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Dietary supplement

Vitamin K Complex Ingredients & Drug Interactions

by Wellness Resources

Vitamin K Complex label
See full label image
Capsule Category: Vitamin
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Vitamin K Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Vitamin K Complex is a dietary supplement by Wellness Resources with 1 active ingredient. Its ingredients are commonly taken for supporting normal blood clotting, bone health, heart and vascular health.Based on those ingredients, 2 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Vitamin K. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Vitamin K Complex by Wellness Resources

Ask about any prescription or over-the-counter medication and we check it for interactions with Vitamin K Complex by Wellness Resources — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Vitamin K Complex by Wellness Resources

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • “Vitamin K” is listed as a grouped ingredient — the label gives one combined amount (1,600 mcg) without saying how much of each component you get.

This product contains 3 active ingredients, all forms of vitamin K: Vitamin K2, Vitamin K1, and K2Vital. Vitamin K is a fat-soluble vitamin your body uses to make proteins that help blood clot and support bone health.

The product also contains cellulose and rice hull as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports bone strength and arterial health.
  • We looked for evidence on: Cardiovascular disease (CVD), Osteoporosis, Stroke, bone density, vascular calcification, arterial stiffness.
  • The strongest evidence on file: Vitamin K is rated "Possibly Effective" for Osteoporosis (Natural Medicines).
  • Also on file: Vitamin K is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Stroke.

Both Vitamin K2 and Vitamin K1 are rated Effective for treating clotting problems caused by low vitamin K (hypoprothrombinemia), vitamin K-dependent clotting factor deficiency, and hemorrhagic disease. They're also rated Effective for reversing warfarin's effects when that's medically necessary.

For osteoporosis, the evidence is Possibly Effective — the science is less established, but there's some promise.

The evidence, ingredient by ingredient Vitamin K

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

When taken by mouth, vitamin K is generally well tolerated. The most common side effects are nausea, diarrhea, abdominal pain, and stomach upset — usually mild to moderate.

Serious reactions are rare. Normal food amounts of vitamin K are fine; if you're considering supplements, check with your doctor first, especially if you're on any blood-thinning medication.

During pregnancy and lactation, vitamin K is rated Likely Safe.

Side effects, ingredient by ingredient Vitamin K

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin K.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 2 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Most important: warfarin (Coumadin) and other blood thinners. Vitamin K in this product blocks warfarin's effects (Major severity).

Check the interaction tool on this page with your exact medications before starting.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product works well for supporting clotting factors and bone health in people who aren't on warfarin or other blood thinners. If you take warfarin, ask your pharmacist or doctor before adding this — the interaction is Major and can undo your blood thinner's protection.

For anyone else on regular medications, check with us or your pharmacist first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 23, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Vitamin K Complex, straight from the product label.

Brand Wellness Resources
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Feb 23, 2025
DSLD ID 320661
Product type Vitamin
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Vitamin K Complex by Wellness Resources, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
IngredientAmount% DV
Vitamin K1600 mcg1333%
Vitamin K2500 mcg--
Vitamin K11000 mcg--
K2Vital100 mcg--

Other ingredients: Cellulose, Rice hull

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Vitamin K complex contains two biologically active forms of vitamin K2 as MK-4 and MK-7 along with vitamin K1. It supports bone strength and arterial health.

Vitamin K1 and K2 as MK-4 and MK-7

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Directions: Take 1 capsule, up to 3 times per day.

Brand IP Statement(s)

Wellness resources since 1985

K2Vital is a registered trademark of Kappa BioScience AS.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Vitamin K Complex by Wellness Resources label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Vitamin K Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Vitamin K Complex by Wellness Resources

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Vitamin K

Interacts with
2 drugs
1600 mcg per serving

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but suppl...

Vitamin K monograph & interactions

Other (inactive) ingredients: Cellulose, Rice hull. These complete the product’s ingredient list but are not active constituents.

Interaction report

Vitamin K Complex by Wellness Resources Drug Interactions

Want to check YOUR meds against Vitamin K Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2Drugs
2 Major

Ingredients driving the most interactions

Vitamin K 2

Individual Drug Interactions

The ingredients in Vitamin K Complex interact with 2 drugs. Click any drug to see the details.

