OmegaXL Ingredients & Drug Interactions
by Great Healthworks
What is this page for?
First and foremost: checking OmegaXL against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
OmegaXL is a dietary supplement by Great Healthworks with 1 active ingredient. Its ingredients are commonly taken for osteoarthritis joint pain, rheumatoid arthritis symptoms, joint stiffness and mobility.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of OmegaXL by Great Healthworks
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
OmegaXL contains one active ingredient: Green Lipped Mussel (Perna canaliculus) oil extract, sourced from New Zealand. The rest of the capsule is made up of inactive ingredients — gelatin, glycerin, and purified water — which act as binders and capsule material.
Does it work?
Not established
The evidence for Green Lipped Mussel extract isn't established in our data. We hold insufficient reliable evidence to rate it for asthma, ADHD, breast cancer, or exercise-induced muscle soreness — the conditions in our records.
That doesn't mean it doesn't work; it means the clinical trials we have aren't strong enough to say one way or the other.
How safe is it?
Well-documented data
Green Lipped Mussel is generally well tolerated, but if you have a shellfish allergy, you should avoid this product. The most common side effects when taken by mouth are abdominal pain, acid reflux, diarrhea, flatulence, and nausea.
Very rarely, serious liver inflammation (hepatitis) has been reported with certain extracts, and some liver function abnormalities have been documented. If you have any liver concerns, discuss this with your pharmacist before starting.
Do not use this product during pregnancy — the safety data advises against it. Breastfeeding safety hasn't been established, so it's best avoided while nursing as well.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredients we could check. Still, run your medications through the search tool on this page before you start.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
OmegaXL is a single-ingredient Green Lipped Mussel supplement with no documented medication interactions in our data. It's generally well tolerated, but anyone with a shellfish allergy should skip it, and it's not recommended in pregnancy or while breastfeeding.
Talk to your pharmacist if you have liver concerns or are taking any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about OmegaXL, straight from the product label.
| Brand | Great Healthworks |
|---|---|
| Net contents | 60 Softgel Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 239679 |
| Product type | Other Combinations |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for OmegaXL by Great Healthworks, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Omega XL Proprietary Blend | 300 mg | -- |
| Green Lipped Mussel (Perna canaliculus) Oil extract | 0 NP | -- |
Other ingredients: Gelatin, Glycerin, purified Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement take two (2) soft gel capsules 1-3 times per day, preferably with food.
Formula
OmegaXL contains the proprietary all natural Green Lipped Mussel Oil Extract, PCSO-524. Sourced from the pure waters of New Zealand, OmegaXL contains 30 free fatty acids including EPA, DHA, ETA and OTA.
A powerful essential fatty acid combination from the pristine waters of New Zealand Contains 30 free fatty acids
Formulation
In clinical studies, the active ingredient in OmegaXL (PCSO-524) has been shown to support joint mobility and respiratory function.
Free of: shellfish protein, artificial ingredients, milk, yeast, corn and gluten.
Precautions
Warning: Consult a licensed health care professional before taking any supplement. Discontinue immediately if any side effects occur. Do not use if safety seal is broken or missing.
Do not use if you are pregnant or nursing.
Keep out of the reach of children.
Storage
Keep in a cool, dry place with lid tightly closed.
Brand IP Statement(s)
Copyright 2018
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
OmegaXL by Great Healthworks label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in OmegaXL by Great Healthworks
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Softgel Capsule(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.
Omega XL Proprietary Blend
Other (inactive) ingredients: Gelatin, Glycerin, Purified Water. These complete the product’s ingredient list but are not active constituents.
OmegaXL by Great Healthworks Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in OmegaXL. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for OmegaXL, from the product label.
Great Healthworks
- Name
- Great HealthWorks, Inc.
- Street Address
- 4150 SW 28th Way
- City
- Fort Lauderdale
- State
- FL
- ZipCode
- 33312
OmegaXL by Great Healthworks: Common Questions
Does OmegaXL by Great Healthworks interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
I have a shellfish allergy — can I take OmegaXL?
What are the most common side effects?
Is it safe to take OmegaXL while I'm pregnant or breastfeeding?
Can OmegaXL help with arthritis or joint pain?
Does this product interact with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if OmegaXL is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind OmegaXL’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
OmegaXL's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 12 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
New Zealand Green-lipped Mussel 12 references
- Miller T, Wu H. In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract. N Z Med J 1984;97:355-7.
- Gibson SLM, Gibson RG. The treatment of arthritis with a lipid extract of Perna canaliculus: a randomised trial. Complement Ther Med 1998;6:122-6.
- Gibson RG, Gibson SL, Conway V, Chappell D. Perna canaliculus in the treatment of arthritis. Practitioner 1980;224:955-60.
- Fabrin, B. [Possible toxic hepatitis after intake of an alternative preparation]. Ugeskr.Laeger 6-13-1988;150(24):1474-1475.
- Gibson, R. G. and Gibson, S. L. Green-lipped mussel extract in arthritis. Lancet 2-21-1981;1(8217):439. PubMed
- Ahern, M. J., Milazzo, S. C., and Dymock, R. Granulomatous hepatitis and Seatone. Med J Aust 8-9-1980;2(3):151-152. PubMed
- Croft, J. E. Granulomatous hepatitis and Seatone. Med J Aust 10-4-1980;2(7):401-402. PubMed
- Lau, S., Chiu, P. K., Chu, E. M. Y., Cheng, I. Y. W., Tang, W. M., Man, R. Y. K., and Halpern, G. M. Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study. Progress in Nutrition
- Gruenwald, J., Graubaum, H., Hansen, K., and Grube, B. Efficacy and tolerability of a combination of LYPRINOL and high concentrations of EPA and DHA in inflammatory rheumatoid disorders... eicosapentaenoic acid... decosahexaenoid acid. Advances in Therap PubMed
- Coulson S, Vecchio P, Gramotnev H, Vitetta L. Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study. Inflammopharmacology 2012;20:71-6. PubMed
- Sukumaran S, Pittman KB, Patterson WK, et al. A phase I study to determine the safety, tolerability and maximum tolerated dose of green-lipped mussel (Perna canaliculus) lipid extract, in patients with advanced prostate and breast cancer. Ann Oncol 2010;2 PubMed
- Lello J, Liang A, Robinson E, et al. Treatment of children's asthma with a lipid extract of the new Zealand green lipped mussel (Perna canaliculus) (Lyprinol®)-A double blind, randomized controlled trial in children with moderate to serve chronic obstruct
See these in context on the New Zealand Green-lipped Mussel monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC