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Dietary supplement

Optimal Choline Complex Ingredients & Drug Interactions

by Pure Nootropics

Optimal Choline Complex label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Optimal Choline Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Optimal Choline Complex is a dietary supplement by Pure Nootropics with 2 active ingredients. Its ingredients are commonly taken for memory and learning support, age-related cognitive decline, alzheimer's disease and dementia (under study).Based on those ingredients, 16 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Alpha-Glycerylphosphorylcholine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Optimal Choline Complex by Pure Nootropics

Ask about any prescription or over-the-counter medication and we check it for interactions with Optimal Choline Complex by Pure Nootropics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Optimal Choline Complex by Pure Nootropics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains 2 active ingredients. Alpha-GPC (alpha-glycerylphosphorylcholine) is a compound that provides choline to your brain and nervous system.

Citicoline is another choline-supporting compound that works similarly. Both are meant to support brain function and memory.

The capsules also contain several inactive ingredients — hypromellose, dicalcium phosphate dihydrate, silicon dioxide, and stearate — which are standard binders and fillers.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports overall brain function cognition memory concentration.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Stroke, Vascular dementia — and 4 related terms.
  • The strongest evidence on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Citicoline is rated "Possibly Effective" for Age-related cognitive decline.
  • Also on file: Citicoline is rated "Possibly Ineffective" for Stroke.

Alpha-GPC is possibly effective for Alzheimer disease based on the evidence we have. For cognitive function, brain tumors, vascular dementia, and stroke, the evidence isn't strong enough to rate it one way or another.

Citicoline is possibly effective for age-related cognitive decline and glaucoma. For Alzheimer disease, traumatic brain injury, and cardiac arrest, we don't have enough reliable evidence to say.

For stroke, current evidence suggests it may not help.

The evidence, ingredient by ingredient Alpha-gpc Citicoline

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Both ingredients are generally well tolerated in studies, but long-term safety data isn't fully established. Alpha-GPC is rarely associated with dizziness, headache, insomnia, nausea, vomiting, diarrhea, and heartburn when taken by mouth.

A rare but serious concern: oral alpha-GPC used for at least 2 months has been rarely linked to stroke compared with non-users or shorter-term users. Citicoline may cause similar mild side effects — headache, insomnia, nausea, diarrhea, and back pain — in some patients.

There isn't enough safety data for either ingredient during pregnancy or breastfeeding, so it's best to avoid both unless your doctor advises otherwise.

Side effects, ingredient by ingredient Alpha-gpc Citicoline

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Alpha-gpc.
  • The most serious interaction on file is rated Minor.
  • For scale: 16 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take scopolamine (Transderm Scop), a motion sickness patch, let your pharmacist know — alpha-GPC may weaken how well it works. For any other prescription medications, use the interaction checker below to be sure.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

This product may be worth considering if you're interested in brain health support, especially for age-related memory changes — though evidence is mixed on how well it works. If you're pregnant, breastfeeding, or using scopolamine or other prescription medications, talk with your pharmacist or doctor first.

The long-term safety picture isn't complete, so check in with us before starting if you have any health concerns.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Optimal Choline Complex, straight from the product label.

Brand Pure Nootropics
Barcode (UPC) 865441000008
Net contents 60 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 316597
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Optimal Choline Complex by Pure Nootropics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
865441000008
IngredientAmount% DV
Alpha-Glycerylphosphorylcholine100 mg--
Citicoline200 mg--

Other ingredients: Hypromellose, Dicalcium Phosphate Dihydrate, Silicon Dioxide, Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take 1 capsule up to two times per day or as recommended by your healthcare practitioner.

Precautions

Warning: Consult with a healthcare practitioner before taking this.

Do not take this if you are pregnant, nursing or under the age of 18.

Do not take this if you are pregnant, nursing or under the age of 18.

If you experience adverse reactions from taking this product, discontinue immediately and contact a healthcare practitioner.

Keep out of reach of children.

Formulation

Cognition Concentration Memory

Supports Overall Brain Function

Always Non-GMO Preservative Free Gluten Free

General Statements

Unlock your potential

FDA Statement of Identity

Dietary Supplement

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Storage

Store in a cool, dry place.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Optimal Choline Complex by Pure Nootropics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Optimal Choline Complex label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Optimal Choline Complex by Pure Nootropics

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Alpha-Glycerylphosphorylcholine

Interacts with
16 drugs
100 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-Glycerylphosphorylcholine monograph & interactions

Citicoline

No known
interactions
200 mg per serving

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken f...

Citicoline monograph & interactions

Other (inactive) ingredients: Hypromellose, Dicalcium Phosphate Dihydrate, Silicon Dioxide, Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Optimal Choline Complex by Pure Nootropics Drug Interactions

Want to check YOUR meds against Optimal Choline Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
16Drugs
16 Minor

Ingredients driving the most interactions

Alpha-Glycerylphosphorylcholine 16

Individual Drug Interactions

The ingredients in Optimal Choline Complex interact with 16 drugs. Click any drug to see the details.

1 of the 2 ingredients in Optimal Choline Complex interact with drugs. Each result below shows which ingredient is responsible. Alpha-Glycerylphosphorylcholine

Each ingredient & the kinds of drugs it affects

For each ingredient in Optimal Choline Complex with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Alpha-Glycerylphosphorylcholine1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-Glycerylphosphorylcholine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Optimal Choline Complex, from the product label.

Pure Nootropics

See all Pure Nootropics products
Name
Pure Nootropics, LLC
Street Address
P.O. Box 6827
City
Albuquerque
State
NM
ZipCode
87197
Web Address
purenootropics.net
Pharmacist Counseling Corner

Optimal Choline Complex by Pure Nootropics: Common Questions

Does Optimal Choline Complex by Pure Nootropics interact with any medications?
Yes. Based on its ingredients, Optimal Choline Complex has a known interaction with 16 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Optimal Choline Complex contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this help my memory?
Alpha-GPC is possibly effective for Alzheimer disease. For general cognitive function and age-related memory loss, the evidence isn't strong enough yet to say for sure. Citicoline is possibly effective for age-related cognitive decline. Bottom line: there's some promise, but results vary.
Can I take this while pregnant or breastfeeding?
There isn't enough safety data for either ingredient during pregnancy or breastfeeding. The safety data advises against using them unless your doctor tells you to. Talk with your doctor or pharmacist for personalized advice based on your situation.
What are the common side effects?
Both ingredients are generally well tolerated. Rarely, alpha-GPC may cause dizziness, headache, insomnia, nausea, or diarrhea. Citicoline may cause similar mild effects like headache, insomnia, nausea, back pain, or diarrhea in some people. Most people don't experience these.
Is there anything serious I should know about?
Alpha-GPC has been rarely linked to stroke when used for at least 2 months. This is uncommon, but it's worth discussing with your doctor if you have stroke risk factors or take blood thinners.
What is citicoline for?
Citicoline is a compound that supports brain function and choline levels. It's possibly effective for age-related cognitive decline and glaucoma, though evidence for other brain conditions is still being studied.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Optimal Choline Complex label
Go deeper

The Full Monographs Behind Optimal Choline Complex’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Citicoline

Citicoline is a naturally occurring compound involved in making brain cell membranes and the messenger chemical acetylcholine. It is popularly taken for memory, focus, and brain aging, and s...

Read the full Citicoline monograph →
Sources

Sources & How We Checked

Optimal Choline Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Citicoline 11 references
  1. Spiers PA, Myers D, Hochanadel GS, et al. Citicoline improves verbal memory in aging. Arch Neurol 1996;53:441-8. PubMed
  2. Fioravanti M, Yanagi M. Cytidinediphosphocholine (CDP-choline) for cognitive and behavioural disturbances associated with chronic cerebral disorders in the elderly. Cochrane Database Syst Rev 2005;(2):CD000269. PubMed
  3. Conant R, Schauss AG. Therapeutic applications of citicoline for stroke and cognitive function in the elderly: A review of the literature. Altern Med Rev 2004;9:17-31.
  4. Warach, S., Pettigrew, L. C., Dashe, J. F., Pullicino, P., Lefkowitz, D. M., Sabounjian, L., Harnett, K., Schwiderski, U., and Gammans, R. Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 0 DOI
  5. Lukas, S. E., Kouri, E. M., Rhee, C., Madrid, A., and Renshaw, P. F. Effects of short-term citicoline treatment on acute cocaine intoxication and cardiovascular effects. Psychopharmacology.(Berl.) 2001;157(2):163-167. PubMed
  6. Dinsdale, J. R., Griffiths, G. K., Castello, J., Maddock, J., Ortiz, J. A., and Aylward, M. CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers. Arzneimittelforschung. 1983;33(7A):1061-1065.
  7. Clark BC, Georgekutty J, Berul CI. Myocardial ischemia secondary to synthetic cannabinoid (K2) use in pediatric patients. J Pediatr 2015;167(3):757-61.e1. PubMed
  8. Ghajar A, Gholamian F, Tabatabei-Motlagh M, et al. Citicoline (CDP-choline) add-on therapy to risperidone for treatment of negative symptoms in patients with stable schizophrenia: a double-blind, randomized placebo-controlled trial. Hum Psychopharmacol. 2
  9. Castagna A, Manzo C, Fabbo A, Lacava R, Ruberto C, Ruotolo G. The CITIMERIVA Study: CITIcoline plus MEmantina plus RIVAstigmine in Older Patients Affected with Alzheimer's Disease. Clin Drug Investig. 2021 Feb;41(2):177-182. PubMed
  10. Jeong H, Yoon S, Sung YH, et al. Effects of cytidine-5'-diphosphate choline on gray matter volumes in methamphetamine-dependent patients: A randomized, double-blind, placebo-controlled study. J Psychiatr Res 2021;143:215-221. PubMed
  11. Nakazaki E, Mah E, Sanoshy K, Citrolo D, Watanabe F. Citicoline and Memory Function in Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. J Nutr 2021;151(8):2153-2160. PubMed

See these in context on the Citicoline monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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