1 of the 1 ingredient in Vitamin K Complex interact with drugs. Each result below shows which ingredient is responsible. Vitamin K

Each ingredient & the kinds of drugs it affects

For each ingredient in Vitamin K Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin K1 drug type · 2 drugs

Warfarin (Coumadin)

Vitamin K can antagonize and reverse the therapeutic effects of warfarin.
Vitamin K antagonizes the effects of warfarin. Excessive vitamin K intake, either from supplements or from changes in the diet, can reduce the anticoagulant effect of warfarin.

Likelihood Likely Evidence C
Vitamin K full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Vitamin K Complex, from the product label.

Wellness Resources

See all Wellness Resources products
Name
Wellness Resources, Inc.
Street Address
7155 Amundson Avenue
City
Edina
State
MN
ZipCode
55439
Phone Number
800-717-9355
Web Address
www.wellnessresources.com
Pharmacist Counseling Corner

Vitamin K Complex by Wellness Resources: Common Questions

Does Vitamin K Complex by Wellness Resources interact with any medications?
Yes. Based on its ingredients, Vitamin K Complex has a known interaction with 2 medications, including 2 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Vitamin K Complex contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin?
Not without talking to your doctor or pharmacist first. Vitamin K blocks warfarin's ability to thin your blood, which could be dangerous. You'll need personalized medical advice on whether this product is right for you.
What are the side effects?
When taken by mouth, the most common ones are nausea, diarrhea, stomach pain, and upset stomach. These are usually mild to moderate. Serious side effects are rare.
Is vitamin K safe during pregnancy?
Yes — Vitamin K2 and Vitamin K1 are both rated Likely Safe during pregnancy and breastfeeding.
What does vitamin K actually do?
Your body needs it to make proteins that help blood clot and to support bone health. This product contains three forms — K2, K1, and K2Vital — all serving that same function.
Is this proven to help with osteoporosis?
There's some promise, but the evidence isn't strong yet. Vitamin K is rated Possibly Effective for osteoporosis, meaning research suggests it might help but we're not certain.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Vitamin K Complex is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Vitamin K Complex label
Go deeper

The Full Monographs Behind Vitamin K Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin K

Interacts with 2 drugs

Vitamin K is an essential nutrient your body needs for normal blood clotting and to support healthy bones. Most people get enough from food, but supplements are sometimes used for deficiency...

Read the full Vitamin K monograph →
Sources

Sources & How We Checked

Vitamin K Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin K 11 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  3. Crowther MA, Ageno W, Garcia D, et al. Oral vitamin K versus placebo to correct excessive anticoagulation in patients receiving warfarin: a randomized trial. Ann Intern Med. 2009;150(5):293-300. PubMed
  4. Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation? Nutr Rev. 2010;68(3):178-81. PubMed
  5. Kim JS, Nafziger AN, Gaedigk A, et al. Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe. J Clin Pharmacol. 2001 Jul;41(7):715-22. PubMed
  6. Riegert-Johnson, D. L. and Volcheck, G. W. The incidence of anaphylaxis following intravenous phytonadione (vitamin K1): a 5-year retrospective review. Ann.Allergy Asthma Immunol. 2002;89(4):400-406. PubMed
  7. Dezee, K. J., Shimeall, W. T., Douglas, K. M., Shumway, N. M., and O'malley, P. G. Treatment of excessive anticoagulation with phytonadione (vitamin K): a meta-analysis. Arch.Intern.Med. 2-27-2006;166(4):391-397. DOI
  8. Dentali, F., Ageno, W., and Crowther, M. Treatment of coumarin-associated coagulopathy: a systematic review and proposed treatment algorithms. J.Thromb.Haemost. 2006;4(9):1853-1863. PubMed
  9. Caluwé R, Vandecasteele S, Van Vlem B, Vermeer C, De Vriese AS. Vitamin K2 supplementation in haemodialysis patients: a randomized dose-finding study. Nephrol Dial Transplant. 2014;29(7):1385-90.
  10. Huang ZB, Wan SL, Lu YJ, Ning L, Liu C, Fan SW. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015;26(3):1175-86. PubMed
  11. Hunnali CR, Devi U, Kitchanan S, Sethuraman G. Three Different Regimens for Vitamin K Birth Prophylaxis in Infants Born Preterm: A Randomized Clinical Trial. J Pediatr 2023;255:98-104. PubMed

See these in context on the Vitamin K monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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