No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Olive Leaf 500 mg Ingredients & Drug Interactions

by GNC Herbal Plus

Olive Leaf 500 mg label
See full label image
Capsule Category: Botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Olive Leaf 500 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Olive Leaf 500 mg is a dietary supplement by GNC Herbal Plus with 1 active ingredient. Its ingredients are commonly taken for heart health, high blood pressure, high cholesterol.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Olive Leaf 500 mg by GNC Herbal Plus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: 500 mg of olive leaf extract per capsule. Olive leaf extract is a concentrated form of compounds from the olive plant leaf.

The capsule itself is made from vegetable cellulose, and the fill includes cellulose as an inactive ingredient.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Olive product and its label doesn't state a use — see Olive's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold shows insufficient reliable evidence to rate olive leaf extract for osteoporosis, indigestion (dyspepsia), preventing respiratory infections related to exercise, shingles (herpes zoster), influenza, or osteoarthritis. That means we don't have strong data yet saying whether it works or doesn't work for these uses — the science simply isn't there to back them up.

The evidence, ingredient by ingredient Olive

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Olive fruit and olive oil are very safe foods, but concentrated olive leaf supplements are less well studied. The most common side effects reported in trials are headache and stomach discomfort.

One person in a trial reported skin problems and acne. If you're allergic to olive tree pollen or have seasonal respiratory allergies, be aware that olive tree pollen can trigger those reactions.

Because the safety profile of concentrated supplements isn't as clear as whole foods, talk with your doctor or pharmacist before you start, especially if you have any health conditions.

Side effects, ingredient by ingredient Olive

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. That's not a guarantee none exist — it just means we have no evidence of them.

If you take any medications, confirm with your doctor or pharmacist that this product won't affect them.

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. No medication interactions are currently documented, and safety information is well characterized.

Olive Leaf 500 mg from GNC is a single-ingredient supplement with no documented medication interactions we've found. However, evidence that it works for any specific condition is weak or nonexistent.

It's generally well tolerated, though headache and stomach upset can happen, and concentrated olive leaf supplements aren't as thoroughly studied as olive oil or whole olives as food. Check with your doctor or pharmacist before adding this to your routine.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 23, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Olive Leaf 500 mg, straight from the product label.

Brand GNC Herbal Plus
Barcode (UPC) 048107128913
Net contents 100 Capsule(s)
Market status On market
Date entered into DSLD Jun 23, 2017
DSLD ID 74666
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Olive Leaf 500 mg by GNC Herbal Plus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
UPC/BARCODE
048107128913
IngredientAmount% DV
Olive leaf extract500 mg--

Other ingredients: Cellulose, Vegetable Cellulose Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Discontinue use two weeks prior to surgery.

Storage

Store in a cool, dry place.

FDA Statement of Identity

Herbal Supplement

General Statements

Supports general well-being

Standardized extract

Potency verified by GNC procedure #5351. Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

Formulation

Vegetarian

No sugar, no artificial colors, no artificial flavors, sodium free, no wheat, gluten free, no soy, no dairy, yeast free.

General

CODE 196132 ARG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one to two capsules daily.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Olive Leaf 500 mg by GNC Herbal Plus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Olive Leaf 500 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Olive Leaf 500 mg by GNC Herbal Plus

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Olive leaf extract

No known
interactions
500 mg per serving Form: Oleuropein

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyr...

Olive leaf extract monograph & interactions

Other (inactive) ingredients: Cellulose, Vegetable Cellulose Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Olive Leaf 500 mg by GNC Herbal Plus Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Olive Leaf 500 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Olive Leaf 500 mg, from the product label.

GNC Herbal Plus

See all GNC Herbal Plus products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Olive Leaf 500 mg by GNC Herbal Plus: Common Questions

Does Olive Leaf 500 mg by GNC Herbal Plus interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Olive Leaf 500 mg. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Olive Leaf 500 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take olive leaf extract if I'm pregnant or breastfeeding?
We don't have safety data on file for olive leaf extract in pregnancy or lactation. Because concentrated supplements are less well studied than whole foods, talk with your doctor or pharmacist about whether it's right for you before you use it.
Does this really work for the flu or shingles?
The evidence we hold shows insufficient reliable evidence to rate olive leaf extract for either influenza or shingles. That means we don't yet have strong data saying it works or doesn't work — you'd want to rely on proven treatments your doctor recommends instead.
What are the side effects?
Olive leaf extract seems to be well tolerated overall. The most common side effects in trials were headache and stomach discomfort. One person reported acne. If you have seasonal allergies to olive tree pollen, this product could trigger that reaction.
Is olive leaf extract just like eating olives or olive oil?
No — this is a concentrated supplement, not food. Olives and olive oil as foods are very safe, but concentrated supplements like this one are less well studied. That's why it's wise to check with your doctor or pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Olive Leaf 500 mg is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Olive Leaf 500 mg label
Go deeper

The Full Monographs Behind Olive Leaf 500 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Olive

Olive comes from the same tree that gives us olives and olive oil, and its leaf and fruit contain antioxidant compounds like oleuropein and hydroxytyrosol. Olive oil as part of a Mediterrane...

Read the full Olive monograph →
Sources

Sources & How We Checked

Olive Leaf 500 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Olive 2 references
  1. Liccardi G, D'Amato M, D'Amato G. Oleaceae pollinosis: a review. Int Arch Allergy Immunol 1996;111:210-7. PubMed
  2. Somerville V, Moore R, Braakhuis A. The effect of olive leaf extract on upper respiratory illness in high school athletes: A randomised control trial. Nutrients. 2019;11(2). pii: E358. PubMed

See these in context on the Olive monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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