PEA400 Ingredients & Drug Interactions
What is this page for?
First and foremost: checking PEA400 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PEA400 is a dietary supplement by Natural Factors with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of PEA400 by Natural Factors
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
PEA400 contains one active ingredient: palmitoylethanolamide (PEA), a compound your body produces naturally. The capsule also includes microcrystalline cellulose, a vegetarian capsule shell, magnesium stearate, stearic acid, and silica — these are inactive ingredients used to hold the supplement together and make it easier to swallow.
Does it work?
Not established
PEA shows possibly effective evidence for osteoarthritis — the most established use we have data for. For spinal cord injury, the evidence points toward possibly ineffective.
For cannabis use disorder, autism spectrum disorder, carpal tunnel syndrome, and migraine headache, the evidence isn't yet established enough to rate. If you're considering PEA for a condition other than osteoarthritis, talk with your doctor about what the current evidence suggests and whether it makes sense for your situation.
How safe is it?
Well-documented data
PEA is generally well tolerated in studies, though long-term safety data are limited — meaning we don't have years of follow-up yet. The most common side effect when taken by mouth is nausea, which is usually mild.
A small number of people applying PEA topically reported stinging, scaling, or reddening, but these effects occurred at the same rate as the vehicle (carrier) alone. The safety data advise against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe for you or your baby.
If you're pregnant, nursing, or planning either, talk with your doctor or pharmacist before taking this product.
Meds to double-check
No known interactions
No interactions are documented in our data for palmitoylethanolamide. Use the search tool on this page to check your specific medications, and confirm with your doctor or pharmacist before you begin.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
PEA400 is a single-ingredient supplement with some evidence for osteoarthritis and generally mild side effects in the studies we have. The biggest gaps are long-term safety and interaction data — we simply don't have years of follow-up or detailed medication cross-checks.
If you're pregnant, nursing, or taking regular medications, check with your own doctor or pharmacist before starting it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PEA400, straight from the product label.
| Brand | Natural Factors |
|---|---|
| Barcode (UPC) | 068958027005 |
| Net contents | 90 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 22, 2021 |
| DSLD ID | 247505 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PEA400 by Natural Factors, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Palmitoylethanolamide | 400 mg | -- |
Other ingredients: Microcrystalline Cellulose, Vegetarian Capsule, Magnesium Stearate, Stearic Acid, Silica
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Seals/Symbols
isura Non-GMO - Mass Spec Documentation - Lab tested
Suggested/Recommended/Usage/Directions
Suggested Usage: 1 capsule 1-3 times per day or as directed by a health professional.
Precautions
Cautions: As with any supplement, consult your health professional before use if you are pregnant, breastfeeding, or trying to conceive, or if you are taking medication, have a medical condition, or anticipate a surgery.
Keep out of reach of children.
Sealed for your protection. Do not use if seal is broken.
Formula
PEA (palmitoylethanolamide) is a fatty-acid like compound naturally found in foods. Natural Factors PEA is naturally produced from fractionated non-GMO safflower oil. It then undergoes a micronization process for improved solubility and absorption. PEA has been shown to be helpful in managing occasional pain and discomfort.
Naturally produced from fractioned non-GMO safflower oil.
There are two sources of PEA commercially available. Synthetic forms require the use of powerful synthetic solvents. PEA can be naturally derived from safflower oil. PEA400 only utilizes naturally derived palmitoylethanolamide from safflower seed.
PEA400 (Palmitoylethanolamide)
Formulation
Manufactured by Natural Factors to ensure safety and potency in accordance with Good Manufacturing Practices (GMP) of the FDA and Health Canada.
Contains no artificial colors, preservatives, or sweeteners; no dairy, starch, sugar, wheat, gluten, yeast, soy, corn, egg, fish, shellfish, animal products, salt, tree nuts, or GMOs.
Suitable for vegetarians/vegans.
For occasional pain & discomfort
Highest Purity
The Power of Phytoresponse! PhytoResponse refers to plant foods and herbs that can modulate and positively influence the Endocannabinoid System (ECS) directly or indirectly and support the body’s production of endocannabinoids with non-cannabis, plant-based botanical compounds. The ECS promotes homeostasis, or balance. The Power of Pea and the Endocannabinoid System PEA (N-palmitoylethanolamide) is an endogenous fatty acid amide that belongs to the family of biologically active lipids that are increased by the body to soothe discomfort. PEA is a member of the ECS with several biological functions, including neuromodulatory activity in the central nervous system. It has been demonstrated to be effective on the different inflammatory mechanisms that develop and maintain both neurogenic and neuropathic pain.
Storage
For freshness, store in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Product of Canada Recyclable container and label.
Phyto Response Endocannabinoid System
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Isura is a trademark of ISURA.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PEA400 by Natural Factors label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PEA400 by Natural Factors
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsOther (inactive) ingredients: Microcrystalline Cellulose, Vegetarian Capsule, Magnesium Stearate, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.
PEA400 by Natural Factors Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in PEA400. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for PEA400, from the product label.
PEA400 by Natural Factors: Common Questions
Does PEA400 by Natural Factors interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is PEA, and what's it supposed to do?
Is PEA safe if I'm pregnant or breastfeeding?
What side effects might I notice?
Does this product interact with my medications?
Why does the label say long-term safety data are limited?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PEA400 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PEA400’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
PEA400's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 4 references
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC