PEA 400 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking PEA 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PEA 400 mg is a dietary supplement by Harvest Naturals with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of PEA 400 mg by Harvest Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: palmitoylethanolamide (PEA), a compound naturally found in the body that research has explored for joint and nerve-related concerns. The capsule also holds rice flour and cellulose as inactive ingredients to form and stabilize the tablet.
Does it work?
Moderate evidence
The evidence for palmitoylethanolamide is mixed. Research suggests it may be helpful for osteoarthritis, though the data isn't conclusive.
For spinal cord injury, current evidence points toward it being ineffective. For allergic rhinitis (hay fever), autism spectrum disorder, bipolar disorder, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), there isn't enough reliable evidence yet to say whether it works or doesn't.
How safe is it?
Well-documented data
Palmitoylethanolamide appears to be generally well tolerated in studies, but long-term safety data remain limited. The most commonly reported side effect in trials is nausea.
Rarely, users have reported drowsiness, a floating sensation, or mild, temporary digestive upset. Safety data during pregnancy and breastfeeding are insufficient — the product facts advise against use in both cases because there isn't enough information to know either way.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient we could check. Even so, confirm with your own doctor or pharmacist before taking this product alongside any medication, just to be certain.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
PEA 400 mg may be worth considering if you're exploring options for osteoarthritis, though the evidence is not definitive. If you're pregnant, breastfeeding, or dealing with a condition for which the data is limited, talk with your doctor or pharmacist before taking it — they can help weigh whether it fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PEA 400 mg, straight from the product label.
| Brand | Harvest Naturals |
|---|---|
| Barcode (UPC) | 810039266021 |
| Net contents | 400 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 321626 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PEA 400 mg by Harvest Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Palmitoylethanolamide | 400 mg | -- |
Other ingredients: Rice Flour, Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: As a dietary supplement, take 1 capsule (~400 mg). Taken once daily, or as directed by a qualified health professional.
Storage
Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.
Formulation
Allergens: This product contains no soy, dairy & byproducts, eggs, fish, shellfish, wheat, gluten, tree nuts, or sesame seeds.
Precautions
Warning: Keep out of the reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s).
Always consult with a qualified health physician before taking any new dietary supplement.
FDA Disclaimer Statement
These statements have not been evaluated by the Food & Drug Administration. this product is not intended to diagnose, treat, cure or prevent any disease.
Formula
Palmitoylethanolamide 400mg
FDA Statement of Identity
Dietary Supplement
General Statements
Scan for COA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PEA 400 mg by Harvest Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PEA 400 mg by Harvest Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container400 Amounts shown are per serving.
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsOther (inactive) ingredients: Rice Flour, Cellulose. These complete the product’s ingredient list but are not active constituents.
PEA 400 mg by Harvest Naturals Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in PEA 400 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for PEA 400 mg, from the product label.
Harvest Naturals
See all Harvest Naturals products- Name
- Supplement Partners, LLC
- Street Address
- 1607 W. Whispering Wind Dr.
- City
- Phoenix
- State
- AZ
- ZipCode
- 85085
- Web Address
- www.HRsupplements.com
PEA 400 mg by Harvest Naturals: Common Questions
Does PEA 400 mg by Harvest Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is palmitoylethanolamide (PEA)?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I notice?
Does this work for hay fever?
Will this interact with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PEA 400 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PEA 400 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
PEA 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 5 references
- Bacci C, Cassetta G, Emanuele B, Berengo M. Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery. ISRN Surg. 2011;2011:917350. PubMed
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC