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Dietary supplement

Natural Pineapple Enzyme Bromelain Ingredients & Drug Interactions

by American Health

Natural Pineapple Enzyme Bromelain label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Natural Pineapple Enzyme Bromelain against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Natural Pineapple Enzyme Bromelain is a dietary supplement by American Health with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and nasal congestion, digestion support.Based on those ingredients, 141 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bromelain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Natural Pineapple Enzyme Bromelain by American Health

Ask about any prescription or over-the-counter medication and we check it for interactions with Natural Pineapple Enzyme Bromelain by American Health — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Natural Pineapple Enzyme Bromelain by American Health

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bromelain, a natural enzyme derived from pineapple. Bromelain is the fruit's digestive enzyme.

The tablet also contains several inactive ingredients (dextrose, vegetable cellulose, dicalcium phosphate, calcium silicate, vegetable magnesium stearate, and stearic acid) that help form and preserve the tablet.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: natural digestive enzyme for protein digestion.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence on bromelain's effectiveness for its commonly marketed uses—allergic rhinitis (hay fever), burns, cancer, chemotherapy-related nerve pain, chronic venous insufficiency, and diabetes—is insufficient to establish whether it works. The data we hold does not show a reliable rating for any of these conditions.

The evidence, ingredient by ingredient Bromelain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Taken by mouth, bromelain is generally well tolerated in the short term, though long-term safety data is limited. The most common side effects are diarrhea, flatulence, stomach upset, and headache.

Some people may have allergic reactions—especially those sensitive to pineapple—and if inhaled (not typical for tablets), bromelain can trigger asthma-like symptoms and throat irritation. During pregnancy, there isn't enough safety data, so it's best avoided.

Safety while breastfeeding is also unknown, so avoid it then too. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Bromelain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bromelain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 141 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you're on blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel)—bromelain may increase bleeding risk. If you take tetracycline antibiotics like doxycycline, also mention it, though the real-world risk is less clear.

Any regular medications should be run through the checker below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bromelain may help some people, but we don't have solid evidence it works for the conditions it's often marketed for. The main concern is bleeding risk if you take blood thinners or antiplatelet drugs.

If you're on any regular medications, especially blood thinners or antibiotics, check with your doctor or pharmacist before starting it. It's not recommended during pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Natural Pineapple Enzyme Bromelain, straight from the product label.

Brand American Health
Barcode (UPC) 076630025911
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Jan 25, 2012
DSLD ID 4386
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Natural Pineapple Enzyme Bromelain by American Health, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
076630025911
IngredientAmount% DV
Bromelain500 mg--

Other ingredients: Dextrose, Vegetable Cellulose, Dicalcium Phosphate, Calcium Silicate, Vegetable Magnesium Stearate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

dietary supplement

Suggested/Recommended/Usage/Directions

DIRECTIONS: For adults, take one (1) tablet two to four times daily, after meals.

Precautions

Keep out of reach of children.

WARNING: If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use.

Discontinue use and consult your doctor if any adverse reactions occur.

Do not use if seal under cap is broken or missing.

FDA Disclaimer Statement

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Store at room temperature.

Formula

Derived from the stems of pineapple, Bromelain is a natural digestive enzyme that helps to digest protein in the gastrointestinal tract.*

General Statements

500 mg 600 GDU/gram

Natural Digestive Enzyme*

Visit www.AmericanHealthUS.com for our complete line of products

General

PROD. NO. 2591 B7411 06C

Brand IP Statement(s)

© 2012 American Health, Inc.

Formulation

Vegetarian Formula

No Gluten, No Yeast, No Wheat, No Milk or Milk Derivatives, No Lactose, No Soy, No Egg, No Grapefruit, No Preservatives, No Artificial Color, No Artificial Flavor, No Sodium.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Natural Pineapple Enzyme Bromelain by American Health label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Natural Pineapple Enzyme Bromelain label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Natural Pineapple Enzyme Bromelain by American Health

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Bromelain

Interacts with
141 drugs
500 mg per serving Form: Pineapple

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early st...

Bromelain monograph & interactions

Other (inactive) ingredients: Dextrose, Vegetable Cellulose, Dicalcium Phosphate, Calcium Silicate, Vegetable Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Natural Pineapple Enzyme Bromelain by American Health Drug Interactions

Want to check YOUR meds against Natural Pineapple Enzyme Bromelain?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
141Drugs
122 Moderate 19 Minor

Ingredients driving the most interactions

Bromelain 141

Individual Drug Interactions

The ingredients in Natural Pineapple Enzyme Bromelain interact with 141 drugs. Click any drug to see the details.

1 of the 1 ingredient in Natural Pineapple Enzyme Bromelain interact with drugs. Each result below shows which ingredient is responsible. Bromelain

Each ingredient & the kinds of drugs it affects

For each ingredient in Natural Pineapple Enzyme Bromelain with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bromelain2 drug types · 141 drugs

Anticoagulant/Antiplatelet Drugs

Bromelain may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
There is one case report of a patient experiencing minor bruising while taking bromelain with naproxen. Bromelain is thought to have antiplatelet activity. Whether this interaction is of concern with topical bromelain is unclear. Interference with coagulation of burn wounds has been reported in a patient receiving bromelain-based enzymatic debridement. However, observational research has found that topical bromelain debridement is not associated with increases or decreases in laboratory markers of coagulation when compared with surgical debridement.

Likelihood Possible Evidence D
Tetracycline Antibiotics

Theoretically, bromelain might increase levels of tetracycline antibiotics.
Laboratory research suggests that bromelain might increase the absorption of tetracycline antibiotics. However, a study in healthy adults reported no difference in tetracycline plasma levels when a 500 mg dose was taken with or without bromelain 80 mg.

Likelihood Possible Evidence B
Bromelain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Natural Pineapple Enzyme Bromelain, from the product label.

American Health

See all American Health products
Name
American Health, Inc.
City
Ronkonkoma
State
NY
ZipCode
11779
Phone Number
800-445-7137
Pharmacist Counseling Corner

Natural Pineapple Enzyme Bromelain by American Health: Common Questions

Does Natural Pineapple Enzyme Bromelain by American Health interact with any medications?
Yes. Based on its ingredients, Natural Pineapple Enzyme Bromelain has a known interaction with 141 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Natural Pineapple Enzyme Bromelain contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is bromelain, and where does it come from?
Bromelain is a natural enzyme found in pineapple fruit. It's a digestive enzyme the plant produces, and it's extracted for use in supplements like this one.
Can I take this if I'm pregnant or breastfeeding?
No. There isn't enough safety data during pregnancy, so it's best avoided then. Safety while breastfeeding is also unknown, so avoid it during that time too. Talk with your doctor or pharmacist before taking bromelain if either applies to you.
What side effects might I experience?
Most common are diarrhea, flatulence, stomach upset, and headache when taken by mouth. Some people may have allergic reactions, especially if sensitive to pineapple. Stop and contact your healthcare provider if you experience unusual bruising, signs of an allergic reaction, or severe stomach problems.
Does bromelain actually work for hay fever, burns, or other conditions?
We don't have enough reliable evidence to say whether it works for the conditions it's commonly marketed for—hay fever, burns, cancer, nerve pain from chemotherapy, circulation problems, or diabetes. More research would be needed to establish real benefit.
Is bromelain the only active ingredient in this product?
Yes. The tablet contains one active ingredient—bromelain—plus several inactive ingredients (fillers and binders) that help form the tablet.
Why do I need to check this with my blood thinner medication?
Bromelain appears to have mild blood-thinning activity and may increase your bleeding risk if combined with anticoagulants or antiplatelet drugs like warfarin or aspirin. There's even a case report of bruising when bromelain was taken with the pain reliever naproxen. Check with your doctor or pharmacist before adding it to your regimen.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Natural Pineapple Enzyme Bromelain is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Natural Pineapple Enzyme Bromelain label
Go deeper

The Full Monographs Behind Natural Pineapple Enzyme Bromelain’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bromelain

Interacts with 141 drugs

Bromelain is a group of protein-digesting enzymes from pineapple that people take mainly for inflammation, swelling, and sinus problems. Some early studies are promising, but the overall evi...

Read the full Bromelain monograph →
Sources

Sources & How We Checked

Natural Pineapple Enzyme Bromelain's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 19 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bromelain 19 references
  1. Nettis E, Napoli G, Ferrannini A, Tursi A. IgE-mediated allergy to bromelain. Allergy 2001;56:257-8. PubMed
  2. Taussig SJ, Batkin S. Bromelain, the enzyme complex of pineapple (Ananas comosus) and its clinical application. An update. J Ethnopharmacol 1988;22:191-203.. PubMed
  3. Bradbrook ID, Morrison PJ, Rogers HJ. The effect of bromelain on the absorption of orally administered tetracycline. Br J Clin Pharmacol 1978;6:552-4. PubMed
  4. Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5.
  5. Brien S, Lewith G, Walker AF, et al. Bromelain as an adjunctive treatment for moderate-to-severe osteoarthritis of the knee: a randomized placebo-controlled pilot study. QJM 2006;99:841-50. PubMed
  6. Mori S, Ojima Y, Hirose T, et al. The clinical effect of proteolytic enzyme containing bromelain and trypsin on urinary tract infection evaluated by double blind method. Acta Obstet Gynaecol Jpn 1972;19:147-53.
  7. Glaser D, Hilberg T. The influence of bromelain on platelet count and platelet activity in vitro. Platelets 2006;17:37-41. PubMed
  8. Heinicke R M, van der Wal L, Yokoyama M. Effect of bromelain (Ananase) on human platelet aggregation. Experientia 1972;28:844-5. PubMed
  9. Gailhofer, G., Wilders-Truschnig, M., Smolle, J., and Ludvan, M. Asthma caused by bromelain: an occupational allergy. Clin Allergy 1988;18(5):445-450. PubMed
  10. Mattei, O., Fabri, G., and Farina, G. [Occupational health experience regarding four cases of asthma due to bromelain (author's transl)]. Medicina del Lavoro 1979;70(5):404-409.
  11. Galleguillos, F. and Rodriguez, J. C. Asthma caused by bromelin inhalation. Clin Allergy 1978;8(1):21-24. PubMed
  12. Perez-Camo I, Quirce S, Duran MA, and et al. Latex allergy: evidence of cross-reactivity with papain and bromelain [abstract]. Allergy 1996;51(suppl 31):48.
  13. Martin GJ, Ehrenreich J, and Asbell N. Bromelain: pineapple proteases with anti-edema activity. Exp Med Surg 1962;20:227-247.
  14. Kasemsuk T, Saengpetch N, Sibmooh N, Unchern S. Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis. Clin Rheumatol. 2016 Oct;35(10):2531-40. PubMed
  15. Kutlu Ö, DemirbaS A, Elmas ÖF, Güvenç U, Metin A. Fixed drug eruption: a new side effect of bromelain. Contact Dermatitis 2020. Online ahead of print. PubMed
  16. Shoham Y, Shapira E, Haik J, et al. Bromelain-based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial. Wound Repair Regen 2021;29(6):899-907. PubMed
  17. Pfister P, Garcia Wendel PD, Kim BS, et al. Coagulation side effects of enzymatic debridement in burned patients. Burns 2022. PubMed
  18. Hasham S, Riyat H, Fletcher A, O'Boyle CP, Alexander S. To bleed or not to bleed? Case series and discussion of haemorrhage risk with enzymatic debridement in burn injuries. Scars Burn Heal 2023;9:20595131231168333. PubMed
  19. Leelakanok N, Petchsomrit A, Janurai T, Saechan C, Sunsandee N. Efficacy and safety of bromelain: A systematic review and meta-analysis. Nutr Health 2023. PubMed

See these in context on the Bromelain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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