Odorless Garlic 1,000 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Odorless Garlic 1,000 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Odorless Garlic 1,000 mg is a dietary supplement by NewtonEverett with 1 active ingredient. Its ingredients are commonly taken for high blood pressure, high cholesterol, heart health.Based on those ingredients, 989 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are odorless Garlic extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Odorless Garlic 1,000 mg by NewtonEverett
Ask about any prescription or over-the-counter medication and we check it for interactions with Odorless Garlic 1,000 mg by NewtonEverett — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Odorless Garlic 1,000 mg by NewtonEverett
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: odorless garlic extract at 1,000 mg per softgel. Garlic extract is a concentrated form of the compound garlic, designed to deliver its active constituents without the strong smell associated with fresh or cooked garlic.
The softgel also includes inactive ingredients — soybean oil, gelatin, vegetable glycerin, and water — which serve as the capsule and carrier.
Does it work?
Moderate evidence
The data show garlic extract is possibly effective for several conditions. These include helping with gum disease (periodontitis), nonalcoholic fatty liver disease (NAFLD), type 2 diabetes, high blood pressure (hypertension), and hardening of the arteries (atherosclerosis). "Possibly effective" means there's some human research support, but the evidence isn't yet conclusive or robust.
Talk with your doctor about whether this supplement makes sense for your specific situation.
How safe is it?
Well-documented data
When taken by mouth, garlic extract is generally well tolerated, though some people experience stomach upset, gas, flatulence, bad breath, and nausea. A small number of individuals report allergic reactions, skin reactions like rashes or contact dermatitis, or rarely, bleeding concerns.
The safety data notes that food amounts of garlic are likely fine, but concentrated supplement doses haven't been extensively studied — your doctor's approval is wise before you start, especially if you're pregnant, breastfeeding, or have a bleeding disorder. There is no pregnancy or breastfeeding safety data on file for this ingredient.
Meds to double-check
Moderate interaction found
Before taking this product, check with your pharmacist if you use blood thinners or antiplatelet drugs like warfarin, aspirin, or clopidogrel; blood pressure medications; diabetes drugs; HIV protease inhibitors; or tacrolimus. Garlic extract affects how your body processes many medications and carries a documented risk of increased bleeding.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.
Odorless Garlic may appeal to you if you're interested in natural support for blood pressure, blood sugar, or liver health — and you want to avoid garlic's characteristic odor. But because it interacts with blood thinners, blood pressure drugs, diabetes medications, and several other classes, you need to run this past your pharmacist or doctor first, especially if you're on any prescription.
It's generally well tolerated, but it's not a product to start on your own.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Odorless Garlic 1,000 mg, straight from the product label.
| Brand | NewtonEverett |
|---|---|
| Barcode (UPC) | 818423027395 |
| Net contents | 120 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Jun 23, 2021 |
| DSLD ID | 248885 |
| Product type | Botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Odorless Garlic 1,000 mg by NewtonEverett, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| odorless Garlic extract | 10 mg | -- |
Other ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Pure Potent Bioavailable We are driven to deliver highly potent, ultra-pure nutritional products with uncompromised quality. Our premium-grade liquid softgels are designed to provide an ideal delivery vehicle for maximum absorption and enhanced bioavailability.
Contains No: Artificial color, flavor or sweetener, preservatives, sugar, starch, milk, lactose, gluten, wheat, yeast or fish.
Not suitable for vegetarians.
Non-GMO Gluten free
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: For adults, take 1 softgel four times daily, preferably with meals.
Precautions
Warning: If you are pregnant, nursing, taking any medications, planning any medical procedure or have any medical condition, consult your doctor before use.
Discontinue use and consult your doctor if any adverse reactions occur.
Keep out of reach of children.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Odorless Garlic 1,000 mg by NewtonEverett label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Odorless Garlic 1,000 mg by NewtonEverett
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container120 Amounts shown are per serving.
Odorless Garlic extract
Interacts with989 drugs
Garlic is a common food and supplement that may modestly help with blood pressure and cholesterol, though the evidence is mixed and effects are usuall...
