Palmitoylethanolamide (PEA) 400 mg Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Palmitoylethanolamide (PEA) 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Palmitoylethanolamide (PEA) 400 mg is a dietary supplement by Harvest Naturals with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Palmitoylethanolamide (PEA) 400 mg by Harvest Naturals
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: palmitoylethanolamide (PEA), a naturally occurring compound. The capsule also holds cellulose and rice flour as inactive ingredients to bind and fill the capsule.
Does it work?
Moderate evidence
PEA is possibly effective for osteoarthritis. For spinal cord injury, it's rated possibly ineffective.
For allergic rhinitis (hay fever), autism spectrum disorder, bipolar disorder, and amyotrophic lateral sclerosis (ALS), the evidence is too limited or unreliable for us to rate its effectiveness — we simply don't have enough data to know either way.
How safe is it?
Well-documented data
PEA is generally well tolerated in studies, though long-term safety data are limited. The most common side effect from taking it by mouth is nausea.
A small number of people have reported drowsiness, a floating sensation, or mild stomach discomfort, though these are rare and typically temporary. The safety data advises against use during pregnancy and while breastfeeding — there isn't enough information to know it's safe in those situations.
Meds to double-check
No known interactions
No interactions are documented in our data for PEA. That said, absence of documented interactions is not proof none exist — if you're on any medications, ask your pharmacist to double-check before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
If you're looking at PEA for osteoarthritis, there's some evidence it may help. For other conditions, the evidence is either too weak or hasn't been studied enough to say.
Because long-term safety data are limited and it's not recommended in pregnancy or while breastfeeding, talk with your doctor or pharmacist before starting it to make sure it fits your situation.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Palmitoylethanolamide (PEA) 400 mg, straight from the product label.
| Brand | Harvest Naturals |
|---|---|
| Barcode (UPC) | 810039261668 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 22, 2023 |
| DSLD ID | 287085 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Palmitoylethanolamide (PEA) 400 mg by Harvest Naturals, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Palmitoylethanolamide | 400 mg | -- |
Other ingredients: Cellulose, Rice Flour
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Natural pain relief
Allergens: This product contains NO soy, dairy & byproducts, eggs, fish, shellfish, wheat, gluten, tree nuts, or sesame seeds.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 1 capsule (~400 mg). Taken once daily, or as directed by a qualified health professional.
General Statements
Scan for code
Storage
Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.
Precautions
Allergens: This product contains NO soy, dairy & byproducts, eggs, fish, shellfish, wheat, gluten, tree nuts, or sesame seeds.
Warning: Keep out of reach of children.
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s). Always consult with a qualified health physician before taking any new dietary supplement.
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions and/or taking prescription drug(s) or OTC medication(s). Always consult with a qualified health physician before taking any new dietary supplement.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Palmitoylethanolamide (PEA) 400 mg by Harvest Naturals label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Palmitoylethanolamide (PEA) 400 mg by Harvest Naturals
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsOther (inactive) ingredients: Cellulose, Rice Flour. These complete the product’s ingredient list but are not active constituents.
Palmitoylethanolamide (PEA) 400 mg by Harvest Naturals Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Palmitoylethanolamide (PEA) 400 mg. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Palmitoylethanolamide (PEA) 400 mg, from the product label.
Harvest Naturals
See all Harvest Naturals products- Name
- Supplement Partners LLC
- Street Address
- 1607 W. Whispering Wind Dr.
- City
- Phoenix
- State
- AZ
- ZipCode
- 85085
- Web Address
- www.HRsupplements.com
Palmitoylethanolamide (PEA) 400 mg by Harvest Naturals: Common Questions
Does Palmitoylethanolamide (PEA) 400 mg by Harvest Naturals interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take PEA if I'm pregnant or breastfeeding?
What's the most common side effect?
Will PEA help with my osteoarthritis?
Is PEA safe to use long-term?
Does PEA interact with any medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Palmitoylethanolamide (PEA) 400 mg is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Palmitoylethanolamide (PEA) 400 mg’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Palmitoylethanolamide (PEA) 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 5 references
- Bacci C, Cassetta G, Emanuele B, Berengo M. Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery. ISRN Surg. 2011;2011:917350. PubMed
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC