PEA Ingredients & Drug Interactions
What is this page for?
First and foremost: checking PEA against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PEA is a dietary supplement by Pure Nootropics with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of PEA by Pure Nootropics
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: palmitoylethanolamide (PEA), a compound your body naturally produces. It's included here at a dose intended to support certain inflammatory and pain-related conditions.
The capsule itself contains inactive ingredients — hypromellose, rice flour, and stearate — which help form and preserve the capsule.
Does it work?
Moderate evidence
Palmitoylethanolamide has the strongest evidence for osteoarthritis, where it's rated possibly effective. For spinal cord injury, the evidence points to possibly ineffective.
For migraine, carpal tunnel syndrome, autism spectrum disorder, and cannabis use disorder, we don't have enough reliable evidence yet to say whether it works.
How safe is it?
Well-documented data
Palmitoylethanolamide is generally well tolerated. The most commonly reported side effect when taken orally is nausea, which is mild.
A small number of people applying it topically (about 13%) experienced itching, stinging, scaling, or redness, but these effects occurred no more often than with the vehicle (cream base) alone. Long-term safety data are limited, so caution is warranted with extended use.
The safety data advises against use during pregnancy and while breastfeeding due to insufficient information. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your pharmacist or doctor before using this product.
Meds to double-check
No known interactions
No interactions are documented in our data for the medications we checked. You're welcome to search your specific prescriptions in the tool on this page for extra reassurance.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
Pure Nootropics PEA may be worth considering if you're dealing with osteoarthritis and want to explore a natural option. Since the evidence for other conditions is weak or absent, you'll want to clarify with your pharmacist whether it fits your specific situation.
It's generally well tolerated, though nausea can occur — and you'll want to avoid it if you're pregnant or breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PEA, straight from the product label.
| Brand | Pure Nootropics |
|---|---|
| Barcode (UPC) | 00854051008000 |
| Net contents | 90 Vegetarian Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2024 |
| DSLD ID | 316600 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PEA by Pure Nootropics, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Palmitoylethanolamide | 400 mg | -- |
Other ingredients: Hypromellose, Rice Flour, Stearate
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions
Warning: Consult with a healthcare practitioner before taking this. If you experience adverse reactions from taking this product, discontinue immediately and contact a healthcare practitioner.
Do not take this if you are pregnant, nursing, or under the age of 18.
Do not take this if you are pregnant, nursing, or under the age of 18. Keep out of reach of children
Formulation
Supports healthy inflammation response and can help relieve discomfort
Micronized for higher bioavailability
Always Non-GMO No added preservatives
Quality-tested
General Statements
Unlock your potential
FDA Statement of Identity
Dietary Supplement
Formula
Pea (Palmitoylethanolamide)
Suggested/Recommended/Usage/Directions
Suggested Use: Take 1 capsule daily or as recommended by your healthcare practitioner.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. this product is not intended to diagnose, treat, cure, or prevent any disease.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PEA by Pure Nootropics label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PEA by Pure Nootropics
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsOther (inactive) ingredients: Hypromellose, Rice Flour, Stearate. These complete the product’s ingredient list but are not active constituents.
PEA by Pure Nootropics Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in PEA. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for PEA, from the product label.
Pure Nootropics
See all Pure Nootropics products- Name
- Pure Nootropics, LLC
- Street Address
- P.O. Box 6827
- City
- Albuquerque
- State
- NM
- ZipCode
- 87197
- Phone Number
- 424-738-0385
- Web Address
- purenootropics.net
PEA by Pure Nootropics: Common Questions
Does PEA by Pure Nootropics interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is PEA and what does it do?
Can I take this if I'm pregnant or breastfeeding?
What side effects might I experience?
Does this work for migraine or other conditions?
Will this interact with my medications?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PEA is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PEA’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
PEA's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 4 references
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC