Omega XL Ingredients & Drug Interactions
by Great Healthworks
What is this page for?
First and foremost: checking Omega XL against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Omega XL is a dietary supplement by Great Healthworks with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis symptoms, joint stiffness and mobility.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Omega XL by Great Healthworks
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Omega XL has one active ingredient: Green Lipped Mussel Oil extract from the New Zealand green-lipped mussel (Perna canaliculus). The product also contains gelatin, glycerin, and purified water as inactive ingredients that form the softgel capsule.
Does it work?
Not established
The evidence for Green Lipped Mussel Oil extract is not well established in the data we hold. Studies have looked at it for asthma, ADHD, breast cancer, and exercise-induced muscle soreness, but the current evidence is insufficient to rate whether it actually works for any of these uses.
If you're thinking about using it for a specific condition, talk with your pharmacist or doctor about what the science actually supports right now.
How safe is it?
Well-documented data
Green Lipped Mussel Oil extract is generally well tolerated. The most common side effects reported with oral use are abdominal pain, acid reflux, diarrhea, flatulence, and nausea.
Rare cases of serious liver problems (hepatitis and liver function abnormalities) have been reported with a specific mussel extract called Seatone, so liver monitoring may be wise if you use this product long-term. Anyone with a shellfish allergy should avoid it entirely.
During pregnancy, there isn't enough safety data, so it's best avoided. While breastfeeding, safety hasn't been established, so skip it unless your doctor advises otherwise.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient we could check. That said, check your exact medications with the search tool on this page before you start — it's always good to be sure.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
Omega XL is generally well tolerated and has no documented medication interactions in our data, but its effectiveness for any condition is not well proven. If you have a shellfish allergy, stay away from it.
Pregnant or breastfeeding? Talk to your pharmacist or doctor first.
If you experience any stomach upset or signs of liver trouble, stop and check with your pharmacist.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2019.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Omega XL, straight from the product label.
| Brand | Great Healthworks |
|---|---|
| Net contents | 300 Softgel Capsule(s) |
| Market status | Off market |
| Date entered into DSLD | Aug 23, 2019 |
| DSLD ID | 206083 |
| Product type | Other Combinations |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Omega XL by Great Healthworks, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Omega XL Proprietary Blend | 300 mg | -- |
| Green Lipped Mussel (Perna canaliculus) Oil extract | 0 NP | -- |
Other ingredients: Gelatin, Glycerin, purified Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
A powerful essential Fatty Acid combination from the pristine waters of New Zealand Contains: 30 free Fatty Acids
Omega XL contains the patented all natural Green Lipped Mussel Oil extract, PCSO-524. Sourced from the pure waters of New Zealand. Omega XL contains 30 free Fatty Acids including EPA, DHA, ETA and OTA. In clinical studies the active ingredient in Omega XL (PCSO-524) has been shown to support joint mobility and respiratory function.
FDA Statement of Identity
Dietary Supplement
Formulation
Free of: Shellfish Protein, artificial ingredients, milk, yeast, corn and gluten.
Suggested/Recommended/Usage/Directions
Suggested use: Take two (2) soft gel capsules 1-3 times per day preferably with meals.
Precautions
Note: If you are pregnant or lactating, consult your health care professional before using this product.
Do not use if safety seal is broken or missing.
For adult use only.
Keep out of reach of children.
Storage
Keep in a cool, dry place with lid tightly closed.
General Statements
Made in the USA
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Omega XL by Great Healthworks label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Omega XL by Great Healthworks
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container150 Amounts shown are per serving.
Omega XL Proprietary Blend
Other (inactive) ingredients: Gelatin, Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.
Omega XL by Great Healthworks Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Omega XL. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Omega XL, from the product label.
Great Healthworks
- Name
- Great HealthWorks, Inc.
- Street Address
- 4150 SW 28th Way
- City
- Fort Lauderdale
- State
- FL
- ZipCode
- 33312
Omega XL by Great Healthworks: Common Questions
Does Omega XL by Great Healthworks interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm allergic to shellfish?
Is it safe during pregnancy or while breastfeeding?
What side effects might I experience?
Does Green Lipped Mussel Oil actually work for anything?
What's in the capsule besides the active ingredient?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Omega XL is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Omega XL’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Omega XL's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
New Zealand Green-lipped Mussel 12 references
- Miller T, Wu H. In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. N Z Med J 1984;97:355-7.
- Gibson SLM, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial. Complement Ther Med 1998;6:122-6.
- Gibson RG, Gibson SL, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner 1980;224:955-60.
- Fabrin, B. [Possible toxic hepatitis after intake of an alternative preparation]. Ugeskr.Laeger 6-13-1988;150(24):1474-1475.
- Gibson, R. G. and Gibson, S. L. Green-lipped mussel extract in arthritis. Lancet 2-21-1981;1(8217):439. PubMed
- Ahern, M. J., Milazzo, S. C., and Dymock, R. Granulomatous hepatitis and Seatone. Med J Aust 8-9-1980;2(3):151-152. PubMed
- Croft, J. E. Granulomatous hepatitis and Seatone. Med J Aust 10-4-1980;2(7):401-402. PubMed
- Lau, S., Chiu, P. K., Chu, E. M. Y., Cheng, I. Y. W., Tang, W. M., Man, R. Y. K., and Halpern, G. M. Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study. Progress in Nutrition
- Gruenwald, J., Graubaum, H., Hansen, K., and Grube, B. Efficacy and tolerability of a combination of LYPRINOL and high concentrations of EPA and DHA in inflammatory rheumatoid disorders... eicosapentaenoic acid... decosahexaenoid acid. Advances in Therap PubMed
- Coulson S, Vecchio P, Gramotnev H, Vitetta L. Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study. Inflammopharmacology 2012;20:71-6. PubMed
- Sukumaran S, Pittman KB, Patterson WK, et al. A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer. Ann Oncol 2010;2 PubMed
- Lello J, Liang A, Robinson E, et al. Treatment of children's asthma with a lipid extract of the new Zealand green lipped mussel (Perna canaliculus) (Lyprinol®)-A double blind, randomized controlled trial in children with moderate to serve chronic obstruct
See these in context on the New Zealand Green-lipped Mussel monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC