Multizyme Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Multizyme against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Multizyme is a dietary supplement by SP Standard Process with 9 active ingredients. Its ingredients are commonly taken for digestive support for protein digestion, wound cleaning (debridement of dead tissue), sore throat and inflammation.Based on those ingredients, 514 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Fig, Bromelain, Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Multizyme by SP Standard Process
Ask about any prescription or over-the-counter medication and we check it for interactions with Multizyme by SP Standard Process — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Multizyme by SP Standard Process
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Multizyme contains 9 ingredients, including three active digestive enzymes: amylase (breaks down starches), lipase (breaks down fats), and papain (a protein-digesting enzyme from papaya). The product also contains bromelain, another protein-digesting enzyme from pineapple; fig, which is a fruit concentrate; and defatted almonds.
The remaining ingredients are a proprietary blend (its components are listed separately), stearic acid, and pancreatin (a pancreatic enzyme concentrate). The inactive ingredients—gelatin, lactose, water, and calcium stearate—serve as the capsule and binding materials.
Does it work?
Couldn't assess
The evidence backing these ingredients is not established in the data we hold. Papain, bromelain, fig, lipase, and defatted almonds all carry insufficient reliable evidence ratings for the conditions they're typically used for—everything from digestive support to skin health and constipation.
That doesn't mean they don't work; it means the clinical evidence isn't solid enough yet to rate them.
How safe is it?
Well-documented data
Most of these ingredients are generally well tolerated when used short-term at typical doses. Papain and bromelain may cause digestive upset, allergic reactions (itchy eyes, runny nose, sneezing, abdominal cramps, diarrhea), or in rare cases with high papain doses, serious stomach irritation.
Bromelain can trigger allergic reactions including asthma if inhaled. Fig fruit as food is safe for pregnancy and breastfeeding if you're not allergic, but concentrated fig leaf products lack safety data—avoid them in pregnancy and while breastfeeding.
Defatted almonds are safe as food in pregnancy and breastfeeding unless you have a tree-nut allergy. Lipase has no reported side effects in adults, though safety data during pregnancy and breastfeeding is limited; if you have serious digestive conditions, use only under medical guidance.
Meds to double-check
Moderate interaction found
Before taking Multizyme, check with us if you take blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel), diabetes drugs or insulin, tetracycline antibiotics, or photosensitizing drugs (amitriptyline, quinolone antibiotics, sulfa drugs). These are the medication types with documented Moderate or Minor interactions in this product.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Multizyme is a digestive enzyme blend best suited for people looking to support digestion. If you take warfarin, any blood thinner, diabetes medication, insulin, or drugs that cause sun sensitivity, check your medications with us first.
Pregnant or breastfeeding people should talk to their doctor or pharmacist before starting, especially if taking concentrated fig products. Anyone with a tree-nut allergy should avoid this product.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Multizyme, straight from the product label.
| Brand | SP Standard Process |
|---|---|
| Barcode (UPC) | 812122011327 |
| Net contents | 150 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 239753 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Multizyme by SP Standard Process, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Stearic Acid | 0 NP | -- |
| Cholesterol | 5 mg | 2% |
| Cellulose | 0 NP | -- |
| Proprietary Blend | 340 mg | -- |
| Amylase | 0 NP | -- |
| Papain | 0 NP | -- |
| Bromelain | 0 NP | -- |
| Lipase | 0 NP | -- |
| Fig | 0 NP | -- |
| defatted Almonds | 0 NP | -- |
| Pancreatin (3X) | 0 NP | -- |
Other ingredients: Gelatin, Lactose, Water, Calcium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: One capsule per meal, or as directed.
Formulation
Gluten free
General Statements
Whole food supplements since 1929
Precautions
Caution: This product is processed in a facility that manufactures other products containing soy, milk, egg, wheat, peanut, tree nuts, fish, and shellfish.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Multizyme by SP Standard Process label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Multizyme by SP Standard Process
These are the 9 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container150 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Stearic Acid
- › Cellulose
- › Amylase
- › Papain
- › Bromelain
- › Lipase
- › Fig
- › Defatted Almonds
- › Pancreatin (3X)
Other (inactive) ingredients: Gelatin, Lactose, Water, Calcium Stearate. These complete the product’s ingredient list but are not active constituents.
Multizyme by SP Standard Process Drug Interactions
HelloPharmacist Interaction Report
Multizyme by SP Standard Process contains several ingredients with documented interactions with medications.
Papain carries a Moderate interaction with warfarin (Coumadin), a blood thinner—papain may increase warfarin's effects and raise your bleeding risk. One patient on stable warfarin developed significantly elevated INR levels after taking a papain supplement.
Read the full breakdown — every affected drug type, severity by severity
Bromelain also has Moderate interactions with blood thinners and antiplatelet drugs (like aspirin), potentially raising bleeding risk; it carries a Minor interaction with tetracycline antibiotics, which bromelain may help your body absorb more readily. Fig interacts with blood-sugar medications at Moderate severity—both diabetes drugs and insulin—since fig leaf may lower blood glucose further.
Fig also poses a Moderate photosensitivity risk if you take drugs that make your skin sun-sensitive, such as certain antibiotics or amitriptyline.
Lipase, defatted almonds, and three other ingredients (stearic acid, cellulose, and amylase) either show no documented interactions or could not be checked in our data. Altogether, these interactions span 512 individual medications.
Please check your exact medications with the search tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Multizyme?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Multizyme interact with 514 drugs. Click any drug to see the details.
3 of the 9 ingredients in Multizyme interact with drugs. Each result below shows which ingredient is responsible. Fig Bromelain Papain
AbciximabReoPro
How Abciximab interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.
Read the full Fig + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Acenocoumarol interactionAcepromazineAtravet
How Acepromazine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acepromazine interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Multizyme — through 2 ingredients. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Ibuprofen interactionBromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Acetaminophen, Ibuprofen interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Read the full Fig + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
FigAntidiabetes Drugs, Photosensitizing Drugs Moderate
Interaction Summary
Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.
Read the full Fig + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Multizyme — through 1 ingredient. Tap an ingredient for the detail:
BromelainAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Bromelain + Acetylsalicylic Acid interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Multizyme with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Fig
Antidiabetes Drugs
Theoretically, fig leaf might enhance the blood glucose lowering effects of hypoglycemic drugs.
A small clinical study in patients with type 1 diabetes shows that consuming a tea made from fig leaves modestly reduces postprandial glucose levels and insulin requirements.
Insulin
Fig leaf may enhance the blood glucose lowering effects of insulin.
A small clinical study in patients with type 1 diabetes shows that consuming a tea made from fig leaves modestly reduces postprandial glucose levels and insulin requirements.
Photosensitizing Drugs
Theoretically, fig might increase the risk of photosensitivity when used in combination with photosensitizing drugs.
Many cases of photodermatitis from fig leaf have been reported. Some drugs that also cause photosensitivity include amitriptyline (Elavil), quinolones (Ciprofloxacin, others), sulfa drugs (Septra, Bactrim, others), and tetracycline.
Bromelain
Anticoagulant/Antiplatelet Drugs
Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.
Tetracycline Antibiotics
Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.
Papain
Warfarin (Coumadin)
Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.
Brand information
Manufacturer and brand details for Multizyme, from the product label.
SP Standard Process
See all SP Standard Process products- Name
- Standard Process Inc.
- Street Address
- 1200 West Royal Lee Drive
- City
- Palmyra
- State
- WI
- ZipCode
- 53156
Multizyme by SP Standard Process: Common Questions
Does Multizyme by SP Standard Process interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take Multizyme if I'm pregnant?
Is Multizyme safe while breastfeeding?
What does this product do?
Can I take this if I have a tree-nut allergy?
What are the most common side effects?
Can I take this with my diabetes medication?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Multizyme is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Multizyme’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Papain
Interacts with 2 drugsPapain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...
Read the full Papain monograph → Herb & supplement monographBromelain
Interacts with 141 drugsBromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...
Read the full Bromelain monograph → Herb & supplement monographLipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographFig
Interacts with 410 drugsFig (Ficus carica) is a common fruit that has long been used as a gentle food remedy for constipation, and its leaves are used traditionally for blood sugar and coughs. The fruit is a safe a...
Read the full Fig monograph → Herb & supplement monographSweet Almond
Sweet almonds are a nutritious tree nut rich in healthy fats, fiber, protein, vitamin E, and minerals, and they are generally safe and healthy to eat as part of a balanced diet. Almond oil i...
Read the full Sweet Almond monograph →Sources & How We Checked
Multizyme's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 48 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Papain 11 references
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
- Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
- Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
- Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
- Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
- Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
- Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
- Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
- Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
- Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed
Bromelain 19 references
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