No known drug interactions for the matched ingredients — not a guarantee none exist. Check your meds →
Dietary supplement

Comfort Support Ingredients & Drug Interactions

by GNC Preventive Nutrition

Comfort Support label
See full label image
Capsule Category: Fat/fatty Acid
No known interaction
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Comfort Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line No known interaction

Comfort Support is a dietary supplement by GNC Preventive Nutrition with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.

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HelloPharmacist Scorecard of Comfort Support by GNC Preventive Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Comfort Support contains one active ingredient: Palmitoylethanolamide (PEA), marketed here as Levagen Palmitic Acid Monoethanolamide. It's a naturally occurring compound in the body that some research suggests may help with joint discomfort and inflammation.

The capsule also holds several inactive ingredients — cellulose, gelatin, povidone, polysorbate 80, magnesium stearate, stearic acid, and silica — which are standard fillers and binders.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Palmitoylethanolamide (pea)'s own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support body's natural anti-inflammatory response.
  • We looked for evidence on: Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Complex regional pain syndrome, Diabetic neuropathy, Dysmenorrhea, Endometriosis, Fibromyalgia — and 4 related terms.
  • The closest evidence on file: Palmitoylethanolamide (pea) is rated "Insufficient Reliable Evidence To Rate" for Migraine headache (Natural Medicines).
  • Also on file: Palmitoylethanolamide (pea) is rated "Insufficient Reliable Evidence To Rate" for Inflammatory bowel disease (IBD), Diabetic neuropathy, Fibromyalgia, Interstitial cystitis, and more.

The evidence for Palmitoylethanolamide is mixed and incomplete. For osteoarthritis, the data suggests it's possibly effective — meaning there's some promise, but the evidence isn't conclusive.

For spinal cord injury, the available research points toward it being possibly ineffective. As for cannabis use disorder, autism spectrum disorder, carpal tunnel syndrome, and migraine headache, we don't have enough reliable evidence in our data to rate how well it works.

If you're considering Comfort Support for any of these conditions, talk it over with your doctor to see if the current evidence matches your needs.

The evidence, ingredient by ingredient Palmitoylethanolamide (pea)

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Palmitoylethanolamide is generally well tolerated in the studies we have, though long-term safety data are limited, so caution is warranted if you're thinking about taking it for months or years. The most common side effect reported orally is nausea, which has been rare and mild when it does occur.

A few people in trials reported mild, short-lived stomach symptoms. The safety data advises against use during pregnancy and while breastfeeding due to insufficient information — talk with your doctor or pharmacist if you're pregnant, planning to become pregnant, or nursing and wondering whether this product is right for you.

Side effects, ingredient by ingredient Palmitoylethanolamide (pea)

Meds to double-check

No known interactions
Known Interaction Concern · database check
No known interactions

No medication interactions are currently documented for the matched ingredients — that isn't a guarantee none exist.

Why this rating?
  • None of the 1 matched ingredient has a documented medication interaction on file.

No interactions are documented in our data for the ingredients we could check. Before taking Comfort Support, check your exact medications with the tool on this page and discuss the product with your doctor or pharmacist to make sure it's appropriate for you.

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. No medication interactions are currently documented, and safety information is well characterized.

Comfort Support may be worth considering if you have osteoarthritis and want to explore a supplement with some research behind it, though the evidence is still emerging. If you're taking any medications, run them through the interaction checker on this page and confirm with your doctor or pharmacist that it fits your health picture.

Avoid it during pregnancy and breastfeeding unless your healthcare provider advises otherwise, and keep in mind that long-term safety data are limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Comfort Support, straight from the product label.

Brand GNC Preventive Nutrition
Barcode (UPC) 048107161712
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Nov 21, 2016
DSLD ID 67178
Product type Fat/fatty Acid
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Comfort Support by GNC Preventive Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
048107161712
IngredientAmount% DV
Levagen Palmitic Acid Monoethanolamide150 mg--

Other ingredients: Cellulose, Gelatin, Povidone, Polysorbate 80, Magnesium Stearate, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Keep out of reach of children.

Warning: Consult your physician prior to using this product if you are pregnant, nursing, taking medication, or have a medical condition.

Discontinue use two weeks prior to surgery. For adult use only.

Storage

Store in a cool, dry place.

General Statements

New

Physician formulated nutrition solutions - Clinically proven to support the body's natural anti-inflammatory response

Conforms to USP <2091> for weight. Meets USP <2040> disintegration.

This product is endorsed by the physicians on the GNC Medical Advisory Board.

Formula

Powered by Levagen

Seals/Symbols

Physician endorsed

GF Gluten free

FDA Statement of Identity

Dietary Supplement

General

CODE 619621 JQG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one capsule twice daily.

Formulation

No Sugar, no Starch, no Artificial Colors, no Artificial Flavors, Sodium free, no Wheat, Gluten free, no Corn, no Soy, no Dairy, Yeast free.

Brand IP Statement(s)

Levagen is a trademark of Gencor.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Comfort Support by GNC Preventive Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Comfort Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Comfort Support by GNC Preventive Nutrition

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Levagen Palmitic Acid Monoethanolamide

No known
interactions
150 mg per serving

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...

Levagen Palmitic Acid Monoethanolamide monograph & interactions

Other (inactive) ingredients: Cellulose, Gelatin, Povidone, Polysorbate 80, Magnesium Stearate, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

Comfort Support by GNC Preventive Nutrition Drug Interactions

We don’t currently list any known drug interactions for the mapped ingredients in Comfort Support. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.

The maker

Brand information

Manufacturer and brand details for Comfort Support, from the product label.

GNC Preventive Nutrition

See all GNC Preventive Nutrition products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Comfort Support by GNC Preventive Nutrition: Common Questions

Does Comfort Support by GNC Preventive Nutrition interact with any medications?
We do not currently list a known interaction for the mapped ingredients in Comfort Support. This does not guarantee none exist, so confirm with your pharmacist.
How can one product interact with so many drugs?
Comfort Support contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Palmitoylethanolamide (PEA) and what does it do?
Palmitoylethanolamide is a compound your body makes naturally. In Comfort Support, it's included because some research suggests it may help ease joint discomfort and inflammation, particularly in osteoarthritis. The evidence is still developing, so talk with your doctor about whether it's the right choice for your situation.
Does Comfort Support actually work for arthritis?
For osteoarthritis specifically, the evidence suggests it's possibly effective — meaning there's some research support, but it's not definitive. For other conditions listed on the label, the evidence is either inconclusive or points toward limited benefit. Your doctor can help you decide if it's worth trying given your own symptoms.
Can I take Comfort Support if I'm pregnant or breastfeeding?
The safety data advise against use during pregnancy and while breastfeeding because there isn't enough information to know whether it's safe. If you're pregnant, planning to become pregnant, or nursing, talk with your doctor or pharmacist before starting this product.
What are the side effects?
Palmitoylethanolamide is generally well tolerated. The most common side effect is nausea, though it's been rare and mild when it occurs. A small number of people reported mild, short-lived stomach discomfort. Most people don't experience any problems, but everyone is different — if you notice unusual symptoms, stop taking it and let your pharmacist or doctor know.
Will Comfort Support interact with my medications?
No interactions are documented in our data for Palmitoylethanolamide with the medications we've checked. That said, check your exact prescriptions and over-the-counter drugs using the interaction tool on this page, and ask your doctor or pharmacist if you have any concerns about combining it with your regimen.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Comfort Support is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Comfort Support label
Go deeper

The Full Monographs Behind Comfort Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Palmitoylethanolamide (pea)

Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it may help certain types of chronic and ne...

Read the full Palmitoylethanolamide (pea) monograph →
Sources

Sources & How We Checked

Comfort Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 4 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Palmitoylethanolamide (pea) 4 references
  1. Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
  2. Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
  3. Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
  4. Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed

See these in context on the Palmitoylethanolamide (pea) monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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