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Dietary supplement

Pantethine 300 mg Ingredients & Drug Interactions

by NOW

Pantethine 300 mg label
See full label image
Softgel Capsule Category: Vitamin
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pantethine 300 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pantethine 300 mg is a dietary supplement by NOW with 1 active ingredient. Its ingredients are commonly taken for high cholesterol, high triglycerides, heart health support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pantethine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pantethine 300 mg by NOW

Ask about any prescription or over-the-counter medication and we check it for interactions with Pantethine 300 mg by NOW — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pantethine 300 mg by NOW

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pantethine, a form of vitamin B5 (pantothenic acid) that your body converts into compounds it uses for energy and fat metabolism. The softgel capsule itself is made from gelatin and filled with rice bran oil, sunflower lecithin, and beeswax — these are inactive ingredients that help deliver the pantethine.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports healthy serum lipids within normal range.
  • We looked for evidence on: Hyperlipidemia, Hyperlipoproteinemia, dyslipidemia, cholesterol management.
  • The strongest evidence on file: Pantethine is rated "Possibly Effective" for Hyperlipoproteinemia (Natural Medicines).
  • Also on file: Pantethine is rated "Insufficient Reliable Evidence To Rate" for Hyperlipidemia.

The evidence for pantethine is mixed. It's rated possibly effective for high cholesterol and fat disorders (hyperlipoproteinemia).

For athletic performance and general high cholesterol (hyperlipidemia), we don't have enough reliable evidence to say whether it works. The same goes for a rare neurological condition called pantothenate kinase-associated neurodegeneration — the data simply isn't established in what we hold.

The evidence, ingredient by ingredient Pantethine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pantethine is generally well tolerated in research studies, though long-term safety data are limited. The most common side effects are mild digestive complaints: nausea, vomiting, diarrhea, stomach discomfort, bloating, and gas.

Rarely, mild itching has been reported. Because there isn't enough reliable safety data, it's best to avoid it unless your doctor advises otherwise.

Safety during breastfeeding has not been well studied, so caution is advised if you're nursing.

Side effects, ingredient by ingredient Pantethine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pantethine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking NOW Pantethine 300 mg, check with your doctor or pharmacist if you take any anticoagulant (blood thinner) or antiplatelet medications — pantethine may increase bleeding risk with these drugs. The interaction is moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're interested in pantethine for high cholesterol or fat disorders, the evidence shows it may help — but if you take blood thinners or antiplatelet medications, you'll need to clear it with your doctor or pharmacist first because of bleeding risk. The digestive side effects are usually mild.

Because long-term safety data are sparse, talk it over with your own healthcare provider before you start.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pantethine 300 mg, straight from the product label.

Brand NOW
Barcode (UPC) 733739004871
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Feb 25, 2021
DSLD ID 244401
Product type Vitamin
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pantethine 300 mg by NOW, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
UPC/BARCODE
733739004871
IngredientAmount% DV
Pantethine300 mg--

Other ingredients: Softgel Capsule, Rice Bran Oil, Sunflower Lecithin, Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Take 1 softgel 2 to 3 times daily with food.

Formula

Pantethine is a highly absorbable and biologically active form of pantothenic acid (vitamin B-5). Pantethine is a precursor in the formation of coenzyme A (CoA), an essential cofactor for lipid, carbohydrate, and protein metabolism. Pantethine also helps to support proper cholesterol production and fat storage in the liver, which can help to promote healthy body fat distribution. It has been shown in clinical studies to assist in the maintenance of already healthy serum lipid levels for the support of a healthy cardiovascular system when used in conjunction with a healthy diet.

Triangle K (Kosher)

Vitamins

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: For adults only. May cause minor gastrointestinal discomfort.

Consult physician if pregnant/nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Contains Gelatin

Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients. Produced in a GMP facility that processes other ingredients containing these allergens.

Formulation

Cardiovascular health Supports healthy serum lipids already within the normal range

Non-GMO

Not manufactured with yeast, wheat, gluten, milk, egg, fish or shellfish ingredients.

Natural color variation may occur in this product.

FDA Statement of Identity

A Dietary Supplement

Seals/Symbols

Triangle K (Kosher)

GMP quality assured

General Statements

Family owned since 1968.

Storage

Store in a cool, dry place after opening.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pantethine 300 mg by NOW label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pantethine 300 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pantethine 300 mg by NOW

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Pantethine

Interacts with
122 drugs
300 mg per serving

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence i...

