Bio CoQ10 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Bio CoQ10 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Bio CoQ10 is a dietary supplement by Return Healthy with 1 active ingredient. Its ingredients are commonly taken for heart health, statin-related muscle aches, migraine prevention.Based on those ingredients, 198 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Coenzyme Q10, Natural. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Bio CoQ10 by Return Healthy
Ask about any prescription or over-the-counter medication and we check it for interactions with Bio CoQ10 by Return Healthy — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Bio CoQ10 by Return Healthy
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Bio CoQ10 is a single-ingredient supplement containing coenzyme Q10 derived from natural sources in softgel form. Coenzyme Q10 is a compound your body produces naturally and uses to generate energy in your cells; it also acts as an antioxidant.
The softgel also contains inactive ingredients including medium-chain triglycerides, sunflower lecithin, vitamin E, mixed tocopherols, gelatin, purified water, glycerine, and annatto for color.
Does it work?
Strong evidence
The evidence supporting coenzyme Q10 is strongest for replacing low CoQ10 levels in the body — that's rated likely effective. For other conditions, the data is more limited.
It's possibly effective for fibromyalgia, migraine headaches, congestive heart failure, and diabetic neuropathy — meaning there's some promising research, but we don't yet have enough to be certain. If you're interested in this supplement for one of those uses, talk it over with your doctor about whether it makes sense for you.
How safe is it?
Well-documented data
Coenzyme Q10 is generally well tolerated when taken as directed. The most common side effects — affecting less than 1% of people — are mild gastrointestinal symptoms like stomach discomfort, nausea, diarrhea, or heartburn; dividing larger daily doses (above 100 mg) can help reduce these.
Headache, dizziness, and insomnia have been reported occasionally. Skin itching and rashes are rare.
There isn't enough data to know if this supplement is safe in pregnancy, so if you're pregnant, check with your doctor before starting. Safety during breastfeeding hasn't been well studied either — talk to your doctor or pharmacist for personalized advice.
Meds to double-check
Moderate interaction found
Before you start Bio CoQ10, double-check your medications. Warfarin (a blood thinner) is the top concern — coenzyme Q10 may reduce how well it works.
If you're on chemotherapy, especially alkylating agents, discuss this supplement with your oncologist. People taking blood pressure drugs should also run this by their doctor, as coenzyme Q10 might add to the effect.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
Bio CoQ10 might be worth considering if you're dealing with fibromyalgia, migraines, heart failure, or diabetic nerve pain and want to explore a supplement with some research behind it. But if you take warfarin or undergo chemotherapy, you need to talk with your prescriber first.
Same goes if you're on blood pressure medication or are pregnant or breastfeeding — check with your pharmacist or doctor before adding this in.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Bio CoQ10, straight from the product label.
| Brand | Return Healthy |
|---|---|
| Net contents | 60 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2023 |
| DSLD ID | 282156 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | Nutrient, All Other |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Bio CoQ10 by Return Healthy, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Coenzyme Q10, Natural | 100 mg | -- |
Other ingredients: Medium Chain Triglycerides, Sunflower Lecithin, Vitamin E, High Gamma mixed Tocopherols, Gelatin, Water, Purified, Glycerine, Annatto
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Bio CoQ10 features a proprietary vitamin E, MCT and lecithin-based bioavailability technology exclusive to Return Healthy
Formulation
Does not contain gluten.
Notice: Color, size or shape may appear different between lots.
Storage
Store at room temperature.
Precautions
Keep out of reach of children.
Report any adverse reactions to: (435) 624-1329
Brand IP Statement(s)
Return Healthy Empowered wellness
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Recommended use: As a dietary supplement, take one softgel per day with a meal, or as directed by your health care practitioner.
General Statements
For more information, visit ReturnHealthy.com
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Bio CoQ10 by Return Healthy label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Bio CoQ10 by Return Healthy
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container60 Amounts shown are per serving.
Coenzyme Q10, Natural
Interacts with198 drugs
CoQ10 is a vitamin-like substance your body makes naturally that helps cells produce energy and acts as an antioxidant. It is generally well tolerated...
Coenzyme Q10, Natural monograph & interactionsOther (inactive) ingredients: Medium Chain Triglycerides, Sunflower Lecithin, Vitamin E, High Gamma mixed Tocopherols, Gelatin, Water, Purified, Glycerine, Annatto. These complete the product’s ingredient list but are not active constituents.
Bio CoQ10 by Return Healthy Drug Interactions
HelloPharmacist Interaction Report
Bio CoQ10 by Return Healthy contains coenzyme Q10, which does interact with certain medications.
The most serious concern is with warfarin (Coumadin), a blood thinner — coenzyme Q10 has a structure similar to vitamin K and may work against warfarin's effects, reducing how well it prevents clots. Four cases of weakened warfarin activity linked to coenzyme Q10 have been reported.
Read the full breakdown — every affected drug type, severity by severity
Coenzyme Q10 may also theoretically interfere with some chemotherapy drugs, particularly alkylating agents like cyclophosphamide. Because coenzyme Q10 is an antioxidant, it could potentially shield cancer cells from drugs that work by creating oxidative stress.
If you're undergoing chemotherapy, this is worth discussing with your oncologist before starting this supplement.
One more consideration: coenzyme Q10 might have a minor additive effect with blood pressure medications. Some research suggests it can lower blood pressure on its own, though results have been mixed.
If you take drugs to manage high blood pressure, your doctor may want to monitor you.
Additionally, one smaller concern is that if you're taking drugs that lower blood pressure, the combination might add up. Altogether, these interactions span 196 individual medications.
Run your specific prescriptions through the medication checker on this page before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Bio CoQ10?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Bio CoQ10 interact with 198 drugs. Click any drug to see the details.
1 of the 1 ingredient in Bio CoQ10 interact with drugs. Each result below shows which ingredient is responsible. Coenzyme Q10, Natural
AltretamineHexalen
How Altretamine interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Altretamine interactionBendamustineBelrapzo, Treanda, Vivimusta
How Bendamustine interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Bendamustine interactionBendamustine HydrochlorideBendeka
How Bendamustine Hydrochloride interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Bendamustine Hydrochloride interactionBusulfanBusulfex, Myleran
How Busulfan interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Busulfan interactionCarboplatinParaplatin
How Carboplatin interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Carboplatin interactionCarmustineBiCNU, Gliadel, Gliadel Wafer
How Carmustine interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Carmustine interactionChlorambucilLeukeran
How Chlorambucil interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Chlorambucil interactionCisplatinPlatinol-AQ
How Cisplatin interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Cisplatin interactionCyclophosphamideCytoxan, Neosar
How Cyclophosphamide interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Cyclophosphamide interactionDacarbazineDTIC-Dome
How Dacarbazine interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Dacarbazine interactionEstramustine Phosphate SodiumEmcyt
How Estramustine Phosphate Sodium interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Estramustine Phosphate Sodium interactionIfosfamideIfex
How Ifosfamide interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Ifosfamide interactionLomustineCeenu
How Lomustine interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Lomustine interactionLurbinectedinZepzelca
How Lurbinectedin interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Lurbinectedin interactionMechlorethamine HydrochlorideValchlor
How Mechlorethamine Hydrochloride interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Mechlorethamine Hydrochloride interactionMelphalanAlkeran, Hepzato
How Melphalan interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Melphalan interactionMelphalan FlufenamidePepaxto
How Melphalan Flufenamide interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Melphalan Flufenamide interactionMelphalan HydrochlorideEvomela
How Melphalan Hydrochloride interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Melphalan Hydrochloride interactionOxaliplatinEloxatin
How Oxaliplatin interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Oxaliplatin interactionProcarbazineMatulane
How Procarbazine interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Procarbazine interactionStreptozocinZanosar
How Streptozocin interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Streptozocin interactionTemozolomideTemodar
How Temozolomide interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Temozolomide interactionThiotepaTepadina, Thioplex
How Thiotepa interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Thiotepa interactionTrabectedinYondelis
How Trabectedin interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAlkylating Agents Moderate
Interaction Summary
Coenzyme Q10 has antioxidant effects.
Read the full Coenzyme Q10, Natural + Trabectedin interactionWarfarinWarfarin
How Warfarin interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalWarfarin (coumadin) Moderate
Interaction Summary
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Read the full Coenzyme Q10, Natural + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalWarfarin (coumadin) Moderate
Interaction Summary
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Read the full Coenzyme Q10, Natural + Warfarin Sodium interactionAcebutololRhotral, Sectral
How Acebutolol interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAntihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10, Natural + Acebutolol interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAntihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10, Natural + Acetazolamide interactionAliskirenTekturna
How Aliskiren interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAntihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10, Natural + Aliskiren interactionAmbrisentanLetairis, Volibris
How Ambrisentan interacts with Bio CoQ10 — through 1 ingredient. Tap an ingredient for the detail:
Coenzyme Q10, NaturalAntihypertensive Drugs Minor
Interaction Summary
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Read the full Coenzyme Q10, Natural + Ambrisentan interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Bio CoQ10 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Coenzyme Q10, Natural
Alkylating Agents
Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.
Warfarin (Coumadin)
Coenzyme Q10 is chemically similar to menaquinone and might have vitamin K-like procoagulant effects, which could decrease the effects of warfarin.
Concomitant use of coenzyme Q10 and warfarin might reduce the anticoagulant effects of warfarin. Four cases of decreased warfarin efficacy thought to be due to coenzyme Q10 have been reported. However, there is some preliminary clinical research that suggests coenzyme Q10 might not significantly decrease the effects of warfarin in patients who have a stable INR.
Antihypertensive Drugs
Theoretically, coenzyme Q10 might have additive effects with antihypertensive drugs.
Some clinical research shows that coenzyme Q10 can significantly lower blood pressure, although other studies have shown conflicting results.
Brand information
Manufacturer and brand details for Bio CoQ10, from the product label.
Return Healthy
See all Return Healthy products- Name
- Return Healthy LLC
- Street Address
- 163 W. 1600 S. Suite 4
- City
- St George
- State
- UT
- ZipCode
- 84770-6715
- Phone Number
- (435) 624-1329
- Web Address
- ReturnHealthy.com
Bio CoQ10 by Return Healthy: Common Questions
Does Bio CoQ10 by Return Healthy interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Will this interfere with my warfarin?
What are the most common side effects?
Is this safe during pregnancy?
Can I use this while breastfeeding?
Does coenzyme Q10 actually work for migraines?
Why are medium-chain triglycerides and vitamin E in this if they're not the main ingredient?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Bio CoQ10 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Bio CoQ10’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Bio CoQ10's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 40 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Coenzyme Q10 40 references
- Kamikawa T, Kobayashi A, Yamashita T, et al. Effects of coenzyme Q10 on exercise tolerance in chronic stable angina pectoris. Am J Cardiol 1985;56:247-51. PubMed
- Langsjoen P, Willis R, Folkers K. Treatment of essential hypertension with coenzyme Q10. Mol Aspects Med 1994;S265-72. PubMed
- Spigset O. Reduced effect of warfarin caused by ubidecarenone. Lancet 1994;334:1372-3. PubMed
- Singh RB, Niaz MA, Rastogi SS, et al. Effect of hydrosoluble coenzyme Q10 on blood pressures and insulin resistance in hypertensive patients with coronary artery disease. J Hum Hypertens 1999;13:203-8. PubMed
- Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84. PubMed
- Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6. PubMed
- Langsjoen PH, Langsjoen PH, Folkers K. Long-term efficacy and safety of coenzyme Q10 therapy for idiopathic dilated cardiomyopathy. Am J Cardiol 1990;65:521-3. PubMed
- Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. DOI
- Landbo C, Almdal TP. [Interaction between warfarin and coenzyme Q10]. Ugeskr Laeger 1998;160:3226-7.
- Baggio E, Gandini R, Plauncher AC, et al. Italian multicenter study on the safety and efficacy of coenzyme Q10 as adjunctive therapy in heart failure. CoQ10 Drug Surveillance Investigators. Mol Aspects Med 1994;15 Suppl:S287-94. PubMed
- Burke BE, Neuenschwander R, Olson RD. Randomized, double-blind, placebo-controlled trial of coenzyme Q10 in isolated systolic hypertension. South Med J 2001;94:1112-7. PubMed
- The Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease. Neurology 2001;57:397-404.
- Hodgson JM, Watts GF, Playford DA, et al. Coenzyme Q10 improves blood pressure and glycaemic control: a controlled trial in subjects with type 2 diabetes. Eur J Clin Nutr 2002;56:1137-42. PubMed
- Singh RB, Neki NS, Kartikey K, et al. Effect of coenzyme Q10 on risk of atherosclerosis in patients with recent myocardial infarction. Mol Cell Biochem 2003;246:75-82. DOI
- Porterfield LM. Why did the response to warfarin change? RN 2000;63:107.
- Sandor PS, Di Clemente L, Coppola G, et al. Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial. Neurology 2005;64:713-5. PubMed
- Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost 2002;87:1075-6. DOI
- Berman M, Erman A, Ben-Gal T, et al. Coenzyme Q10 in patients with end-stage heart failure awaiting cardiac transplantation: a randomized, placebo-controlled study. Clin Cardiol 2004;27:295–9. PubMed
- Storch A, Jost WH, Vieregge P, et al. Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease. Arch Neurol 2007;64:938-44. DOI
- Digiesi V, Cantini F, Oradei A, et al. Coenzyme Q10 in essential hypertension. Mol Aspects Med 1994;15 Suppl:s257-63. PubMed
- Yamagami T, Takagi M, Akagami H, et al. Effect of coenzyme Q10 on essential hypertension, a double blind controlled study. In: Folkers KA, Yamamura Y, eds. Biomedical and Clinical Aspects of Coenzyme Q, Vol. 5. Amsterdam: Elsevier Science Publications, 19
- Ho MJ, Bellusci A, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension (review). Cochrane Database Syst Rev 2009;(4):CD007435. PubMed
- Rosenfeldt, F. L., Haas, S. J., Krum, H., Hadj, A., Ng, K., Leong, J. Y., and Watts, G. F. Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials. J Hum.Hypertens. 2007;21(4):297-306. PubMed
- Stamelou, M., Reuss, A., Pilatus, U., Magerkurth, J., Niklowitz, P., Eggert, K. M., Krisp, A., Menke, T., Schade-Brittinger, C., Oertel, W. H., and Hoglinger, G. U. Short-term effects of coenzyme Q10 in progressive supranuclear palsy: a randomized, place DOI
- Keogh A, Fenton S, Leslie C, et al. Randomised double-blind, placebo-controlled trial of coenzyme Q, therapy in class II and III systolic heart failure. Heart Lung Circ. 2003;12:135-41.
- Gane, E. J., Weilert, F., Orr, D. W., Keogh, G. F., Gibson, M., Lockhart, M. M., Frampton, C. M., Taylor, K. M., Smith, R. A., and Murphy, M. P. The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C
- Lynch, D. R., Perlman, S. L., and Meier, T. A phase 3, double-blind, placebo-controlled trial of idebenone in friedreich ataxia. Arch Neurol. 2010;67(8):941-947. PubMed
- Young, J. M., Florkowski, C. M., Molyneux, S. L., McEwan, R. G., Frampton, C. M., Nicholls, M. G., Scott, R. S., and George, P. M. A randomized, double-blind, placebo-controlled crossover study of coenzyme Q10 therapy in hypertensive patients with the me
- Ishiyama, T., Morita, Y., Toyama, S., Yamagami, T., and Tsukamoto, N. A clinical study of the effect of coenzyme Q on congestive heart failure. Jpn.Heart J 1976;17(1):32-42. PubMed
- Matthews, P. M., Ford, B., Dandurand, R. J., Eidelman, D. H., O'Connor, D., Sherwin, A., Karpati, G., Andermann, F., and Arnold, D. L. Coenzyme Q10 with multiple vitamins is generally ineffective in treatment of mitochondrial disease. Neurology 1993;43(5
- Malm, C., Svensson, M., Sjoberg, B., Ekblom, B., and Sjodin, B. Supplementation with ubiquinone-10 causes cellular damage during intense exercise. Acta Physiol Scand. 1996;157(4):511-512. PubMed
- Singh, R. B., Wander, G. S., Rastogi, A., Shukla, P. K., Mittal, A., Sharma, J. P., Mehrotra, S. K., Kapoor, R., and Chopra, R. K. Randomized, double-blind placebo-controlled trial of coenzyme Q10 in patients with acute myocardial infarction. Cardiovasc. PubMed
- Digiesi V, Cantini F, and Brodbeck B. Effect of coenzyme Q10 on essential arterial hypertension. Current Therapeutic Research 1990;47(5):841-845.
- Parkinson Study Group QE3 Investigators, Beal MF, Oakes D, et al. A randomized clinical trial of high-dosage coenzyme Q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014;71(5):543-52.
- Alehagen U, Johansson P, Bjornstedt M, et al. Cardiovascular mortality and N-terminal-proBNP reduced after combined selenium and coenzyme Q10 supplementation: A 5-year prospective randomized double-blind placebo-controlled trial among elderly Swedish citi
- Ho MJ, Li EC, Wright JM. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Cochrane Database Syst Rev. 2016 Mar 3;3:CD007435. doi: 10.1002/14651858.CD007435.pub3. PubMed
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