Discomfort Relief Berry Flavor Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Discomfort Relief Berry Flavor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Discomfort Relief Berry Flavor is a dietary supplement by Life Extension with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Discomfort Relief Berry Flavor by Life Extension
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product has one active ingredient: palmitoylethanolamide (PEA), a compound your body naturally produces that may help ease discomfort, particularly from osteoarthritis. The rest of the tablet is made up of inactive ingredients — fillers and binders like maltodextrin, mannitol, and microcrystalline cellulose, plus red beet, citric acid, stevia extract, and berry flavoring.
Does it work?
Not established
PEA is rated possibly effective for osteoarthritis discomfort. For spinal cord injury, the evidence suggests it's possibly ineffective.
For allergic rhinitis (hay fever), autism spectrum disorder, bipolar disorder, and amyotrophic lateral sclerosis (ALS), there isn't enough reliable evidence yet to know whether it works.
How safe is it?
Well-documented data
PEA is generally well tolerated in studies, but long-term safety data are limited, so this isn't something to count on for years without checking in with your doctor. The most common side effect reported orally is nausea.
A small number of trial participants reported drowsiness or a floating sensation, and mild, temporary stomach upset has been rarely reported. The safety data advises against use during pregnancy and breastfeeding because there isn't enough information to know it's safe — talk with your doctor or pharmacist about whether it's right for you.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient in this product. That said, always confirm with your own doctor or pharmacist before combining any supplement with your medications.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
This product may help with osteoarthritis discomfort if you're looking for a natural option. It's generally well tolerated, though nausea is the most common side effect.
If you're pregnant, breastfeeding, or taking any medications, check with your own doctor or pharmacist before starting.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Discomfort Relief Berry Flavor, straight from the product label.
| Brand | Life Extension |
|---|---|
| Barcode (UPC) | 737870230366 |
| Net contents | 60 Vegetarian Chewable Tablet(s) |
| Market status | On market |
| Date entered into DSLD | May 21, 2025 |
| DSLD ID | 328415 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Tablet Or Pill |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Discomfort Relief Berry Flavor by Life Extension, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Palmitoylethanolamide | 600 mg | -- |
Other ingredients: Maltodextrin, Mannitol, Microcrystalline Cellulose, Xylitol, Red Beet, Stearate, Berry flavor, Citric Acid, Stearic Acid, Silica, Stevia extract, Starch
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Scan for product info
Precautions
Read the entire label and follow the directions carefully prior to use. Do not swallow tablets whole.
Warnings: Keep out of reach of children.
Do not exceed recommended dose. Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
To report a serious adverse event or obtain product information, contact 1-866-280-2852.
Suggested/Recommended/Usage/Directions
Directions: Chew one (1) tablet once or twice daily, or as recommended by a healthcare practitioner. Do not swallow tablets whole.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Formulation
Gluten Free Non GMO Le Certified
For occasional minor pain and discomfort
Seals/Symbols
Non GMO Le Certified
FDA Statement of Identity
Dietary Supplement
Storage
Store tightly closed in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Discomfort Relief Berry Flavor by Life Extension label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Discomfort Relief Berry Flavor by Life Extension
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Chewable Tablet(s) Dosage formTablet Or Pill Servings per container60 Amounts shown are per serving.
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsOther (inactive) ingredients: Maltodextrin, Mannitol, Microcrystalline Cellulose, Xylitol, Red Beet, Stearate, Berry flavor, Citric Acid, Stearic Acid, Silica, Stevia extract, Starch. These complete the product’s ingredient list but are not active constituents.
Discomfort Relief Berry Flavor by Life Extension Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Discomfort Relief Berry Flavor. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Discomfort Relief Berry Flavor, from the product label.
Life Extension
See all Life Extension products- Name
- Quality Supplements and Vitamins, Inc.
- City
- Ft. Lauderdale
- State
- FL
- ZipCode
- 33309
- Phone Number
- 1-866-280-2852
- Web Address
- LifeExtension.com
Discomfort Relief Berry Flavor by Life Extension: Common Questions
Does Discomfort Relief Berry Flavor by Life Extension interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is palmitoylethanolamide (PEA)?
Can I take this while pregnant or breastfeeding?
What side effects might I notice?
How long is it safe to take this?
Does it work for hay fever or other conditions?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Discomfort Relief Berry Flavor is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Discomfort Relief Berry Flavor’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Discomfort Relief Berry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 5 references
- Bacci C, Cassetta G, Emanuele B, Berengo M. Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery. ISRN Surg. 2011;2011:917350. PubMed
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC