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Dietary supplement

On Your Game Ingredients & Drug Interactions

by BioSil

On Your Game label
See full label image
Capsule Category: Single Vitamin And Mineral
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking On Your Game against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

On Your Game is a dietary supplement by BioSil with 2 active ingredients. Its ingredients are commonly taken for liver health and fatty liver, brain and memory support, prenatal nutrition and fetal development.Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Choline. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against On Your Game by BioSil

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HelloPharmacist Scorecard of On Your Game by BioSil

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

On Your Game contains two active ingredients: choline and silicon. Choline is a nutrient that supports brain function and acts as a building block for acetylcholine, a chemical messenger in your nervous system.

Silicon is a trace mineral that may support bone structure and strength. The capsule shell and microcrystalline cellulose are inactive ingredients that help form and fill the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Joint health and cartilage support.
  • We looked for evidence on: Osteoporosis, Joint function, Cartilage integrity, Connective tissue health.
  • The strongest evidence on file: Silicon is rated "Possibly Effective" for Osteoporosis (Natural Medicines).

The evidence for this product is mixed. Choline is rated possibly ineffective for athletic performance, and the data on its use for cognitive decline, liver health during IV nutrition support, hay fever, and Alzheimer's disease is insufficient to establish how well it works.

Silicon is rated possibly effective for osteoporosis, though evidence for hair loss and dental issues is not yet established. The overall effectiveness of this combination product isn't clearly defined in the data we hold.

The evidence, ingredient by ingredient Choline Silicon

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both choline and silicon are generally well tolerated at normal supplement doses. However, choline at high doses—above 3.5 grams daily—can cause fishy body odor, nausea, vomiting, diarrhea, and sweating.

Long-term safety data for high-dose silicon supplementation is limited. Regarding pregnancy and breastfeeding: choline is rated likely safe during both pregnancy and lactation, though your doctor should advise on appropriate dosing.

Silicon is rated likely safe in pregnancy but should be avoided while breastfeeding due to insufficient safety data.

Side effects, ingredient by ingredient Choline Silicon

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Choline.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start On Your Game, check with your doctor or pharmacist if you take any anticholinergic medications (such as atropine, scopolamine, or certain antihistamines and antipsychotics). Choline can theoretically interfere with how these drugs work.

No interactions are documented for silicon among the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

On Your Game may appeal to you if you're interested in supporting bone health and brain function with minimal side-effect risk at standard doses. If you take any anticholinergic medications—including atropine or similar drugs for muscle spasms or certain digestive issues—check with your doctor or pharmacist before starting, because choline may reduce how well those medications work.

Discuss this product with your own healthcare provider to make sure it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about On Your Game, straight from the product label.

Brand BioSil
Barcode (UPC) 5425010391736
Net contents 120 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Sep 21, 2017
DSLD ID 77057
Product type Single Vitamin And Mineral
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult Male (18-50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for On Your Game by BioSil, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
5425010391736
IngredientAmount% DV
Choline100 mg18%
Silicon5 mg--

Other ingredients: Microcrystalline Cellulose, purified Water, Capsule Shell

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding or trying to conceive, or if you are taking medication, have a medical condition or anticipate a surgery.

Keep out of the reach of children.

Sealed for your protection. Do not use if seal is broken.

Formulation

This Product Does Not Contain: Gluten, wheat, soy, corn, yeast, dairy, sugar, starch, egg, fish, shellfish, peanuts or tree nuts, animal products, GMOs or artificial colors, preservatives or sweeteners.

V Vegan Vegetarian

Suitable for vegetarians/vegans.

Seals/Symbols

V Vegan Vegetarian

isura Non-GMO - Mass spec Documentation - Lab tested

Storage

Store in a cool dry place.

Store at 59(0) - 86(0) F Protect from light and moisture.

Brand IP Statement(s)

ch-OSA, the ch-OSA logo, the Vegetarian logo and BioSil are all registered trademarks of Bio Minerals NV. On Your Game, Cartilage Fragmentation Inhibitor, and the clinical facts box are trademarks of Bio Minerals NV. ch-OSA is protected by US patents 5,922,360, 7,968,528 and 8,771,757

Cartilage Fragmentation Inhibitor

2016 Bio Minerals NV

On Your Game has been clinically proven in rigorous double-blind, placebo-controlled clinical trials.

Clinical facts Choline-stabilized orthosilicic acid (ch-OSA) Clinically Proven Dosage For Men: 1 capsule, twice daily Clinically Proven For: Joint comfort Clinically Proven For: Joint flexibility Clinically Proven For:Joint mobility

In a separate clinical trial, ch-OSA, the active ingredient in On Your Game, was clinically proven to generate collagen, the primary component of tendons, ligaments and cartilage.

Clinically proven cartilage fragmentation inhibitor Damaged Fragments from degrading cartilage cause discomfort and loss of flexibility Healthy On Your Game inhibits cartilage fragmentation creating increased joint comfort and flexibility

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

ch-OSA Original Formula

Clinically proven for men

Clinically proven joint relief for men

Joint relief for men

A quantum leap in men's joint health

In a double-blind placebo-controlled clinical trial, On Your Game was proven to inhibit the fragmentation of cartilage, improve the condition of cartilage, relieve joint discomfort, increase flexibility and increase range of motion in men.

General Statements

Whole joint protection - Inhibits cartilage breakdown Relieves joint discomfort - Improves mobility - Improves flexibility

Cartilage - Tendons - Ligaments

Made in Belgium

Researchers employed the gold standard WOMAC rating system to measure clinical results. Biochemical markers were used to measure and analyze cartilage fragmentation. All results were measured against a placebo group after 12 weeks and had a "p" value <0.05 making them statistically significant.

Clinical trial results 0 WOMAC total WOMAC pain WOMAC stiffness WOMAC physical limitation -10 -17 -22 -13 -16 -20 -30 -40 -43 -41 -50 -48 -48 Placebo ch-OSA *pc0.05 versus placebo Relieves joint discomfort 48% Reduces stiffness 48% Improves physical function 41%

Geusens P. et al., presentation at EULAR 2014, Annals of Rheumatic Disease - the EULAR Journal 2014, 73. Suppl. 2. Results may vary

Clinically proven Increases flexibility Increases range of motion Improves cartilage condition

Product facts

Damaged cartilage releases "cartilage fragments" into joints, causing you to experience discomfort, loss of flexibility and diminished range of motion. Your cartilage can become damaged directly due to injury, or indirectly through damage to tendons and ligaments.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one capsule, twice daily, with or without food.

General

R1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

On Your Game by BioSil label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

On Your Game label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in On Your Game by BioSil

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Choline

Interacts with
16 drugs
100 mg per serving Form: ch-OSA

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like egg...

Choline monograph & interactions

Silicon

No known
interactions
5 mg per serving Form: Choline-stabilized Orthosilicic Acid

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for h...

Silicon monograph & interactions

Other (inactive) ingredients: Microcrystalline Cellulose, Purified Water, Capsule Shell. These complete the product’s ingredient list but are not active constituents.

Interaction report

On Your Game by BioSil Drug Interactions

Want to check YOUR meds against On Your Game?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Choline 16

Individual Drug Interactions

The ingredients in On Your Game interact with 16 drugs. Click any drug to see the details.

1 of the 2 ingredients in On Your Game interact with drugs. Each result below shows which ingredient is responsible. Choline

Each ingredient & the kinds of drugs it affects

For each ingredient in On Your Game with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Choline1 drug type · 16 drugs

Atropine

Theoretically, choline might decrease the effects of atropine in the brain.
Animal research shows that administering choline one hour before administering atropine can attenuate atropine-induced decreases in brain levels of acetylcholine. Theoretically, concomitant use of choline and atropine may decrease the effects of atropine.

Likelihood Possible Evidence D
Choline full monograph & interactions
The maker

Brand information

Manufacturer and brand details for On Your Game, from the product label.

BioSil

See all BioSil products
Name
Bio Minerals NV
State
Destelbergen
Pharmacist Counseling Corner

On Your Game by BioSil: Common Questions

Does On Your Game by BioSil interact with any medications?
Yes. Based on its ingredients, On Your Game has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
On Your Game contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant or breastfeeding?
Choline is rated likely safe in both pregnancy and breastfeeding, and in fact your choline needs are higher while breastfeeding. Silicon is likely safe in pregnancy but should be avoided while breastfeeding due to insufficient safety data. Talk with your doctor or pharmacist about dosing that's right for you during these times.
Does choline have side effects?
At normal doses, choline is well tolerated. At very high doses—above 3.5 grams daily—it can cause fishy body odor, nausea, vomiting, diarrhea, salivation, and sweating. The dose in this product should be well below that threshold, but check the label to be sure.
What is choline supposed to do?
Choline is a nutrient that supports brain function and helps form acetylcholine, a chemical messenger in your nervous system. However, the evidence that choline supplements help with athletic performance, age-related cognitive decline, or Alzheimer's disease is not yet established.
Is silicon safe to take long-term?
Silicon from food and water is not associated with adverse effects. However, long-term safety of silicon supplements at higher doses has not been well studied, so the data on extended use is limited.
Will this help my bones?
Silicon is rated possibly effective for osteoporosis based on current evidence. The evidence for its use in hair loss and dental problems is not yet established.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

On Your Game label
Go deeper

The Full Monographs Behind On Your Game’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Choline

Interacts with 16 drugs

Choline is an essential nutrient your body needs for liver function, brain health, and nerve signaling, and many people get enough from foods like eggs, meat, and fish. Supplements may help...

Read the full Choline monograph → Herb & supplement monograph

Silicon

Silicon is a trace mineral found in the body and in foods like oats, barley, and certain fruits and vegetables, and it is popular in supplements for hair, skin, nail, and bone health. Some s...

Read the full Silicon monograph →
Sources

Sources & How We Checked

On Your Game's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 33 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Choline 14 references
  1. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  2. Cho E, Willett WC, Colditz GA, et al. Dietary choline and betaine and the risk of distal colorectal adenoma in women. J Natl Cancer Inst 2007;99:1224-31. PubMed
  3. Schmidt, C., Abicht, A., Krampfl, K., Voss, W., Stucka, R., Mildner, G., Petrova, S., Schara, U., Mortier, W., Bufler, J., Huebner, A., and Lochmuller, H. Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyl
  4. Tamminga, C., Smith, R. C., Chang, S., Haraszti, J. S., and Davis, J. M. Depression associated with oral choline. Lancet 10-23-1976;2(7991):905. PubMed
  5. Wood, J. L. and Allison, R. G. Effects of consumption of choline and lecithin on neurological and cardiovascular systems. Fed.Proc. 1982;41(14):3015-3021.
  6. Growdon, J. H. and Gelenberg, A. J. Choline and lecithin administration to patients with tardive dyskinesia. Trans.Am.Neurol.Assoc. 1978;103:95-99.
  7. Smith, C. M., Swash, M., Exton-Smith, A. N., Phillips, M. J., Overstall, P. W., Piper, M. E., and Bailey, M. R. Choline therapy in Alzheimer's disease. Lancet 8-5-1978;2(8084):318. PubMed
  8. Morrison, L. M. and W. F. Gonzales. Choline in coronary atherosclerosis. Amer.Heart J. 1950;39:729.
  9. Christie, J. G. Blackburn 1. M. Glen A. I. M. Zeisel S. Shering A. & Yates C. M. Effects of choline and lecithin on CSF choline levels and on cognitive functioning in patients with presenile dementia of the Alzheimer type. Nutrition and the brain 1979;5
  10. Sidhu N, Davies S, Nadarajah A, et al. Oral choline supplementation for postoperative pain. Br J Anaesth 2013;111(2):249-55. PubMed
  11. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol spectrum disorders has high feasibility and tolerability. Nutr Res. 2013;33(11):897-904. PubMed
  12. Wozniak JR, Fuglestad AJ, Eckerle JK, et al. Choline supplementation in children with fetal alcohol disorders: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2015;102(5): 1113-25.
  13. Ross RG, Hunter SK, McCarthy L, et al. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013;170(3):290-8. PubMed
  14. Food and Nutrition Board, Institute of Medicine. Choline. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B-6, Vitamin B-12, Pantothenic Acid, Biotin, and Choline. Washington D.C.: National Academy Press; 1998:390-422.

See these in context on the Choline monograph →

Silicon 19 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  2. Jugdaohsingh R, Anderson SH, Tucker KL, et al. Dietary silicon intake and absorption. Am J Clin Nutr 2002;75:887-93. PubMed
  3. Ichiyanagi O, Sasagawa I, Adachi Y, et al. Silica urolithiasis without magnesium trisilicate intake. Urol Int 1998;61:39-42. PubMed
  4. Levison DA, Crocker PR, Banim S, Wallace DM. Silica stones in the urinary bladder. Lancet 1982;1:704-5. PubMed
  5. Lee MH, Lee YH, Hsu TH, et al. Silica stone--development due to long time oral trisilicate intake. Scand J Urol Nephrol 1993;27:267-9. PubMed
  6. Cruz Guerra, N. A., Gomez Garcia, M. A., Lovaco, Castellano F., Saez Garrido, J. C., Garcia, Cuerpo E., and Escudero, Barrilero A. [Silica urolithiasis: report of a new case]. Actas Urol.Esp 2000;24(2):202-204.
  7. Merget, R., Bauer, T., Kupper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R., and Bruening, T. Health hazards due to the inhalation of amorphous silica. Arch Toxicol. 2002;75(11-12):625-634. PubMed
  8. Khuder, S. A., Peshimam, A. Z., and Agraharam, S. Environmental risk factors for rheumatoid arthritis. Rev Environ Health 2002;17(4):307-315. PubMed
  9. McLaughlin, J. K., Chow, W. H., and Levy, L. S. Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J Toxicol.Environ Health 4-25-1997;50(6):553-566. DOI
  10. Pelucchi, C., Pira, E., Piolatto, G., Coggiola, M., Carta, P., and La, Vecchia C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996-2005. Ann.Oncol. 2006;17(7):1039-1050. PubMed
  11. Gillissen, A., Gessner, C., Hammerschmidt, S., Hoheisel, G., and Wirtz, H. [Health significance of inhaled particles]. Dtsch.Med Wochenschr. 3-24-2006;131(12):639-644.
  12. Hu, J. F., Qu, H., and Wang, J. Z. [Meta analysis for relationship between exposure of free silicon dioxide and lung tumor]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2006;24(7):415-417.
  13. Jugdaohsingh, R. Silicon and bone health. J Nutr Health Aging 2007;11(2):99-110.
  14. Lacasse, Y., Martin, S., Gagne, D., and Lakhal, L. Dose-response meta-analysis of silica and lung cancer. Cancer Causes Control 2009;20(6):925-933. PubMed
  15. McCormic, Z. D., Khuder, S. S., Aryal, B. K., Ames, A. L., and Khuder, S. A. Occupational silica exposure as a risk factor for scleroderma: a meta-analysis. Int Arch Occup.Environ Health 2010;83(7):763-769. PubMed
  16. Haddad, F. S. and Kouyoumdjian, A. Silica stones in humans. Urol.Int 1986;41(1):70-76. PubMed
  17. Tervaert, J. W., Stegeman, C. A., and Kallenberg, C. G. Silicon exposure and vasculitis. Curr Opin.Rheumatol 1998;10(1):12-17. PubMed
  18. Steenland, K. and Stayner, L. Silica, asbestos, man-made mineral fibers, and cancer. Cancer Causes Control 1997;8(3):491-503. PubMed
  19. Boqué N, Valls RM, Pedret A, Puiggrós F, Arola L, Solà R. Relative absorption of silicon from different formulations of dietary supplements: a pilot randomized, double-blind, crossover post-prandial study. Sci Rep 2021;11(1):16479. PubMed

See these in context on the Silicon monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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