n-zimes Ingredients & Drug Interactions
by Swanson
What is this page for?
First and foremost: checking n-zimes against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
n-zimes is a dietary supplement by Swanson with 12 active ingredients. Its ingredients are commonly taken for digestive support, bloating and gas, fat digestion.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of n-zimes by Swanson
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
N-Zimes contains 12 active ingredients, all digestive enzymes designed to support the breakdown of food. The blend includes amylase (for starches), lipase (for fats), protease variants (for proteins), cellulase (for fiber), glucoamylase, beta-glucanase, phytase, hemicellulase, diastase, peptidase, and a proprietary enzyme blend.
The inactive ingredients are rice bran, hypromellose, dextrin, and maltodextrin — used as fillers and capsule material.
Does it work?
Not established
The evidence for most of these enzymes isn't well established in the data we hold. Lipase and phytase both have insufficient reliable evidence for the conditions they're marketed for — including inflammatory bowel disease, dyspepsia (indigestion), iron deficiency anemia, and zinc deficiency.
Protease enzymes in this product have no effectiveness ratings in our system. If you're considering this for a specific digestive complaint, it's worth talking to your doctor or pharmacist about what the research actually shows for your situation.
How safe is it?
Well-documented data
The enzyme blends in this product are generally well tolerated by most adults, though a small number of people may experience digestive upset or allergic reactions. Lipase should only be used under medical guidance if you have serious digestive conditions.
Occupational exposure to airborne phytase and protease has caused allergic reactions in some workers — though ingesting the supplement is different from inhaling powder. There isn't enough safety data during pregnancy; phytase and protease are best avoided in pregnancy unless your doctor advises it.
Breastfeeding safety hasn't been well studied, so check with your healthcare provider first.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. However, several enzymes in this product could not be checked against medications because we hold no interaction information for them.
If you take any prescription medications, run them through the search tool on this page to be sure.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
N-Zimes is a multi-enzyme blend aimed at general digestive support, and no interactions are documented for the ingredients we checked. The evidence for how well it works for specific conditions isn't strong in our data.
If you have digestive issues, serious gut conditions, or you're pregnant or breastfeeding, talk it over with your doctor or pharmacist before starting — they can weigh whether this product fits your individual situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 5 of 12 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about n-zimes, straight from the product label.
| Brand | Swanson |
|---|---|
| Barcode (UPC) | 087614025025 |
| Net contents | 90 Veggie Cap(s) |
| Market status | On market |
| Date entered into DSLD | Apr 23, 2024 |
| DSLD ID | 308683 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for n-zimes by Swanson, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Amylase | 0 NP | -- |
| Lipase | 0 NP | -- |
| Cellulase | 0 NP | -- |
| Peptidase | 0 NP | -- |
| Glucoamylase | 0 NP | -- |
| Beta-Glucanase | 0 NP | -- |
| Phytase | 0 NP | -- |
| Hemicellulase | 0 NP | -- |
| Diastase | 0 NP | -- |
| Protease 4.5 | 0 NP | -- |
| Protease 3 | 0 NP | -- |
| Protease 6 | 0 NP | -- |
| Proprietary Enzyme Blend | 280 mg | -- |
| CereCalase | 25 mg | -- |
Other ingredients: Rice Bran, Hypromellose, Dextrin, Maltodextrin
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Aids in digestion of carbohydrates, proteins and fats Supports healthy digestion and maximizes nutrient absorption
Digestive health
General Statements
Science-Backed Quality Since 1969
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take one veggie capsule with water immediately before each meal.
Brand IP Statement(s)
CereCalase and n-zimes are registered trademarks of National Enzyme Co.
Precautions
Warning: For adults only. Keep out of reach of children.
Consult your physician before using this or any product if you are pregnant or nursing, taking medication or have a medical condition.
Do not use if seal is broken.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Full Spectrum featuring CereCalase
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
n-zimes by Swanson label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in n-zimes by Swanson
These are the 12 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Veggie Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Enzyme Blend
- › Amylase
- › Lipase
- › Cellulase
- › Peptidase
- › Glucoamylase
- › Diastase
- › Protease 4.5
- › Protease 3
- › Protease 6
CereCalase
- › Beta-Glucanase
- › Phytase
- › Hemicellulase
Other (inactive) ingredients: Rice Bran, Hypromellose, Dextrin, Maltodextrin. These complete the product’s ingredient list but are not active constituents.
n-zimes by Swanson Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in n-zimes. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for n-zimes, from the product label.
Swanson
See all Swanson products- Name
- Swanson Health Products
- City
- Fargo
- State
- ND
- ZipCode
- 58104
- Phone Number
- 1-800-437-4148
- Web Address
- swanson.com
n-zimes by Swanson: Common Questions
Does n-zimes by Swanson interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take N-Zimes while I'm pregnant?
Is it safe to breastfeed while taking this?
What are these enzymes supposed to do?
Does this product actually work for digestive problems?
Are there any side effects I should watch for?
Does it have any fillers or other inactive ingredients?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if n-zimes is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind n-zimes’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Lipase
Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...
Read the full Lipase monograph → Herb & supplement monographProteolytic Enzymes (proteases)
Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...
Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monographPhytase
Phytase is an enzyme that breaks down phytic acid (phytate) found in grains, beans, nuts, and seeds, which can free up minerals like iron, zinc, and calcium for absorption. It is widely used...
Read the full Phytase monograph →Sources & How We Checked
n-zimes's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 11 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Lipase 1 reference
- Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed
Phytase 7 references
- Lei XG, Weaver JD, Mullaney E, Ullah AH, Azain MJ. Phytase, a new life for an "old" enzyme. Annu Rev Anim Biosci. 2013;1:283-309. PubMed
- Smuts CM, Matsungo TM, Malan L, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2 PubMed
- van Heemst RC, Sander I, Rooyackers J, et al. Hypersensitivity pneumonitis caused by occupational exposure to phytase. Eur Respir J. 2009;33(6):1507-9. PubMed
- Baur X, Melching-Kollmuss S, Koops F, Strassburger K, Zober A. IgE-mediated allergy to phytase -- a new animal feed additive. Allergy. 2002;57(10):943-5. PubMed
- Doekes G, Kamminga N, Helwegen L, Heederik D. Occupational IgE sensitisation to phytase, a phosphatase derived from Aspergillus niger. Occup Environ Med. 1999;56(7):454-9. PubMed
- Brnic M, Hurrell RF, Songré-Ouattara LT, et al. Effect of phytase on zinc absorption from a millet-based porridge fed to young Burkinabe children. Eur J Clin Nutr. 2017;71(1):137-141. PubMed
- Koshy JC, Sharabi SE, Feldman EM, Hollier LH Jr, Patrinely JR, Soparkar CN. Effect of dietary zinc and phytase supplementation on botulinum toxin treatments. J Drugs Dermatol. 2012;11(4):507-12.
Proteolytic Enzymes (proteases) 3 references
- Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
- Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
- Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed
See these in context on the Proteolytic Enzymes (proteases) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC