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Dietary supplement

Nicotinamide 1000 mg Ingredients & Drug Interactions

by Biophix

Nicotinamide 1000 mg label
See full label image
Tablet Or Pill Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nicotinamide 1000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nicotinamide 1000 mg is a dietary supplement by Biophix with 1 active ingredient. Its ingredients are commonly taken for acne and skin health, pellagra (niacin deficiency), anti-aging and skin tone.Based on those ingredients, 124 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nicotinamide. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nicotinamide 1000 mg by Biophix

Ask about any prescription or over-the-counter medication and we check it for interactions with Nicotinamide 1000 mg by Biophix — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nicotinamide 1000 mg by Biophix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Biophix Nicotinamide 1000 mg is a single-ingredient supplement — one 1000 mg tablet of niacinamide (also called nicotinamide), a form of vitamin B3. The inactive ingredients are stearic acid, dicalcium phosphate, rice bran, hydroxypropyl methylcellulose, magnesium stearate, silica, and pharmaceutical glaze, which are fillers, binders, and capsule materials.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Niacinamide's overall clinical evidence instead.

Strong

Strong clinical evidence supports Niacinamide for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Pellagra — rated "Likely Effective" (Natural Medicines).
  • On file: Acne — rated "Possibly Effective" (Natural Medicines).
  • On file: Diabetes — rated "Possibly Effective" (Natural Medicines).
  • On file: Osteoarthritis — rated "Possibly Effective" (Natural Medicines).
  • On file: Hyperphosphatemia — rated "Possibly Effective" (Natural Medicines).

The evidence for niacinamide in this dose is strongest for preventing and treating pellagra (a B3 deficiency disease) — that's rated Likely Effective. There's possible evidence it may help with acne, high phosphate levels in the blood (hyperphosphatemia), osteoarthritis, and type 2 diabetes, though the data aren't yet solid.

For brain tumors, the available evidence suggests it's not effective. If you're taking this for one of those conditions, talk it over with your doctor about what the science actually supports.

The evidence, ingredient by ingredient Niacinamide

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

At normal food amounts and standard prenatal-vitamin doses, niacinamide is well tolerated and considered safe during pregnancy and breastfeeding. High supplemental doses — like the 1000 mg in this tablet — should be discussed with your doctor or pharmacist first, especially if you're pregnant or nursing.

At higher doses, you may experience dizziness, drowsiness, itching, nausea, vomiting, heartburn, or rash. Large doses can also cause stomach upset, flatulence, and diarrhea.

These side effects are generally mild, but they're worth watching for.

Side effects, ingredient by ingredient Niacinamide

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Niacinamide.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 124 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check before taking this if you're on blood thinners (anticoagulants) or antiplatelet drugs like warfarin — niacinamide may make them stronger. Also watch if you take seizure medications like carbamazepine or primidone; this supplement may raise their levels.

Use the search tool on this page to check your specific medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

Nicotinamide 1000 mg is mainly used for pellagra prevention and treatment, with some possible benefit for acne, joint pain, and blood sugar — though the evidence for those isn't strong. The main caution is if you take blood thinners or seizure medications; this supplement may increase their effects.

Before you start, check with your own doctor or pharmacist, especially if you're on any prescription drugs or have plans to become pregnant or breastfeed.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nicotinamide 1000 mg, straight from the product label.

Brand Biophix
Barcode (UPC) X00161CUPL
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Sep 22, 2022
DSLD ID 276051
Product type Vitamin
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nicotinamide 1000 mg by Biophix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Sustained Release Tablet(s)
Maximum serving Sizes:
1 Sustained Release Tablet(s)
Servings per container
60
UPC/BARCODE
X00161CUPL
IngredientAmount% DV
Nicotinamide1000 mg6250%

Other ingredients: Stearic Acid, Dicalcium Phosphate, Rice Bran, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica, Pharmaceutical Glaze

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested usage: As a dietary supplement take one tablet daily.

Formula

Nicotinamide is a water-soluble amide of nicotinic acid. It is an essential member of the B-vitamin family and it does not cause a niacin flush. Biophix Maximum Strength Nicotinamide has been formulated to produce a gradual release over a prolonged period of time using a proprietary Micro-Sphere Sustained Release System. Nicotinamide and niacin are two different forms of vitamin B-3.

Maximum Strength Nicotinamide 1,000 mg

High potency vitamin, gluten free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Made in USA Manufactured In A GMP Inspected Facility

Formulation

Made in USA Manufactured In A GMP Inspected Facility

Micro-Sphere Sustained Release System Flush-free sustained release GMP tested

High potency vitamin, gluten free

Vegan

Free from artificial colors, flavoring, sweeteners, and preservatives. Free from the common allergens wheat, corn, soy and milk. Not manufactured with gluten, titanium dioxide, carnauba wax, talc, yeast, hexane. Hypo-allergenic.

Free from artificial colors, flavoring, sweeteners, and preservatives. Free from the common allergens wheat, corn, soy and milk. Not manufactured with gluten, titanium dioxide, carnauba wax, talc, yeast, hexane. Hypo-allergenic.

Gluten free GMO free

GMP tested

FDA Statement of Identity

Dietary Supplement

Precautions

Caution: For adults only.

Consult a physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not eat freshness packet. Keep in bottle.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nicotinamide 1000 mg by Biophix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nicotinamide 1000 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nicotinamide 1000 mg by Biophix

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Sustained Release Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.

Nicotinamide

Interacts with
124 drugs
1000 mg per serving Form: Nicotinic Amide Niacin, Vitamin B-3

Niacinamide (also called nicotinamide) is a form of vitamin B3 used in supplements and skin-care products. It is well established for preventing and t...

Nicotinamide monograph & interactions

Other (inactive) ingredients: Stearic Acid, Dicalcium Phosphate, Rice Bran, Hydroxypropyl Methylcellulose, Magnesium Stearate, Silica, Pharmaceutical Glaze. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nicotinamide 1000 mg by Biophix Drug Interactions

Want to check YOUR meds against Nicotinamide 1000 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
124Drugs
124 Moderate

Ingredients driving the most interactions

Nicotinamide 124

Individual Drug Interactions

The ingredients in Nicotinamide 1000 mg interact with 124 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nicotinamide 1000 mg interact with drugs. Each result below shows which ingredient is responsible. Nicotinamide

Each ingredient & the kinds of drugs it affects

For each ingredient in Nicotinamide 1000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nicotinamide4 drug types · 124 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, niacinamide may have additive effects when used with anticoagulant or antiplatelet drugs, especially in patients on hemodialysis.
Several cases of thrombocytopenia have been reported for hemodialysis patients treated with niacinamide 1 gram daily. Hemodialysis patients receiving niacinamide had almost a three-fold higher risk of developing thrombocytopenia when compared with those receiving placebo.

Likelihood Unlikely Evidence D
Carbamazepine (Tegretol)

Niacinamide might increase the levels and adverse effects of carbamazepine.
Plasma levels of carbamazepine were increased in two children given high-dose niacinamide, 60-80 mg/kg/day. This might be due to inhibition of the cytochrome P450 enzymes involved in carbamazepine metabolism. There is not enough data to determine the clinical significance of this interaction.

Likelihood Possible Evidence D
Primidone (Mysoline)

Niacinamide might increase the levels and adverse effects of primidone.
Case reports in children suggest niacinamide 60-100 mg/kg/day reduces hepatic metabolism of primidone to phenobarbital, and reduces the overall clearance rate of primidone; however, there is not enough data to determine the clinical significance of this potential interaction.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is limited evidence that niacinamide may increase the anticoagulant effects of warfarin.
In a case report, a patient on warfarin developed an elevated international normalized ratio (INR) of 8.4 after taking niacinamide 500 mg twice daily for 10 days. The patient's INR was previously stable, ranging between 2 and 3, with no other changes to current medications or diet reported. The elevated INR returned to the therapeutic range after receiving vitamin K and discontinuing niacinamide.

Likelihood Possible Evidence D
Nicotinamide full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nicotinamide 1000 mg, from the product label.

Biophix

See all Biophix products
Name
Biophix Health & Nutrition
Street Address
4131 SW 47th Ave. Unit 1404
City
Davie
State
FL
ZipCode
33314
Phone Number
305-861-0898
Web Address
www.biophix.com
Pharmacist Counseling Corner

Nicotinamide 1000 mg by Biophix: Common Questions

Does Nicotinamide 1000 mg by Biophix interact with any medications?
Yes. Based on its ingredients, Nicotinamide 1000 mg has a known interaction with 124 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nicotinamide 1000 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is nicotinamide safe to take during pregnancy?
The amounts in food and standard prenatal vitamins are considered safe. This supplement is 1000 mg — a high dose — so talk with your doctor or pharmacist before taking it during pregnancy to make sure it's right for you.
Will this help my acne?
There's some evidence niacinamide may help with acne, but it's not yet strong enough to call it proven. Your doctor can tell you whether it's worth trying as part of your acne treatment.
What are the most common side effects?
At higher doses, dizziness, drowsiness, itching, stomach upset, nausea, vomiting, and rash are the most common. Most people tolerate it fairly well, but if you notice any of these, let your pharmacist know.
Can I take this if I'm on a blood thinner?
There's a documented risk that niacinamide may add to the blood-thinning effect. Check with your doctor or pharmacist before starting — they'll know your exact medication and whether it's safe for you.
What is nicotinamide used for?
Nicotinamide (vitamin B3) is mainly proven to prevent and treat pellagra, a B3 deficiency. There's also possible evidence it may help with acne, joint pain, high blood phosphate, and blood sugar control, though those benefits aren't as well established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nicotinamide 1000 mg label
Go deeper

The Full Monographs Behind Nicotinamide 1000 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Niacinamide

Interacts with 124 drugs

Niacinamide (also called nicotinamide) is a form of vitamin B3 used in supplements and skin-care products. It is well established for preventing and treating vitamin B3 deficiency, and there...

Read the full Niacinamide monograph →
Sources

Sources & How We Checked

Nicotinamide 1000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Niacinamide 22 references
  1. Pozzilli P, Browne PD, Kolb H. Meta-analysis of nicotinamide treatment in patients with recent-onset IDDM. The Nicotinamide Trialists. Diabetes Care 1996;19:1357-63. PubMed
  2. Greenbaum CJ, Kahn SE, Palmer JP. Nicotinamide's effects on glucose metabolism in subjects at risk for IDDM. Diabetes 1996;45:1631-4. DOI
  3. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  4. Anon. Niacinamide Monograph. Alt Med Rev 2002;7:525-9.
  5. Miralbell R, Mornex F, Greiner R, et al. Accelerated radiotherapy, carbogen, and nicotinamide in glioblastoma multiforme: report of European Organization for Research and Treatment of Cancer trial 22933. J Clin Oncol 1999;17:3143-9. PubMed
  6. Fatigante L, Ducci F, Cartei F, et al. Carbogen and nicotinamide combined with unconventional radiotherapy in glioblastoma multiforme: a new modality treatment. Int J Radiat Oncol Biol Phys 1997;37:499-504. PubMed
  7. Hoskin PJ, Stratford MR, Saunders MI, et al. Administration of nicotinamide during chart: pharmacokinetics, dose escalation, and clinical toxicity. Int J Radiat Oncol Biol Phys 1995;32:1111-9. PubMed
  8. Papa CM. Niacinamide and acanthosis nigricans (letter). Arch Dermatol 1984;120:1281. DOI
  9. Bourgeois BF, Dodson WE, Ferrendelli JA. Interactions between primidone, carbamazepine, and nicotinamide. Neurology 1982;32:1122-6.
  10. Visalli N, Cavallo MG, Signore A, et al. A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset type 1 diabetes (the IMDIAB VI). Diabetes Metab Res Rev 1999;15:181-5. DOI
  11. Rottembourg JB, Launay-Vacher V, Massard J. Thrombocytopenia induced by nicotinamide in hemodialysis patients. Kidney Int. 2005;68(6):2911-2. PubMed
  12. Fabbrocini G, Cantelli M, Monfrecola G. Topical nicotinamide for seborrheic dermatitis: an open randomized study. J Dermatolog Treat. 2014 Jun;25(3):241-5. PubMed
  13. Khodaeiani E, Fouladi RF, Amirnia M, Saeidi M, Karimi ER. Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris. Int J Dermatol. 2013 Aug;52(8):999-1004. PubMed
  14. Zhang Y, Ma T, Zhang P. Efficacy and safety of nicotinamide on phosphorus metabolism in hemodialysis patients: A systematic review and meta-analysis. Medicine (Baltimore). 2018;97(41):e12731. PubMed
  15. Ketteler M, Wiecek A, Rosenkranz AR, et al. Efficacy and Safety of a Novel Nicotinamide Modified-Release Formulation in the Treatment of Refractory Hyperphosphatemia in Patients Receiving Hemodialysis-A Randomized Clinical Trial. Kidney Int Rep 2020;6(3): PubMed
  16. Mainville L, Smilga AS, Fortin PR. Effect of Nicotinamide in Skin Cancer and Actinic Keratoses Chemoprophylaxis, and Adverse Effects Related to Nicotinamide: A Systematic Review and Meta-Analysis. J Cutan Med Surg 2022;26(3):297-308. PubMed
  17. Nouh AH, Elshahid AR, Kadah AS, Zeyada YA. Topical niacinamide (Nicotinamide) treatment for discoid lupus erythematosus (DLE): A prospective pilot study. J Cosmet Dermatol 2023.
  18. El-Khalawany M, Nouh AH, Kadah AS, Elsheikh M, Said M. Evaluation of safety and efficacy of topical 4% nicotinamide in treatment of psoriasis; among a representative sample of Egyptians (an analytical observational study). Dermatol Ther 2022;35(9):e15734. PubMed
  19. Zhang H, George-Washburn EA, Hashemi KB, et al. Oral Nicotinamide for Actinic Keratosis Prevention in Kidney Transplant Recipients: A Pilot Double-Blind, Randomized, Placebo-Controlled Trial. Transplant Proc 2023;55(9):2079-2084. PubMed
  20. Oh HJ, Bae SC, Oh IJ, et al. Nicotinamide in Combination with EGFR-TKIs for the Treatment of Stage IV Lung Adenocarcinoma with EGFR Mutations: A Randomized Double-Blind (Phase IIb) Trial. Clin Cancer Res 2024;30(8):1478-1487. PubMed
  21. Schepers L, Jans I, Pot GK, Smilde AJ, Hofstra JM, de Roos NM. The Effect of Niacinamide Supplementation on Phosphate Concentrations in Dutch Dialysis Patients: A Randomized Crossover Trial. J Ren Nutr 2024;34(5):454-462. PubMed
  22. Markham DJ, Barbosa NS, Degesys CA. Elevated International Normalized Ratio After Initiation of Niacin and Niacinamide Chemoprophylaxis for Patients on Warfarin. Dermatol Surg 2024;50(7):690-692. PubMed

See these in context on the Niacinamide monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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