemia), vitamin K-dependent clotting factor deficiency, problems from warfarin anticoagulation, and hemorrhagic disease. For osteoporosis, the evidence is less clear; it's rated possibly effective, meaning some research suggests a benefit but more evidence is needed.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, vitamin K is generally well tolerated in most people. The most common side effects are mild — nausea, diarrhea, stomach upset, and abdominal pain — and occur in a small number of users.

The safety data supports vitamin K as likely safe during pregnancy and lactation. That said, normal dietary amounts are fine, but if you're taking a supplement, check with your doctor first, especially if you're on any blood-thinning medication.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Blood thinners (anticoagulants) — particularly warfarin — interact with this product at Major severity. Vitamin K can reverse warfarin's blood-thinning effect, so you must check with your doctor or pharmacist before taking MK-7 if you're on any blood thinner.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

MK-7 is a straightforward vitamin K supplement useful if your doctor has identified a vitamin K deficiency or if you're interested in bone health support. The critical point is blood thinners — if you take warfarin or any similar medication, you must talk to your doctor or pharmacist before starting this product.

Even people not on blood thinners should confirm it's right for them with their own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 23, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MK-7, straight from the product label.

Brand Healthy Directions
Barcode (UPC) 678829292328
Net contents 30 Softgel(s)
Market status On market
Date entered into DSLD Jul 23, 2020
DSLD ID 230560
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MK-7 by Healthy Directions, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
30
UPC/BARCODE
678829292328
IngredientAmount% DV
Menaquinone-7150 mcg--

Other ingredients: Medium Chain Triglycerides, Gelatin, Glycerin, Olive Oil, purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

MK-7 is menaquinone-7, also known as vitamin K2.

150 mcg per serving

Formulation

Unconditionally guaranteed for purity and labeled potency.

For bone and heart health support Aids in calcium absorption

GF Gluten Free

Storage

Store bottle in a cool, dry place.

Brand IP Statement(s)

MenaQ7 is a registered trademark of NattoPharma ASA, Norway; Patented in the United States and Canada. US Patent Numbers 8,728,553 & 8,354,129; Canada Patent Number 2,347,387

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Clinical Grade

Almost out? Call 1-866-599-9491 www.healthydirections.com

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 softgel daily.

Precautions

Precautions: Consult a health care practitioner before use if you take warfarin or other blood thinning products, or are pregnant or nursing, have a serious medical condition, or use any medications.

Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MK-7 by Healthy Directions label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MK-7 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MK-7 by Healthy Directions

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Menaquinone-7

Interacts with
2 drugs
150 mcg per serving Form: Vitamin K2

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Menaquinone-7 monograph & interactions

Other (inactive) ingredients: Medium Chain Triglycerides, Gelatin, Glycerin, Olive Oil, Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

MK-7 by Healthy Directions Drug Interactions

Want to check YOUR meds against MK-7?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Menaquinone-7 2

Individual Drug Interactions

The ingredients in MK-7 interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in MK-7 interact with drugs. Each result below shows which ingredient is responsible. Menaquinone-7

Each ingredient & the kinds of drugs it affects

For each ingredient in MK-7 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Menaquinone-71 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Menaquinone-7 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MK-7, from the product label.

Healthy Directions

See all Healthy Directions products
Name
Healthy Directions
City
Bethesda
State
MD
ZipCode
20817
Web Address
healthydirections.com
Pharmacist Counseling Corner

MK-7 by Healthy Directions: Common Questions

Does MK-7 by Healthy Directions interact with any medications?
Yes. Based on its ingredients, MK-7 has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MK-7 contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
No, not without your doctor's approval. Vitamin K directly opposes warfarin's effect and can make it less effective at preventing clots. Talk to your doctor or pharmacist before taking any vitamin K supplement if you're anticoagulated.
What are the side effects?
Most people tolerate it well. The most common side effects are mild — nausea, diarrhea, stomach upset, and abdominal pain — and only happen in a small number of people.
Is it safe during pregnancy?
Yes. Vitamin K is rated likely safe during pregnancy and lactation based on the safety data we have.
What does menaquinone-7 do?
It's a form of vitamin K that helps your blood clot properly. Research also suggests it may play a role in bone health, though that evidence is still developing.
Why does the label say to check with my doctor?
Because even though dietary vitamin K is fine, supplements are a different story — especially if you're on any blood thinner or other medication. Your doctor or pharmacist can tell you if it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MK-7 label
Go deeper

The Full Monographs Behind MK-7’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

MK-7's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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