No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

PEA Ultra Ingredients & Drug Interactions

by Wellness Resources

PEA Ultra label
See full label image
Capsule Category: Non-nutrient/non-botanical
No known interaction
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking PEA Ultra against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

PEA Ultra is a dietary supplement by Wellness Resources with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of PEA Ultra by Wellness Resources

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

PEA Ultra contains one active ingredient: palmitoylethanolamide (PEA), a compound your body produces naturally. It's thought to work by calming inflammation and nerve signals.

The capsule itself is made from cellulose, with magnesium stearate and cellulose as inactive ingredients to help hold it together.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Palmitoylethanolamide (pea)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: stress response, mood, relaxation, and nerve function.
  • We looked for evidence on: Neuropathic pain, Diabetic neuropathy, Sciatica, Carpal tunnel syndrome, Complex regional pain syndrome, Fibromyalgia — and 4 related terms.
  • The closest evidence on file: Palmitoylethanolamide (pea) is rated "Insufficient Reliable Evidence To Rate" for Carpal tunnel syndrome (Natural Medicines).
  • Also on file: Palmitoylethanolamide (pea) is rated "Insufficient Reliable Evidence To Rate" for Migraine headache, Depression, Diabetic neuropathy, Fibromyalgia, and more.

The evidence for PEA is mixed. It's possibly effective for osteoarthritis — the condition with the strongest data behind it.

For migraine headache, carpal tunnel syndrome, autism spectrum disorder, and cannabis use disorder, the evidence isn't yet reliable enough to say whether it works. For spinal cord injury, current data suggest it's possibly ineffective.

The evidence, ingredient by ingredient Palmitoylethanolamide (pea)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

PEA is generally well tolerated in studies, but we don't have long-term safety data yet, so caution is warranted if you're thinking of taking it for months or years. The most common side effect when taken by mouth is nausea, and it's mild when it happens.

The safety data advises against use during pregnancy and while breastfeeding — there isn't enough information to know whether it's safe in those situations.

Side effects, ingredient by ingredient Palmitoylethanolamide (pea)

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients in PEA Ultra. That said, check your exact medications on this page before you start, just to be sure.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

If you have osteoarthritis and want to try PEA, the evidence is there to consider it — and it doesn't appear to clash with other medications. Pregnant or breastfeeding?

Skip it until you've talked with your doctor. If nausea is a concern for you, mention that to your pharmacist when you pick it up.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PEA Ultra, straight from the product label.

Brand Wellness Resources
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2025
DSLD ID 320631
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PEA Ultra by Wellness Resources, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
IngredientAmount% DV
Levagen+300 mg--

Other ingredients: Capsule, Cellulose, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

PEA Ultra contains an advanced form of PEA for superior absorption. PEA supports the body's endocannabinoid system to promote healthy stress response, mood, relaxation, and nerve function, as well as joint function and comfort.

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule, up to 2 times per day.

Brand IP Statement(s)

Wellness Resources since 1985

Levagen+ is a registered trademark of Gencor.

Formulation

Nerve support and comfort

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

PEA Ultra by Wellness Resources label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

PEA Ultra label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in PEA Ultra by Wellness Resources

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Levagen+

No known
interactions
300 mg per serving Form: Palmitoylethanolamide

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...

Levagen+ monograph & interactions

Other (inactive) ingredients: Capsule, Cellulose, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

PEA Ultra by Wellness Resources Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in PEA Ultra. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for PEA Ultra, from the product label.

Wellness Resources

See all Wellness Resources products
Name
Wellness Resources, Inc.
Street Address
7155 Amundson Ave.
City
Minneapolis
State
MN
ZipCode
55439
Phone Number
800-717-9355
Web Address
www.wellnessresources.com
Pharmacist Counseling Corner

PEA Ultra by Wellness Resources: Common Questions

Does PEA Ultra by Wellness Resources interact with any medications?
We do not currently list a known interaction for the mapped ingredients in PEA Ultra. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
PEA Ultra contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is PEA, and what's it supposed to do?
PEA is palmitoylethanolamide, a compound your body makes on its own. It's thought to reduce inflammation and calm nerve signals. The evidence is strongest for osteoarthritis — it's possibly effective for that — but research is still emerging for other uses.
Can I take this while I'm pregnant or breastfeeding?
No — there isn't enough safety data, so the evidence advises against it during pregnancy and while breastfeeding. Talk with your doctor if you're pregnant, planning to become pregnant, or nursing and want to weigh your options.
What are the side effects?
PEA is generally well tolerated. Nausea is the most common side effect when taken by mouth, and it tends to be mild. Long-term safety data are limited, so we don't know what happens if you take it for a very long time.
Does PEA interact with medications?
No interactions are documented in our data for PEA. That doesn't guarantee none exist, but it's a positive sign. Run your exact medications through the checker on this page to be certain.
Will this work for my migraine or carpal tunnel?
The evidence for those conditions isn't yet reliable enough to say. The strongest data are for osteoarthritis. If you're interested in trying PEA for another condition, talk with your pharmacist or doctor about whether it makes sense for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PEA Ultra is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PEA Ultra label
Go deeper

The Full Monographs Behind PEA Ultra’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Palmitoylethanolamide (pea)

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it may help certain types of chronic and ne...

Read the full Palmitoylethanolamide (pea) monograph →
Sources

Sources & How We Checked

PEA Ultra's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Palmitoylethanolamide (pea) 4 references
  1. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
  2. Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
  3. Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
  4. Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed

See these in context on the Palmitoylethanolamide (pea) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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