Interactions on record — worth a quick check against your medications. Based on 7 of 9 ingredients. Check your meds →
Dietary supplement

Phospholipid Synergy Ingredients & Drug Interactions

by Return Healthy

Phospholipid Synergy label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phospholipid Synergy against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Phospholipid Synergy is a dietary supplement by Return Healthy with 9 active ingredients. Its ingredients are commonly taken for digestive and gut health, prebiotic to support good bacteria, constipation relief.Based on those ingredients, 981 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin E, Phosphatidylserine, Shilajit Extract, Powder. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Phospholipid Synergy by Return Healthy

Ask about any prescription or over-the-counter medication and we check it for interactions with Phospholipid Synergy by Return Healthy — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Phospholipid Synergy by Return Healthy

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 9 of its 9 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Phospholipid Synergy contains 9 active ingredients centered on phospholipids—fats that are natural components of cell membranes. The formula includes phosphatidylserine, phosphatidylcholine, alpha-glycerylphosphorylcholine (alpha-GPC), phosphatidylethanolamine, and phosphatidylinositol.

These are paired with fructooligosaccharides (a prebiotic fiber), palmitoylethanolamide (PEA, a naturally occurring fatty acid compound), vitamin E, and shilajit extract. The powder also contains soy phospholipids and maltodextrin as inactive ingredients.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Strong

Strong clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Vitamin E deficiency — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Ataxia with vitamin E deficiency (AVED) — rated "Effective" (Vitamin E) (Natural Medicines).
  • On file: Age-related cognitive decline — rated "Possibly Effective" (Phosphatidylserine) (Natural Medicines).
  • On file: Alzheimer disease — rated "Possibly Effective" (Alpha-gpc) (Natural Medicines).
  • On file: Beta-thalassemia — rated "Possibly Effective" (Vitamin E) (Natural Medicines).

Evidence for this product's effects is mixed and often limited. Phosphatidylserine is possibly effective for age-related cognitive decline and Alzheimer disease.

Alpha-GPC is possibly effective for Alzheimer disease. Vitamin E is effective for vitamin E deficiency and possibly effective for Alzheimer disease and other conditions.

Palmitoylethanolamide is possibly effective for osteoarthritis. Phosphatidylcholine is possibly effective for ulcerative colitis.

For most other uses listed—including ADHD, athletic performance, general cognitive function, and sexual dysfunction—the evidence we hold is insufficient to rate effectiveness, meaning research has not yet established whether these ingredients work for those purposes.

The evidence, ingredient by ingredient Fructo-oligosaccharides (fos) Palmitoylethanolamide (pea) Phosphatidylserine Alpha-gpc Phosphatidylcholine Vitamin E Shilajit

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most ingredients are generally well tolerated in studies, though long-term safety data are often limited. Common mild side effects from individual ingredients include gastrointestinal upset (bloating, gas, nausea, diarrhea), headache, and insomnia.

Vitamin E at high doses carries a rare but serious risk of bleeding and hemorrhagic stroke. Alpha-GPC use for at least 2 months has been rarely associated with elevated stroke risk.

Shilajit poses a rare allergy risk and must be a purified, tested product to avoid heavy metal contamination. Pregnancy and breastfeeding: safety data are insufficient for most ingredients.

Palmitoylethanolamide and phosphatidylserine should be avoided in pregnancy and while breastfeeding due to lack of safety information. Shilajit should likewise be avoided in both pregnancy and breastfeeding.

Phosphatidylcholine is needed in pregnancy but supplement safety beyond food sources is not well studied—check with your doctor. Data on the remaining ingredients during pregnancy and lactation are not on file.

Side effects, ingredient by ingredient Fructo-oligosaccharides (fos) Palmitoylethanolamide (pea) Phosphatidylserine Alpha-gpc Phosphatidylcholine Vitamin E Shilajit

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 4 of the 7 matched ingredients can interact with medications — Vitamin E, Phosphatidylserine, Alpha-gpc, Shilajit.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; cancer treatments; diabetes medications.
  • For scale: 982 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Phospholipid Synergy, check with your pharmacist if you take any of these: blood thinners or antiplatelet drugs (anticoagulants and antiplatelets—Moderate risk), antidiabetes drugs (Moderate risk), anticholinergic or cholinergic medications (Moderate risk), chemotherapy drugs such as alkylating agents or antitumor antibiotics (Moderate risk), cyclosporine, niacin, CYP3A4 substrate drugs, selumetinib, or scopolamine patches (Moderate or Minor risk).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with strong clinical evidence behind its ingredients' uses. Moderate medication interactions have been identified, and safety information is well characterized.

This product is mainly aimed at cognitive support and is generally well tolerated by most people at recommended doses. However, if you take anticoagulants, antiplatelet drugs, diabetes medications, anticholinergic or cholinergic drugs, or certain chemotherapy agents, you should check your exact medications with our tool before starting.

If you're pregnant or breastfeeding, talk with your doctor or pharmacist first—safety data are sparse for several ingredients.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phospholipid Synergy, straight from the product label.

Brand Return Healthy
Barcode (UPC) 860008157416
Net contents 9.5 Ounce(s); 270 Gram(s)
Market status On market
Date entered into DSLD Jul 25, 2024
DSLD ID 313318
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phospholipid Synergy by Return Healthy, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4.5 Gram(s)
Maximum serving Sizes:
4.5 Gram(s)
Servings per container
60
UPC/BARCODE
860008157416
IngredientAmount% DV
Fructooligosaccharides90 mg--
Palmitoylethanolamide150 mg--
Phosphatidylserine55 mg--
Alpha-Glycerylphosphorylcholine75 mg--
Phosphatidylcholine1500 mg--
Vitamin E45 mg--
Phosphatidylethanolamine600 mg--
Phosphatidylinositol415 mg--
Shilajit Extract, Powder90 mg--

Other ingredients: Soy Phospholipids, Maltodextrin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take 1 scoop (4.5 grams) twice daily or as directed by your healthcare practitioner. Blend, shake, or briskly stir into 8 fluid ounces of room temperature liquid.

Formulation

Notice: This is a natural product that may exhibit color, taste, and density variations from lot to lot.

Brain structure and function care Liver & nerve health Repair nutrients

Gluten free, dairy free, and vegan

Gluten free, dairy free, and vegan

Precautions

Do not use if security seal is broken or missing.

Keep out of reach of children.

Caution: Individuals who are pregnant or lactating should consult with their health care practitioner before using this product.

Storage

Storage: Keep closed in a cool, dry place away from direct light.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to treat, diagnose, cure or prevent any disease.

General Statements

For more information, visit ReturnHealthy.com

ReturnHealthy Empowered Wellness

Formula

Cell membrane phospholipids

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phospholipid Synergy by Return Healthy label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phospholipid Synergy label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phospholipid Synergy by Return Healthy

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size4.5 Gram(s) Dosage formPowder Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Fructooligosaccharides

No known
interactions
90 mg per serving

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are gener...

Fructooligosaccharides monograph & interactions

Palmitoylethanolamide

No known
interactions
150 mg per serving

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...

Palmitoylethanolamide monograph & interactions

Phosphatidylserine

Interacts with
219 drugs
55 mg per serving

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Alpha-Glycerylphosphorylcholine

Interacts with
16 drugs
75 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-Glycerylphosphorylcholine monograph & interactions

Phosphatidylcholine

No known
interactions
1500 mg per serving

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, bu...

Phosphatidylcholine monograph & interactions

Vitamin E

Interacts with
764 drugs
45 mg per serving Form: Vitamin E Succinate

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correc...

Vitamin E monograph & interactions

Phosphatidylethanolamine

600 mg per serving

Phosphatidylinositol

415 mg per serving

Shilajit Extract, Powder

Interacts with
86 drugs
90 mg per serving Form: Fulvic Acid

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and v...

Shilajit Extract, Powder monograph & interactions

Other (inactive) ingredients: Soy Phospholipids, Maltodextrin. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phospholipid Synergy by Return Healthy Drug Interactions

Want to check YOUR meds against Phospholipid Synergy?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
981Drugs
980 Moderate 1 Minor

Ingredients driving the most interactions

Vitamin E 764
Phosphatidylserine 219
Shilajit Extract, Powder 86
Alpha-Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Phospholipid Synergy interact with 981 drugs. Click any drug to see the details.

4 of the 9 ingredients in Phospholipid Synergy interact with drugs. Each result below shows which ingredient is responsible. Vitamin E Phosphatidylserine Shilajit Extract, Powder Alpha-Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Phospholipid Synergy with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin E8 drug types · 764 drugs

Alkylating Agents

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of alkylating agents.
There's concern that antioxidants could reduce the activity of chemotherapy drugs which generate free radicals, such as cyclophosphamide, chlorambucil, carmustine, busulfan, and thiotepa. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Anticoagulant/Antiplatelet Drugs

Concomitant use of vitamin E and anticoagulant or antiplatelet agents might increase the risk of bleeding.
Vitamin E seems to inhibit of platelet aggregation and antagonize the effects of vitamin K-dependent clotting factors. These effects appear to be dose-dependent, and are probably only likely to be clinically significant with doses of at least 800 units daily. Mixed tocopherols, such as those found in food, might have a greater antiplatelet effect than alpha-tocopherol. RRR alpha-tocopherol (natural vitamin E) 1000 IU daily antagonizes vitamin K-dependent clotting factors. Advise patients to avoid high doses of vitamin E, especially in people with low vitamin K intake or other risk factors for bleeding.

Likelihood Possible Evidence B
Antitumor Antibiotics

Theoretically, antioxidant effects of vitamin E might reduce the effectiveness of antitumor antibiotics.
There's concern that antioxidants could reduce the activity of antitumor antibiotic drugs such as doxorubicin, which generate free radicals. However, some researchers theorize that antioxidants might make chemotherapy more effective by reducing oxidative stress that might interfere with apoptosis (cell death) of cancer cells. More evidence is needed to determine what effect, if any, antioxidants such as vitamin E have on chemotherapy involving antitumor antibiotics. Advise patients to consult their oncologist before using vitamin E supplements, especially in high doses.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

A specific form of vitamin E might increase absorption and levels of cyclosporine.
There is some evidence that one specific formulation of vitamin E (D-alpha-tocopheryl-polyethylene glycol-1000 succinate, TPGS, tocophersolan, Liqui-E) might increase absorption of cyclosporine. This vitamin E formulation forms micelles which seems to increase absorption of cyclosporine by 40% to 72% in some patients. However, this interaction is unlikely to occur with the usual forms of vitamin E.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, vitamin E might induce metabolism of CYP3A4, possibly reducing the levels CYP3A4 substrates.
Vitamin E appears to bind with the nuclear receptor, pregnane X receptor (PXR), which results in increased expression of CYP3A4. Although the clinical significance of this is not known, use caution when considering concomitant use of vitamin E and other drugs affected by these enzymes.

Likelihood Possible Evidence D
Selumetinib (Koselugo)

Taking selumetinib with vitamin E can result in a total daily dose of vitamin E that exceeds safe limits and therefore might increase the risk of bleeding.
Selumetinib contains 48-54 IU vitamin E per capsule. The increased risk of bleeding with vitamin E appears to be dose-dependent. Be cautious when using selumetinib in combination with supplemental vitamin E, especially in patients at higher risk of bleed, such as those with chronic conditions and those taking antiplatelet drugs.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Using vitamin E with warfarin might increase the risk of bleeding.
Due to interference with production of vitamin K-dependent clotting factors, use of more than 400 IU of vitamin E daily with warfarin might increase prothrombin time (PT), INR, and the risk of bleeding,. At a dose of 1000 IU per day, vitamin E can antagonize vitamin K-dependent clotting factors even in people not taking warfarin. Limited clinical evidence suggests that doses up to 1200 IU daily may be used safely by patients taking warfarin, but this may not be applicable in all patient populations.

Likelihood Possible Evidence B
Niacin

Vitamin E might decrease the beneficial effects of niacin on high-density lipoprotein (HDL) cholesterol levels.
A combination of niacin and simvastatin (Zocor) effectively raises high-density lipoprotein (HDL) cholesterol levels in people with coronary disease and low HDL levels. Clinical research shows that taking a combination of antioxidants (vitamin C, vitamin E, beta-carotene, and selenium) along with niacin and simvastatin (Zocor) attenuates this rise in HDL, specifically the HDL-2 and apolipoprotein A1 fractions, by more than 50%. Vitamin E alone combined with a statin does not seem to decrease HDL levels. It is not known whether the adverse effect on HDL is due to one of the other antioxidants or to the combination. It also is not known whether it will occur in other patient populations.

Likelihood Possible Evidence A
Vitamin E full monograph & interactions

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
Phosphatidylserine full monograph & interactions

Shilajit Extract, Powder1 drug type · 86 drugs

Antidiabetes Drugs

Taking shilajit with antidiabetes drugs might increase the risk of hypoglycemia.
Most human and animal research shows that shilajit can decrease fasting plasma glucose levels. In an animal model, shilajit 100 mg per kg daily enhanced the glucose-lowering ability of both glibenclamide and metformin when given in combination over a 4 week period. Monitor blood glucose levels closely. Dose adjustments might be necessary.

Likelihood Possible Evidence D
Shilajit Extract, Powder full monograph & interactions

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Phospholipid Synergy, from the product label.

Return Healthy

See all Return Healthy products
Name
Return Healthy LLC
Street Address
230 N 1680 E, Suite G-1
City
St George
State
Utah
ZipCode
84790
Phone Number
(435) 213-4801
Web Address
ReturnHealthy.com
Pharmacist Counseling Corner

Phospholipid Synergy by Return Healthy: Common Questions

Does Phospholipid Synergy by Return Healthy interact with any medications?
Yes. Based on its ingredients, Phospholipid Synergy has a known interaction with 981 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phospholipid Synergy contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What does phosphatidylserine actually do?
Phosphatidylserine is a natural phospholipid found in cell membranes. In this product, it's included for cognitive support—research shows it's possibly effective for age-related cognitive decline and Alzheimer disease. It's thought to support brain cell function and structure.
Is this safe if I'm trying to get pregnant or am pregnant?
No single answer applies here. Palmitoylethanolamide, phosphatidylserine, and shilajit should be avoided in pregnancy due to insufficient safety data. Phosphatidylcholine is needed in pregnancy, but supplement safety beyond what you get from food is not well studied—check with your doctor before taking this product if you're pregnant or planning pregnancy.
What side effects might I notice?
The most common are gastrointestinal—bloating, gas, flatulence, nausea, diarrhea, or abdominal upset. Headache and insomnia are also reported. Most are mild. At high doses, vitamin E can rarely increase bleeding risk.
Does it actually work for memory and brain health?
Some ingredients show promise. Phosphatidylserine and alpha-GPC are possibly effective for Alzheimer disease, and vitamin E is possibly effective for age-related cognitive decline. For other cognitive claims, the evidence we have is not yet established as effective.
Can I take this with my diabetes medication?
Not without checking first. Shilajit in this product can lower blood sugar and may enhance the effect of antidiabetes drugs, increasing your risk of low blood sugar (hypoglycemia). Talk to your pharmacist before combining them.
Is this powder formula free of fillers?
No—it contains maltodextrin as an inactive ingredient along with soy phospholipids. If you need to avoid these, this product may not be right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phospholipid Synergy is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phospholipid Synergy label
Go deeper

The Full Monographs Behind Phospholipid Synergy’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Palmitoylethanolamide (pea)

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it may help certain types of chronic and ne...

Read the full Palmitoylethanolamide (pea) monograph → Herb & supplement monograph

Phosphatidylserine

Interacts with 219 drugs

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...

Read the full Phosphatidylserine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Phosphatidylcholine

Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...

Read the full Phosphatidylcholine monograph → Herb & supplement monograph

Vitamin E

Interacts with 764 drugs

Vitamin E is an essential fat-soluble vitamin and antioxidant that most people get in adequate amounts from a normal diet. Supplements can help correct a true deficiency, but high-dose vitam...

Read the full Vitamin E monograph → Herb & supplement monograph

Shilajit

Interacts with 86 drugs

Shilajit is a sticky, tar-like substance found in rocks of mountain ranges like the Himalayas, used in traditional Ayurvedic medicine for energy and vitality. Human evidence is limited and m...

Read the full Shilajit monograph →
Sources

Sources & How We Checked

Phospholipid Synergy's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 110 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Fructo-oligosaccharides (fos) 6 references
  1. Briet F, et al. Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. Eur J Clin Nutr 1995;49:501-7.
  2. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria in healthy humans. J Nutr 1999;129:113-6. PubMed
  3. Cummings JH, Macfarlane GT, Englyst HN. Prebiotic digestion and fermentation. Am J Clin Nutr 2001;73:415S-420S. PubMed
  4. Souza DDS, Tahan S, Weber TK, Araujo-Filho HB, de Morais MB. Randomized, double-blind, placebo-controlled parallel clinical trial assessing the effect of fructooligosaccharides in infants with constipation. Nutrients. 2018;10(11). pii: E1602. PubMed
  5. Andermann TM, Fouladi F, Tamburini FB, et al. A Fructo-Oligosaccharide Prebiotic Is Well Tolerated in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation: A Phase I Dose-Escalation Trial. Transplant Cell Ther 2021;27(11):932. PubMed
  6. Dou Y, Yu X, Luo Y, Chen B, Ma D, Zhu J. Effect of Fructooligosaccharides Supplementation on the Gut Microbiota in Human: A Systematic Review and Meta-Analysis. Nutrients 2022;14(16):3298. PubMed

See these in context on the Fructo-oligosaccharides (fos) monograph →

Palmitoylethanolamide (pea) 4 references
  1. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
  2. Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
  3. Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
  4. Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed

See these in context on the Palmitoylethanolamide (pea) monograph →

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
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Alpha-gpc 4 references
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Phosphatidylcholine 15 references
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Vitamin E 64 references
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Shilajit 8 references
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  7. Jafari M, Forootanfar H, Ameri A, et al. Antioxidant, cytotoxic and hyperalgesia-suppressing activity of a native Shilajit obtained from Bahr Aseman mountains. Pak J Pharm Sci 2019;32(5):2167-2173. DOI
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