Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

PEA Soothe Support Ingredients & Drug Interactions

by Neurobiologix

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

PEA Soothe Support is a dietary supplement by Neurobiologix with 2 active ingredients. Its ingredients are commonly taken for heart and blood vessel health, antioxidant support, anti-aging.Based on those ingredients, 822 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Resveratrol. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of PEA Soothe Support by Neurobiologix

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

PEA Soothe Support contains 2 active ingredients: resveratrol and palmitoylethanolamide (PEA). Resveratrol is a compound found in grapes, berries, and red wine; palmitoylethanolamide is a naturally occurring fatty acid that your body produces.

The capsules also contain inactive ingredients—hypromellose, ascorbyl palmitate, silicon dioxide, and microcrystalline cellulose—which are binders and capsule materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Reduce inflammation and support nerve health.
  • We looked for evidence on: Neuropathic pain, Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Fibromyalgia, Complex regional pain syndrome, Sciatica, Carpal tunnel syndrome — and 4 related terms.
  • The strongest evidence on file: Palmitoylethanolamide (pea) is rated "Possibly Effective" for Osteoarthritis (Natural Medicines).
  • Also on file: Resveratrol is rated "Insufficient Reliable Evidence To Rate" for Osteoarthritis, Rheumatoid arthritis (RA), Sciatica.
  • Also on file: Palmitoylethanolamide (pea) is rated "Insufficient Reliable Evidence To Rate" for Carpal tunnel syndrome, Inflammatory bowel disease (IBD), Atopic dermatitis (eczema).

Resveratrol has possibly effective evidence for obesity and allergic rhinitis (hay fever), though the research is not definitive. It's rated possibly ineffective for cardiovascular disease and high cholesterol.

Palmitoylethanolamide (PEA) has possibly effective evidence for osteoarthritis. For other conditions listed in the product facts—spinal cord injury, cannabis use disorder, autism spectrum disorder, carpal tunnel syndrome, and migraine headache—the evidence for PEA is either insufficient or shows possible ineffectiveness.

The evidence, ingredient by ingredient Resveratrol Palmitoylethanolamide (pea)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Resveratrol is generally well tolerated at typical supplement doses. At higher doses, it may cause digestive upset, diarrhea, or loose stools; long-term safety at high doses isn't fully known.

Rare reports include headache, fatigue, and in one case, a skin rash that cleared after stopping. Palmitoylethanolamide is also generally well tolerated, with nausea as the most common side effect, though it's been reported rarely.

The safety data advises against both ingredients during pregnancy and breastfeeding, as there isn't enough information to know they're safe in those situations—talk with your doctor or pharmacist for personalized advice if you're pregnant or nursing.

Side effects, ingredient by ingredient Resveratrol Palmitoylethanolamide (pea)

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Resveratrol.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 823 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start, check with your pharmacist if you take blood thinners or antiplatelet drugs like warfarin, aspirin, or clopidogrel—resveratrol may increase bleeding risk. You should also double-check any medications broken down by your liver (CYP2C19, CYP1A2, CYP3A4, or CYP2E1 substrates), as resveratrol may raise their blood levels.

Use the medication checker below to look up your specific drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

PEA Soothe Support may be worth considering if you're looking at resveratrol for obesity or hay fever, or PEA for osteoarthritis support. If you take any blood thinners, antiplatelet drugs, or medications metabolized by your liver, check with your pharmacist before starting this product—the resveratrol interaction is real.

Pregnant or breastfeeding? Talk to your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about PEA Soothe Support, straight from the product label.

Brand Neurobiologix
Barcode (UPC) 854998006502
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 327698
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for PEA Soothe Support by Neurobiologix, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
854998006502
IngredientAmount% DV
Resveratrol50 mg--
Pamitoylethanolamide350 mg--

Other ingredients: Hypromellose, Ascorbyl Palmitate, Silicon Dioxide, Microcrystalline Cellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Take 1 capsule twice daily or as directed by your healthcare practitioner.

Formula

Palmitoylethanolamide (PEA) is a bio-identical fatty acid amide that is normally synthesized by healthy tissue in the human body in response to inflammation. PEA is made by various plants and animals and is present throughout the animal kingdom. PEA can be found in many different tissues including glia, neurons, retina, white blood cells, mast cells and adipocytes.

Formulation

Supplementing with PEA has been scientifically shown to naturally assist in the reduction of inflammation and to have neuro-protective and possibly pain control effects.

Exclusive formula Enhanced formula Professional grade

Non GMO Palmitoylethanolamide

Gluten free

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Precautions

Caution: Keep out of reach of children. Consult with your healthcare practitioner on proper dosage for children under 5 years of age.

If you are pregnant or nursing please consult with your healthcare practitioner.

Professional use only

Seals/Symbols

GMP Good Manufacturing Practice Consistent Quality

FDA Statement of Identity

Dietary Supplement

See for yourself

PEA Soothe Support by Neurobiologix label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in PEA Soothe Support by Neurobiologix

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Resveratrol

Interacts with
822 drugs
50 mg per serving Form: Polygonum cuspidatum Root Extract

Resveratrol is a plant compound found in red grapes, berries, and peanuts that is popular for heart health, anti-aging, and antioxidant support. While...

Resveratrol monograph & interactions

Pamitoylethanolamide

No known
interactions
350 mg per serving

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...

Pamitoylethanolamide monograph & interactions

Other (inactive) ingredients: Hypromellose, Ascorbyl Palmitate, Silicon Dioxide, Microcrystalline Cellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

PEA Soothe Support by Neurobiologix Drug Interactions

Want to check YOUR meds against PEA Soothe Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
822Drugs
822 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in PEA Soothe Support with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Resveratrol5 drug types · 822 drugs

Anticoagulant/Antiplatelet Drugs

Resveratrol may have antiplatelet effects and may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Resveratrol seems to have antiplatelet effects.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP1A2.
In vitro research shows that resveratrol can inhibit CYP1A2 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP2C19.
In vitro research shows that resveratrol can inhibit CYP2C19 enzymes. However, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Resveratrol might increase levels of drugs metabolized by CYP2E1.
In vitro research suggests that resveratrol inhibits CYP2E1 isoenzyme. Also, a pharmacokinetic study shows that taking resveratrol 500 mg daily for 10 days prior to taking a single dose of chlorzoxazone 250 mg increases the maximum concentration of chlorzoxazone by about 54%, the area under the curve of chlorzoxazone by about 72%, and the half-life of chlorzoxazone by about 35%. Chlorzoxazone is used as a probe drug for CYP2E1.

Likelihood Probable Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, resveratrol might increase levels of drugs metabolized by CYP3A4.
In vitro research shows that resveratrol can inhibit the CYP3A4 enzyme. However, clinical research shows that taking resveratrol 3000 mg daily for 8 weeks does not necessitate dose adjustments to medications metabolized by CYP3A4.

Likelihood Possible Evidence D
The maker

Brand information

Manufacturer and brand details for PEA Soothe Support, from the product label.

Neurobiologix

See all Neurobiologix products
Name
Neurobiologix, Inc.
Street Address
13376 N. Hwy 183, Ste 126
City
Austin
State
TX
ZipCode
78750
Phone Number
866-500-5388
Web Address
www.neurobiologix.com
Pharmacist Counseling Corner

PEA Soothe Support by Neurobiologix: Common Questions

Does PEA Soothe Support by Neurobiologix interact with any medications?
Yes. Based on its ingredients, PEA Soothe Support has a known interaction with 822 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
PEA Soothe Support contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is palmitoylethanolamide (PEA)?
PEA is a fatty acid your body makes naturally. In this supplement, it's an active ingredient studied for conditions like osteoarthritis. When used as a concentrated supplement, it's generally well tolerated, though nausea is the most commonly reported side effect.
Can I take this if I'm on aspirin or another blood thinner?
Not without talking to your pharmacist first. Resveratrol in this product may increase bleeding risk when combined with blood thinners or antiplatelet drugs like warfarin, aspirin, or clopidogrel. You need a professional to weigh the risk for your specific situation.
What side effects might resveratrol cause?
At typical supplement doses, it's generally well tolerated. Higher doses may cause digestive upset, diarrhea, or loose stools. Rare reports include headache, fatigue, and skin rash. If you experience any of these, stop and talk to your pharmacist.
Is this safe to use while pregnant or breastfeeding?
There isn't enough safety information for either ingredient to recommend them during pregnancy or breastfeeding. Talk with your doctor or pharmacist about whether this product is right for you in those situations.
Does this work for weight loss?
Resveratrol has possibly effective evidence for obesity, meaning the research suggests a potential benefit but isn't definitive. The science isn't conclusive, so results aren't guaranteed. It's one tool to consider alongside diet and exercise, not a replacement for them.
Will this affect my other medications?
Resveratrol can theoretically raise blood levels of many drugs broken down by your liver. The real impact depends on the dose in this product and your specific medications. Use the medication checker on this page to look up your prescriptions, and talk to your pharmacist if anything comes up.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if PEA Soothe Support is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

PEA Soothe Support label
Sources

Sources & How We Checked

PEA Soothe Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 28 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Resveratrol 24 references
  1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem 1997;30:91-113.
  2. Pace-Asciak CR, Rounova O, Hahn SE, et al. Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clin Chim Acta 1996;246:163-82. PubMed
  3. Bertelli AA, Giovannini L, Bernini W, et al. Antiplatelet activity of cis-resveratrol. Drugs Exp Clin Res 1996;22:61-3.
  4. Pace-Asciak CR, Hahn S, Diamandis EP, et al. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease. Clin Chim Acta 1995;235:207-19.
  5. Bertelli A, Bertelli AA, Gozzini A, Giovannini L. Plasma and tissue resveratrol concentrations and pharmacological activity. Drugs Exp Clin Res 1998;24:133-8.
  6. Bertelli AA, Giovannini L, Giannessi D, et al. Antiplatelet activity of synthetic and natural resveratrol in red wine. Int J Tissue React 1995;17:1-3.
  7. Piver B, Berthou F, Dreano Y, Lucas D. Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components. Toxicol Lett 2001;125:83-91. PubMed
  8. Chang, T. K., Chen, J., and Lee, W. B. Differential inhibition and inactivation of human CYP1 enzymes by trans-resveratrol: evidence for mechanism-based inactivation of CYP1A2. J.Pharmacol.Exp.Ther. 2001;299(3):874-882.
  9. Dobrydneva, Y., Williams, R. L., and Blackmore, P. F. trans-Resveratrol inhibits calcium influx in thrombin-stimulated human platelets. Br.J.Pharmacol. 1999;128(1):149-157.
  10. Kirk, R. I., Deitch, J. A., Wu, J. M., and Lerea, K. M. Resveratrol decreases early signaling events in washed platelets but has little effect on platalet in whole food. Blood Cells Mol.Dis. 2000;26(2):144-150.
  11. Zbikowska, H. M. and Olas, B. Antioxidants with carcinostatic activity (resveratrol, vitamin E and selenium) in modulation of blood platelet adhesion. J Physiol Pharmacol. 2000;51(3):513-520.
  12. Olas, B., Wachowicz, B., Saluk-Juszczak, J., and Zielinski, T. Effect of resveratrol, a natural polyphenolic compound, on platelet activation induced by endotoxin or thrombin. Thromb.Res 8-15-2002;107(3-4):141-145. PubMed
  13. Yu, C., Shin, Y. G., Kosmeder, J. W., Pezzuto, J. M., and van Breemen, R. B. Liquid chromatography/tandem mass spectrometric determination of inhibition of human cytochrome P450 isozymes by resveratrol and resveratrol-3-sulfate. Rapid Commun.Mass Spectro PubMed
  14. Ma, Z. H. and Ma, Q. Y. Resveratrol: a medical drug for acute pancreatitis. World J Gastroenterol. 6-7-2005;11(21):3171-3174. PubMed
  15. la, Porte C., Voduc, N., Zhang, G., Seguin, I., Tardiff, D., Singhal, N., and Cameron, D. W. Steady-State pharmacokinetics and tolerability of trans-resveratrol 2000 mg twice daily with food, quercetin and alcohol (ethanol) in healthy human subjects. Cli PubMed
  16. Brown, V. A., Patel, K. R., Viskaduraki, M., Crowell, J. A., Perloff, M., Booth, T. D., Vasilinin, G., Sen, A., Schinas, A. M., Piccirilli, G., Brown, K., Steward, W. P., Gescher, A. J., and Brenner, D. E. Repeat dose study of the cancer chemopreventive
  17. Pendurthi, U. R., Williams, J. T., and Rao, L. V. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells : A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. PubMed
  18. Chachay VS, Macdonald GA, Martin JH, Whitehead JP, O'Moore-Sullivan TM, Lee P, Franklin M, Klein K, Taylor PJ, Ferguson M, Coombes JS, Thomas GP, Cowin GJ, Kirkpatrick CM, Prins JB, Hickman IJ. Resveratrol does not benefit patients with nonalcoholic fatty
  19. Bedada SK, Neerati P. Resveratrol Pretreatment Affects CYP2E1 Activity of Chlorzoxazone in Healthy Human Volunteers. Phytother Res. 2016;30(3):463-8. PubMed
  20. Lin CT, Sun XY, Lin AX. Supplementation with high-dose trans-resveratrol improves ultrafiltration in peritoneal dialysis patients: a prospective, randomized, double-blind study. Ren Fail. 2016;38(2):214-21. PubMed
  21. Li Q, Yang G, Xu H, Tang S, Lee WY. Effects of resveratrol supplementation on bone quality: a systematic review and meta-analysis of randomized controlled trials. BMC Complement Med Ther 2021;21(1):214. PubMed
  22. McCreary MR, Schnell PM, Rhoda DA. Randomized double-blind placebo-controlled proof-of-concept trial of resveratrol for outpatient treatment of mild coronavirus disease (COVID-19). Sci Rep 2022;12(1):10978. PubMed
  23. Abdelhaleem IA, Brakat AM, Adayel HM, Asla MM, Rizk MA, Aboalfetoh AY. The effects of resveratrol on glycemic control and cardiometabolic parameters in patients with T2DM: A systematic review and meta-analysis. Med Clin (Barc) 2022;158(12):576-585. PubMed
  24. Badaoui A. Allergic contact dermatitis to resveratrol and Scutellaria baicalensis root extract in a cosmetic product. Contact Dermatitis 2022.

See these in context on the Resveratrol monograph →

Palmitoylethanolamide (pea) 4 references
  1. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
  2. Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
  3. Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
  4. Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed

See these in context on the Palmitoylethanolamide (pea) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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