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Dietary supplement

Pau d'Arco Ingredients & Drug Interactions

by Herb Pharm

Pau d'Arco label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau d'Arco against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau d'Arco is a dietary supplement by Herb Pharm with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco inner bark (Handroanthus impetiginosus) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau d'Arco by Herb Pharm

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau d'Arco by Herb Pharm — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau d'Arco by Herb Pharm

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: pau d'arco inner bark extract from Handroanthus impetiginosus. It also includes distilled water, certified organic cane alcohol, and certified organic vegetable glycerin as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pau D'arco product and its label doesn't state a use — see Pau D'arco's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pau d'arco's benefits is not yet established in reliable trials. We have insufficient data to rate its use for cancer, peptic ulcers, wound healing, or dysmenorrhea.

That doesn't mean it doesn't work—it means human studies haven't been done or weren't conclusive enough to make a claim.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Human safety data for pau d'arco is limited, and the supplement may cause side effects at higher doses. At doses of lapachol above 1.5 grams daily, it can cause anemia, increased bleeding risk, severe nausea, vomiting, and diarrhea.

Occupational exposure to pau d'arco sawdust has caused asthma and skin reactions; oral use is different, but it underscores the plant's potency. During pregnancy, the safety data advises against use—the supplement is rated possibly unsafe due to possible harm to a developing baby and lack of safety information.

There isn't enough data to know if it's safe while breastfeeding, so it's best to avoid it then too. Talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or breastfeeding.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check this supplement before taking it if you're on any blood thinner or antiplatelet drug—including prescription anticoagulants, aspirin, or NSAIDs like ibuprofen. Pau d'arco has a documented moderate-severity interaction with these medications and may increase your bleeding risk.

Your doctor or pharmacist can help you decide if it's safe for you.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'Arco may be of interest to those exploring traditional herbal remedies, but the evidence for its effectiveness isn't established yet, and it carries a moderate bleeding risk with blood thinners. It's not recommended during pregnancy or while breastfeeding.

If you take any anticoagulant or antiplatelet medication, or if you're pregnant or breastfeeding, talk with your doctor or pharmacist before starting it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau d'Arco, straight from the product label.

Brand Herb Pharm
Barcode (UPC) 090800000058
Net contents 1 fl. Oz.; 30 mL
Market status On market
Date entered into DSLD Feb 25, 2019
DSLD ID 199912
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau d'Arco by Herb Pharm, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
0.7 mL
Maximum serving Sizes:
0.7 mL
Servings per container
42
UPC/BARCODE
090800000058
IngredientAmount% DV
Pau d'Arco inner bark (Handroanthus impetiginosus) extract704 mg--

Other ingredients: distilled Water, certified organic Cane Alcohol, certified organic Vegetable Glycerin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use Shake well before using Add 1 full squeeze of the dropper bulb to 2 oz. of water or juice, 2 to 4 times per day. Best taken between meals.

Precautions

Keep out of the reach of children

Storage

Store away from heat & light

General

013

Formula

Handroanthus impetiginosus

Pau d'Arco liquid extract (Lapacho - Taheebo)

General Statements

Cleanse & Detoxify

Dry herb / menstruum ratio: 1:4

FDA Statement of Identity

Herbal Supplement

Formulation

Gluten-free

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau d'Arco by Herb Pharm label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau d'Arco label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau d'Arco by Herb Pharm

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size0.7 mL Dosage formLiquid Servings per container42 Amounts shown are per serving.

Pau d'Arco inner bark (Handroanthus impetiginosus) extract

Interacts with
122 drugs
704 mg per serving

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco inner bark (Handroanthus impetiginosus) extract monograph & interactions

Other (inactive) ingredients: Distilled Water, Certified organic Cane Alcohol, Certified organic Vegetable Glycerin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau d'Arco by Herb Pharm Drug Interactions

Want to check YOUR meds against Pau d'Arco?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco inner bark (Handroanthus impetiginosus) extract 122

Individual Drug Interactions

The ingredients in Pau d'Arco interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau d'Arco interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco inner bark (Handroanthus impetiginosus) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau d'Arco with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco inner bark (Handroanthus impetiginosus) extract1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco inner bark (Handroanthus impetiginosus) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau d'Arco, from the product label.

Herb Pharm

See all Herb Pharm products
Name
Herb Pharm
City
Williams
State
OR
ZipCode
97544
Phone Number
800-348-4372
Web Address
www.herb-pharm.com
Pharmacist Counseling Corner

Pau d'Arco by Herb Pharm: Common Questions

Does Pau d'Arco by Herb Pharm interact with any medications?
Yes. Based on its ingredients, Pau d'Arco has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau d'Arco contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is pau d'arco used for?
Traditionally, pau d'arco has been used for cancer, peptic ulcers, wound healing, and period pain (dysmenorrhea). However, we don't have reliable human evidence yet to confirm it works for any of these conditions.
Can I take this if I'm on aspirin or ibuprofen?
Not without checking first. Pau d'arco may increase bleeding risk when combined with aspirin, ibuprofen, or other antiplatelet and anticoagulant drugs. Talk with your doctor or pharmacist before adding it to your routine.
Is pau d'arco safe during pregnancy?
No. The safety data advises against use during pregnancy due to possible harm to a developing baby and lack of safety information. If you're pregnant or planning to become pregnant, speak with your doctor or pharmacist.
What are the side effects at normal doses?
Human safety data is limited. At higher doses (lapachol above 1.5 grams daily), it may cause anemia, bleeding risk, severe nausea, vomiting, and diarrhea. At typical doses, side effects aren't well documented.
Can I breastfeed while taking this?
There isn't enough safety information to know either way. It's best to avoid it while breastfeeding and talk with your doctor or pharmacist for personalized advice.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau d'Arco label
Go deeper

The Full Monographs Behind Pau d'Arco’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau d'Arco's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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