PEA Ultra Ingredients & Drug Interactions
What is this page for?
First and foremost: checking PEA Ultra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PEA Ultra is a dietary supplement by Wellness Resources with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of PEA Ultra by Wellness Resources
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
PEA Ultra is a single-ingredient supplement: palmitoylethanolamide (PEA), also sold as Levagen+. PEA is a naturally occurring compound in the body that may play a role in managing inflammation and pain.
The capsule itself contains cellulose and magnesium stearate as inactive ingredients.
Does it work?
Not established
The evidence for PEA is mixed. It's rated possibly effective for osteoarthritis — meaning some research supports benefit, but more robust data would strengthen the claim.
For spinal cord injury, current evidence rates it possibly ineffective. For allergic rhinitis (hay fever), autism spectrum disorder, bipolar disorder, and amyotrophic lateral sclerosis (ALS), we don't yet have enough reliable evidence to know whether it helps or doesn't.
If you're considering this for a specific condition, talk with your doctor about what the current research actually supports for your situation.
How safe is it?
Well-documented data
PEA appears generally well tolerated in studies, though long-term safety data are limited — so we don't yet know how it holds up with years of use. The most commonly reported side effect in trials was nausea.
A small number of people have reported drowsiness or a floating sensation, and rarely, mild, short-lived digestive upset. Avoid this product during pregnancy and while breastfeeding — there isn't enough safety information to know it's safe in either situation.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient in this product. That said, safety against all medications hasn't been fully studied, so check your exact medications with your doctor or pharmacist before you start.
The bottom line
Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.
PEA Ultra may be worth considering if you're exploring options for osteoarthritis, though the evidence is not definitive. Because long-term safety data are sparse and pregnancy and breastfeeding safety are unknown, it's not for everyone.
Talk with your doctor or pharmacist before starting, especially if you're pregnant, nursing, or taking other medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PEA Ultra, straight from the product label.
| Brand | Wellness Resources |
|---|---|
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 320631 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PEA Ultra by Wellness Resources, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Levagen+ | 300 mg | -- |
Other ingredients: Capsule, Cellulose, Magnesium Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
PEA Ultra contains an advanced form of PEA for superior absorption. PEA supports the body's endocannabinoid system to promote healthy stress response, mood, relaxation, and nerve function, as well as joint function and comfort.
FDA Disclaimer Statement
These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
Suggested/Recommended/Usage/Directions
Directions: Take 1 capsule, up to 2 times per day.
Brand IP Statement(s)
Wellness Resources since 1985
Levagen+ is a registered trademark of Gencor.
Formulation
Nerve support and comfort
FDA Statement of Identity
Dietary Supplement
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PEA Ultra by Wellness Resources label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PEA Ultra by Wellness Resources
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Levagen+
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Levagen+ monograph & interactionsOther (inactive) ingredients: Capsule, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.
PEA Ultra by Wellness Resources Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in PEA Ultra. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for PEA Ultra, from the product label.
Wellness Resources
See all Wellness Resources products- Name
- Wellness Resources, Inc.
- Street Address
- 7155 Amundson Ave.
- City
- Minneapolis
- State
- MN
- ZipCode
- 55439
- Phone Number
- 800-717-9355
- Web Address
- www.wellnessresources.com
PEA Ultra by Wellness Resources: Common Questions
Does PEA Ultra by Wellness Resources interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take PEA Ultra if I'm pregnant or breastfeeding?
What side effects might I notice?
Does PEA actually work for arthritis?
What exactly is PEA?
How long does it take to work?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PEA Ultra is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PEA Ultra’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
PEA Ultra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 5 references
- Bacci C, Cassetta G, Emanuele B, Berengo M. Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery. ISRN Surg. 2011;2011:917350. PubMed
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC