Discomfort Relief Berry Flavor Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Discomfort Relief Berry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Discomfort Relief Berry Flavor is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Discomfort Relief Berry Flavor by Life Extension
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has one active ingredient: palmitoylethanolamide (PEA), a naturally occurring compound in your body thought to support comfort and ease of movement. The rest is inactive ingredients — maltodextrin, mannitol, microcrystalline cellulose, xylitol, red beet, stearate, berry flavor, citric acid, stearic acid, silica, stevia extract, and starch — which give the tablet its form and taste.
Does it work?
Moderate evidence
The data supports PEA as possibly effective for osteoarthritis discomfort. For spinal cord injury, the evidence suggests it may not be effective.
For migraine headache, carpal tunnel syndrome, autism spectrum disorder, and cannabis use disorder, we don't yet have enough reliable evidence to rate how well it works. If you're considering this for osteoarthritis, the evidence is your strongest lead — for other uses, talk with your pharmacist about what research exists outside our data.
How safe is it?
Well-documented data
PEA is generally well tolerated in studies, though long-term safety information is limited. The most common side effect reported orally is nausea, which occurs rarely and mildly.
There isn't enough safety data to use this product during pregnancy or while breastfeeding — the facts advise against both. If you're pregnant, nursing, or planning to become pregnant, talk with your doctor or pharmacist before starting.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient in this product. That said, if you take any prescription medications, run them through the checker below before you start — documented absence isn't the same as proven safety.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
If you're dealing with osteoarthritis discomfort and want an option with minimal documented side effects, this is worth a conversation with your pharmacist. Pregnant or nursing folks should skip it.
Because long-term safety data are sparse, it's a reasonable time to check in with your pharmacist about how long you plan to take it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Discomfort Relief Berry Flavor, straight from the product label.
| Brand | Life Extension |
|---|---|
| Barcode (UPC) | 737870230366 |
| Net contents | 60 Vegetarian Chewable Tablet(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 328415 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Discomfort Relief Berry Flavor by Life Extension, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Palmitoylethanolamide | 600 mg | -- |
Other ingredients: Maltodextrin, Mannitol, Microcrystalline Cellulose, Xylitol, Red Beet, Stearate, Berry flavor, Citric Acid, Stearic Acid, Silica, Stevia extract, Starch
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Scan for product info
Precautions
Read the entire label and follow the directions carefully prior to use. Do not swallow tablets whole.
Warnings: Keep out of reach of children.
Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
To report a serious adverse event or obtain product information, contact 1-866-280-2852.
Suggested/Recommended/Usage/Directions
Directions: Chew one (1) tablet once or twice daily, or as recommended by a healthcare practitioner. Do not swallow tablets whole.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Gluten Free Non GMO Le Certified
For occasional minor pain and discomfort
Seals/Symbols
Non GMO Le Certified
FDA Statement of Identity
Dietary Supplement
Storage
Store tightly closed in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Discomfort Relief Berry Flavor by Life Extension label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Discomfort Relief Berry Flavor by Life Extension
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsOther (inactive) ingredients: Maltodextrin, Mannitol, Microcrystalline Cellulose, Xylitol, Red Beet, Stearate, Berry flavor, Citric Acid, Stearic Acid, Silica, Stevia extract, Starch. These complete the product’s ingredient list but are not active constituents.
Discomfort Relief Berry Flavor by Life Extension Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Discomfort Relief Berry Flavor. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Discomfort Relief Berry Flavor, from the product label.
Life Extension
See all Life Extension products- Name
- Quality Supplements and Vitamins, Inc.
- City
- Ft. Lauderdale
- State
- FL
- ZipCode
- 33309
- Phone Number
- 1-866-280-2852
- Web Address
- LifeExtension.com
Discomfort Relief Berry Flavor by Life Extension: Common Questions
Does Discomfort Relief Berry Flavor by Life Extension interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take while I'm pregnant?
Can I take this while breastfeeding?
What is palmitoylethanolamide (PEA)?
What are the side effects?
Does this really work for osteoarthritis?
Can I take this with my other medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Discomfort Relief Berry Flavor is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Discomfort Relief Berry Flavor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Discomfort Relief Berry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 4 references
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC