Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Papaya Enzyme Chewable Ingredients & Drug Interactions

by BIOVEA

Papaya Enzyme Chewable label
See full label image
Tablet Or Pill Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Papaya Enzyme Chewable against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Papaya Enzyme Chewable is a dietary supplement by BIOVEA with 3 active ingredients. Its ingredients are commonly taken for digestion and bloating, muscle soreness and exercise recovery, inflammation and swelling.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Papain. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Papaya Enzyme Chewable by BIOVEA

Ask about any prescription or over-the-counter medication and we check it for interactions with Papaya Enzyme Chewable by BIOVEA — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Papaya Enzyme Chewable by BIOVEA

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This chewable contains 3 active enzymes: protease, alpha-amylase, and papain. Proteolytic enzymes like protease break down proteins in your digestive tract.

Alpha-amylase breaks down starches. Papain, derived from papaya, also works as a protein-digesting enzyme.

The tablet also contains inactive ingredients — fructose, calcium carbonate, papaya flavor, vegetable stearin, corn starch, and magnesium stearate — that help hold the tablet together and give it flavor.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Digestive support for protein digestion.
  • We looked for evidence on: Exercise-induced muscle soreness, Wound healing, Inflammation, Bloating.
  • The closest evidence on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle soreness (Natural Medicines).
  • Also on file: Papain is rated "Insufficient Reliable Evidence To Rate" for Wound healing.

The evidence for papain isn't established in the data we hold. The facts list several uses it's been studied for — cancer, dental cavities, radiation skin damage, muscle soreness after exercise, shingles, and intestinal parasites — but all ratings are insufficient reliable evidence.

That means the research so far doesn't support or refute its use for any of these. For protease and alpha-amylase, no effectiveness ratings are on file.

The evidence, ingredient by ingredient Proteolytic Enzymes (proteases) Papain

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Protease is generally well tolerated by most adults, though it can cause digestive upset or allergic reactions in some people. Papain is also generally tolerated at normal doses when taken by mouth short-term, but high doses may be unsafe and can rarely cause severe stomach inflammation or even holes in the esophagus.

Allergic reactions — itchy eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea — are the most common concern for people sensitive to papain. The safety data advises against protease in pregnancy unless prescribed by a doctor, and concentrated papain and unripe papaya products should be avoided in pregnancy due to safety concerns.

Neither ingredient has enough reliable data to recommend during breastfeeding without medical advice — talk with your doctor or pharmacist if you're nursing.

Side effects, ingredient by ingredient Proteolytic Enzymes (proteases) Papain

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Papain.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

The main concern is warfarin (Coumadin) and other blood thinners — papain may increase their effects and raise your bleeding risk. Check your exact medications using the search tool on this page, and talk with your doctor or pharmacist before combining this product with any prescription drug.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is an enzyme blend meant to help with digestion. If you take warfarin or another blood thinner, you need to check with your doctor or pharmacist before using it — papain can make blood thinners stronger.

If you're pregnant, breastfeeding, or have a known papaya allergy, discuss this supplement with your healthcare provider before starting.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Papaya Enzyme Chewable, straight from the product label.

Brand BIOVEA
Barcode (UPC) 787500067114
Net contents 100 Vegetarian Tablet(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303226
Product type Non-nutrient/non-botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Papaya Enzyme Chewable by BIOVEA, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
Servings per container
100
UPC/BARCODE
787500067114
IngredientAmount% DV
Protease2 mg--
Alpha-Amylase2 mg--
Papain15 mg--

Other ingredients: Fructose, Calcium Carbonate, Papaya flavor, Vegetable Stearin, Corn Starch, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Contains no salt, dairy, yeast, wheat, gluten, soy, preservatives or artificial colors.

Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, adults chew one (1) tablet with meals, or as directed by a health care professional.

Storage

Store in a cool, dry place and away from direct light.

Precautions

Keep out of reach of children.

Brand IP Statement(s)

Biovea Premium quality guaranteed - since 2001

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Papaya Enzyme Chewable by BIOVEA label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Papaya Enzyme Chewable label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Papaya Enzyme Chewable by BIOVEA

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Servings per container100 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protease

No known
interactions
2 mg per serving

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), tr...

Protease monograph & interactions

Alpha-Amylase

2 mg per serving

Papain

Interacts with
2 drugs
15 mg per serving Form: Papaya

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food an...

Papain monograph & interactions

Other (inactive) ingredients: Fructose, Calcium Carbonate, Papaya flavor, Vegetable Stearin, Corn Starch, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Papaya Enzyme Chewable by BIOVEA Drug Interactions

Want to check YOUR meds against Papaya Enzyme Chewable?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Moderate

Ingredients driving the most interactions

Papain 2

Individual Drug Interactions

The ingredients in Papaya Enzyme Chewable interact with 2 drugs. Click any drug to see the details.

1 of the 3 ingredients in Papaya Enzyme Chewable interact with drugs. Each result below shows which ingredient is responsible. Papain

Each ingredient & the kinds of drugs it affects

For each ingredient in Papaya Enzyme Chewable with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Papain1 drug type · 2 drugs

Warfarin (Coumadin)

Theoretically, papain might increase the effects and side effects of warfarin.
In one case report, a patient previously stable on warfarin was found to have an international normalization ratio (INR) of 7.4, which was attributed to ingestion of a supplement containing papain from papaya extract.

Likelihood Possible Evidence D
Papain full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Papaya Enzyme Chewable, from the product label.

BIOVEA

See all BIOVEA products
Name
BIOVEA
Street Address
9160 E. Bahia Dr.
City
Scottsdale
State
AZ
ZipCode
85260
Web Address
www.biovea.com
Pharmacist Counseling Corner

Papaya Enzyme Chewable by BIOVEA: Common Questions

Does Papaya Enzyme Chewable by BIOVEA interact with any medications?
Yes. Based on its ingredients, Papaya Enzyme Chewable has a known interaction with 2 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Papaya Enzyme Chewable contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
The safety data advises against protease in pregnancy unless your doctor prescribes it, and concentrated papain should be avoided in pregnancy. During breastfeeding, there isn't enough reliable data for either ingredient to recommend use without medical advice. Talk with your doctor or pharmacist about whether this product is right for you.
What if I'm allergic to papaya?
Since papain comes from papaya, you should avoid this product if you have a known papaya allergy. Allergic reactions to papain can include itchy eyes, runny nose, sneezing, stomach cramps, sweating, and diarrhea. If you're sensitive to papaya, this isn't the right choice for you.
Will this help with digestion or muscle soreness?
The evidence for papain hasn't been established in our data for those uses — or for any use listed here. All the conditions it's been studied for (muscle soreness, dental cavities, cancer, shingles, parasites, and radiation skin damage) show insufficient reliable evidence, meaning the research so far doesn't back it up or rule it out. Talk with your doctor if you're looking for help with a specific health concern.
What are the common side effects?
Protease and papain are generally well tolerated, but some people experience digestive upset, allergic reactions, or both. Papain specifically can cause itchy eyes, runny nose, sneezing, stomach cramps, sweating, or diarrhea in people sensitive to it. High doses of papain may be unsafe and can cause severe stomach inflammation or esophageal damage.
Does this product have any fillers?
Yes, it contains several inactive ingredients: fructose, calcium carbonate, papaya flavor, vegetable stearin, corn starch, and magnesium stearate. These help hold the tablet together and give it flavor, but aren't the active enzymes.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Papaya Enzyme Chewable is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Papaya Enzyme Chewable label
Go deeper

The Full Monographs Behind Papaya Enzyme Chewable’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Papain

Interacts with 2 drugs

Papain is a protein-digesting enzyme from the papaya plant that is used in digestive supplements and some topical products. While it has clear food and laboratory uses, strong human evidence...

Read the full Papain monograph →
Sources

Sources & How We Checked

Papaya Enzyme Chewable's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Papain 11 references
  1. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  2. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). Drug Saf 1997;17:342-56.
  3. Shuttleworth D, Hill S, Marks R, Connelly DM. Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 1988;119:535-40.
  4. Mansfield LE, Ting S, Haverly RW, Yoo TJ. The incidence and clinical implications of hypersensitivity to papain in an allergic population, confirmed by blinded oral challenge. Ann Allergy 1985;55:541-3.
  5. Martin, T., Uhder, K., Kurek, R., Roeddiger, S., Schneider, L., Vogt, H. G., Heyd, R., and Zamboglou, N. Does prophylactic treatment with proteolytic enzymes reduce acute toxicity of adjuvant pelvic irradiation? Results of a double-blind randomized trial PubMed
  6. Walker-Renard, P. Update on the medicinal management of phytobezoars. Am J Gastroenterol. 1993;88(10):1663-1666.
  7. Tymoszuk D, Wiszniewska M, Walusiak-Skorupa J. Papain-induced occupational rhinoconjunctivitis and asthma - A case report. Med Pr 2016;67(1):109-12. PubMed
  8. Soto-Mera MT, López-Rico MR, Filgueira JF, et al. Occupational allergy to papain. Allergy 2000;55(10):983-4. PubMed
  9. Tarlo SM, Shaikh W, Bell B, et al. Papain-induced allergic reactions. Clin Allergy 1978;8(3):207-15. PubMed
  10. Baur X, König G, Bencze K, Fruhmann G. Clinical symptoms and results of skin test, RAST and bronchial provocation test in thirty-three papain workers: Evidence for strong immunogenic potency and clinically relevant proteolytic e?ects of airborne papain. C
  11. Novey HS, Keenan WJ, Fairshter RD, Wells ID, Wilson AF, Culver BD. Pulmonary disease in workers exposed to papain: clinico-physiological and immunological studies. Clin Allergy 1980;10(6):721-31. PubMed

See these in context on the Papain monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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