Odorless Garlic extract monograph & interactionsOther (inactive) ingredients: Soybean Oil, Gelatin, Vegetable Glycerin, Water. These complete the product’s ingredient list but are not active constituents.
Odorless Garlic 1,000 mg by NewtonEverett Drug Interactions
HelloPharmacist Interaction Report
Odorless Garlic 1,000 mg by NewtonEverett has documented interactions with a substantial number of medications.
The most serious concern is with blood thinners (anticoagulants) and antiplatelet drugs — garlic may increase your bleeding risk because it can thin the blood itself and raise prothrombin time (a measure of how long blood takes to clot). This applies to warfarin (Coumadin) in particular, where there's a documented case of patients' blood-thinning levels rising unexpectedly when they combined garlic with the drug.
Read the full breakdown — every affected drug type, severity by severity
You'll also want to check with your pharmacist if you take blood pressure medications (antihypertensives), diabetes drugs, or HIV protease inhibitors. Garlic can lower blood pressure and blood sugar on its own, so combining it with drugs that do the same may push those levels too low.
Garlic may also change how your body processes certain medications broken down by your liver's CYP3A4 and CYP2E1 enzymes, potentially raising or lowering drug levels in unpredictable ways. There's also a case report of a transplant patient on tacrolimus (Prograf) who experienced elevated drug levels and liver damage after taking a high-dose garlic supplement.
No ingredient in this product has been documented to have zero interactions. Altogether, these interactions span 977 individual medications.
Use the medication checker on this page to search your exact prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Odorless Garlic 1,000 mg?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Odorless Garlic 1,000 mg interact with 989 drugs. Click any drug to see the details.
1 of the 1 ingredient in Odorless Garlic 1,000 mg interact with drugs. Each result below shows which ingredient is responsible. odorless Garlic extract
Ado-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Odorless Garlic Extract + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Odorless Garlic Extract + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Odorless Garlic Extract + Acarbose interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAntihypertensive Drugs Moderate
Interaction Summary
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
Read the full Odorless Garlic Extract + Acebutolol interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Odorless Garlic Extract + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractAnticoagulant/antiplatelet Drugs, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Odorless Garlic Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 2e1 (cyp2e1) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Garlic might increase levels of drugs metabolized by CYP2E1.
Read the full Odorless Garlic Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Odorless Garlic 1,000 mg — through 1 ingredient. Tap an ingredient for the detail:
Odorless Garlic ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2e1 (cyp2e1) Substrates Moderate
Interaction Summary
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4.
Read the full Odorless Garlic Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Odorless Garlic 1,000 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
odorless Garlic extract
Anticoagulant/Antiplatelet Drugs
Garlic may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time.
Antidiabetes Drugs
Theoretically, taking garlic with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research suggests that garlic and garlic extract lower blood glucose levels in healthy and diabetic individuals.
Antihypertensive Drugs
Theoretically, taking garlic with antihypertensive drugs might increase the risk of hypotension.
In human research, both garlic and garlic extracts have blood pressure-lowering effects.
Atazanavir (Reyataz)
Theoretically, garlic might decrease levels and effects of atazanavir.
In a case report, a patient consuming six stir-fried garlic cloves three times weekly developed suboptimal atazanavir levels and increases in HIV viral load. While the exact cause of this interaction is unclear, there is speculation that garlic might decrease the intestinal absorption of atazanavir or increase its metabolism by inducing cytochrome P450 3A4 (CYP3A4). Until more is known, advise patients not to consume large amounts of garlic while taking atazanavir.
Cytochrome P450 2E1 (Cyp2E1) Substrates
Garlic might increase levels of drugs metabolized by CYP2E1.
Clinical research suggests garlic oil can inhibit the activity of CYP2E1 by 39%. Use garlic oil cautiously in patients taking drugs metabolized by these enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, garlic products containing allicin might induce intestinal CYP3A4 and inhibit hepatic CYP3A4. This may increase or decrease levels of drugs metabolized by CYP3A4.
Some human research suggests that garlic may induce INTESTINAL CYP3A4, reducing levels of drugs metabolized by this enzyme. This is primarily based on a study showing that taking a specific allicin-containing garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induced CYP3A4 in the gut mucosa. Another study shows that giving docetaxel intravenously, bypassing the CYP3A4 enzymes in the gut mucosa, along with the same specific garlic product for 12 consecutive days, does not affect docetaxel levels. Conversely, there is concern that garlic may inhibit HEPATIC CYP3A4. In a single case report, increased tacrolimus levels and liver injury occurred in a liver transplant patient after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. Several other studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Isoniazid
Theoretically, garlic might decrease levels of isoniazid.
Animal research suggests that an aqueous extract of garlic reduces isoniazid levels by about 65%. Garlic reduced the maximum concentration (Cmax) and area under the curve (AUC), but not the half-life, of isoniazid. This suggests that garlic extract might inhibit isoniazid absorption across the intestinal mucosa; however, the exact mechanism of this potential interaction is not known.
Protease Inhibitors (Pis)
Theoretically, garlic products containing allicin might decrease levels of PIs.
Protease inhibitors are metabolized by cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4, reducing plasma levels of protease inhibitors. This is primarily based on a study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces levels of saquinavir, a PI, by approximately 50%. It is speculated that the allicin constituent induce CYP3A4 in the gut mucosa. Several studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin.
Saquinavir (Fortovase, Invirase)
Theoretically, garlic containing allicin might decrease levels of saquinavir.
Saquinavir is a substrate of cytochrome P450 3A4 (CYP3A4) isoenzymes. There is concern that garlic products containing allicin might induce intestinal CYP3A4 and cause subtherapeutic levels of saquinavir. This is primarily based on a pharmacokinetic study showing that taking a specific garlic product (GarliPure Maximum Allicin Formula, Natrol Inc.) twice daily for 3 days reduces saquinavir levels by approximately 50%. It is speculated that the allicin constituent induces CYP3A4 in the gut mucosa. Several pharmacokinetic studies have evaluated the impact of other garlic formulations on CYP3A4 substrates and have found no effect. Most of the products in these studies provided little or no allicin. Until more is known about this potential interaction, use garlic containing allicin cautiously in patients taking saquinavir.
Sofosbuvir (Sovaldi)
Theoretically, taking garlic with sofosbuvir might decrease its effectiveness.
Animal research in rats shows that giving aged garlic extract 120 mg/kg orally daily for 14 days decreases the area under the concentration time curve (AUC) after a single sofosbuvir dose of 40 mg/kg by 36%, increases the clearance by 63%, and decreases the plasma concentrations at 1 and 8 hours by 35% and 58%, respectively. This interaction is hypothesized to be due to induction of intestinal P-glycoprotein expression by garlic.
Tacrolimus (Prograf)
Theoretically, garlic might increase levels of tacrolimus.
In one case report, a liver transplant patient taking tacrolimus experienced increased tacrolimus levels and liver injury after taking a specific garlic supplement (Garlicin Cardio, Nature's Way) at up to three times the manufacturer recommended dose for 7 days. It is speculated that garlic inhibited hepatic cytochrome P450 3A4 (CYP3A4), which increased plasma levels of tacrolimus.
Warfarin (Coumadin)
Theoretically, garlic might increase the risk of bleeding with warfarin.
Raw garlic and a variety of garlic extracts have antiplatelet activity and can increase prothrombin time. In addition, there is a report of two patients who experienced an increase in a previously stabilized international normalized ratio (INR) with concomitant garlic and warfarin use. However, this report has been subsequently debated due to limited clinical information. Other clinical studies have not identified an effect of garlic on INR, warfarin pharmacokinetics, or bleeding risk. More evidence is needed to determine the safety of using garlic with warfarin.
Brand information
Manufacturer and brand details for Odorless Garlic 1,000 mg, from the product label.
NewtonEverett
See all NewtonEverett products- Name
- Newton-Everett Nutraceuticals
- Street Address
- 9160 E. Bahia Dr.
- City
- Scottsdale
- State
- AZ
- ZipCode
- 85260
- Web Address
- www.newton-everett.com
Odorless Garlic 1,000 mg by NewtonEverett: Common Questions
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The Full Monographs Behind Odorless Garlic 1,000 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Odorless Garlic 1,000 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 154 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Garlic 154 references
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