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Dietary supplement

OncoPLEX ES Ingredients & Drug Interactions

by XYMOGEN

OncoPLEX ES label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking OncoPLEX ES against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

OncoPLEX ES is a dietary supplement by XYMOGEN with 1 active ingredient. Its ingredients are commonly taken for general nutrition and antioxidant support, heart and digestive health, detoxification support.Based on those ingredients, 187 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are TrueBroc. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against OncoPLEX ES by XYMOGEN

Ask about any prescription or over-the-counter medication and we check it for interactions with OncoPLEX ES by XYMOGEN — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of OncoPLEX ES by XYMOGEN

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

OncoPLEX ES contains one active ingredient: TrueBroc, a broccoli extract. Broccoli is a cruciferous vegetable whose concentrated form is used in supplements for its bioactive compounds, particularly glucosinolates.

The product also contains several inactive ingredients (hypromellose, water, stearic acid, magnesium stearate, medium chain triglyceride oil, and silica) that serve as the capsule shell, binder, and flow agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded Broccoli's overall clinical evidence instead.

Moderate

Some clinical evidence supports Broccoli for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredient's overall clinical evidence instead.
  • On file: Colorectal cancer — rated "Possibly Effective" (Natural Medicines).

The evidence for broccoli in colorectal cancer prevention is rated possibly effective—meaning there's some promising research, but it's not yet definitive. For bladder cancer, breast cancer, fibromyalgia, and gastric cancer, the data we hold shows insufficient reliable evidence to make a rating one way or the other.

If you're considering this supplement for any of these conditions, talk with your doctor about what the current research supports for your situation.

The evidence, ingredient by ingredient Broccoli

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Broccoli as a food is generally well tolerated in normal amounts. However, concentrated broccoli supplements are less studied than whole broccoli, and the safety data available advises caution—your doctor should approve use of a concentrated extract before you start.

The most common side effects reported from broccoli seed and sprout extracts are loose stools, diarrhea, abdominal pain, and cramping, especially at higher doses. Topical contact with broccoli has occasionally caused allergic reactions and contact dermatitis in sensitive individuals.

The safety data shows this supplement is likely safe in pregnancy and lactation, though concentrated extracts remain less studied than whole food.

Side effects, ingredient by ingredient Broccoli

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Broccoli.
  • The most serious interaction on file is rated Moderate.
  • For scale: 187 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking OncoPLEX ES, check with your doctor or pharmacist about any medications processed through your liver—especially those metabolized by the CYP2A6 enzyme (the most serious concern) and CYP1A2 enzyme. Broccoli extract can significantly reduce the levels of drugs handled by these pathways, which may weaken their effects.

Use the interaction checker on this page to search your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

OncoPLEX ES may be worth considering if you're interested in broccoli's potential role in colorectal cancer support and your doctor thinks it's appropriate for you. The main caution is that its concentrated form hasn't been as thoroughly studied as whole broccoli, and it can speed up how your liver clears certain medications—potentially making them less effective.

Before you start, talk with your doctor or pharmacist about whether it fits your health picture and whether it could interfere with any of your current medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about OncoPLEX ES, straight from the product label.

Brand XYMOGEN
Barcode (UPC) 871149002404
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 303794
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), No Allergies, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for OncoPLEX ES by XYMOGEN, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
871149002404
IngredientAmount% DV
TrueBroc100 mg--

Other ingredients: Hypromellose, Water, Stearic Acid, Magnesium Stearate, Medium Chain Triglyceride Oil, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

DIRECTIONS: Take one capsule twice daily, or as directed by your healthcare professional.

Precautions

Consult your healthcare professional prior to use.

Individuals taking medication should discuss potential interactions with their healthcare professional.

Do not use if tamper seal is damaged.

STORAGE: Keep closed in a cool, dry place out of reach of children.

Formula

TrueBroc broccoli seed extract is obtained using a patented process to extract glucoraphanin (also known as sulforaphane glucosinolate or “sgs”) from its most concentrated cruciferous source—broccoli seeds. Glucoraphanin is enzymatically converted to the extensively researched isothiocyanate known as sulforaphane (SFN). Research suggests that SFN supports long-lasting antioxidant activity and the production of detoxification enzymes. It also extends support to the immune, nervous, and cardiovascular systems, addressing the maintenance of good health throughout adult life. OncoPLEX ES provides 100 mg of glucoraphanin per capsule.

TrueBroc Powerful antioxidant protection

Concentrated Glucoraphanin

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

STORAGE: Keep closed in a cool, dry place out of reach of children.

Formulation

FORMULATED TO EXCLUDE: Wheat, gluten, corn, yeast, soy, animal and dairy products, fish, shellfish, peanuts, tree nuts, egg, sesame, ingredients derived from genetically modified organisms (GMOs), artificial colors, artificial sweeteners, and artificial preservatives.

Clinically tested

Vegetarian caps

Brand IP Statement(s)

S1. TrueBroc is protected by trademarks and patents of Brassica Protection Products LLC: www.brassica.com/ip

Xymogen Exclusive professional formulas

Copyright 2022 XYMOGEN

FDA Statement of Identity

Dietary Supplement

Seals/Symbols

ePV (ePedigree Verification)

Vegetarian caps

GMP compliant third-party verified

General Statements

Scan to learn more! This package is completely recyclable

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See for yourself

OncoPLEX ES by XYMOGEN label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

OncoPLEX ES label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in OncoPLEX ES by XYMOGEN

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

TrueBroc

Interacts with
187 drugs
100 mg per serving Form: Glucoraphanin

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for...

TrueBroc monograph & interactions

Other (inactive) ingredients: Hypromellose, Water, Stearic Acid, Magnesium Stearate, Medium Chain Triglyceride Oil, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

OncoPLEX ES by XYMOGEN Drug Interactions

Want to check YOUR meds against OncoPLEX ES?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
187Drugs
187 Moderate

Ingredients driving the most interactions

TrueBroc 187

Individual Drug Interactions

The ingredients in OncoPLEX ES interact with 187 drugs. Click any drug to see the details.

1 of the 1 ingredient in OncoPLEX ES interact with drugs. Each result below shows which ingredient is responsible. TrueBroc

Each ingredient & the kinds of drugs it affects

For each ingredient in OncoPLEX ES with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

TrueBroc2 drug types · 187 drugs

Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP1A2.
Pharmacokinetic research in humans shows that eating 500 grams of fresh broccoli daily for 6-12 days can increase CYP1A2 activity by 10% to 200%. Induction of CYP1A2 activity by broccoli is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, broccoli might reduce the levels and effects of drugs metabolized by CYP2A6.
Pharmacokinetic research in humans shows that eating 500 grams of broccoli daily for 6 days increases CYP2A6 activity by 135% to 550%. Induction of CYP2A6 activity is attributed to its glucosinolate constituents.

Likelihood Possible Evidence B
TrueBroc full monograph & interactions
The maker

Brand information

Manufacturer and brand details for OncoPLEX ES, from the product label.

XYMOGEN

See all XYMOGEN products
Name
XYMOGEN Exclusive Professional Formulas
Street Address
6900 Kingspointe Pkwy.
City
Orlando
State
FL
ZipCode
32819
Phone Number
800-647-6100
Web Address
www.xymogen.com
Pharmacist Counseling Corner

OncoPLEX ES by XYMOGEN: Common Questions

Does OncoPLEX ES by XYMOGEN interact with any medications?
Yes. Based on its ingredients, OncoPLEX ES has a known interaction with 187 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
OncoPLEX ES contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is TrueBroc?
TrueBroc is a concentrated broccoli extract, which means the active compounds from broccoli are extracted and concentrated into a supplement form. It contains glucosinolates, the compounds in broccoli that our body converts into other bioactive substances.
Does broccoli extract actually prevent cancer?
The research shows broccoli is possibly effective for colorectal cancer prevention, meaning there's some promising evidence but it's not yet proven. For other cancers—bladder, breast, and gastric—we don't yet have reliable enough evidence to say whether it helps. Talk with your doctor about whether broccoli supplementation makes sense as part of your overall approach.
What side effects might I notice?
The most common side effects from broccoli extracts are digestive issues: loose stools, diarrhea, stomach pain, or cramping—especially at higher doses. If you have sensitive skin, topical contact with broccoli can occasionally trigger allergic reactions.
Is it safe to take during pregnancy or while breastfeeding?
The safety data rates broccoli as likely safe during pregnancy and lactation. However, because concentrated extracts are less studied than whole broccoli as a food, it's a good idea to confirm with your doctor before starting it while pregnant or nursing.
Why does the interaction checker show so many medications?
Broccoli speeds up two of your liver's major enzyme systems—CYP2A6 and CYP1A2—that break down many different medications. Even though broccoli's effect is real, whether it actually matters for your specific drugs depends on the dose, which medications you take, and your individual metabolism. That's why checking your exact list is important.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

OncoPLEX ES label
Go deeper

The Full Monographs Behind OncoPLEX ES’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Broccoli

Interacts with 187 drugs

Broccoli is a nutritious cruciferous vegetable rich in fiber, vitamins, and plant compounds like sulforaphane that have drawn scientific interest for health benefits. Eating broccoli as food...

Read the full Broccoli monograph →
Sources

Sources & How We Checked

OncoPLEX ES's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 5 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Broccoli 5 references
  1. Kristal AR, Lampe JW. Brassica vegetables and prostate cancer risk: a review of the epidemiological evidence. Nutr Cancer 2002;42:1-9. PubMed
  2. Chakrabarti A, Prais L, Foulds IS. Allergic contact dermatitis to broccoli. Br J Dermatol 2003;148:172-3. PubMed
  3. Hakooz, N. and Hamdan, I. Effects of dietary broccoli on human in vivo caffeine metabolism: a pilot study on a group of Jordanian volunteers. Curr Drug Metab 2007;8(1):9-15. PubMed
  4. Kall MA, Vang O, Clausen J. Effects of dietary broccoli on human drug metabolising activity. Cancer Lett. 1997;114(1-2):169-70. PubMed
  5. Bauman JE, Hsu CH, Centuori S, et al. Randomized Crossover Trial Evaluating Detoxification of Tobacco Carcinogens by Broccoli Seed and Sprout Extract in Current Smokers. Cancers (Basel). 2022;14(9):2129. Published 2022 Apr 24. PubMed

See these in context on the Broccoli monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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