PEA (Palmitoylethanolamide) Ingredients & Drug Interactions
What is this page for?
First and foremost: checking PEA (Palmitoylethanolamide) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PEA (Palmitoylethanolamide) is a dietary supplement by Lake Avenue Nutrition with 1 active ingredient. Its ingredients are commonly taken for chronic pain, nerve (neuropathic) pain, inflammation.We don’t currently list a known drug interaction for its mapped ingredients — but that doesn’t guarantee none exist, so always confirm with your pharmacist.
HelloPharmacist Scorecard of PEA (Palmitoylethanolamide) by Lake Avenue Nutrition
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
This product contains one active ingredient: palmitoylethanolamide (PEA), a naturally occurring fatty acid compound your body produces. The capsule also holds several inactive ingredients — modified cellulose, modified vegetable starch, rice, rice extract, gum arabic, sunflower oil, and silicon dioxide — which serve as fillers and binders.
Does it work?
Moderate evidence
The evidence for PEA is mixed. It's rated possibly effective for osteoarthritis, meaning some studies show promise, though the data aren't conclusive.
For spinal cord injury, it's rated possibly ineffective. The evidence isn't established for hay fever, ALS, autism spectrum disorder, and bipolar disorder — we simply don't have enough reliable studies to know either way.
How safe is it?
Well-documented data
PEA is generally well tolerated in studies, but long-term safety data are limited, so we don't know how it holds up over years of use. The most common side effect reported orally is nausea.
A small number of trial participants reported drowsiness or a floating sensation, and mild, short-lived digestive symptoms have rarely been noted. Don't use this product during pregnancy or while breastfeeding — there isn't enough safety information to know either way.
Talk with your doctor or pharmacist for personalized guidance if you're pregnant, nursing, or planning to become pregnant.
Meds to double-check
No known interactions
No interactions are documented in our data for the ingredient we checked. That said, always confirm your exact medications with your doctor or pharmacist before taking any new supplement, especially if you're on prescription drugs.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. No medication interactions are currently documented, and safety information is well characterized.
PEA may be worth considering if you have osteoarthritis and want to explore a natural option, though the evidence is still developing. If you're pregnant, breastfeeding, or take any medications, check with your doctor or pharmacist before starting.
Nausea is the most commonly reported side effect, and long-term safety data are sparse.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PEA (Palmitoylethanolamide), straight from the product label.
| Brand | Lake Avenue Nutrition |
|---|---|
| Barcode (UPC) | 898220015962 |
| Net contents | 365 Veggie Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Nov 22, 2023 |
| DSLD ID | 299369 |
| Product type | Non-nutrient/non-botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PEA (Palmitoylethanolamide) by Lake Avenue Nutrition, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Palmitoylethanolamide | 600 mg | -- |
Other ingredients: Modified Cellulose, modified Vegetable Starch, Rice, Rice extract, Gum Arabic, Sunflower Oil, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Suggested use: Take 2 capsules daily with food, or as recommended by a healthcare practitioner.
Formulation
Formulated without: GMOs, gluten or soy.
Supports relief from occasional minor discomfort
Not manufactured with milk, egg, fish, crustacean, shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten.
Precautions
Warnings: Keep out of reach of children.
As with all dietary supplements, it is recommended to consult with a healthcare professional before adding something new to your health and wellness regimen. Sealed for your protection. Do not use if seal is missing or broken.
Not manufactured with milk, egg, fish, crustacean, shellfish, tree nuts, peanuts, wheat, soy, sesame, or gluten. Produced in a third-party, audited and registered cGMP compliant facility that may process other products that contain these allergens or ingredients.
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Lake Avenue Nutrition is a registered trademark of Madre Labs, LLC
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PEA (Palmitoylethanolamide) by Lake Avenue Nutrition label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PEA (Palmitoylethanolamide) by Lake Avenue Nutrition
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container183 Amounts shown are per serving.
Palmitoylethanolamide
No knowninteractions
Palmitoylethanolamide (PEA) is a fat-like molecule made naturally in the body and studied mainly for pain and inflammation. Some research suggests it...
Palmitoylethanolamide monograph & interactionsOther (inactive) ingredients: Modified Cellulose, Modified Vegetable Starch, Rice, Rice extract, Gum Arabic, Sunflower Oil, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
PEA (Palmitoylethanolamide) by Lake Avenue Nutrition Drug Interactions
We don’t currently list any known drug interactions for the mapped ingredients in PEA (Palmitoylethanolamide). This doesn’t guarantee none exist — always confirm with your pharmacist before combining a supplement with your medications.
Brand information
Manufacturer and brand details for PEA (Palmitoylethanolamide), from the product label.
Lake Avenue Nutrition
See all Lake Avenue Nutrition products- Name
- Madre Labs, LLC
- Street Address
- 301 N. Lake Ave., Ste. 500
- City
- Pasadena
- State
- CA
- ZipCode
- 91101
- Web Address
- lakeavenuenutrition.com
PEA (Palmitoylethanolamide) by Lake Avenue Nutrition: Common Questions
Does PEA (Palmitoylethanolamide) by Lake Avenue Nutrition interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is palmitoylethanolamide (PEA)?
Can I take this while I'm pregnant?
Is PEA effective for all the conditions listed?
What side effects should I watch for?
Is this safe to take long-term?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PEA (Palmitoylethanolamide) is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PEA (Palmitoylethanolamide)’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
PEA (Palmitoylethanolamide)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 5 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Palmitoylethanolamide (pea) 5 references
- Bacci C, Cassetta G, Emanuele B, Berengo M. Randomized split-mouth study on postoperative effects of palmitoylethanolamide for impacted lower third molar surgery. ISRN Surg. 2011;2011:917350. PubMed
- Indraccolo U, Barbieri F. Effect of palmitoylethanolamide-polydatin combination on chronic pelvic pain associated with endometriosis: preliminary observations. Eur J Obstet Gynecol Reprod Biol. 2010 May;150(1):76-9. PubMed
- Murina F, Graziottin A, Felice R, Radici G, Tognocchi C. Vestibulodynia: synergy between palmitoylethanolamide + transpolydatin and transcutaneous electrical nerve stimulation. J Low Genit Tract Dis. 2013 Apr;17(2):111-6.
- Papetti L, Sforza G, Tullo G, et al. Tolerability of palmitoylethanolamide in a pediatric population suffering from migraine: A pilot study. Pain Res Manag 2020;2020:3938640. PubMed
- Visse K, Blome C, Phan NQ, Augustin M, Ständer S. Efficacy of body lotion containing N-palmitoylethanolamine in subjects with chronic pruritus due to dry skin: A dermatocosmetic study. Acta Derm Venereol. 2017;97(5):639-641. PubMed
See these in context on the Palmitoylethanolamide (pea) monograph →
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC