Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Organic Apple Cider Vinegar Plus Blood Sugar Support Ingredients & Drug Interactions

by GT Genesis Today

Organic Apple Cider Vinegar Plus Blood Sugar Support label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Apple Cider Vinegar Plus Blood Sugar Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Apple Cider Vinegar Plus Blood Sugar Support is a dietary supplement by GT Genesis Today with 5 active ingredients. Its ingredients are commonly taken for blood sugar support, weight management, digestive upset.Based on those ingredients, 985 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are organic Gymnema sylvestre powder, organic Ceylon Cinnamon bark powder, organic unfiltered Apple Cider Vinegar. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 4 active ingredients. Organic unfiltered apple cider vinegar is the base, paired with organic yacon syrup, organic Ceylon cinnamon bark powder, and organic gymnema sylvestre powder.

These are mixed into a liquid form with purified water as an inactive ingredient.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: supports healthy blood sugar levels.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Metabolic syndrome, Hyperlipidemia, Obesity, Glycemic control — and 1 related terms.
  • The closest evidence on file: Ceylon Cinnamon is rated "Possibly Ineffective" for Diabetes (Natural Medicines).
  • Also on file: Ceylon Cinnamon is rated "Possibly Ineffective" for Obesity.
  • Also on file: Ceylon Cinnamon is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (prediabetes).

The evidence we hold doesn't establish that this product works for blood sugar support or any other condition. Apple cider vinegar, Ceylon cinnamon, and gymnema sylvestre all carry effectiveness ratings of insufficient reliable evidence or possibly ineffective for the claims they're often marketed for—including diabetes and blood sugar control.

The product's name suggests a blood sugar benefit, but the data supporting that claim remains limited.

The evidence, ingredient by ingredient Apple Cider Vinegar Ceylon Cinnamon Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Apple cider vinegar is well tolerated in food amounts, but larger medicinal doses carry more risk. Long-term use in significant quantities has been linked to low potassium, high renin levels, and bone loss.

Food amounts of Ceylon cinnamon are likely fine, but supplement-strength doses are less studied. Gymnema is generally well tolerated short-term, but a rare case of liver inflammation has been reported.

There's insufficient safety data for gymnema in pregnancy and lactation—the data advises against use in both. For apple cider vinegar and Ceylon cinnamon, pregnancy safety data is mixed or limited; talk with your doctor or pharmacist for personalized advice on use while pregnant or breastfeeding.

Side effects, ingredient by ingredient Apple Cider Vinegar Ceylon Cinnamon Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Ceylon Cinnamon, Apple Cider Vinegar, Gymnema.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications.
  • For scale: 986 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take digoxin (a heart rhythm medication), diuretics or water pills, insulin, other antidiabetes drugs, blood pressure medications, or any drug metabolized by your liver's CYP1A2, CYP2C9, or CYP3A4 enzymes. Phenacetin and tolbutamide carry specific Moderate-severity interactions with gymnema.

The combination of apple cider vinegar and low potassium risk is a particular concern if you're on heart medications or potassium-depleting drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product combines three ingredients with documented interactions with common medications, especially those for heart rhythm, blood pressure, diabetes, and water balance. If you take any prescription medications—particularly digoxin, diuretics, insulin, antidiabetes drugs, or blood pressure medications—check with your doctor or pharmacist before adding this supplement.

Even if you're not on medications, the evidence for blood sugar benefit is not established.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 24, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Apple Cider Vinegar Plus Blood Sugar Support, straight from the product label.

Brand GT Genesis Today
Barcode (UPC) 812711017068
Net contents 16 fl. Oz.; 1 PT; 473 mL
Market status On market
Date entered into DSLD May 24, 2017
DSLD ID 73902
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Kosher, Organic, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 fl. Oz.
Maximum serving Sizes:
1 fl. Oz.
Servings per container
16
UPC/BARCODE
812711017068
IngredientAmount% DV
Calories15 Calorie(s)--
Total Carbohydrates3 Gram(s)1%
Sugar1 Gram(s)--
organic unfiltered Apple Cider Vinegar15 Gram(s)--
organic Yacon Syrup2 Gram(s)--
organic Ceylon Cinnamon bark powder1 Gram(s)--
organic Gymnema sylvestre powder200 mg--

Other ingredients: purified Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Supports healthy blood sugar levels

We source, formulate and test Apple Cider Vinegar plus blood sugar support for purity and taste before offering it to you to ensure it meets the high standards you expect from Genesis Today.

Flash pasteurized for your protection.

Due to the natural ingredients in this product, taste, color and consistency may vary.

Naturally occurring prebiotics

Austin based

2 HDPE This bottle is made from 100% recyclable plastic

BPA free Non-Toxic plastic No Phthalates No Bisphenol-A

Formulation

Genesis Today's Apple Cider Vinegar plus blood sugar support is a USDA organic, low glycemic dietary supplement that supports overall wellness and healthy blood sugar levels.

Apple Cider Vinegar plus blood sugar support is vegetarian, gluten-free, USDA organic, and kosher.

Apple Cider Vinegar plus blood sugar support is vegetarian, gluten-free, USDA organic, and kosher.

Apple Cider Vinegar plus blood sugar support is vegetarian, gluten-free, USDA organic, and kosher.

V Vegetarian

Gluten free Soy free Dairy free

USDA Organic

Certified organic by Organic Certifiers

Formula

Each serving provides organic, unfiltered Apple Cider Vinegar complemented with a synergistic mix of ceylon cinnamon plus gymnema sylvestre extract. Extracted from the yacon plant, organic yacon syrup is added as a low-glycemic sweetener, delivering naturally-occurring prebiotics (fructooligosaccharides).

Apple Cider Vinegar plus blood sugar support is vegetarian, gluten-free, USDA organic, and kosher.

Organic ceylon cinnamon Organic gymnema sylvestre

K Certified Kosher by Tablet-K

Suggested/Recommended/Usage/Directions

Shake well

Best if used by expiration date. Once opened, consume contents within 30 days.

Directions: Consume one (1) serving of Genesis Today's apple cider vinegar dietary supplement before meals as is or mix with 4 to 8 oz. of water or juice as desired. Additional servings can be taken throughout the day.

Storage

Refrigerate after opening.

Store in a cool, dry place.

Precautions

Do not use if seal around cap is broken.

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

V Vegetarian

Low GI Low Glycemic

USDA Organic

K

Gluten free

Soy free

Dairy free

FDA Statement of Identity

Dietary Supplement

General

RDL22-067 LSGT7068-1

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Apple Cider Vinegar Plus Blood Sugar Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 fl. Oz. Dosage formLiquid Servings per container16 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

1 Gram(s) per serving

Organic unfiltered Apple Cider Vinegar

Interacts with
162 drugs
15 Gram(s) per serving

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of...

Organic unfiltered Apple Cider Vinegar monograph & interactions

Organic Yacon Syrup

2 Gram(s) per serving

Organic Ceylon Cinnamon bark powder

Interacts with
258 drugs
1 Gram(s) per serving

Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evid...

Organic Ceylon Cinnamon bark powder monograph & interactions

Organic Gymnema sylvestre powder

Interacts with
851 drugs
200 mg per serving

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human stu...

Organic Gymnema sylvestre powder monograph & interactions

Other (inactive) ingredients: Purified Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today Drug Interactions

Want to check YOUR meds against Organic Apple Cider Vinegar Plus Blood Sugar Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
985Drugs
504 Moderate 481 Minor

Ingredients driving the most interactions

organic Gymnema sylvestre powder 851
organic Ceylon Cinnamon bark powder 258
organic unfiltered Apple Cider Vinegar 162

Individual Drug Interactions

The ingredients in Organic Apple Cider Vinegar Plus Blood Sugar Support interact with 985 drugs. Click any drug to see the details.

3 of the 5 ingredients in Organic Apple Cider Vinegar Plus Blood Sugar Support interact with drugs. Each result below shows which ingredient is responsible. organic Gymnema sylvestre powder organic Ceylon Cinnamon bark powder organic unfiltered Apple Cider Vinegar

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Apple Cider Vinegar Plus Blood Sugar Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

organic Gymnema sylvestre powder6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
organic Gymnema sylvestre powder full monograph & interactions

organic Ceylon Cinnamon bark powder2 drug types · 258 drugs

Antidiabetes Drugs

Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.
Ceylon cinnamon may lower blood glucose levels. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, Ceylon cinnamon might have additive effects with antihypertensive drugs and increase the risk of hypotension.
Animal research shows that Ceylon cinnamon extract has vasorelaxant properties and reduces blood pressure in rat models of hypertension, possibly via inhibition of calcium influx through L-type voltage-sensitive channels.

Likelihood Possible Evidence D
organic Ceylon Cinnamon bark powder full monograph & interactions

organic unfiltered Apple Cider Vinegar4 drug types · 162 drugs

Digoxin (Lanoxin)

Theoretically, concomitant use of apple cider vinegar with digoxin might increase the risk of cardiac toxicity.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar could decrease potassium levels, increasing the risk of toxicity with digoxin.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, concomitant use of apple cider vinegar with diuretic drugs might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. There is some concern that people taking apple cider vinegar along with potassium depleting diuretics might have an increased risk for hypokalemia.

Likelihood Possible Evidence D
Insulin

Theoretically, concomitant use of apple cider vinegar with insulin might increase the risk of hypokalemia.
A case of hypokalemia related to chronic use of apple cider vinegar has been reported. Theoretically, overuse of apple cider vinegar concomitantly with insulin might increase the risk of hypokalemia.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, taking apple cider vinegar with antidiabetes drugs might increase the risk of hypoglycemia.
Apple cider vinegar might reduce fasting and postprandial blood glucose levels and decrease gastric emptying in people with diabetes. However, not all research agrees. Theoretically, it might have additive effects on glucose levels when used with antidiabetes drugs.

Likelihood Possible Evidence B
organic unfiltered Apple Cider Vinegar full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Apple Cider Vinegar Plus Blood Sugar Support, from the product label.

GT Genesis Today

See all GT Genesis Today products
Name
Genesis Today, Inc.
City
Austin
State
TX
ZipCode
78744
Phone Number
(800) 916-6642
Web Address
GenesisToday.com
Pharmacist Counseling Corner

Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today: Common Questions

Does Organic Apple Cider Vinegar Plus Blood Sugar Support by GT Genesis Today interact with any medications?
Yes. Based on its ingredients, Organic Apple Cider Vinegar Plus Blood Sugar Support has a known interaction with 985 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Apple Cider Vinegar Plus Blood Sugar Support contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on a blood sugar medication?
Not without talking to your doctor or pharmacist first. Apple cider vinegar, Ceylon cinnamon, and gymnema sylvestre all carry Moderate-severity interactions with antidiabetes drugs and insulin, meaning they may lower blood sugar further and increase the risk of low blood sugar (hypoglycemia). Your doctor may need to adjust your dose.
Is this safe to take long-term?
The safety data is limited for long-term use at supplement doses. Apple cider vinegar in particular has been linked to low potassium, bone loss, and other issues with chronic use in large amounts. Ceylon cinnamon and gymnema are generally well tolerated short-term, but long-term safety at these doses isn't well established.
Can I take this while pregnant or breastfeeding?
The data on pregnancy and breastfeeding safety is mixed or insufficient. Ceylon cinnamon is rated likely safe in pregnancy but likely unsafe for some uses; gymnema is best avoided in both pregnancy and lactation due to insufficient safety data. Talk with your doctor or pharmacist for personalized advice.
What does gymnema sylvestre do?
Gymnema is included for its traditional use in blood sugar support, but the evidence we hold is insufficient to confirm it works. It does interact with your liver's drug-processing enzymes, which is why it matters if you're on certain medications.
Does this actually help with blood sugar?
The evidence is not established. Apple cider vinegar, Ceylon cinnamon, and gymnema are all rated either insufficient reliable evidence or possibly ineffective for diabetes and blood sugar control in the data we hold.
What are the most common side effects?
At food amounts, apple cider vinegar and Ceylon cinnamon are well tolerated. Ceylon cinnamon may cause bloating, upset stomach, or nausea; gymnema is generally well tolerated short-term. At higher medicinal doses or with long-term use, risks rise, including low potassium from vinegar and rare liver inflammation from gymnema.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Organic Apple Cider Vinegar Plus Blood Sugar Support is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Apple Cider Vinegar Plus Blood Sugar Support label
Go deeper

The Full Monographs Behind Organic Apple Cider Vinegar Plus Blood Sugar Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Apple Cider Vinegar

Interacts with 162 drugs

Apple cider vinegar is a fermented apple product that many people use hoping to help with blood sugar, weight, or digestion. The evidence for most of these uses is limited and mixed, and the...

Read the full Apple Cider Vinegar monograph → Herb & supplement monograph

Ceylon Cinnamon

Interacts with 258 drugs

Ceylon cinnamon is the so-called 'true' cinnamon, valued as a spice and used in traditional medicine for blood sugar, cholesterol, and digestion. Evidence for most health benefits is limited...

Read the full Ceylon Cinnamon monograph → Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

Organic Apple Cider Vinegar Plus Blood Sugar Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 45 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Apple Cider Vinegar 11 references
  1. Lhotta K, Hofle G, Gasser R, Finkenstedt G. Hypokalemia, hyperreninemia, and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80:242-3. PubMed
  2. Hill LL, Woodruff LH, Foote JC, Barreto-Alcoba M. Esophageal injury by apple cider vinegar tablets and subsequent evaluation of products. J Am Diet Assoc 2005;105:1141-4. PubMed
  3. Hlebowicz J, Darwiche G, Björgell O, Almér LO. Effect of apple cider vinegar on delayed gastric emptying in patients with type 1 diabetes mellitus: a pilot study. BMC Gastroenterol 2007;7:46. PubMed
  4. Johnston CS, Kim CM, Buller AJ. Vinegar improves insulin sensitivity to a high-carbohydrate meal in subjects with insulin resistance or type 2 diabetes. Diabetes Care 2004;27:281-2. PubMed
  5. Lhotta, K., Hofle, G., Gasser, R., and Finkenstedt, G. Hypokalemia, hyperreninemia and osteoporosis in a patient ingesting large amounts of cider vinegar. Nephron 1998;80(2):242-243. PubMed
  6. Bunick CG, Lott JP, Warren CB, et al. Chemical burn from topical apple cider vinegar. J Am Acad Dermatol 2012;67(4):e143-4. PubMed
  7. Feldstein S, Afshar M, Krakowski AC. Chemical Burn from Vinegar Following an Internet-based Protocol for Self-removal of Nevi. J Clin Aesthet Dermatol. 2015 Jun;8(6):50.
  8. Luu LA, Flowers RH, Kellams AL, et al. Apple cider vinegar soaks [0.5%] as a treatment for atopic dermatitis do not improve skin barrier integrity. Pediatr Dermatol. 2019;36(5):634-639. PubMed
  9. Hadi A, Pourmasoumi M, Najafgholizadeh A, Clark CCT, Esmaillzadeh A. The effect of apple cider vinegar on lipid profiles and glycemic parameters: a systematic review and meta-analysis of randomized clinical trials. BMC Complement Med Ther 2021;21(1):179. PubMed
  10. Feise NK, Johnston CS. Commercial vinegar tablets do not display the same physiological benefits for managing postprandial glucose concentrations as liquid vinegar. J Nutr Metab 2020;2020:9098739. PubMed
  11. Gheflati A, Bashiri R, Ghadiri-Anari A, Reza JZ, Kord MT, Nadjarzadeh A. The effect of apple vinegar consumption on glycemic indices, blood pressure, oxidative stress, and homocysteine in patients with type 2 diabetes and dyslipidemia: A randomized contro

See these in context on the Apple Cider Vinegar monograph →

Ceylon Cinnamon 22 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  3. Choi HK, Jung GW, Moon KH, et al. Clinical study of SS-Cream in patients with lifelong premature ejaculation. Urology 2000;55:257-61. PubMed
  4. Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
  5. Anderson RA, Broadhurst CL, Polansky MM, et al. Isolation and Characterization of Polyphenol Type-A Polymers from Cinnamon with Insulin-like Biological Activity. J Agric Food Chem 2004;52:65-70. PubMed
  6. Jarvill-Taylor KJ, Anderson RA, Graves DJ. A hydroxychalcone derived from cinnamon functions as a mimetic for insulin in 3T3-L1 adipocytes. J Am Coll Nutr 2001;20:327-36. PubMed
  7. Onderoglu S, Sozer S, Erbil KM, et al. The evaluation of long-term effcts of cinnamon bark and olive leaf on toxicity induced by streptozotocin administration to rats. J Pharm Pharmacol 1999;51:1305-12.
  8. Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from spices. Contact Dermatitis 1996;35:157-62. PubMed
  9. Ranasinghe P, Jayawardena R, Galappaththy P, et al. Response to Akilen et al. Efficacy and safety of 'true' cinnamon (Cinnamomum zeylanicum) as a pharmaceutical agent in diabetes: a systematic review and meta-analysis. Diabet Med 2013 Apr;30(4):506-7.
  10. Oliveira JdA, da Silva IC, Trindade LA, et al. Safety and tolerability of essential oil from Cinnamomum zeylanicum blume leaves with action on oral candidosis and its effect on the physical properties of the acylic resin. Evid Based Complement Alternat Me
  11. Ranasinghe P, Pigera S, Premakumara GA, et al. Medicinal properties of 'true' cinnamon (Cinnamomum zeylanicum): a systematic review. BMC Complement Altern Med 2013;13:275. PubMed
  12. Ranasinghe P, Galappaththy P. Health benefits of Ceylon cinnamon (Cinnamomum zeylanicum): a summary of the current evidence. Ceylon Med J 2016;61(1):1-5. PubMed
  13. Nyadjeu P, Dongmo A, Nguelefack TB, Kamanyi A. Antihypertensive and vasorelaxant effects of Cinnamomum zeylanicum stem bark aqueous extracts. J Complement Integr Med 2011;8.
  14. Wansi SL, Nyadjeu P, Ngamga D, et al. Blood pressure lowering effect of the ethanol extract from the stembark of Cinnamomum zeylanicum (lauraceae) in rats. Pharmacol online 2007;3:166-76.
  15. Admani S, Hill H, Jacob SE. Cinnamon Sugar Scrub Dermatitis: "Natural" Is Not Always Best. Pediatr Dermatol. 2017;34(1):e42-e43. PubMed
  16. Isaac-Renton M, Li MK, Parsons LM. Cinnamon spice and everything not nice: many features of intraoral allergy to cinnamic aldehyde. Dermatitis. 2015;26(3):116-21. PubMed
  17. Vandersall A, Katta R. Eyelid dermatitis as a manifestation of systemic contact dermatitis to cinnamon. Dermatitis. 2015 Jul-Aug;26(4):189. PubMed
  18. Brancheau D, Patel B, Zughaib M. Do cinnamon supplements cause acute hepatitis? Am J Case Rep 2015;16:250-4. PubMed
  19. Ranasinghe P, Jayawardena R, Pigera S, et al. Evaluation of pharmacodynamic properties and safety of Cinnamomum zeylanicum (Ceylon cinnamon) in healthy adults: a phase I clinical trial. BMC Complement Altern Med 2017;17(1):550. PubMed
  20. Zareie A, Sahebkar A, Khorvash F, Bagherniya M, Hasanzadeh A, Askari G. Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double-blind placebo-controlled trial. Phytother Res 2020;34(11):2945-52. PubMed
  21. Zobeiri M, Parvizi F, Shahpiri Z, et al. Evaluation of the effectiveness of cinnamon oil soft capsule in patients with functional dyspepsia: A randomized double-blind placebo-controlled clinical trial. Evid Based Complement Alternat Med 2021;2021:6634115. PubMed
  22. Chase C, Doyle A, John SS, Laurent T, Griffith S. Post-operative haemorrhage secondary to cinnamon use. A case report. Int J Surg Case Rep 2022;95:107179. PubMed

See these in context on the Ceylon Cinnamon monograph →

Gymnema 12 references
  1. Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
  2. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
  3. Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
  4. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
  5. Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
  6. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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