Palmitoylethanolamide Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Palmitoylethanolamide against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Palmitoylethanolamide is a dietary supplement by Nootropics Depot with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of Palmitoylethanolamide by Nootropics Depot
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: palmitoylethanolamide (often called PEA). It's a fatty acid compound that your body naturally produces.
The powder form lets you measure your own dose. There are no inactive ingredients listed in the formulation.
Does it work?
Moderate evidence
The evidence for palmitoylethanolamide is mixed. It's rated possibly effective for osteoarthritis, meaning some studies support it but the evidence isn't conclusive.
For spinal cord injury, the data suggest it's probably not effective. For cannabis use disorder, autism spectrum disorder, carpal tunnel syndrome, and migraine headache, we don't have enough reliable evidence yet to say whether it works.
How safe is it?
Well-documented data
Palmitoylethanolamide is generally well tolerated in studies, though long-term safety data are limited. The most common side effect when taken by mouth is nausea, and it's been rarely reported to cause mild, temporary stomach symptoms.
When applied to skin, a small number of trial participants experienced itching, stinging, scaling, or redness with dry skin, but these didn't happen more often than with plain lotion alone. There isn't enough safety information to recommend it during pregnancy or breastfeeding.
If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this supplement.
Meds to double-check
No known interactions
No interactions are documented for palmitoylethanolamide in our data. Even so, it's smart to confirm with your doctor or pharmacist that it won't interfere with anything you're currently taking.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. No medication interactions are currently documented, and safety information is well characterized.
Palmitoylethanolamide may be worth considering if you're exploring options for osteoarthritis, though the evidence is still developing. It's generally well tolerated, but long-term safety data are sparse.
If you're pregnant, breastfeeding, or taking any medications, check with your own doctor or pharmacist before you start.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Palmitoylethanolamide, straight from the product label.
| Brand | Nootropics Depot |
|---|---|
| Net contents | 60 Gram(s); 2.11 Ounce(s) |
| Market status | On market |
| Date entered into DSLD | Aug 23, 2020 |
| DSLD ID | 232453 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Powder |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Women (not pregnant or lactating) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Palmitoylethanolamide by Nootropics Depot, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Palmitoylethanolamide | 400 mg | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity
Dietary Supplement
Precautions
Disclaimer: Always consult with a qualified health physician before taking any new dietary supplement.
Warning: Keep out of reach of children. Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).
Do not take this or any other supplement if under the age of 18, pregnant or nursing a baby, or if you have any known or suspected medical conditions, and/or taking prescription drug(s) or OTC medication(s).
FDA Disclaimer Statement
This product is not intended to diagnose, treat, cure or prevent any diseases. These statements have not been evaluated by the Food & Drug Administration.
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement, take 400mg once daily.
General Statements
Transfer scoops are not accurate forms of measurement. A milligram scale is needed to accurately measure dosages.
Storage
Storage: Store in a cool and dry place. Keep away from direct sunlight and heat.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Palmitoylethanolamide by Nootropics Depot label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Palmitoylethanolamide by Nootropics Depot
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size0.4 Gram(s) Dosage formPowder Servings per container150 Amounts shown are per serving.
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsPalmitoylethanolamide by Nootropics Depot Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in Palmitoylethanolamide. This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for Palmitoylethanolamide, from the product label.
Nootropics Depot
See all Nootropics Depot products- Name
- Nootropics Depot
- Street Address
- 8380 S. Kyrene Rd. Ste. 110
- City
- Tempe
- State
- AZ
- ZipCode
- 85284
- Web Address
- nootropicsdepot.com
Palmitoylethanolamide by Nootropics Depot: Common Questions
Does Palmitoylethanolamide by Nootropics Depot interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this while pregnant or breastfeeding?
What is palmitoylethanolamide used for?
What are the side effects?
How long has this ingredient been studied?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Palmitoylethanolamide is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Palmitoylethanolamide’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Palmitoylethanolamide's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 4 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 4 references
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC