Coenzyme Q10 - Ifex (Ifosfamide) Interaction

Herbal: Coenzyme Q10
Also Known As: CoQ10

Drug: Ifosfamide
Brand names: Ifex

Medical Content Editor
Last updated May 11, 2025

Interaction Details

Ifosfamide is classified as belonging to the following category: Alkylating Agents

Coenzyme Q10 has antioxidant effects. Theoretically, this may reduce the activity of chemotherapy drugs that generate free radicals.
Theoretically, antioxidants such as coenzyme Q10 might protect tumor cells from chemotherapeutic agents that work by inducing oxidative stress, such as alkylating agents (e.g., cyclophosphamide) and radiation therapy. The clinical importance of this interaction is unknown.

Interaction Rating

Moderate

Likelihood of Occurrence

Possible

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists

References

  • Portakal O, Ozkaya O, Erden Inal M, et al. Coenzyme Q10 concentrations and antioxidant status in tissues of breast cancer patients. Clin Biochem 2000;33:279-84.
  • Lund EL, Quistorff B, Spang-Thomsen M, Kristjansen PE. Effect of radiation therapy on small-cell lung cancer is reduced by ubiquinone intake. Folia Microbiol (Praha) 1998;43:505-6.

Coenzyme Q10 Overview

Coenzyme Q10, also known as CoQ10, is a naturally occurring substance that is found in every cell of the body and plays an essential role in energy production within the mitochondria, which are the powerhouse of the cells. CoQ10 also acts as an antioxidant, protecting cells from damage caused by harmful free radicals. While CoQ10 is endogenous, meaning our body can produce it on its own, levels can decrease with age, with certain medications (e.g., statins) or due to certain medical conditions. In such cases, supplementation with CoQ10 may be beneficial. Additionally, CoQ10 supplements have been studied for a variety of health benefits, including improving heart health, reducing inflammation, and potentially even aiding in the treatment of neurological disorders such as Parkinson's disease. However, it's important to note that while some studies have shown potential benefits, the research on CoQ10 supplementation is still ongoing, and more studies are needed to fully understand its effects on the body.
See More Information Regarding Coenzyme Q10

Ifosfamide Overview

  • Ifosfamide is used in combination with other medications to treat cancer of the testicles that has not improved or that has worsened after treatment with other medications or radiation therapy. Ifosfamide is in a class of medications called alkylating agents. It works by slowing or stopping the growth of cancer cells in your body.

See More Information Regarding Ifosfamide Injection

Coenzyme Q10 - More Interactions

Coenzyme Q10 interacts with 195 drugs

Interaction Rating Key

These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.

Major The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur.
Moderate Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur.
Minor Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction.
Unknown No interactions have been reported or no interaction data is currently available.

Visit Our Drug-Herbal Interaction Checker

Drug-Herbal Interaction Checker

Check your medications for potential interactions with herbal supplements

Popular Interaction Pages

Lobelia - Eflornithine
Sessile Oak - Venlafaxine
Spotted Geranium - Quinacrine
Sodium - Acetic Acid, Propylene Glycol Diacetate, Hydrocortisone
Bay Leaf - Calcium Carbonate
Diosmin - Thiotepa
Ignatius Bean - Sofosbuvir
Pokeweed - Phenobarbital, Phenytoin
Black Walnut - Esomeprazole, Naproxen
Date Palm - Pegfilgrastim-bmez
Oak Moss - Nateglinide
Cowhage - Urinary Tract Combination
Alpha-lipoic Acid - Fluvastatin
Gum Arabic - Bacitracin, Neomycin, Polymyxin B, Lidocaine
Cardamom - Iloprost
Perilla - Mitoxantrone
Couch Grass - Olopatadine Hydrochloride, Mometasone Furoate
Camu Camu - Methenamine, Phenyl Salicylate, Methylene Blue
Patricia Kane (pk) Protocol - Iodoquinol
Coffee Charcoal - Rolapitant Hydrochloride

Return to the main supplement interaction checker page

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Drug descriptions are provided by MedlinePlus.

Dr. Brian Staiger, PharmD

Ask A Pharmacist About Your Herbal Questions!

Dr. Brian Staiger, PharmD

In addition to being a clinical pharmacist specializing in pharmacotherapy, Dr. Brian Staiger is a registered herbalist through the American Herbalist Guild. He has combined his passion for pharmacy practice with the study of medical ethnobotany to improve patient care. Feel free to reach out about any of your herbal or medication questions!

Ask A Pharmacist