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Dietary supplement

Original Gymnema Leaf Extract 600 mg Ingredients & Drug Interactions

by Herbal Goodness

Original Gymnema Leaf Extract 600 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Original Gymnema Leaf Extract 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Original Gymnema Leaf Extract 600 mg is a dietary supplement by Herbal Goodness with 1 active ingredient. Its ingredients are commonly taken for blood sugar support, type 2 diabetes, sugar cravings.Based on those ingredients, 851 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Gymnema leaf extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Original Gymnema Leaf Extract 600 mg by Herbal Goodness

Ask about any prescription or over-the-counter medication and we check it for interactions with Original Gymnema Leaf Extract 600 mg by Herbal Goodness — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Original Gymnema Leaf Extract 600 mg by Herbal Goodness

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: gymnema leaf extract, 600 mg per capsule. Gymnema is a plant used traditionally to support blood sugar management.

The capsule itself is made from hypromellose and rice hull concentrate, which are inactive ingredients that serve as the capsule shell and filler.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Gymnema's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Supports healthy pancreatic function and carbohydrate metabolism.
  • We looked for evidence on: Diabetes, Impaired glucose tolerance (prediabetes), Metabolic syndrome, blood sugar control, glucose metabolism.
  • The closest evidence on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Diabetes (Natural Medicines).
  • Also on file: Gymnema is rated "Insufficient Reliable Evidence To Rate" for Impaired glucose tolerance (prediabetes), Metabolic syndrome.

The evidence we hold doesn't establish that gymnema is effective for diabetes, prediabetes (impaired glucose tolerance), obesity, or metabolic syndrome—the data shows insufficient reliable evidence to rate it for any of these purposes. If you're considering it for blood sugar management, talk with your doctor about whether the research supports its use for your situation.

The evidence, ingredient by ingredient Gymnema

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Gymnema is generally well tolerated in the short term, though quality varies between products and brands. The main safety concern is that it lowers blood sugar, which matters if you take diabetes medications.

Rare cases of liver injury (hepatitis, including one with aplastic anemia) have been reported in people using gymnema, so watch for weakness, fatigue, yellowing of the skin or eyes, or unusual bruising and report them to your doctor right away. There isn't enough safety data to recommend this product during pregnancy or while breastfeeding.

If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before taking it.

Side effects, ingredient by ingredient Gymnema

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Gymnema.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 852 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your doctor or pharmacist if you're on antidiabetes drugs (blood sugar medications)—gymnema can increase their effect and lower your blood sugar too much. Also double-check any medications your liver processes, especially those broken down by CYP1A2, CYP2C9, or CYP3A4 enzymes, since gymnema can change their levels.

Use the medication checker on this page to search your prescriptions.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Gymnema leaf extract may be worth considering if you're interested in traditional blood sugar support—but the evidence for its effectiveness isn't established in our data. The main caution is that it interacts with antidiabetes medications and affects how your liver processes a broad range of drugs.

If you take any prescription medications, check them with your pharmacist or doctor before you start, and watch for signs of liver problems.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 14, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Original Gymnema Leaf Extract 600 mg, straight from the product label.

Brand Herbal Goodness
Barcode (UPC) 850035852118
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Dec 14, 2023
DSLD ID 301083
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Original Gymnema Leaf Extract 600 mg by Herbal Goodness, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
850035852118
IngredientAmount% DV
Gymnema leaf extract1200 mg--

Other ingredients: Hypromellose, Rice Hull Concentrate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Gymnema has been used in Ayerduvia practices as a herb whose unique chemistry promotes the metabolism of refined carbohydrates and supports healthy pancreatic functions.

Approved Keto Friendly

Original Gymnema Leaf Extract 600MG/Capsule

Certified Kosher by Orthodox Union OU (Kosher)

General Statements

100% Women Owned 10% of Profits & Ethical trade

Impact We do right by others We believe in business for social good and give 10% of profits to support the education of African girls. Sustainability We respect mother earth We believe in the environment and fairtrade practices.

Instagram herbalgoodnessco Twitter herbal_goodness Visit HerbalGoodnessCo.com to learn more

Women Owned

Formulation

Quality We only use The Best Made from the highest quality herbs, our products are tested to the highest standard by 3rd party certifiers.

Fairly Traded

Sugar destroyer & pancreatic support

Seals/Symbols

Packaged in the USA

OU (Kosher)

FDA Disclaimer Statement

These statements have not been evaluated by the Food ad Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 2 capsules with meal or as directed by a qualified health care professional.

Storage

Warning: Store tightly closed in a cool dry place.

Precautions

Do not use if inner seal or tamper evident seal is broken.

If pregnant or have a medical condition, consult your physician before using this herbal product.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Original Gymnema Leaf Extract 600 mg by Herbal Goodness label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Original Gymnema Leaf Extract 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Original Gymnema Leaf Extract 600 mg by Herbal Goodness

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Gymnema leaf extract

Interacts with
851 drugs
1200 mg per serving

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human stu...

Gymnema leaf extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Rice Hull Concentrate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Original Gymnema Leaf Extract 600 mg by Herbal Goodness Drug Interactions

Want to check YOUR meds against Original Gymnema Leaf Extract 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
851Drugs
347 Moderate 504 Minor

Ingredients driving the most interactions

Gymnema leaf extract 851

Individual Drug Interactions

The ingredients in Original Gymnema Leaf Extract 600 mg interact with 851 drugs. Click any drug to see the details.

1 of the 1 ingredient in Original Gymnema Leaf Extract 600 mg interact with drugs. Each result below shows which ingredient is responsible. Gymnema leaf extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Original Gymnema Leaf Extract 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Gymnema leaf extract6 drug types · 851 drugs

Antidiabetes Drugs

Theoretically, taking gymnema with antidiabetes drugs might increase the risk of hypoglycemia.
Gymnema reduces blood glucose levels in some human and animal research. In human studies, it has been shown to enhance the blood glucose lowering effects of hypoglycemic drugs. However, other research in adults with prediabetes or metabolic syndrome suggests that gymnema does not reduce fasting levels of blood glucose. Until more is known, monitor blood glucose levels closely.

Likelihood Probable Evidence B
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP1A2.
Animal and in vitro research shows that gymnema can inhibit the CYP1A2 enzyme. In one animal study, oral administration of gymnema for 7 days increased the plasma concentrations of phenacetin, a CYP1A2 substrate, by about 1.4-fold and reduced the clearance of phenacetin by about 29%.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, gymnema might increase or decrease levels of drugs metabolized by CYP2C9.
Animal research shows that gymnema can induce the CYP2C9 enzyme. In one animal study, gymnema caused a 2.4-fold increase in the clearance of tolbutamide, a CYP2C9 substrate, in rats. In vitro research also shows that gymnema can inhibit CYP2C9.

Likelihood Possible Evidence D
Phenacetin

Theoretically, taking gymnema with phenacetin might increase the levels of phenacetin.
Animal research shows that gymnema, administered orally for 7 days, decreases the clearance of phenacetin in a dose-dependent manner by about 21% to 29% and increases plasma levels about 1.3- to 1.4-fold when compared to control.

Likelihood Possible Evidence D
Tolbutamide (Orinase)

Theoretically, taking gymnema with tolbutamide might the decrease levels of tolbutamide.
Animal research shows that gymnema, administered orally for 7 days, increases the clearance of tolbutamide by 2.4-fold when compared to control.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, gymnema might increase levels of drugs metabolized by CYP3A4.
One in vitro study using rat liver microsomes shows that gymnema can modestly inhibit the CYP3A4 enzyme. However, other in vitro research using human liver microsomes shows that gymnema does not affect CYP3A4 activity. Animal research also shows that gymnema does not alter the function of CYP3A4. In one study in rats, oral administration of gymnema for 7 days did not alter the clearance of amlodipine, a CYP3A4 substrate.

Likelihood Unlikely Evidence D
Gymnema leaf extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Original Gymnema Leaf Extract 600 mg, from the product label.

Herbal Goodness

See all Herbal Goodness products
Name
Herbal Goodness
Street Address
2150 S. Central Expressway, Suite 200
City
McKinney
State
TX
ZipCode
75070
Phone Number
800-820-4829
Web Address
herbalgoodnessco.com
Pharmacist Counseling Corner

Original Gymnema Leaf Extract 600 mg by Herbal Goodness: Common Questions

Does Original Gymnema Leaf Extract 600 mg by Herbal Goodness interact with any medications?
Yes. Based on its ingredients, Original Gymnema Leaf Extract 600 mg has a known interaction with 851 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Original Gymnema Leaf Extract 600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take gymnema if I'm on diabetes medication?
You should check with your doctor or pharmacist first. Gymnema lowers blood sugar on its own and can boost the effect of diabetes medications, which raises the risk of low blood sugar. Your doctor may need to adjust your medication dose if you add this.
Is gymnema safe to use during pregnancy or breastfeeding?
No—there isn't enough safety data, so it's best avoided during pregnancy and while breastfeeding. Talk with your doctor or pharmacist if you're pregnant, planning pregnancy, or nursing and want to use it.
What are the side effects of gymnema?
It's generally well tolerated, but rare cases of liver injury have been reported. Watch for weakness, fatigue, yellowing of the skin or eyes, or unusual bruising—these can be signs of liver problems, and you should report them to your doctor right away.
Does this product work for blood sugar control or weight loss?
The evidence we hold doesn't establish that gymnema is effective for diabetes, prediabetes, obesity, or metabolic syndrome. If you're thinking about using it for any of these, talk with your doctor about whether research supports it for your needs.
Are there any fillers or other ingredients in this capsule?
Yes. The capsule contains hypromellose and rice hull concentrate, which help form and fill the capsule. The active ingredient is gymnema leaf extract at 600 mg.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Original Gymnema Leaf Extract 600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Original Gymnema Leaf Extract 600 mg label
Go deeper

The Full Monographs Behind Original Gymnema Leaf Extract 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gymnema

Interacts with 851 drugs

Gymnema is an Ayurvedic herb best known for possibly helping lower blood sugar and reducing the taste of sweetness on the tongue. Some early human studies are encouraging for blood sugar sup...

Read the full Gymnema monograph →
Sources

Sources & How We Checked

Original Gymnema Leaf Extract 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gymnema 12 references
  1. Shanmugasundaram ER, Rajeswari G, Baskaran K, et al. Use of Gymnema sylvestre leaf extract in the control of blood glucose in insulin-dependent diabetes mellitus. J Ethnopharmacol 1990;30:281-94. PubMed
  2. Baskaran K, Kizar Ahamath B, Radha Shanmugasundaram K, Shanmugasundaram ER. Antidiabetic effect of leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol 1990;30:295-300.
  3. Kamble B, Gupta A, Moothedath I, Khatal L, Janrao S, Jadhav A, et al. Effects of Gymnema sylvestre extract on the pharmacokinetics and pharmacodynamics of glimepiride in streptozotocin induced diabetic rats. Chem Biol Interact. 2016;245:30-8. PubMed
  4. Tiwari P, Mishra BN, Sangwan NS. Phytochemical and pharmacological properties of Gymnema sylvestre: an important medicinal plant. Biomed Res Int. 2014; 2014:830285.
  5. Fabio GD, Romanucci V, De Marco A, Zarrelli A. Triterpenoids from Gymnema sylvestre and their pharmacological activities. Molecules. 2014;19(8):10956-81. PubMed
  6. Shiyovich A, Sztarkier I, Nesher L. Toxic hepatitis induced by Gymnema sylvestre, a natural remedy for type 2 diabetes mellitus. Am J Med Sci. 2010;340(6):514-7. PubMed
  7. Zuniga LY, Gonzalez-Ortiz M, Martinez-Abundis E. Effect of gymnema sylvestre administration on metabolic syndrome, insulin sensitivity, and insulin secretion. J Med Food. 2017 Aug;20(8):750-54.
  8. Rammohan B, Samit K, Chinmoy D, et al. Human cytochrome P450 enzyme modulation by gymnema sylvestre: a predictive safety evaluation by LC-MS/MS. Pharmacogn Mag. 2016 Jul;12(Suppl 4):S389-S394.
  9. Vaghela M, Sahu N, Kharkar P, Pandita N. In vivo pharmacokinetic interaction by ethanolic extract of gymnema sylvestre with CYP2C9 (tolbutamide), CYP3A4 (amlodipine) and CYP1A2 (phenacetin) in rats. Chem Biol Interact. 2017 Dec 25;278:141-151. PubMed
  10. Vaghela M, Iyer K, Pandita N. In vitro inhibitory effect of gymnema sylvestre extracts and total gymnemic acids fraction on select cytochrome P450 activities in rat liver microsomes. Eur J Drug Metab Pharmacokinet. 2017 Oct 10. PubMed
  11. Gaytán Martínez LA, Sánchez-Ruiz LA, Zuñiga LY, González-Ortiz M, Martínez-Abundis E. Effect of Gymnema sylvestre administration on glycemic control, insulin secretion, and insulin sensitivity in patients with impaired glucose tolerance. J Med Food. 2021;
  12. Philips CA, Theruvath AH, Ravindran R. Toxic hepatitis-associated aplastic anaemia after dual homeopathic remedies and Gymnema sylvestre use. BMJ Case Rep 2022;15(3):e247867. PubMed

See these in context on the Gymnema monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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