Pantethine monograph & interactions

Other (inactive) ingredients: Softgel Capsule, Rice Bran Oil, Sunflower Lecithin, Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pantethine 300 mg by NOW Drug Interactions

Want to check YOUR meds against Pantethine 300 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pantethine 122

Individual Drug Interactions

The ingredients in Pantethine 300 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pantethine 300 mg interact with drugs. Each result below shows which ingredient is responsible. Pantethine

Each ingredient & the kinds of drugs it affects

For each ingredient in Pantethine 300 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pantethine1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pantethine might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Some evidence suggests that pantethine reduces platelet aggregation.

Likelihood Possible Evidence B
Pantethine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pantethine 300 mg, from the product label.

NOW

See all NOW products
Name
NOW Foods
Street Address
395 S. Glen Ellyn Rd.
City
Bloomingdale
State
IL
ZipCode
60108
Web Address
www.nowfoods.com
Pharmacist Counseling Corner

Pantethine 300 mg by NOW: Common Questions

Does Pantethine 300 mg by NOW interact with any medications?
Yes. Based on its ingredients, Pantethine 300 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pantethine 300 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pantethine, and what does it do in the body?
Pantethine is a form of vitamin B5. Your body converts it into compounds that help you produce energy and metabolize fats. It's thought to have a role in managing cholesterol and other blood lipids.
Does pantethine actually work for high cholesterol?
For high cholesterol and fat disorders (hyperlipoproteinemia), pantethine is rated possibly effective — meaning there's some evidence it may help, but it's not definitive. For general high cholesterol, the evidence isn't reliable enough to say one way or the other.
What side effects might I experience?
Most side effects are mild digestive complaints: nausea, vomiting, diarrhea, bloating, gas, and stomach discomfort. Rarely, mild itching has been reported. These tend to be mild and resolve on their own.
Is pantethine safe to use long-term?
Pantethine is generally well tolerated in studies, but long-term safety data are limited. Because we don't have enough long-term data, it's best to avoid it unless your doctor advises otherwise. Talk with your doctor about how long it's safe for you to take it.
Can I take pantethine if I'm pregnant or breastfeeding?
There isn't enough data on pantethine's safety during breastfeeding, so caution is advised if you're nursing. For pregnancy safety, the data isn't on file — talk with your doctor or pharmacist to decide what's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pantethine 300 mg label
Go deeper

The Full Monographs Behind Pantethine 300 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pantethine

Interacts with 122 drugs

Pantethine is a derivative of vitamin B5 (pantothenic acid) that some studies suggest may modestly lower cholesterol and triglycerides. The evidence is limited and not strong enough to repla...

Read the full Pantethine monograph →
Sources

Sources & How We Checked

Pantethine 300 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pantethine 9 references
  1. Da Col PG, Cattin L, Fonda M, et al. Pantethine in the treatment of hypercholesterolemia: a randomized double-blind trial versus tiadenol. Curr Ther Res 1984;36:314-22.
  2. Rubba P, Postaiglione B, De Simone F, et al. Comparative evaluation of the lipid-lowering effects of fenofibrate and pantethine in type II hyperlipoproteinemia. Curr Ther Res 1985;38:719-27.
  3. Coronel F, Tornero F, Torrente J, et al. Treatment of hyperlipemia in diabetic patients on dialysis with a physiological substance. Am J Nephrol 1991;11:32-6.. PubMed
  4. Agrati AM, Ambrosi G, Ferraro G, Palmieri. Gemfibrozil efficacy vs pantethine in dyslipoproteinemic patients: a controlled study. Curr Ther Res 1989;45:650-63.
  5. Rumberger, J. A., Napolitano, J., Azumano, I., Kamiya, T., and Evans, M. Pantethine, a derivative of vitamin B(5) used as a nutritional supplement, favorably alters low-density lipoprotein cholesterol metabolism in low- to moderate-cardiovascular risk No
  6. Hiramatsu, K., Nozaki, H., and Arimori, S. Influence of pantethine on platelet volume, microviscosity, lipid composition and functions in diabetes mellitus with hyperlipidemia. Tokai J.Exp.Clin.Med. 1981;6(1):49-57.
  7. McRae MP. Treatment of hyperlipoproteinemia with pantethine: A review and analysis of efficacy and tolerability. Nutrition Res 2005;25:319-333. DOI
  8. Cattin, L., Da Col, P. G., Fonda, M., Mameli, M. G., and Fergulio, G. A. Treatment of hypercholesterolemia with pantethine and fenofibrate; open randomized study on 43 subjects. Current Therapeutic Research 1985;38(Sep):386-395.
  9. Evans M, Rumberger JA, Azumano I, Napolitano JJ, Citrolo D, Kamiya T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded

See these in context on the Pantethine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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