Drug & supplement interaction

Alpha-gpc + Methscopolamine Bromide

Methscopolamine Bromide brand name: Pamine.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Alpha-gpc has a minor interaction with Methscopolamine Bromide. Theoretically, alpha-GPC might decrease the effects of scopolamine.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Alpha-gpc and Methscopolamine Bromide

Here is the interaction we found between these two, with the evidence behind it.

Minor

SCOPOLAMINE (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.
Severity Minor Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version. Methscopolamine (Pamine) works by blocking acetylcholine, the body's signal for things like stomach acid, gut cramping, and saliva. Alpha-GPC does the opposite. It hands your body more raw material to make acetylcholine. So in theory, Alpha-GPC could push against what Pamine is trying to do and slightly soften its benefit.

In plain terms, you might notice Pamine working a little less well, for example a bit more stomach cramping or acid than usual. Honestly though, this is mostly theoretical and based on weak evidence with injected scopolamine, not Pamine pills, so it may not matter much in real life. I wouldn't stop either one on your own. Just mention to your pharmacist or doctor that you take both, and watch how you feel.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Alpha-gpc Also Interacts With Other Medications

Alpha-gpc has 15 minor known drug interactions in our database — the Methscopolamine Bromide one above is one of them. If you take anything else, check it against the full list below.

Minor 15 No known interaction 2,815 (incl. Methscopolamine Bromide)
Taking anything else?

Check Another of Your Medications Against Alpha-gpc

Covers the 2,830 medications we’ve checked against Alpha-gpc. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Methscopolamine Bromide

This page covers Alpha-gpc only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methscopolamine Bromide page lists 48 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Grapefruit (major), Henbane (major), Scopolia (major) and Angel's Trumpet (moderate).

By severity: 4 major · 32 moderate · 12 minor.

From our pharmacist’s overview on the Methscopolamine Bromide page

“Anyone prescribed methscopolamine (Pamine), an anticholinergic that quiets stomach cramping and acid, should treat this list with real vigilance, starting with the four entries rated major. Most of the ingredients here share the drug's own drying, gut-slowing chemistry, nightshade herbs like henbane among them, and stacking them can pi…”

Reviewed by 2 · Jul 18, 2026

Open the Methscopolamine Bromide interaction page

One more smart check

Taking Alpha-gpc as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,138 real supplement products containing Alpha-gpc, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Alpha-gpc. Your product may carry other ingredients that interact with Methscopolamine Bromide too, on top of Alpha-gpc — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Alpha-gpc and Methscopolamine Bromide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Alpha-gpc
Top 25%

#146 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methscopolamine Bromide
Steady interest

#1,897 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Alpha-gpc

What is Alpha-gpc?

Alpha-gpc
  • Memory and learning support
  • Age-related cognitive decline
  • Alzheimer's disease and dementia (under study)
  • Athletic and physical performance
  • Source of choline

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence in healthy people is limited. Talk to your pharmacist or doctor before starting it, especially if you take other medicines or have a health condition.

Read the full Alpha-gpc monograph & all interactions
Keep checking

Other Drugs & Alpha-gpc

Browse every other medication we’ve checked against Alpha-gpc — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
15Minor
2,814No known interaction
15 Minor 2,814 No interaction
Minor

15 interactions

No interaction 2,814 drugs checked — show the list

We also checked Alpha-gpc against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,814 medications checked with no known interaction — see the full Alpha-gpc list.

See the full Alpha-gpc interactions page
See every supplement checked against Methscopolamine Bromide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Alpha-gpc monograph › Uses, safety, and every drug interaction in one place Methscopolamine Bromide supplement interactions › Every supplement checked against Methscopolamine Bromide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Alpha-gpc and Methscopolamine Bromide Together: Common Questions

Can you take Alpha-gpc with Methscopolamine Bromide?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Alpha-gpc and Methscopolamine Bromide interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.