Major interaction on record — check this product against your medications before combining. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

N.O.Max ER Ingredients & Drug Interactions

by XYMOGEN EP

N.O.Max ER label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking N.O.Max ER against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

N.O.Max ER is a dietary supplement by XYMOGEN EP with 2 active ingredients. Its ingredients are commonly taken for muscle building and recovery, increasing daily protein intake, weight management.Based on those ingredients, 53 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are ACTINOS2 Whey Peptide Fraction. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against N.O.Max ER by XYMOGEN EP

Ask about any prescription or over-the-counter medication and we check it for interactions with N.O.Max ER by XYMOGEN EP — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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Computed from our clinical databases

HelloPharmacist Scorecard of N.O.Max ER by XYMOGEN EP

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Whey Protein.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 53 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 24, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about N.O.Max ER, straight from the product label.

Brand XYMOGEN EP
Market status Off market
Date entered into DSLD Dec 24, 2013
DSLD ID 28260
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses No Claim
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for N.O.Max ER by XYMOGEN EP, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Caplet(s)
Maximum serving Sizes:
3 Caplet(s)
Servings per container
60
IngredientAmount% DV
Arginine Alpha-Ketoglutarate1980 mg--
ACTINOS2 Whey Peptide Fraction150 mg--

Other ingredients: Cellulose and cellulose derivatives, Stearic Acid, Magnesium Stearate, Silica, Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Brand IP Statement(s)

Three scientifically formulated, safe, and effective dietary supplements - ALAmax CR(TM), N.O.max ER(TM), and Resveratin(TM) Plus - seamlessly act as one entity to support the restoration of a lifetime.1

(C) 2012 XYMOGEN

All XYMOGEN(R) Formulas Meet or Exceed cGMP Quality Standards.

N.O.max ER(TM)

DESCRIPTION: N.O.max ER(TM) represent a patented, extended-release nitric oxide precursor.

UP-REGULATED WITH: ACTINOS2(R) NOS-Enhancing Peptide Fraction ACTINOS2 is a trademark of Glanbia plc.

PROTECTED BY U.S. PATENTS: 6,905,707 and 7,579,020.

General Statements

Sharpen your metabolism back to a razor's edge with mitochondrial biogenesis.

Restore Your Metabolic Edge Metabolism is the wellspring of life. Mitochondria, representing a staggering 10% of body weight, are the cornerstone of energy production. Over time, mitochondria age.1 You lose your metabolic "edge". Your appearance, feeling of well-being, and physical capabilities progressively "dull."

For more information, refer to The Secret Life of Mitochondria by Joseph L. Evans, Ph.D.

{chart} N.O.max ER(TM) Resveratin(TM) Plus ALAmax CR(TM) EXERCISE NO SIRT1 AMPK PGC1a - Helps Maintain Mitochondrial Biogenesis/Function - Decreases Free Radicals/Oxidative Stress - Promotes Efficient Metabolic Function - Supports Energy Production - May Help Maintain Exercise Performance - May Help Upregulate Anti-aging Mechanisms

Used as directed, the XYMOGEN Mitochondrial Renewal Kit may help promote: ~ Efficient use of insulin and glucose by the body ~ Conversion of glucose into usable energy ~ Healthy aging* ~ Exercise performance ~ Nitric oxide (NO) production ~ Cardiovascular and endothelial functino ~ Improved antioxidant status and resistance to oxidative stress

PHARMACEUTICAL - GRADE PROFESSIONAL USE ONLY 30-Day Supply

RESTORE YOUR METABOLIC EDGE

This Is How Metabolism Should Look and Feel Metabolism is the process by which your body's cells produce energy. Most of this energy is produced in mitochondria. These cellular "powerhouses" oxidize or "burn" calories, principally from glucose (blood sugar) and fat. Metabolically active cells, such as those of the brain, heart, and muscle, may contain 100s to 1,000s of mitochondria. The more mitochondria inside your cells, the more calories your body can burn. Thus, healthy mitochondria give your metabolism a calorie-burning, energy-generating edge. The process by which new mitochondria are produced inside your body's cells is known as mitochondrial biogenesis. In light of the many metabolic and protective roles played by mitochondria, it's no surprise that mitochondrial biogenesis is critical to delaying the effects of aging and age-associated declines in metabolism (e.g., increased body fat and decreased lean muscle tissue).1,2,3 Mitochondrial biogenesis is a complicated process involving more than 1,000 genes.1 Caloric restriction and aerobic exercise promote mitochondrial biogenesis. However, caloric restriction and consistent aerobic exercise regimens are difficult to maintain. 2,3 Uncomplicate your life with the Mitochondrial Renewal Kit. It contains ingredients that help restore your metabolic edge by activating the critical molecular "switches" that control mitochondrial biogenesis - the very same switches activated by caloric restriction and aerobic exercise.1 Embark on the restoration of your life. Restore your metabolic edge with the Mitochondrial Renewal Kit. Enjoy the look and feel of great metabolism.* 1. Lopez-Lluch G, Irusta PM, Navas P, et al. Exp Gerontol. 2008 Sep;43(9):813-19. 2. Lanza IR, Short DK, Short KR, et al. Diabetes. 2008 Nov;57(11):2933-42. 3. Johnston AP, De Lisio M, Parise G. Appl Physiol Nutr Metab. 2008 Feb;33(1):191-99. Based on emerging experimental research. * For optimal benefit, combine this product with a healthy diet and exercise regimen.

EXCLUSIVE - PATENTED

Patient Benefits

Scientists now refer to nitric oxide (NO) as the "foundation" of cardiovascular health. This tiny molecule is a vasodilator responsible for controlling blood flow to the entire body, which may help support healthy blood flow pressure and promote the health of the endothelium - the inside of blood vessels. With age comes diminished NO levels; that's why since 1998, when three scientists won the Novel Prize for their discovery of NO, researchers have been working to harness its heart-healthy activity. Today, with the application of XYMOGEN's extended-release technology, that activity has been realized with N.O.max ER.

May Help Maintain Healthy Blood Pressure Already in the Normal Range Promotes Endothelial Health Helps Support Vasodilation Nitric Oxide Precursor May Help Promote Cardiovascular Health

CLINICALLY TESTED INGREDIENT - ISSUED U.S. PATENT

Precautions

Individuals with a medical condition (including diabetes or cold sores), that are taking prescription drugs, that are pregnant or lactating, or are under the age of 18 should consult their healthcare practitioner prior to use.

Individuals with a medical condition (including diabetes or cold sores), that are taking prescription drugs, that are pregnant or lactating, or are under the age of 18 should consult their healthcare practitioner prior to use.

Introducing The Restoration of Your Life

STORAGE: Keep closed in a cool, dry place out of reach of children.

Contains: Ingredient derived from Milk (ACTINOS2)

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORAGE: Keep closed in a cool, dry place out of reach of children.

FDA Statement of Identity

Dietary Supplement

Formulation

DOES NOT CONTAIN: Wheat, gluten, corn, yeast, soy, fish, shellfish, peanuts, tree nuts, egg, artificial colors, artificial sweeteners, or preservatives.

Formula

Contains: Ingredient derived from Milk (ACTINOS2)

N.O.max ER(TM)EXTENDED-RELEASE ARGININE ALPHA-KETOGLUTARATE

Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one to two packets per day, or as directed by your healthcare practitioner. Each packet supplies three N.O.max ER, one Resveratin Plus, and one ALAmax CR. Take one packet with 8 oz. water, 30 minutes before breakfast and 30 minutes before lunch.

General

ZLB-BMIOKIT-01 REV. 062612

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

N.O.Max ER by XYMOGEN EP label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

N.O.Max ER label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in N.O.Max ER by XYMOGEN EP

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Caplet(s) Dosage formOther (e.g. Tea Bag) Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Arginine Alpha-Ketoglutarate

1980 mg per serving

ACTINOS2 Whey Peptide Fraction

Interacts with
53 drugs
150 mg per serving

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined...

ACTINOS2 Whey Peptide Fraction monograph & interactions

Other (inactive) ingredients: Cellulose and cellulose derivatives, Stearic Acid, Magnesium Stearate, Silica, Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

N.O.Max ER by XYMOGEN EP Drug Interactions

N.O.Max ER contains 2 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 53 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against N.O.Max ER?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
53Drugs
5 Major 48 Moderate

Ingredients driving the most interactions

ACTINOS2 Whey Peptide Fraction 53

Individual Drug Interactions

The ingredients in N.O.Max ER interact with 53 drugs. Click any drug to see the details.

1 of the 2 ingredients in N.O.Max ER interact with drugs. Each result below shows which ingredient is responsible. ACTINOS2 Whey Peptide Fraction

Each ingredient & the kinds of drugs it affects

For each ingredient in N.O.Max ER with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

ACTINOS2 Whey Peptide Fraction4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
ACTINOS2 Whey Peptide Fraction full monograph & interactions
The maker

Brand information

Manufacturer and brand details for N.O.Max ER, from the product label.

XYMOGEN EP

See all XYMOGEN EP products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

N.O.Max ER by XYMOGEN EP: Common Questions

Does N.O.Max ER by XYMOGEN EP interact with any medications?
Yes. Based on its ingredients, N.O.Max ER has a known interaction with 53 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
N.O.Max ER contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if N.O.Max ER is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

N.O.Max ER label
Go deeper

The Full Monographs Behind N.O.Max ER’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph →
Sources

Sources & How We Checked

N.O.Max ER's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 25 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Whey Protein 25 references
  1. Martindale W. Martindale the Extra Pharmacopoeia. Pharmaceutical Press, 1999.
  2. Maton PN, Burton ME. Antacids revisited: a review of their clinical pharmacology and recommended therapeutic use. Drugs 1999;57:855-70.
  3. Bell SJ. Whey protein concentrates with and without immunoglobulins: a review. J Med Food 2000;3:1-13. PubMed
  4. Nutt JG, Woodward WR, Hammerstad JP, et al. The "on-off" phenomenon in Parkinson's disease. Relation to levodopa absorption and transport. N Engl J Med 1984;310:483-8. PubMed
  5. Baruzzi A, Contin M, Riva R, et al. Influence of meal ingestion time on pharmacokinetics of orally administered levodopa in parkinsonian patients. Clin Neuropharmacol 1987;10:527-37. PubMed
  6. Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol 1987;44:1003-5. PubMed
  7. Eriksson T, Granerus AK, Linde A, et al. "On-off" phenomenon in Parkinson's disease: relationship between dopa and other large neutral amino acids in plasma. Neurology 1988;38:1245-8. PubMed
  8. Semla TP, Beizer JL, Higbee MD. Geriatric Dosage Handbook. 4th ed. Hudson, OH: Lexicomp, 1998.
  9. Pletz MW, Petzold P, Allen A, et al. Effect of calcium carbonate on bioavailability of orally administered gemifloxacin. Antimicrob Agents Chemother 2003;47:2158-60.. PubMed
  10. Peters ML, Leonard M, Licata AA. Role of alendronate and risedronate in preventing and treating osteoporosis. Cleve Clin J Med 2001;68:945-51. PubMed
  11. Micke, P., Beeh, K. M., and Buhl, R. Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients. Eur.J Nutr 2002;41(1):12-18. PubMed
  12. Chitapanarux, T., Tienboon, P., Pojchamarnwiputh, S., and Leelarungrayub, D. Open-labeled pilot study of cysteine-rich whey protein isolate supplementation for nonalcoholic steatohepatitis patients. J Gastroenterol.Hepatol. 2009;24(6):1045-1050. PubMed
  13. Sataloff, R. T., Bittermann, T., Marks, L., Lurie, D., and Hawkshaw, M. The effects of glutathione enhancement on sensorineural hearing loss. Ear Nose Throat J 2010;89(9):422-433.
  14. Zhu, K., Meng, X., Kerr, D. A., Devine, A., Solah, V., Binns, C. W., and Prince, R. L. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal
  15. Bjorkman, M. P., Pilvi, T. K., Kekkonen, R. A., Korpela, R., and Tilvis, R. S. Similar effects of leucine rich and regular dairy products on muscle mass and functions of older polymyalgia rheumatica patients: a randomized crossover trial. J Nutr Health A
  16. Brun, A. C., Stordal, K., Johannesdottir, G. B., Bentsen, B. S., and Medhus, A. W. The effect of protein composition in liquid meals on gastric emptying rate in children with cerebral palsy. Clin.Nutr 2012;31(1):108-112. PubMed
  17. Gouni-Berthold, I., Schulte, D. M., Krone, W., Lapointe, J. F., Lemieux, P., Predel, H. G., and Berthold, H. K. The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised plac
  18. Errichiello, L., Pezzella, M., Santulli, L., Striano, S., Zara, F., Minetti, C., Mainardi, P., and Striano, P. A proof-of-concept trial of the whey protein alfa-lactalbumin in chronic cortical myoclonus. Mov Disord. 2011;26(14):2573-2575. PubMed
  19. Carcillo, J. A., Dean, J. M., Holubkov, R., Berger, J., Meert, K. L., Anand, K. J., Zimmerman, J., Newth, C. J., Harrison, R., Burr, J., Willson, D. F., and Nicholson, C. The randomized comparative pediatric critical illness stress-induced immune suppres
  20. Chungchunlam, S. M., Moughan, P. J., Henare, S. J., and Ganesh, S. Effect of time of consumption of preloads on measures of satiety in healthy normal weight women. Appetite 2012;59(2):281-288. PubMed
  21. Rencuzogullari I, Börekçi A, Karakoyun S, et al. Coronary thrombosis in three coronary arteries due to whey protein. Am J Emerg Med. 2017;35(4):664.e3-664.e4. PubMed
  22. Silverberg NB. Whey protein precipitating moderate to severe acne flares in 5 teenaged athletes. Case Reports Cutis. 2012;90(2):70-2.
  23. Simonart T. Acne and whey protein supplementation among bodybuilders. Dermatology. 2012;225(3):256-8. PubMed
  24. Pontes TC, Costa Fernandes Filho GM, Pereira Trindade AS, Sobral Filho JF. Incidence of acne vulgaris in young adult users of protein-calorie supplements in the city of João Pessoa-PB. An Bras Dermatol. 2013;88(6):907-12.
  25. Adebamowo CA, Spiegelman D, Berkey CS, et al. Milk consumption and acne in teenaged boys. J Am Acad Dermatol. 2008 May;58(5):787-93. PubMed

See these in context on the Whey Protein monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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